{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T18:50:17Z","timestamp":1793731817829,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.colsurfb.2024.114259","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T06:09:27Z","timestamp":1726726167000},"page":"114259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Facile fabrication of cedrol nanoemulsions with deep transdermal delivery ability and high safety for effective androgenic alopecia treatment"],"prefix":"10.1016","volume":"245","author":[{"given":"Bin","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiyao","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2681-0349","authenticated-orcid":false,"given":"Jing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.colsurfb.2024.114259_bib1","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1001\/jama.2020.19313","article-title":"Diagnosis and treatment of nonscarring hair loss in primary care in 2021","volume":"325","author":"Mirmirani","year":"2021","journal-title":"JAMA - J. Am. Med Assoc."},{"key":"10.1016\/j.colsurfb.2024.114259_bib2","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1002\/jcc.21224","article-title":"PACKMOL: a package for building initial configurations for molecular dynamics simulations","volume":"30","author":"Mart\u00ednez","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.colsurfb.2024.114259_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12020-017-1280-y","article-title":"Androgenetic alopecia: a review","volume":"57","author":"Lolli","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/j.colsurfb.2024.114259_bib4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/andr.13515","article-title":"Exploring rat corpus cavernosum alterations induced by finasteride treatment and withdrawal","volume":"12","author":"Diviccaro","year":"2024","journal-title":"Andrology"},{"key":"10.1016\/j.colsurfb.2024.114259_bib5","first-page":"3","article-title":"Food and medicine continuum\u2019 \u2013 why we should promote cross-cultural communication between the global East and West","volume":"14","author":"Heinrich","year":"2022","journal-title":"Chin. Herb. Med"},{"key":"10.1016\/j.colsurfb.2024.114259_bib6","first-page":"486","article-title":"Cancer treatment: from traditional Chinese herbal medicine to the liposome delivery system","volume":"1","author":"Fu","year":"2022","journal-title":"Acta Mater. Med."},{"key":"10.1016\/j.colsurfb.2024.114259_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2015.11.012","article-title":"Inhibitory activities of some traditional Chinese herbs against testosterone 5\u03b1-reductase and effects of Cacumen platycladi on hair re-growth in testosterone-treated mice","volume":"177","author":"Zhang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.colsurfb.2024.114259_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123948","article-title":"Synergistic treatment of androgenetic alopecia with follicular co-delivery of minoxidil and cedrol in metal\u2013organic frameworks stabilized by covalently cross-linked cyclodextrins","volume":"654","author":"He","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114259_bib9","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.phytochem.2019.03.009","article-title":"Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana","volume":"162","author":"Luo","year":"2019","journal-title":"Phytochemistry"},{"key":"10.1016\/j.colsurfb.2024.114259_bib10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.biopha.2016.07.022","article-title":"Hair growth promoting activity of cedrol isolated from the leaves of Platycladus orientalis","volume":"83","author":"Zhang","year":"2016","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114259_bib11","doi-asserted-by":"crossref","first-page":"42170","DOI":"10.1039\/C8RA08667B","article-title":"Hair growth promotion effect of cedrol cream and its dermatopharmacokinetics","volume":"8","author":"Zhang","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2024.114259_bib12","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1080\/17425247.2023.2244413","article-title":"Cedrol-loaded dissolvable microneedles based on flexible backing for promoting hair growth","volume":"20","author":"Zhou","year":"2023","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2024.114259_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.153666","article-title":"Temperature-responsive detachable microneedles integrated with minoxidil nanoparticle for effectively promoting hair regrowth","volume":"495","author":"Liao","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2024.114259_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules26061795","article-title":"Hair growth promoting activity of cedrol nanoemulsion in c57bl\/6 mice and its bioavailability","volume":"26","author":"Deng","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2024.114259_bib15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ajps.2022.04.003","article-title":"Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders","volume":"17","author":"Gu","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2024.114259_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e08938","article-title":"Physicochemical and biopharmaceutical aspects influencing skin permeation and role of SLN and NLC for skin drug delivery","volume":"8","author":"Souto","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.colsurfb.2024.114259_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111247","article-title":"Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia","volume":"137","author":"Fu","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114259_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119939","article-title":"Influence of polysorbates (Tweens) on structural and antimicrobial properties for microemulsions","volume":"590","author":"Guo","year":"2020","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114259_bib19","doi-asserted-by":"crossref","first-page":"8230","DOI":"10.1021\/acs.langmuir.8b00658","article-title":"Biomedical platform development of a chlorophyll-based extract for topic photodynamic therapy: mechanical and spectroscopic properties","volume":"34","author":"Campanholi","year":"2018","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2024.114259_bib20","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1\u20132","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.colsurfb.2024.114259_bib21","doi-asserted-by":"crossref","DOI":"10.1063\/5.0004608","article-title":"The ORCA quantum chemistry program package","volume":"152","author":"Neese","year":"2020","journal-title":"J. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2024.114259_bib22","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.colsurfb.2024.114259_bib23","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1021\/ja9621760","article-title":"Development and testing of the opls all-atom force field on conformational energetics and properties of organic liquids","volume":"118","author":"Jorgensen","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2024.114259_bib24","doi-asserted-by":"crossref","first-page":"12916","DOI":"10.1039\/D1NR02652F","article-title":"Molecular dynamics simulations to elucidate translocation and permeation of active from lipid nanoparticle to skin: complemented by experiments","volume":"13","author":"Gupta","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2024.114259_bib25","doi-asserted-by":"crossref","first-page":"35363","DOI":"10.1021\/acsomega.1c04684","article-title":"Evaluation of constrained and restrained molecular dynamics simulation methods for predicting skin lipid permeability","volume":"6","author":"Piasentin","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.colsurfb.2024.114259_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.comtox.2023.100267","article-title":"Multiscale modeling of molecule transport through skin\u2019s deeper layers","volume":"26","author":"Verma","year":"2023","journal-title":"Comput. Toxicol."},{"key":"10.1016\/j.colsurfb.2024.114259_bib27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/acs.jctc.8b01066","article-title":"CHARMM-GUI membrane builder for complex biological membrane simulations with glycolipids and lipoglycans","volume":"15","author":"Lee","year":"2019","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.colsurfb.2024.114259_bib28","first-page":"112","article-title":"Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment","volume":"36","author":"Xiong","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2024.114259_bib29","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jcis.2017.08.011","article-title":"Novel microemulsion-based gels for topical delivery of indomethacin: formulation, physicochemical properties and in vitro drug release studies","volume":"507","author":"Froelich","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2024.114259_bib30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1039\/D1NR04610A","article-title":"Complex nanoemulsion for vitamin delivery: droplet organization and interaction with skin membranes","volume":"14","author":"Machado","year":"2022","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2024.114259_bib31","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1021\/acsanm.0c00717","article-title":"Encapsulation of ferulic acid in lipid nanoparticles as antioxidant for skin: mechanistic understanding through experiment and molecular simulation","volume":"3","author":"Gupta","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.colsurfb.2024.114259_bib32","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1021\/acs.langmuir.2c02550","article-title":"Formulation and skin permeation of active-loaded lipid nanoparticles: evaluation and screening by synergizing molecular dynamics simulations and experiments","volume":"39","author":"Gupta","year":"2023","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2024.114259_bib33","doi-asserted-by":"crossref","first-page":"12234","DOI":"10.1039\/D0RA01692F","article-title":"Molecular mechanism of the skin permeation enhancing effect of ethanol: a molecular dynamics study","volume":"10","author":"Gupta","year":"2020","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2024.114259_bib34","article-title":"PROTAC degraders of androgen receptor-integrated dissolving microneedles for androgenetic alopecia and recrudescence treatment via single topical administration","volume":"7","author":"Wang","year":"2023","journal-title":"Small Methods"},{"key":"10.1016\/j.colsurfb.2024.114259_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115913","article-title":"Justicia procumbens prevents hair loss in androgenic alopecia mice","volume":"170","author":"Kim","year":"2024","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114259_bib36","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1038\/s41467-020-18643-x","article-title":"Fgf and Wnt signaling interaction in the mesenchymal niche regulates the murine hair cycle clock","volume":"11","author":"Harshuk-Shabso","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2024.114259_bib37","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1080\/09546634.2021.1959506","article-title":"Finasteride for hair loss: a review","volume":"33","author":"Gupta","year":"2022","journal-title":"J. Dermatol. Treat."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524005186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524005186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T16:09:50Z","timestamp":1732896590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776524005186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":37,"alternative-id":["S0927776524005186"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.114259","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Facile fabrication of cedrol nanoemulsions with deep transdermal delivery ability and high safety for effective androgenic alopecia treatment","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.114259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114259"}}