{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:40:26Z","timestamp":1784760026073,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.colsurfb.2024.114419","type":"journal-article","created":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T07:34:15Z","timestamp":1732952055000},"page":"114419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Pectin\/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway"],"prefix":"10.1016","volume":"247","author":[{"given":"Shilin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenxin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jien","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2024.114419_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2022.02.028","article-title":"Biomaterials as therapeutic drug carriers for inflammatory bowel disease treatment","volume":"345","author":"Wang","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2024.114419_bib2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1039\/D3BM01645E","article-title":"Advancements in hydrogel-based drug delivery systems for the treatment of inflammatory bowel disease: a review","volume":"12","author":"Liu","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2024.114419_bib3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jconrel.2023.09.033","article-title":"Recent advances on emerging nanomaterials for diagnosis and treatment of inflammatory bowel disease","volume":"363","author":"Fu","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2024.114419_bib4","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.3748\/wjg.v28.i18.1922","article-title":"Novel drug delivery systems for inflammatory bowel disease","volume":"28","author":"Yasmin","year":"2022","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib5","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijbiomac.2022.12.032","article-title":"Multifunctional hydrogels based on chitosan, hyaluronic acid and other biological macromolecules for the treatment of inflammatory bowel disease: a review","volume":"227","author":"Ouyang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134899","article-title":"Application of chitosan as nano carrier in the treatment of inflammatory bowel disease","volume":"278","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib7","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1039\/D3TB00276D","article-title":"Biomaterial-based strategies for immunomodulation in IBD: current and future scenarios","volume":"11","author":"Jori","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.colsurfb.2024.114419_bib8","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.nantod.2017.08.006","article-title":"Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease","volume":"16","author":"Zhang","year":"2017","journal-title":"Nano Today"},{"key":"10.1016\/j.colsurfb.2024.114419_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2021.01.025","article-title":"Immunomodulatory biomaterials and their application in therapies for chronic inflammation-related diseases","volume":"123","author":"Nakkala","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2024.114419_bib10","article-title":"Development of melatonin loaded pectin nanoparticles for the treatment of inflammatory bowel disease: in vitro and in vivo studies","volume":"67","author":"Yener","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1081\/DDC-120030930","article-title":"Insulin-loaded calcium pectinate nanoparticles: effects of pectin molecular weight and formulation pH","volume":"30","author":"Cheng","year":"2004","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114419_bib12","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.carbpol.2011.09.065","article-title":"Thiolated pectin nanoparticles: preparation, characterization and ex vivo corneal permeation study","volume":"87","author":"Sharma","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.114419_bib13","doi-asserted-by":"crossref","first-page":"12102","DOI":"10.1016\/j.carbpol.2023.121025","article-title":"Oral pectin\/oligochitosan microspheres for colon-specific controlled release of quercetin to treat inflammatory bowel disease","volume":"316","author":"Jing","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2024.114419_bib14","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.ijbiomac.2020.09.214","article-title":"Natural proteins and polysaccharides in the development of micro\/nano delivery systems for the treatment of inflammatory bowel disease","volume":"165","author":"Shah","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib15","doi-asserted-by":"crossref","first-page":"588","DOI":"10.3390\/ijms24010588","article-title":"Caffeic acid and diseases-mechanisms of action","volume":"24","author":"Pavl\u00edkov\u00e1","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2024.114419_bib16","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.3390\/foods12101993","article-title":"Optimization of delivery and bioavailability of encapsulated caffeic acid","volume":"12","author":"Stanciauskaite","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.colsurfb.2024.114419_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109610","article-title":"Anti-inflammatory activity of caffeic acid derivatives from Ilex rotunda","volume":"115","author":"Kim","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.foodchem.2018.11.055","article-title":"Effect of cyclodextrin and cosolvent on the solubility and antioxidant activity of caffeic acid","volume":"278","author":"Kfoury","year":"2019","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2024.114419_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131830","article-title":"Water-soluble caffeic acid-dopamine acid-base complex exhibits enhanced bactericidal, antioxidant, and anticancer properties","volume":"374","author":"Mude","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2024.114419_bib20","doi-asserted-by":"crossref","first-page":"7518","DOI":"10.1021\/jp401609p","article-title":"Molecular dynamics simulation of the arginine-assisted solubilization of caffeic acid: intervention in the interaction","volume":"117","author":"Hirano","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.colsurfb.2024.114419_bib21","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2024.114419_bib22","doi-asserted-by":"crossref","first-page":"12117","DOI":"10.1021\/acsnano.3c11257","article-title":"Inhibiting the cGAS-STING pathway in ulcerative colitis with programmable micelles","volume":"18","author":"Uthaman","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2024.114419_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ijpharm.2019.01.022","article-title":"A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems","volume":"558","author":"Shahdadi Sardo","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2024.114419_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.129878","article-title":"Improved detection of reactive oxygen species by DCFH-DA: new insight into self-amplification of fluorescence signal by light irradiation","volume":"339","author":"Yu","year":"2021","journal-title":"Sens. Actuators B-Chem."},{"key":"10.1016\/j.colsurfb.2024.114419_bib25","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3390\/ijms19071985","article-title":"Detection of the mitochondrial membrane potential by the cationic dye jc-1 in l1210 cells with massive overexpression of the plasma membrane ABCB1 drug transporter","volume":"19","author":"Elefantova","year":"2018","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2024.114419_bib26","doi-asserted-by":"crossref","first-page":"4522","DOI":"10.3390\/ma14164522","article-title":"An overview on thermosensitive oral gel based on poloxamer 407","volume":"14","author":"Chen","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.colsurfb.2024.114419_bib27","doi-asserted-by":"crossref","first-page":"16482","DOI":"10.1021\/acsami.3c00562","article-title":"One-pot rapid synthesis of Cu2+\u2009-doped GOD@MOF to amplify the antitumor efficacy of chemodynamic therapy","volume":"15","author":"Li","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2024.114419_bib28","first-page":"57725","article-title":"A flow cytometry-based assay for measuring mitochondrial membrane potential in cardiac myocytes after hypoxia\/reoxygenation","author":"Chen","year":"2018","journal-title":"Jove-J. Vis. Exp."},{"key":"10.1016\/j.colsurfb.2024.114419_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2022.119233","article-title":"The fate of damaged mitochondrial DNA in the cell","volume":"1869","author":"Liao","year":"2022","journal-title":"Biochim. Et. Biophys. Acta-Mol. Cell Res."},{"key":"10.1016\/j.colsurfb.2024.114419_bib30","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib31","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.colsurfb.2024.114419_bib32","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.freeradbiomed.2024.03.012","article-title":"mtDNA regulates cGAS-STING signaling pathway in adenomyosis","volume":"216","author":"Wang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.colsurfb.2024.114419_bib33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.3389\/fcell.2020.00200","article-title":"Mitophagy: an emerging role in aging and age-associated diseases","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.colsurfb.2024.114419_bib34","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","article-title":"Mitophagy and cGAS-STING crosstalk in neuroinflammation","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.colsurfb.2024.114419_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0218003","article-title":"PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses","volume":"14","author":"Bueno","year":"2019","journal-title":"Plos One"},{"key":"10.1016\/j.colsurfb.2024.114419_bib36","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1093\/brain\/awaa246","article-title":"Mitochondrial damage-associated inflammation highlights biomarkers in PRKN\/PINK1 parkinsonism","volume":"143","author":"Borsche","year":"2020","journal-title":"Brain"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524006787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776524006787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T20:34:07Z","timestamp":1737318847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776524006787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":36,"alternative-id":["S0927776524006787"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.114419","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pectin\/caffeic acid nanoparticles in a poloxamer thermosensitive gel for the treatment of ulcerative colitis by inhibiting cGAS-STING pathway","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.114419","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114419"}}