{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:25:34Z","timestamp":1784269534899,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.colsurfb.2024.114487","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T07:20:24Z","timestamp":1735370424000},"page":"114487","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Anticancer therapeutic effect of magnetic guided cobalt ferrite\/doxorubicin-loaded ROS-responsive bilirubin nanoparticles in a colon cancer model"],"prefix":"10.1016","volume":"248","author":[{"given":"Hyo","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reju George","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Kyun","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Yeon","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2024.114487_bib1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics, 2010","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.colsurfb.2024.114487_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2174\/138161210789941847","article-title":"Recent advances in cancer therapy: an overview","volume":"16","author":"Urruticoechea","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.colsurfb.2024.114487_bib3","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.2174\/138161210792389289","article-title":"Current pharmaceutical design of antituberculosis drugs: future perspectives","volume":"16","author":"Speck-Planche","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.colsurfb.2024.114487_bib4","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/nnano.2007.387","article-title":"Nanocarriers as an emerging platform for cancer therapy","volume":"2","author":"Peer","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2024.114487_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7150\/thno.3463","article-title":"Targeting strategies for multifunctional nanoparticles in cancer imaging and therapy","volume":"2","author":"Yu","year":"2012","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2024.114487_bib6","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1039\/C5NR00290G","article-title":"Smart doxorubicin nanoparticles with high drug payload for enhanced chemotherapy against drug resistance and cancer diagnosis","volume":"7","author":"Yu","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2024.114487_bib7","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.actbio.2020.09.014","article-title":"A bilirubin-conjugated chitosan nanotheranostics system as a platform for reactive oxygen species stimuli-responsive hepatic fibrosis therapy","volume":"116","author":"Surendran","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2024.114487_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11020179","article-title":"Reactive oxygen species (ROS) and antioxidants as immunomodulators in exercise: implications for heme oxygenase and bilirubin","volume":"11","author":"Thomas","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2024.114487_bib9","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jconrel.2020.08.054","article-title":"Therapeutic application and construction of bilirubin incorporated nanoparticles","volume":"328","author":"Yao","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2024.114487_bib10","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.biomaterials.2017.04.029","article-title":"PEGylated bilirubin nanoparticle as an anti-oxidative and anti-inflammatory demulcent in pancreatic islet xenotransplantation","volume":"133","author":"Kim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2024.114487_bib11","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.actbio.2020.09.014","article-title":"A bilirubin-conjugated chitosan nanotheranostics system as a platform for reactive oxygen species stimuli-responsive hepatic fibrosis therapy","volume":"116","author":"Surendran","year":"2020","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2024.114487_bib12","doi-asserted-by":"crossref","first-page":"5683","DOI":"10.1039\/C5NR00290G","article-title":"Smart doxorubicin nanoparticles with high drug payload for enhanced chemotherapy against drug resistance and cancer diagnosis","volume":"7","author":"Yu","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2024.114487_bib13","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1515\/nanoph-2021-0207","article-title":"Smart NIR-light and pH responsive doxorubicin-loaded GNRs@SBA-15-SH nanocomposite for chemo-photothermal therapy of cancer","volume":"10","author":"Deinavizadeh","year":"2021","journal-title":"Nanophotonics-Berl."},{"key":"10.1016\/j.colsurfb.2024.114487_bib14","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s10948-018-4939-6","article-title":"Recent advances in iron oxide nanoparticles (IONPs): synthesis and surface modification for biomedical applications","volume":"32","author":"Noqta","year":"2019","journal-title":"J. Supercond. Nov. Magn."},{"key":"10.1016\/j.colsurfb.2024.114487_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901058","article-title":"Magnetic nanoparticles in cancer therapy and diagnosis","volume":"9","author":"Farzin","year":"2020","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.colsurfb.2024.114487_bib16","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1021\/cr068445e","article-title":"Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications","volume":"108","author":"Laurent","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2024.114487_bib17","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","article-title":"The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect","volume":"63","author":"Fang","year":"2011","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2024.114487_bib18","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1039\/C7NR08319J","article-title":"Using PEGylated magnetic nanoparticles to describe the EPR effect in tumor for predicting therapeutic efficacy of micelle drugs","volume":"10","author":"Chen","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2024.114487_bib19","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1515\/ntrev-2020-0111","article-title":"Cobalt magnetic nanoparticles as theranostics: conceivable or forgettable?","volume":"9","author":"Petrarca","year":"2020","journal-title":"Nanotechnol. Rev."},{"key":"10.1016\/j.colsurfb.2024.114487_bib20","article-title":"Recent application of cobalt ferrite nanoparticles as a theranostic agent","volume":"26","author":"Barani","year":"2022","journal-title":"Mater. Today Chem."},{"key":"10.1016\/j.colsurfb.2024.114487_bib21","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.1002\/cphc.201800535","article-title":"Improvement of anticancer drug release by cobalt ferrite magnetic nanoparticles through combined ph and temperature responsive technique","volume":"19","author":"Dey","year":"2018","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.colsurfb.2024.114487_bib22","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.2174\/0929867329666221007113951","article-title":"Cobalt ferrite nanoparticle's safety in biomedical and agricultural applications: a review of recent progress","volume":"30","author":"Shakil","year":"2023","journal-title":"Curr. Med Chem."},{"key":"10.1016\/j.colsurfb.2024.114487_bib23","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.jmmm.2008.11.004","article-title":"Synthesis and magnetic properties of CoFe2O4 ferrite nanoparticles","volume":"321","author":"Zi","year":"2009","journal-title":"J. Magn. Magn. Mater."},{"key":"10.1016\/j.colsurfb.2024.114487_bib24","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.7150\/thno.42564","article-title":"Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics","volume":"10","author":"Zhao","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2024.114487_bib25","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.2174\/0929867311320140007","article-title":"Chitosan nanoparticles for melanoma cancer treatment by Photodynamic Therapy and electrochemotherapy using aminolevulinic acid derivatives","volume":"20","author":"Ferreira","year":"2013","journal-title":"Curr. Med Chem."},{"key":"10.1016\/j.colsurfb.2024.114487_bib26","article-title":"Synthesis and characterization of chitosan-coated magnetite nanoparticles and their application in curcumin drug delivery","volume":"7","author":"Pham","year":"2016","journal-title":"Adv. Nat. Sci. Nanosci."},{"key":"10.1016\/j.colsurfb.2024.114487_bib27","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.3762\/bjnano.7.178","article-title":"Chitosan-based nanoparticles for improved anticancer efficacy and bioavailability of mifepristone","volume":"7","author":"Zhang","year":"2016","journal-title":"Beilstein J. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2024.114487_bib28","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/FPC.0b013e32833ffb56","article-title":"Doxorubicin pathways: pharmacodynamics and adverse effects","volume":"21","author":"Thorn","year":"2011","journal-title":"Pharm. Genom."},{"key":"10.1016\/j.colsurfb.2024.114487_bib29","series-title":"Advances in Precision Medicine Oncology","article-title":"Overview on the Side Effects of Doxorubicin","author":"Chittipolu","year":"2020"},{"key":"10.1016\/j.colsurfb.2024.114487_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1124\/pr.56.2.6","article-title":"Anthracyclines: molecular advances and pharmacologic developments in antitumor activity and cardiotoxicity","volume":"56","author":"Minotti","year":"2004","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.colsurfb.2024.114487_bib31","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/polysaccharides2040048","article-title":"Using chitosan or chitosan derivatives in cancer therapy","volume":"2","author":"Shakil","year":"2021","journal-title":"Polysaccharides"},{"key":"10.1016\/j.colsurfb.2024.114487_bib32","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biomaterials.2017.05.013","article-title":"Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy","volume":"136","author":"Kang","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2024.114487_bib33","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.biomaterials.2015.05.003","article-title":"Multifunctional envelope-type mesoporous silica nanoparticles for pH-responsive drug delivery and magnetic resonance imaging","volume":"60","author":"Chen","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2024.114487_bib34","doi-asserted-by":"crossref","first-page":"7873","DOI":"10.1016\/j.biomaterials.2013.07.012","article-title":"In vivo anti-cancer efficacy of magnetite nanocrystal--based system using locoregional hyperthermia combined with 5-fluorouracil chemotherapy","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2024.114487_bib35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.7150\/thno.21297","article-title":"Enhanced synergism of thermo-chemotherapy for liver cancer with magnetothermally responsive nanocarriers","volume":"8","author":"Li","year":"2018","journal-title":"Theranostics"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652400746X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652400746X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T23:20:06Z","timestamp":1740439206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777652400746X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"alternative-id":["S092777652400746X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.114487","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anticancer therapeutic effect of magnetic guided cobalt ferrite\/doxorubicin-loaded ROS-responsive bilirubin nanoparticles in a colon cancer model","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2024.114487","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114487"}}