{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:14:00Z","timestamp":1791818040374,"version":"4.3.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.colsurfb.2025.114495","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T02:23:56Z","timestamp":1736043836000},"page":"114495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice"],"prefix":"10.1016","volume":"249","author":[{"given":"Peng","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaorong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.114495_bib1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.colsurfb.2025.114495_bib2","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1002\/jbmr.3757","article-title":"The prevalence of osteoporosis in China, a nationwide, multicenter DXA survey","volume":"34","author":"Zeng","year":"2019","journal-title":"J. Bone Min. Res."},{"key":"10.1016\/j.colsurfb.2025.114495_bib3","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1001\/jama.2019.5453","article-title":"Hip fractures in older adults in 2019","volume":"321","author":"Berry","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.colsurfb.2025.114495_bib4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrendo.2016.91","article-title":"Physiological and pathophysiological bone turnover - role of the immune system","volume":"12","author":"Weitzmann","year":"2016","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.colsurfb.2025.114495_bib5","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s11154-010-9153-1","article-title":"Cellular mechanisms of bone remodeling","volume":"11","author":"Eriksen","year":"2010","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.colsurfb.2025.114495_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S2213-8587(17)30184-5","article-title":"Use of bone turnover markers in postmenopausal osteoporosis","volume":"5","author":"Eastell","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.colsurfb.2025.114495_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.7326\/M22-0684","article-title":"Effectiveness and Safety of treatments to prevent fractures in people with low bone mass or primary osteoporosis: a living systematic review and network meta-analysis for the American College of Physicians","volume":"176","author":"Ayers","year":"2023","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.colsurfb.2025.114495_bib8","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/S0140-6736(21)02646-5","article-title":"Drug therapy for osteoporosis in older adults","volume":"399","author":"Reid","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.colsurfb.2025.114495_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1056\/NEJMoa062462","article-title":"Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women","volume":"355","author":"Barrett-Connor","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.colsurfb.2025.114495_bib10","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1159\/000447372","article-title":"Safety of denosumab versus zoledronic acid in patients with bone metastases: a meta-analysis of randomized controlled trials","volume":"39","author":"Chen","year":"2016","journal-title":"Oncol. Res. Treat."},{"key":"10.1016\/j.colsurfb.2025.114495_bib11","article-title":"Citric acid-modified pH-sensitive bone-targeted delivery of estrogen for the treatment of postmenopausal osteoporosis","volume":"22","author":"Chen","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib12","article-title":"Advanced applications of strontium-containing biomaterials in bone tissue engineering","volume":"20","author":"Sheng","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib13","article-title":"Bisphosphonate-incorporated coatings for orthopedic implants functionalization","volume":"22","author":"Zhang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib14","article-title":"Metal-organic frameworks functionalized biomaterials for promoting bone repair","volume":"21","author":"Zhao","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib15","article-title":"Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms","volume":"25","author":"Li","year":"2024","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107054","article-title":"Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: an update since 2010","volume":"200","author":"Lin","year":"2024","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.colsurfb.2025.114495_bib17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ctrv.2015.01.001","article-title":"Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer","volume":"41","author":"Macha","year":"2015","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.colsurfb.2025.114495_bib18","article-title":"Novel one-pot strategy for fabrication of a pH-Responsive bone-targeted drug self-frame delivery system for treatment of osteoporosis","volume":"20","author":"Yang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib19","doi-asserted-by":"crossref","first-page":"8825387","DOI":"10.1155\/2020\/8825387","article-title":"Quercetin: its main pharmacological activity and potential application in clinical medicine","volume":"2020","author":"Yang","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.colsurfb.2025.114495_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117463","article-title":"A review on anti-cancer properties of Quercetin in breast cancer","volume":"248","author":"Ezzati","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.colsurfb.2025.114495_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12071418","article-title":"Exploitation of Quercetin's Antioxidative Properties in Potential Alternative Therapeutic Options for Neurodegenerative Diseases","volume":"12","author":"Rarinca","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2025.114495_bib22","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1039\/D3NH00275F","article-title":"NIR-activated quercetin-based nanogels embedded with CuS nanoclusters for the treatment of drug-resistant biofilms and accelerated chronic wound healing","volume":"8","author":"Nain","year":"2023","journal-title":"Nanoscale Horiz."},{"key":"10.1016\/j.colsurfb.2025.114495_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118106","article-title":"Quercetin improves vascular endothelial function through promotion of autophagy in hypertensive rats","volume":"258","author":"Lin","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.colsurfb.2025.114495_bib24","article-title":"Nano artificial periosteum PLGA\/MgO\/Quercetin accelerates repair of bone defects through promoting osteogenic \u2212 angiogenic coupling effect via Wnt\/ \u03b2-catenin pathway","volume":"16","author":"He","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib25","article-title":"Ignored role of polyphenol in boosting reactive oxygen species generation for polyphenol\/chemodynamic combination therapy","volume":"16","author":"Mao","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.114495_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176448","article-title":"Quercetin as an agent for protecting the bone: a review of the current evidence","volume":"21","author":"Wong","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2025.114495_bib27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/jcb.20071","article-title":"Flavonoid quercetin decreases osteoclastic differentiation induced by RANKL via a mechanism involving NF kappa B and AP-1","volume":"92","author":"Wattel","year":"2004","journal-title":"J. Cell Biochem."},{"key":"10.1016\/j.colsurfb.2025.114495_bib28","doi-asserted-by":"crossref","first-page":"1338951","DOI":"10.3389\/fphar.2024.1338951","article-title":"Pharmacological and mechanistic aspects of quercetin in osteoporosis","volume":"15","author":"Deng","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.colsurfb.2025.114495_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nmat1866","article-title":"Living with cracks: damage and repair in human bone","volume":"6","author":"Taylor","year":"2007","journal-title":"Nat. Mater."},{"key":"10.1016\/j.colsurfb.2025.114495_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nm.2617","article-title":"A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy","volume":"18","author":"Zhang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.colsurfb.2025.114495_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120404","article-title":"Targeting nanoparticles for diagnosis and therapy of bone tumors: opportunities and challenges","volume":"265","author":"Gao","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2025.114495_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120345","article-title":"Bone-targeting polymer vesicles for simultaneous imaging and effective malignant bone tumor treatment","volume":"269","author":"Zhou","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2025.114495_bib33","doi-asserted-by":"crossref","first-page":"7998","DOI":"10.1021\/acs.nanolett.1c02150","article-title":"Bone-targeting polymer vesicles for effective therapy of osteoporosis","volume":"21","author":"Zhou","year":"2021","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2025.114495_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.113029","article-title":"Facile synthesis of curcumin-containing poly(amidoamine) dendrimers as pH-responsive delivery system for osteoporosis treatment","volume":"222","author":"Yang","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.114495_bib35","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1021\/acsnano.7b03197","article-title":"Targeting osteocytes to attenuate early breast cancer bone metastasis by theranostic upconversion nanoparticles with responsive plumbagin release","volume":"11","author":"Qiao","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.114495_bib36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.actbio.2022.11.056","article-title":"Bone-targeted delivery of senolytics to eliminate senescent cells increases bone formation in senile osteoporosis","volume":"157","author":"Xing","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2025.114495_bib37","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1021\/acs.nanolett.9b02916","article-title":"Metal-organic framework nanoparticles for ameliorating breast cancer-associated osteolysis","volume":"20","author":"Pang","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2025.114495_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312081","article-title":"Magnetic aggregation-induced bone-targeting nanocarrier with effects of Piezo1 activation and osteogenic\u2013angiogenic coupling for osteoporotic bone repair","author":"Guan","year":"2024","journal-title":"Adv., Mater."},{"key":"10.1016\/j.colsurfb.2025.114495_bib39","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1146\/annurev.pathmechdis.3.121806.151431","article-title":"The osteoclast: friend or foe?","volume":"3","author":"Novack","year":"2008","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.colsurfb.2025.114495_bib40","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2025.114495_bib41","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1172\/JCI94606","article-title":"The many ways of osteoclast activation","volume":"127","author":"Lorenzo","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.colsurfb.2025.114495_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122331","article-title":"Binding-induced fibrillogenesis peptide inhibits RANKL-mediated osteoclast activation against osteoporosis","volume":"302","author":"Liang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2025.114495_bib43","article-title":"Rational polyelectrolyte nanoparticles endow preosteoclast-targeted siRNA transfection for anabolic therapy of osteoporosis","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci. Adv."},{"key":"10.1016\/j.colsurfb.2025.114495_bib44","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.7150\/thno.30206","article-title":"Pseurotin A inhibits osteoclastogenesis and prevents ovariectomized-induced bone loss by suppressing reactive oxygen species","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114495_bib45","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1001\/jama.2019.15781","article-title":"Bisphosphonates for Postmenopausal Osteoporosis","volume":"322","author":"Ensrud","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.colsurfb.2025.114495_bib46","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12967-017-1230-8","article-title":"Osteoclast profile of medication-related osteonecrosis of the jaw secondary to bisphosphonate therapy: a comparison with osteoradionecrosis and osteomyelitis","volume":"15","author":"Gross","year":"2017","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.colsurfb.2025.114495_bib47","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-pathmechdis-031521-040919","article-title":"Osteoclasts, Master Sculptors of Bone","volume":"18","author":"Veis","year":"2023","journal-title":"Annu Rev. Pathol."},{"key":"10.1016\/j.colsurfb.2025.114495_bib48","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.244798","article-title":"The osteoclast cytoskeleton - current understanding and therapeutic perspectives for osteoporosis","volume":"133","author":"Blangy","year":"2020","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.colsurfb.2025.114495_bib49","doi-asserted-by":"crossref","first-page":"13453","DOI":"10.1073\/pnas.95.23.13453","article-title":"Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice","volume":"95","author":"Saftig","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.colsurfb.2025.114495_bib50","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1034\/j.1600-0854.2003.40206.x","article-title":"Osteoclast ruffled border has distinct subdomains for secretion and degraded matrix uptake","volume":"4","author":"Mulari","year":"2003","journal-title":"Traffic"},{"key":"10.1016\/j.colsurfb.2025.114495_bib51","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2025.114495_bib52","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jcis.2023.10.133","article-title":"Enhancing bone scaffold interfacial reinforcement through in situ growth of metal\u2013organic frameworks (MOFs) on strontium carbonate: achieving high strength and osteoimmunomodulation","volume":"655","author":"Qian","year":"2024","journal-title":"J. Colloid Interface Sci."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525000025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525000025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T04:54:07Z","timestamp":1740372847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525000025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":52,"alternative-id":["S0927776525000025"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114495","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-assembled water soluble and bone-targeting phosphorylated quercetin ameliorates postmenopausal osteoporosis in ovariectomy mice","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114495"}}