{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:02:34Z","timestamp":1784779354059,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2022KY357"],"award-info":[{"award-number":["2022KY357"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202158"],"award-info":[{"award-number":["82202158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471986"],"award-info":[{"award-number":["82471986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2421099"],"award-info":[{"award-number":["W2421099"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171939"],"award-info":[{"award-number":["82171939"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.colsurfb.2025.114724","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T13:02:19Z","timestamp":1745413339000},"page":"114724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Disrupting Cdc42 activation-driven filopodia formation with low-intensity ultrasound and microbubbles: A novel strategy to block ovarian cancer metastasis"],"prefix":"10.1016","volume":"253","author":[{"given":"Xiaoying","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengwei","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhikang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.114724_bib1","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.colsurfb.2025.114724_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jare.2022.09.002","article-title":"The mortalities of female-specific cancers in China and other countries with distinct socioeconomic statuses: a longitudinal study","volume":"49","author":"Jiang","year":"2023","journal-title":"J. Adv. Res"},{"key":"10.1016\/j.colsurfb.2025.114724_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.6004\/jnccn.2021.0007","article-title":"Ovarian cancer, version 2.2020, NCCN clinical practice guidelines in oncology","volume":"19","author":"Armstrong","year":"2021","journal-title":"J. Natl. Compr. Canc Netw."},{"key":"10.1016\/j.colsurfb.2025.114724_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jare.2022.08.014","article-title":"Dualistic classification of high grade serous ovarian carcinoma has its root in spatial heterogeneity","volume":"48","author":"Sun","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.colsurfb.2025.114724_bib5","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.ultrasmedbio.2020.01.002","article-title":"Ultrasound-responsive cavitation nuclei for therapy and drug delivery","volume":"46","author":"Kooiman","year":"2020","journal-title":"Ultrasound Med. Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib6","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.addr.2013.11.008","article-title":"Understanding ultrasound induced sonoporation: definitions and underlying mechanisms","volume":"72","author":"Lentacker","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2025.114724_bib7","doi-asserted-by":"crossref","first-page":"5514","DOI":"10.7150\/thno.40520","article-title":"Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy","volume":"10","author":"Lin","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114724_bib8","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1002\/mp.14867","article-title":"Effect of diagnostic ultrasound and microbubble-enhanced chemotherapy on metastasis of rabbit VX2 tumor","volume":"48","author":"Zhang","year":"2021","journal-title":"Med. Phys."},{"key":"10.1016\/j.colsurfb.2025.114724_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105903","article-title":"Triple-combination therapy assisted with ultrasound-active gold nanoparticles and ultrasound therapy against 3D cisplatin-resistant ovarian cancer model","volume":"82","author":"Kip","year":"2022","journal-title":"Ultrason Sonochem."},{"key":"10.1016\/j.colsurfb.2025.114724_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2024.107078","article-title":"Focused shock waves and inertial cavitation release tumor-associated antigens from renal cell carcinoma","author":"Hosano","year":"2024","journal-title":"Ultrason Sonochem."},{"key":"10.1016\/j.colsurfb.2025.114724_bib11","first-page":"14","article-title":"Wrecking neutrophil extracellular traps and antagonizing cancer-associated neurotransmitters by interpenetrating network hydrogels prevent postsurgical cancer relapse and metastases","volume":"39","author":"Zhou","year":"2024","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2025.114724_bib12","doi-asserted-by":"crossref","DOI":"10.1118\/1.4808149","article-title":"Treatment of human pancreatic cancer using combined ultrasound, microbubbles, and gemcitabine: a clinical case study","volume":"40","author":"Kotopoulis","year":"2013","journal-title":"Med Phys."},{"key":"10.1016\/j.colsurfb.2025.114724_bib13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jconrel.2016.10.007","article-title":"A human clinical trial using ultrasound and microbubbles to enhance gemcitabine treatment of inoperable pancreatic cancer","volume":"243","author":"Dimcevski","year":"2016","journal-title":"J. Control Release"},{"key":"10.1016\/j.colsurfb.2025.114724_bib14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.21147\/j.issn.1000-9604.2018.05.09","article-title":"Clinical study of ultrasound and microbubbles for enhancing chemotherapeutic sensitivity of malignant tumors in digestive system","volume":"30","author":"Wang","year":"2018","journal-title":"Chin. J. Cancer Res"},{"key":"10.1016\/j.colsurfb.2025.114724_bib15","article-title":"Low-intensity continuous ultrasound to inhibit cancer cell migration","volume":"10","author":"Gonzalez","year":"2022","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib16","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrc2622","article-title":"Metastasis: from dissemination to organ-specific colonization","volume":"9","author":"Nguyen","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2025.114724_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s13402-020-00513-9","article-title":"Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles","volume":"43","author":"Yousefi","year":"2020","journal-title":"Cell Oncol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib18","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.7314\/APJCP.2015.16.6.2187","article-title":"Cellular protrusions--lamellipodia, filopodia, invadopodia and podosomes--and their roles in progression of orofacial tumours: current understanding","volume":"16","author":"Alblazi","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.colsurfb.2025.114724_bib19","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1126\/science.279.5350.509","article-title":"Rho GTPases and the actin cytoskeleton","volume":"279","author":"Hall","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2025.114724_bib20","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1242\/jcs.01115","article-title":"Cdc42--the centre of polarity","volume":"117","author":"Etienne-Manneville","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.colsurfb.2025.114724_bib21","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nature01148","article-title":"Rho GTPases in cell biology","volume":"420","author":"Etienne-Manneville","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2025.114724_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.823956","article-title":"Low-Intensity Focused Ultrasound Targeted Microbubble Destruction Enhanced Paclitaxel Sensitivity by Decreasing Autophagy in Paclitaxel-Resistant Ovarian Cancer","volume":"12","author":"Fan","year":"2022","journal-title":"Front Oncol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103733","article-title":"Mechanosensitive channel Piezo1 induces cell apoptosis in pancreatic cancer by ultrasound with microbubbles","volume":"25","author":"Song","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.colsurfb.2025.114724_bib24","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.stem.2022.03.009","article-title":"A small-molecule cocktail promotes mammalian cardiomyocyte proliferation and heart regeneration","volume":"29","author":"Du","year":"2022","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abo2506","article-title":"Isotropic three-dimensional dual-color super-resolution microscopy with metal-induced energy transfer","volume":"8","author":"Thiele","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.colsurfb.2025.114724_bib26","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41593-020-0585-y","article-title":"Cxcr4 distinguishes HSC-derived monocytes from microglia and reveals monocyte immune responses to experimental stroke","volume":"23","author":"Werner","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.colsurfb.2025.114724_bib27","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1101\/gad.519709","article-title":"Autophagy mediates the mitotic senescence transition","volume":"23","author":"Young","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.colsurfb.2025.114724_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s40364-024-00586-w","article-title":"Lung cancer cell-intrinsic IL-15 promotes cell migration and sensitizes murine lung tumors to anti-PD-L1 therapy","volume":"12","author":"Hu","year":"2024","journal-title":"Biomark. Res"},{"key":"10.1016\/j.colsurfb.2025.114724_bib29","article-title":"Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells","author":"Madan","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib30","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1038\/s41467-024-52615-9","article-title":"The estrogen response in fibroblasts promotes ovarian metastases of gastric cancer","volume":"15","author":"Hu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2025.114724_bib31","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1016\/j.cell.2024.06.013","article-title":"Neoadjuvant PARPi or chemotherapy in ovarian cancer informs targeting effector Treg cells for homologous-recombination-deficient tumors","volume":"187","author":"Luo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib32","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj4796","article-title":"An ultrasound-driven immune-boosting molecular machine for systemic tumor suppression","volume":"7","author":"Wang","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.colsurfb.2025.114724_bib33","article-title":"One-dimensional nanosonosensitizer boosted multiple branches of immune responses against MHC-deficient immune-evasive urologic tumor","volume":"11","author":"Yang","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.colsurfb.2025.114724_bib34","first-page":"9","article-title":"Ultrasound-triggered microbubble destruction enhances the radiosensitivity of glioblastoma by inhibiting PGRMC1-mediated autophagy in vitro and in vivo","volume":"9","author":"He","year":"2022","journal-title":"Mil. Med Res"},{"key":"10.1016\/j.colsurfb.2025.114724_bib35","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.7150\/thno.29326","article-title":"Magnetic ternary nanohybrids for nonviral gene delivery of stem cells and applications on cancer therapy","volume":"9","author":"Huang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114724_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1535-6108(01)00002-2","article-title":"Induction of ovarian cancer by defined multiple genetic changes in a mouse model system","volume":"1","author":"Orsulic","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2014.05.002","article-title":"Hematogenous metastasis of ovarian cancer: rethinking mode of spread","volume":"26","author":"Pradeep","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib38","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0092-8674(03)00120-X","article-title":"Cellular motility driven by assembly and disassembly of actin filaments","volume":"112","author":"Pollard","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib39","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/ncb1007-1110","article-title":"The many faces of actin: matching assembly factors with cellular structures","volume":"9","author":"Chhabra","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib40","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2025.114724_bib41","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.celrep.2014.07.050","article-title":"Invadopodia are required for cancer cell extravasation and are a therapeutic target for metastasis","volume":"8","author":"Leong","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.colsurfb.2025.114724_bib42","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.201205169","article-title":"Cdc42 promotes transendothelial migration of cancer cells through beta1 integrin","volume":"199","author":"Reymond","year":"2012","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib43","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13046-022-02441-y","article-title":"ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42","volume":"41","author":"Zhang","year":"2022","journal-title":"J. Exp. Clin. Cancer Res"},{"key":"10.1016\/j.colsurfb.2025.114724_bib44","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1091\/mbc.e13-07-0405","article-title":"Mammalian target of rapamycin and Rictor control neutrophil chemotaxis by regulating Rac\/Cdc42 activity and the actin cytoskeleton","volume":"24","author":"He","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib45","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.tcb.2015.11.003","article-title":"Cdc42 and Cellular Polarity: Emerging Roles at the Golgi","volume":"26","author":"Farhan","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib46","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.cell.2007.05.018","article-title":"GEFs and GAPs: critical elements in the control of small G proteins","volume":"129","author":"Bos","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib47","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1007\/s00330-014-3334-3","article-title":"Activation of microbubbles by low-level therapeutic ultrasound enhances the antitumor effects of doxorubicin","volume":"24","author":"Yang","year":"2014","journal-title":"Eur. Radio."},{"key":"10.1016\/j.colsurfb.2025.114724_bib48","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jare.2020.06.012","article-title":"TRPV4 promotes acoustic wave-mediated BBB opening via Ca(2+)\/PKC-delta pathway","volume":"26","author":"Liao","year":"2020","journal-title":"J. Adv. Res"},{"key":"10.1016\/j.colsurfb.2025.114724_bib49","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ultsonch.2017.05.013","article-title":"Combination of sonodynamic with temozolomide inhibits C6 glioma migration and promotes mitochondrial pathway apoptosis via suppressing NHE-1 expression","volume":"39","author":"Chen","year":"2017","journal-title":"Ultrason Sonochem."},{"key":"10.1016\/j.colsurfb.2025.114724_bib50","doi-asserted-by":"crossref","first-page":"250","DOI":"10.7150\/thno.79186","article-title":"Intravital imaging and cavitation monitoring of antivascular ultrasound in tumor microvasculature","volume":"13","author":"Zhao","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114724_bib51","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jconrel.2024.05.030","article-title":"Ultrasound-induced immune responses in tumors: A systematic review and meta-analysis","volume":"371","author":"Rix","year":"2024","journal-title":"J. Control Release"},{"key":"10.1016\/j.colsurfb.2025.114724_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.216009","article-title":"Mechanical destruction using a minimally invasive Ultrasound Needle induces anti-tumor immune responses and synergizes with the anti-PD-L1 blockade","volume":"554","author":"Tang","year":"2023","journal-title":"Cancer Lett."},{"key":"10.1016\/j.colsurfb.2025.114724_bib53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.ceb.2015.06.007","article-title":"Filopodia in cell adhesion, 3D migration and cancer cell invasion","volume":"36","author":"Jacquemet","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib54","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.7150\/thno.92650","article-title":"The DNA-dependent protein kinase catalytic subunit exacerbates endotoxemia-induced myocardial microvascular injury by disrupting the MOTS-c\/JNK pathway and inducing profilin-mediated lamellipodia degradation","volume":"14","author":"Zou","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114724_bib55","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.7150\/thno.34168","article-title":"GPR124 facilitates pericyte polarization and migration by regulating the formation of filopodia during ischemic injury","volume":"9","author":"Chen","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114724_bib56","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nsmb.1844","article-title":"Molecular mechanisms in signal transduction at the membrane","volume":"17","author":"Groves","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib57","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1126\/science.1175862","article-title":"Actin, a central player in cell shape and movement","volume":"326","author":"Pollard","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2025.114724_bib58","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2014.0071","article-title":"Single-site sonoporation disrupts actin cytoskeleton organization","volume":"11","author":"Chen","year":"2014","journal-title":"J. R. Soc. Interface"},{"key":"10.1016\/j.colsurfb.2025.114724_bib59","article-title":"A dynamical model of oncotripsy by mechanical cell fatigue: selective cancer cell ablation by low-intensity pulsed ultrasound","volume":"476","author":"Schibber","year":"2020","journal-title":"Proc. Math. Phys. Eng. Sci."},{"key":"10.1016\/j.colsurfb.2025.114724_bib60","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1073\/pnas.1015771108","article-title":"Intramembrane cavitation as a unifying mechanism for ultrasound-induced bioeffects","volume":"108","author":"Krasovitski","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.colsurfb.2025.114724_bib61","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0960-9822(03)00170-2","article-title":"Disruption of the Diaphanous-related formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42","volume":"13","author":"Peng","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib62","doi-asserted-by":"crossref","first-page":"5065","DOI":"10.7150\/thno.34014","article-title":"Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development","volume":"9","author":"Zhang","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.114724_bib63","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/s41556-020-0488-x","article-title":"Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions","volume":"22","author":"Muller","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib64","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41556-019-0438-7","article-title":"Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms","volume":"22","author":"Bagci","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114724_bib65","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1091\/mbc.e09-05-0408","article-title":"The BNIP-2 and Cdc42GAP homology (BCH) domain of p50RhoGAP\/Cdc42GAP sequesters RhoA from inactivation by the adjacent GTPase-activating protein domain","volume":"21","author":"Zhou","year":"2010","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.colsurfb.2025.114724_bib66","doi-asserted-by":"crossref","first-page":"7262","DOI":"10.7150\/thno.49116","article-title":"Congenital biliary atresia is correlated with disrupted cell junctions and polarity caused by Cdc42 insufficiency in the liver","volume":"11","author":"Zhou","year":"2021","journal-title":"Theranostics"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525002310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525002310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:21:19Z","timestamp":1784776879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525002310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":66,"alternative-id":["S0927776525002310"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114724","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupting Cdc42 activation-driven filopodia formation with low-intensity ultrasound and microbubbles: A novel strategy to block ovarian cancer metastasis","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114724","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114724"}}