{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:34:36Z","timestamp":1793036076399,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.colsurfb.2025.114805","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T19:45:59Z","timestamp":1747683959000},"page":"114805","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Novel thiol-functionalized hyaluronic acid-based pH-responsive hydrogel: A promising mucoadhesive drug delivery approach toward the treatment of colorectal cancer"],"prefix":"10.1016","volume":"254","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4407-6002","authenticated-orcid":false,"given":"Sobia","family":"Noreen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Pervaiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Farhan","family":"Hanif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hina","family":"Shoukat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irsah","family":"Maqbool","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Azeem","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7525-646X","authenticated-orcid":false,"given":"Hassan","family":"Mahmood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.114805_bib1","article-title":"Recent insights and applications of nanocarriers-based drug delivery systems for colonic drug delivery and cancer therapy","author":"Noreen IM","year":"2025","journal-title":"Crit. Rev. Oncol. \/Hematol."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib2","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1002\/pat.5930","article-title":"Chitosan based hybrid hydrogels for drug delivery: preparation, biodegradation, thermal, and mechanical properties","volume":"34","author":"Kamaci","year":"2023","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.colsurfb.2025.114805_bib3","first-page":"1","article-title":"Fabrication and evaluation of pH sensitive chemically cross-linked interpenetrating network [Gelatin\/Polyvinylpyrrolidone-co-poly (acrylic acid)] for targeted release of 5-fluorouracil","author":"Majeed","year":"2020","journal-title":"Polym. Bull."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114805_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3390\/gels7040153","article-title":"Development of a Polysaccharide-Based Hydrogel Drug Delivery System (DDS): An Update","volume":"7","author":"Pushpamalar","year":"2021","journal-title":"Gels"},{"issue":"11","key":"10.1016\/j.colsurfb.2025.114805_bib5","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1007\/s13346-022-01152-3","article-title":"Natural polysaccharide-based biodegradable polymeric platforms for transdermal drug delivery system: a critical analysis","volume":"12","author":"Noreen","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114805_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202310129","article-title":"AB-s. thiolated poly- and oligosaccharide-based hydrogels for tissue engineering and wound healing","volume":"34","author":"Noreen","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2025.114805_bib7","first-page":"1","article-title":"Synthesis and characterization of pH-sensitive chemically crosslinked block copolymer [Hyaluronic acid\/Poloxamer 407-co-poly (Methacrylic acid)] hydrogels for colon targeting","author":"Noreen","year":"2022","journal-title":"Polym. -Plast. Technol. Mater."},{"issue":"09","key":"10.1016\/j.colsurfb.2025.114805_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.2217\/nnm-2023-0318","article-title":"pH-sensitive docetaxel-loaded chitosan\/thiolated hyaluronic acid polymeric nanoparticles for colorectal cancer","volume":"19","author":"Noreen","year":"2024","journal-title":"Nanomedicine"},{"issue":"21","key":"10.1016\/j.colsurfb.2025.114805_bib9","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.3390\/polym13213785","article-title":"Redox\/ph-responsive biodegradable thiol-hyaluronic acid\/chitosan charge-reversal nanocarriers for triggered drug release","volume":"13","author":"Xia","year":"2021","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib10","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/15685551.2017.1368116","article-title":"Preparation and characterization of pH sensitive crosslinked Linseed polysaccharides-co-acrylic acid\/methacrylic acid hydrogels for controlled delivery of ketoprofen","volume":"20","author":"Shabir","year":"2017","journal-title":"Des. Monomers Polym."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.114805_bib11","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.apsb.2017.03.002","article-title":"Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system","volume":"7","author":"Ci","year":"2017","journal-title":"Acta Pharm. Sin. B"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib12","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0141-3910(95)00041-J","article-title":"Hydrolytic degradation of hyaluronic acid","volume":"48","author":"Tokita","year":"1995","journal-title":"Polym. Degrad. Stab."},{"key":"10.1016\/j.colsurfb.2025.114805_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/masy.200851418","article-title":"editors. Effect of pH on the behavior of hyaluronic acid in dilute and semidilute aqueous solutions","author":"Maleki","year":"2008","journal-title":"Macromol. Symp."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.114805_bib14","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1021\/acs.macromol.9b00889","article-title":"Internal structure of hyaluronic acid hydrogels controlled by iron (III) ion\u2013catechol complexation","volume":"52","author":"Ryu","year":"2019","journal-title":"Macromolecules"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114805_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202310129","article-title":"Thiolated Poly-and Oligosaccharide-Based Hydrogels for Tissue Engineering and Wound Healing","volume":"34","author":"Noreen","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114805_bib16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/gels4040082","article-title":"Evaluation of hydrogels based on oxidized hyaluronic acid for bioprinting","volume":"4","author":"Weis","year":"2018","journal-title":"Gels"},{"issue":"19","key":"10.1016\/j.colsurfb.2025.114805_bib17","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.3390\/ma12193080","article-title":"Hyaluronic acid-conjugated with hyperbranched chlorin e6 using disulfide linkage and its nanophotosensitizer for enhanced photodynamic therapy of cancer cells","volume":"12","author":"Jung","year":"2019","journal-title":"Materials"},{"issue":"10","key":"10.1016\/j.colsurfb.2025.114805_bib18","first-page":"1071","article-title":"Synthesis and characterization of pH-sensitive chemically crosslinked block copolymer [Hyaluronic acid\/Poloxamer 407-co-poly (Methacrylic acid)] hydrogels for colon targeting","volume":"61","author":"Noreen","year":"2022","journal-title":"Polym. -Plast. Technol. Mater."},{"key":"10.1016\/j.colsurfb.2025.114805_bib19","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.carbpol.2015.06.073","article-title":"Synthesis and characterization of thiolated \u03b2-cyclodextrin as a novel mucoadhesive excipient for intra-oral drug delivery","volume":"132","author":"Ijaz","year":"2015","journal-title":"Carbohydr. Polym."},{"issue":"8","key":"10.1016\/j.colsurfb.2025.114805_bib20","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1002\/jps.24514","article-title":"Synthesis and in vitro evaluation of thiolated carrageenan","volume":"104","author":"Suchaoin","year":"2015","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.biomaterials.2010.09.036","article-title":"Development and in vivo evaluation of an oral drug delivery system for paclitaxel","volume":"32","author":"Iqbal","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2025.114805_bib22","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejpb.2016.01.006","article-title":"Novel bioadhesive polymers as intra-articular agents: Chondroitin sulfate-cysteine conjugates","volume":"101","author":"Suchaoin","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib23","doi-asserted-by":"crossref","first-page":"e0263026","DOI":"10.1371\/journal.pone.0263026","article-title":"Development of \u03b2-cyclodextrin\/polyvinypyrrolidone-co-poly (2-acrylamide-2-methylpropane sulphonic acid) hybrid nanogels as nano-drug delivery carriers to enhance the solubility of Rosuvastatin: An in vitro and in vivo evaluation","volume":"17","author":"Shoukat","year":"2022","journal-title":"Plos One"},{"key":"10.1016\/j.colsurfb.2025.114805_bib24","series-title":"The Mathematics of Diffusion","first-page":"32","article-title":"Infinite and semi-infinite media","author":"Crank","year":"1975"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1080\/1539445X.2017.1368559","article-title":"Green synthesis and swelling behavior of Ag-nanocomposite semi-IPN hydrogels and their drug delivery using Dolichos biflorus Linn","volume":"16","author":"Basu","year":"2018","journal-title":"Soft Mater."},{"key":"10.1016\/j.colsurfb.2025.114805_bib26","series-title":"Principles of polymer chemistry","author":"Flory","year":"1953"},{"key":"10.1016\/j.colsurfb.2025.114805_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.eurpolymj.2018.08.035","article-title":"Melamine-based poly (azomethine) hydrogels: Mechanical, biodegradability, drug loading and antibacterial properties","volume":"108","author":"Kamaci","year":"2018","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.colsurfb.2025.114805_bib28","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1007\/s00289-019-02837-5","article-title":"Fabrication and evaluation studies of novel polyvinylpyrrolidone and 2-acrylamido-2-methylpropane sulphonic acid-based crosslinked matrices for controlled release of acyclovir","volume":"77","author":"Shoukat","year":"2020","journal-title":"Polym. Bull."},{"key":"10.1016\/j.colsurfb.2025.114805_bib29","article-title":"Development of \u03b2-cyclodextrin\/chitosan-co-poly (2-acrylamide-2-methylpropane sulphonic acid) cross-linked hybrid IPN-nanogels to enhance the solubility of rosuvastatin: an in vitro and in vivo attributes","volume":"75","author":"Shoukat","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.114805_bib30","article-title":"Rapid self-healing carboxymethyl chitosan\/hyaluronic acid hydrogels with injectable ability for drug delivery","author":"Zhang","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib31","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1515\/bmc-2018-0019","article-title":"In vitro and in vivo evaluation of colon cancer targeted epichlorohydrin crosslinked Portulaca-alginate beads","volume":"9","author":"Asnani","year":"2018","journal-title":"Biomol. Concepts"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ejpb.2004.02.017","article-title":"The use of polymers for dermal and transdermal delivery","volume":"58","author":"Valenta","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2025.114805_bib33","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3389\/fphar.2020.00524","article-title":"Advances in oral drug delivery for regional targeting in the gastrointestinal tract-influence of physiological, pathophysiological and pharmaceutical factors","volume":"11","author":"Hua","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.colsurfb.2025.114805_bib34","first-page":"428","article-title":"MJJocs. Direct UPLC-MS-MS validated method for the quantification of 5-aminolevulinic acid: application to in-vitro assessment of colonic-targeted oral tablets","volume":"49","author":"Alsarra","year":"2011"},{"issue":"73","key":"10.1016\/j.colsurfb.2025.114805_bib35","article-title":"Ex vivo red blood cell hemolysis assay for the evaluation of pH-responsive endosomolytic agents for cytosolic delivery of biomacromolecular drugs","author":"Evans","year":"2013","journal-title":"JoVE (J. Vis. Exp. )"},{"issue":"21","key":"10.1016\/j.colsurfb.2025.114805_bib36","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.3390\/polym13213703","article-title":"Antibacterial and hemocompatible pH-responsive hydrogel for skin wound healing application: In vitro drug release","volume":"13","author":"Khan","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2025.114805_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-021-00776-w","article-title":"Anti-bacterial and wound healing-promoting effects of zinc ferrite nanoparticles","volume":"19","author":"Haghniaz","year":"2021","journal-title":"J. nanobiotechnology"},{"key":"10.1016\/j.colsurfb.2025.114805_bib38","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1007\/s00289-020-03356-4","article-title":"Understanding mechanical characteristics of pH-responsive PEG 4000-based polymeric network for colorectal carcinoma: its acute oral toxicity study","volume":"78","author":"Barkat","year":"2021","journal-title":"Polym. Bull."},{"key":"10.1016\/j.colsurfb.2025.114805_bib39","series-title":"A Novel thiolated hyaluronic acid hydrogel for spinal cord injury repair","author":"Li","year":"2014"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114805_bib40","article-title":"Quantitative analysis of COOH-terminated alkanethiol SAMs on gold nanoparticle surfaces","volume":"3","author":"Nguyen","year":"2012","journal-title":"Adv. Nat. Sci.: Nanosci. Nanotechnol."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.114805_bib41","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4155\/tde-2020-0114","article-title":"Hydrogels as potential drug-delivery systems: Network design and applications","volume":"12","author":"Shoukat","year":"2021","journal-title":"Ther. Deliv."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901396","article-title":"Specialty tough hydrogels and their biomedical applications","volume":"9","author":"Fuchs","year":"2020","journal-title":"Adv. Healthc. Mater."},{"issue":"7","key":"10.1016\/j.colsurfb.2025.114805_bib43","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/gels8070454","article-title":"Poly (N-isopropylacrylamide)-based hydrogels for biomedical applications: a review of the state-of-the-art","volume":"8","author":"Ansari","year":"2022","journal-title":"Gels"},{"key":"10.1016\/j.colsurfb.2025.114805_bib44","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.copbio.2016.02.008","article-title":"Recent advances in hyaluronic acid hydrogels for biomedical applications","volume":"40","author":"Highley","year":"2016","journal-title":"Curr. Opin. Biotechnol."},{"key":"10.1016\/j.colsurfb.2025.114805_bib45","first-page":"154","article-title":"Tailoring hyaluronic acid hydrogels: Impact of cross-linker length and density on skin rejuvenation as injectable dermal fillers and their potential effects on the MAPK signaling pathway suppression","volume":"49","author":"Murugesan","year":"2025","journal-title":"Bioact. Mater."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib46","first-page":"81","article-title":"Effect of hyaluronic acid initial concentration on cross-linking efficiency of hyaluronic acid\u2013based hydrogels used in biomedical and cosmetic applications","volume":"72","author":"Al-Sibani","year":"2017","journal-title":"Die Pharm. - Int. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib47","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-69047-6","article-title":"The use of hyaluronic acid in a 3D biomimetic scaffold supports spheroid formation and the culture of cancer stem cells","volume":"14","author":"Demirel","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2025.114805_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcou.2024.102908","article-title":"Hydrophobic and hydrophilic functional groups and their impact on physical adsorption of CO2 in presence of H2O: A critical review","volume":"86","author":"Gorbounov","year":"2024","journal-title":"J. CO2 Util."},{"key":"10.1016\/j.colsurfb.2025.114805_bib49","article-title":"Impact of surface functional groups and their introduction methods on the mechanisms of CO2 adsorption on porous carbonaceous adsorbents","volume":"3","author":"Petrovic","year":"2022","journal-title":"Carbon Capture Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.114805_bib50","first-page":"1","article-title":"Development of chondroitin sulfate-based mucoadhesive interpenetrating polymeric hydrogels of captopril with adjustable properties as gastro-retentive sustained drug release carriers","author":"Qaiser","year":"2023","journal-title":"Polym. Bull."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.114805_bib51","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/polym10030243","article-title":"Thiolated hyaluronic acid as versatile Mucoadhesive polymer: from the chemistry behind to product developments\u2014what are the capabilities?","volume":"10","author":"Griesser","year":"2018","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2025.114805_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105254","article-title":"Novel multiparticulate pH triggered delayed release chronotherapeutic drug delivery of celecoxib-\u03b2-cyclodextrin inclusion complexes by using Box-Behnken design","volume":"146","author":"Maqbool","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/acspolymersau.1c00049","article-title":"Effect of pH on the properties of hydrogels cross-linked via dynamic Thia-Michael addition bonds","volume":"2","author":"FitzSimons","year":"2021","journal-title":"ACS Polym. Au"},{"issue":"19","key":"10.1016\/j.colsurfb.2025.114805_bib54","doi-asserted-by":"crossref","first-page":"16789","DOI":"10.1021\/acsomega.3c00270","article-title":"Fabrication of an injectable star-polylactide\/thiolated hyaluronate hydrogel as a double drug-delivery system for cancer treatment","volume":"8","author":"Zhang","year":"2023","journal-title":"ACS Omega"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114805_bib55","article-title":"Thiolated poly-and oligosaccharide-based hydrogels for tissue engineering and wound healing","volume":"34","author":"SaBS","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2025.114805_bib56","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.ijpharm.2007.04.019","article-title":"Synthesis and in vitro evaluation of thiolated hyaluronic acid for mucoadhesive drug delivery","volume":"343","author":"Kafedjiiski","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114805_bib57","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.2147\/IJN.S257700","article-title":"Recent advances in designing 5-fluorouracil delivery systems: a stepping stone in the safe treatment of colorectal cancer","author":"Entezar-Almahdi","year":"2020","journal-title":"Int. J. Nanomed."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114805_bib58","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jsps.2016.05.010","article-title":"Prolonged exposure of colon cancer cells to 5-fluorouracil nanoparticles improves its anticancer activity","volume":"25","author":"Tawfik","year":"2017","journal-title":"Saudi Pharm. J."},{"issue":"11","key":"10.1016\/j.colsurfb.2025.114805_bib59","doi-asserted-by":"crossref","first-page":"e0259545","DOI":"10.1371\/journal.pone.0259545","article-title":"Libidibia ferrea (juc\u00e1) anti-inflammatory action: a systematic review of in vivo and in vitro studies","volume":"16","author":"Almeida","year":"2021","journal-title":"Plos One"},{"key":"10.1016\/j.colsurfb.2025.114805_bib60","article-title":"Simulation-based approaches for drug delivery systems: navigating advancements, opportunities, and challenges","author":"Salahshoori","year":"2023","journal-title":"J. Mol. Liq."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib61","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/adv.21659","article-title":"Synthesis and characterization of biodegradable hydrogels for oral delivery of 5-fluorouracil targeted to colon: screening with preliminary in vivo studies","volume":"37","author":"Minhas","year":"2018","journal-title":"Adv. Polym. Technol."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114805_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-10-211","article-title":"Pharmacokinetic properties and antitumor efficacy of the 5-fluorouracil loaded PEG-hydrogel","volume":"10","author":"Yi","year":"2010","journal-title":"BMC Cancer"},{"issue":"18","key":"10.1016\/j.colsurfb.2025.114805_bib63","doi-asserted-by":"crossref","first-page":"11385","DOI":"10.1021\/acs.chemrev.0c01177","article-title":"Translational applications of hydrogels","volume":"121","author":"Correa","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2025.114805_bib64","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s00289-019-03092-4","article-title":"Formulation and evaluation of interpenetrating network of xanthan gum and polyvinylpyrrolidone as a hydrophilic matrix for controlled drug delivery system","volume":"78","author":"Anwar","year":"2021","journal-title":"Polym. Bull."},{"key":"10.1016\/j.colsurfb.2025.114805_bib65","series-title":"Biological Evaluation of Medical Devices as an Essential Part of the Risk Management Process: Updates and Challenges of ISO 10993-1: 2018","author":"Cambiaghi","year":"2018"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525003121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525003121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T18:36:30Z","timestamp":1754764590000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525003121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":65,"alternative-id":["S0927776525003121"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114805","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel thiol-functionalized hyaluronic acid-based pH-responsive hydrogel: A promising mucoadhesive drug delivery approach toward the treatment of colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114805","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114805"}}