{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:31:07Z","timestamp":1785285067274,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["5\/9\/1423\/2022-Nut"],"award-info":[{"award-number":["5\/9\/1423\/2022-Nut"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["MLP-204"],"award-info":[{"award-number":["MLP-204"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["31\/054(0163)\/2020-EMR-I"],"award-info":[{"award-number":["31\/054(0163)\/2020-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["5778"],"award-info":[{"award-number":["5778"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.colsurfb.2025.114836","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T16:15:52Z","timestamp":1748621752000},"page":"114836","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Development and characterization of \u03b1-Lipoic acid amorphous solid dispersion for improved oral bioavailability and modulation of allergic airway inflammation"],"prefix":"10.1016","volume":"254","author":[{"family":"Ruchika","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra Vijay","family":"Tirpude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2423-4704","authenticated-orcid":false,"given":"Ankit","family":"Saneja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.114836_bib1","article-title":"Orally fast dissolving \u03b1-lipoic acid electrospun nanofibers mitigates lipopolysaccharide induced inflammation in RAW 264.7 macrophages","volume":"264","author":"Ruchika","year":"2024","journal-title":"J. Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib2","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3390\/antiox13060706","article-title":"Nanotechnological approaches to enhance the potential of \u03b1-Lipoic acid for application in the clinic","volume":"13","author":"Bellini","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2025.114836_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.113894","article-title":"Vitex negundo Linn. extract alleviates inflammatory aggravation and lung injury by modulating AMPK\/PI3K\/Akt\/p38-NF-\u03baB and TGF-\u03b2\/Smad\/Bcl2\/caspase\/LC3 cascade and macrophages activation in murine model of OVA-LPS induced allergic asthma","volume":"271","author":"Tirpude","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib4","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.puhe.2023.10.030","article-title":"Global, regional, and national trends in osteoarthritis disability-adjusted life years (DALYs) from 1990 to 2019: a comprehensive analysis of the global burden of disease study","volume":"226","author":"Ding","year":"2024","journal-title":"Public Health"},{"key":"10.1016\/j.colsurfb.2025.114836_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12940-024-01060-8","article-title":"Global patterns of asthma burden related to environmental risk factors during 1990\u20132019: an age-period-cohort analysis for global burden of disease study 2019","volume":"23","author":"Zhang","year":"2024","journal-title":"Environ. Health"},{"key":"10.1016\/j.colsurfb.2025.114836_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.100995","article-title":"Cellular and molecular mechanisms of allergic asthma","volume":"85","author":"Koml\u00f3si","year":"2022","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.colsurfb.2025.114836_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155149","article-title":"Phytochemicals as treatment for allergic asthma: therapeutic effects and mechanisms of action","volume":"122","author":"Jasemi","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.colsurfb.2025.114836_bib8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.jaci.2004.04.004","article-title":"\u03b1-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma","volume":"114","author":"Cho","year":"2004","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109713","article-title":"The effects of lipoic acid on respiratory diseases","volume":"116","author":"Guo","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.4314\/tjpr.v21i2.11","article-title":"Protective effect of maternal exposure to \u03b1-lipoic acid during pregnancy and lactation on susceptibility to OVAinduced neonatal asthma","volume":"21","author":"Jiang","year":"2022","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.colsurfb.2025.114836_bib11","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1021\/acs.jafc.2c01685","article-title":"R-\u03b1-Lipoic acid conjugated to d-\u03b1-tocopherol polyethylene glycol 1000 succinate: synthesis, characterization, and effect on antiseizure activity","volume":"70","author":"Ruchika","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2025.114836_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135421","article-title":"Encapsulation of astaxanthin in OSA-starch based amorphous solid dispersions with HPMCAS-HF\/Soluplus\u00ae as effective recrystallization inhibitor","volume":"279","author":"Li","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e34636","article-title":"Curcumin-loaded soluplus\u00ae based ternary solid dispersions with enhanced solubility, dissolution and antibacterial, antioxidant, anti-inflammatory activities","volume":"10","author":"Ishtiaq","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.colsurfb.2025.114836_bib14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3390\/ph14090846","article-title":"Preparation of solid dispersions of simvastatin and soluplus using a single-step organic solvent-free supercritical fluid process for the drug solubility and dissolution rate enhancement","volume":"14","author":"Nandi","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.colsurfb.2025.114836_bib15","article-title":"Leveraging solid solubility and miscibility of etoricoxib in Soluplus\u00ae towards manufacturing of 3D printed etoricoxib tablets by additive manufacturing","author":"Ashokbhai","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114836_bib16","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.powtec.2012.12.038","article-title":"Soluplus\u00ae: a novel polymeric solubilizer for optimization of carvedilol solid dispersions: formulation design and effect of method of preparation","volume":"237","author":"Shamma","year":"2013","journal-title":"Powder Technol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213627","article-title":"Amorphous solid dispersion augments the bioavailability of phloretin and its therapeutic efficacy via targeting mTOR\/SREBP-1c axis in NAFLD mice","volume":"154","author":"Chhimwal","year":"2023","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.colsurfb.2025.114836_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.powtec.2015.04.044","article-title":"Preparation and characterization of solid dispersion using a novel amphiphilic copolymer to enhance dissolution and oral bioavailability of sorafenib","volume":"283","author":"Truong","year":"2015","journal-title":"Powder Technol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib19","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1080\/03639045.2016.1205598","article-title":"Solubility and dissolution performances of spray-dried solid dispersion of Efavirenz in Soluplus","volume":"43","author":"Lavra","year":"2017","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114836_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120245","article-title":"Third-generation solid dispersion combining Soluplus and poloxamer 407 enhances the oral bioavailability of resveratrol","volume":"595","author":"Vasconcelos","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114836_bib21","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.3390\/pharmaceutics14091797","article-title":"Enhancement of the bioavailability and anti-inflammatory activity of glycyrrhetinic acid via novel Soluplus\u00ae\u2014a glycyrrhetinic acid solid dispersion","volume":"14","author":"Wang","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.114836_bib22","doi-asserted-by":"crossref","first-page":"56850","DOI":"10.1021\/acsami.1c16293","article-title":"Quaternary ammonium salts anchored on cross-linked (R)-(+)-lipoic acid nanoparticles for drug-resistant tumor therapy","volume":"13","author":"Zhou","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2025.114836_bib23","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1021\/acs.biomac.0c01321","article-title":"Poly (lipoic acid)-based nanoparticles as self-organized, biocompatible, and corona-free nanovectors","volume":"22","author":"Trzci\u0144ski","year":"2020","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2025.114836_bib24","doi-asserted-by":"crossref","first-page":"3970","DOI":"10.1039\/D3TB02899B","article-title":"Lipoic acid-mediated oral drug delivery system utilizing changes on cell surface thiol expression for the treatment of diabetes and inflammatory diseases","volume":"12","author":"Wu","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.colsurfb.2025.114836_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122581","article-title":"Alpha lipoic acid\u2013loaded electrospun fibrous patch films protect heart in acute myocardial infarction mice by inhibiting oxidative stress","volume":"632","author":"Xie","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114836_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3390\/pharmaceutics12030228","article-title":"Development of novel silica-based formulation of \u03b1-lipoic acid: evaluation of photo and thermal stability of the encapsulated drug","volume":"12","author":"Dolinina","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.114836_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/03639045.2020.1716376","article-title":"Soluplus\u00ae based solid dispersion as fast disintegrating tablets: a combined experimental approach for enhancing the dissolution and antiulcer efficacy of famotidine","volume":"46","author":"Basha","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114836_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/109563","article-title":"Preparation and characterization of solid dispersions of artemether by freeze-dried method","volume":"2015","author":"Ansari","year":"2015","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.colsurfb.2025.114836_bib29","article-title":"A solid dispersion of Citrus reticulata peel biowaste as an effective antiepileptic: sustainable approach toward value addition and agro-industrial waste valorisation","volume":"81","author":"Sharma","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"J. Comput. Methods Prog. Biomed."},{"key":"10.1016\/j.colsurfb.2025.114836_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-020-01849-z","article-title":"Overview of extensively employed polymeric carriers in solid dispersion technology","volume":"21","author":"Nair","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2025.114836_bib32","doi-asserted-by":"crossref","first-page":"10214","DOI":"10.3390\/app131810214","article-title":"Encapsulation of \u03b1-lipoic acid in halloysite nanotubes","volume":"13","author":"Melnyk","year":"2023","journal-title":"Appl. Sci."},{"key":"10.1016\/j.colsurfb.2025.114836_bib33","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1557\/s43578-020-00021-4","article-title":"Study of thermal properties of antioxidant lipoamide and its composites with colloid silica","volume":"36","author":"Dolinina","year":"2021","journal-title":"J. Mater. Res."},{"key":"10.1016\/j.colsurfb.2025.114836_bib34","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s11095-005-4594-z","article-title":"Spray-dried amorphous solid dispersions of simvastatin, a low T g drug: in vitro and in vivo evaluations","volume":"22","author":"Ambike","year":"2005","journal-title":"J. Pharm. Res."},{"key":"10.1016\/j.colsurfb.2025.114836_bib35","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1002\/jps.24541","article-title":"Amorphous solid dispersions: utilization and challenges in drug discovery and development","volume":"104","author":"He","year":"2015","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.114836_bib36","first-page":"1","article-title":"Enhancement of curcumin solubility using a novel solubilizing polymer Soluplus\u00ae","author":"Al-Akayleh","year":"2020","journal-title":"J. Pharm. Innov."},{"key":"10.1016\/j.colsurfb.2025.114836_bib37","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/sci1020048","article-title":"Evaluation of dissolution enhancement of aprepitant drug in ternary pharmaceutical solid dispersions with Soluplus\u00ae and Poloxamer 188 prepared by melt mixing","volume":"1","author":"Nanaki","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2025.114836_bib38","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.3390\/ijms14023639","article-title":"Analysis of the enhanced stability of R (+)-alpha lipoic acid by the complex formation with cyclodextrins","volume":"14","author":"Ikuta","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2025.114836_bib39","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s10973-012-2444-x","article-title":"Thermodynamic analysis of lipoic acid crystallized with additives","volume":"111","author":"Zhang","year":"2013","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.colsurfb.2025.114836_bib40","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.3390\/polym16141961","article-title":"Stability studies of amorphous Ibrutinib prepared using the quench-cooling method and its dispersions with Soluplus\u00ae","volume":"16","author":"Mucha","year":"2024","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2025.114836_bib41","doi-asserted-by":"crossref","first-page":"176","DOI":"10.3390\/pr9010176","article-title":"Evaluation of dissolution profiles of a newly developed solid oral immediate-release formula containing alpha-lipoic acid","volume":"9","author":"Pop","year":"2021","journal-title":"Processes"},{"key":"10.1016\/j.colsurfb.2025.114836_bib42","first-page":"195","article-title":"Enantiomer-selective pharmacokinetics, oral bioavailability, and sex effects of various alpha-lipoic acid dosage forms","author":"Hermann","year":"2014","journal-title":"Clin. Pharmacol. Adv. Appl."},{"key":"10.1016\/j.colsurfb.2025.114836_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/currents.RRN1291","article-title":"Pharmacokinetics of memantine in rats and mice","author":"Beconi","year":"2011","journal-title":"PLoS Curr."},{"key":"10.1016\/j.colsurfb.2025.114836_bib44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1186\/s12951-022-01596-2","article-title":"Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and bioavailability","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2025.114836_bib45","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/bdd.2277","article-title":"Self-emulsifying drug delivery system of (R)-\u03b1-lipoic acid to improve its stability and oral absorption","volume":"42","author":"Banik","year":"2021","journal-title":"Biopharm. Drug Dispos."},{"key":"10.1016\/j.colsurfb.2025.114836_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08171","article-title":"Modulation of COX-2 and NADPH oxidase-4 by alpha-lipoic acid ameliorates busulfan-induced pulmonary injury in rats","volume":"7","author":"Elhadidy","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.colsurfb.2025.114836_bib47","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/19390211.2021.1966152","article-title":"A combination of \u03b1-lipoic acid (ALA) and palmitoylethanolamide (PEA) blocks endotoxin-induced oxidative stress and cytokine storm: a possible intervention for COVID-19","volume":"20","author":"Uberti","year":"2023","journal-title":"J. Diet. Suppl."},{"key":"10.1016\/j.colsurfb.2025.114836_bib48","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.2147\/JAA.S298613","article-title":"Embelin alleviates severe airway inflammation in OVA-LPS-induced rat model of allergic asthma","author":"Azman","year":"2021","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.colsurfb.2025.114836_bib49","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.cyto.2015.07.022","article-title":"Lipopolysaccharide (LPS) exposure differently affects allergic asthma exacerbations and its amelioration by intranasal curcumin in mice","volume":"76","author":"Kumari","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.colsurfb.2025.114836_bib50","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12967-022-03337-3","article-title":"Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4\/NF-kB signaling pathway","volume":"20","author":"Wu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.colsurfb.2025.114836_bib51","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520903663","article-title":"Inhibition of phosphodiesterase suppresses allergic lung inflammation by regulating MCP-1 in an OVA-induced asthma murine model with co-exposure to lipopolysaccharide","volume":"48","author":"Lee","year":"2020","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.colsurfb.2025.114836_bib52","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1186\/s12931-022-02209-0","article-title":"Neutrophil activation and NETosis are the predominant drivers of airway inflammation in an OVA\/CFA\/LPS induced murine model","volume":"23","author":"Xia","year":"2022","journal-title":"Respir. Res."},{"key":"10.1016\/j.colsurfb.2025.114836_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101185","article-title":"Markers of inflammation and their association with muscle strength and mass: a systematic review and meta-analysis","volume":"64","author":"Tuttle","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.colsurfb.2025.114836_bib54","doi-asserted-by":"crossref","first-page":"42675","DOI":"10.1038\/srep42675","article-title":"Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2025.114836_bib55","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S1081-1206(10)60528-5","article-title":"Decrease in airway mucous gene expression caused by treatment with anti-tumor necrosis factor \u03b1 in a murine model of allergic asthma","volume":"103","author":"Busse","year":"2009","journal-title":"Ann. Allergy"},{"key":"10.1016\/j.colsurfb.2025.114836_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16429","article-title":"Experimental allergic airway inflammation impacts gut homeostasis in mice","volume":"9","author":"Nascimento","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.colsurfb.2025.114836_bib57","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1007\/s43032-021-00597-0","article-title":"Melatonin ameliorates LPS-induced testicular nitro-oxidative stress (iNOS\/TNF\u03b1) and inflammation (NF-kB\/COX-2) via modulation of SIRT-1","volume":"28","author":"Kumar","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.colsurfb.2025.114836_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110435","article-title":"\u03b1-Lipoic acid alleviates myocardial injury and induces M2b macrophage polarization after myocardial infarction via HMGB1\/NF-kB signaling pathway","volume":"121","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525003431?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525003431?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:24:09Z","timestamp":1777591449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525003431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":58,"alternative-id":["S0927776525003431"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114836","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and characterization of \u03b1-Lipoic acid amorphous solid dispersion for improved oral bioavailability and modulation of allergic airway inflammation","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114836","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114836"}}