{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T03:14:59Z","timestamp":1782530099115,"version":"3.54.5"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014996","name":"Health Commission of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20240043"],"award-info":[{"award-number":["Y20240043"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.colsurfb.2025.114918","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:40:35Z","timestamp":1751377235000},"page":"114918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["ATB0,+-targeted nanoparticles trigger STAT3-ferroptosis regulatory axis for enhanced gastric cancer therapy"],"prefix":"10.1016","volume":"255","author":[{"given":"Hailun","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiang","family":"Shangguan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyao","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8502-4279","authenticated-orcid":false,"given":"Longfa","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.colsurfb.2025.114918_bib1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13045-023-01451-3","article-title":"Gastric cancer treatment: recent progress and future perspectives","volume":"16","author":"Guan","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.114918_bib2","first-page":"264","article-title":"Current treatment and recent progress in gastric cancer","volume":"71","author":"Joshi","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"8","key":"10.1016\/j.colsurfb.2025.114918_bib3","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/cac2.12193","article-title":"The Chinese Society of clinical oncology (CSCO): clinical guidelines for the diagnosis and treatment of gastric cancer, 2021","volume":"41","author":"Wang","year":"2021","journal-title":"Cancer Commun (Lond)"},{"issue":"10251","key":"10.1016\/j.colsurfb.2025.114918_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0140-6736(20)31288-5","article-title":"Gastric cancer","volume":"396","author":"Smyth","year":"2020","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114918_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/1574892816666210929165729","article-title":"Current advances and outlook in gastric cancer chemoresistance: a review","volume":"17","author":"Zhang","year":"2022","journal-title":"Recent Pat. Anticancer Drug Discov."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114918_bib6","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/bfgp\/ely019","article-title":"Immunotherapy for gastric cancer: dilemmas and prospect","volume":"18","author":"Zhao","year":"2019","journal-title":"Brief. Funct. Genom."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.114918_bib7","doi-asserted-by":"crossref","first-page":"673","DOI":"10.4251\/wjgo.v8.i9.673","article-title":"Molecular mechanisms of chemoresistance in gastric cancer","volume":"8","author":"Shi","year":"2016","journal-title":"World J. Gastrointest. Oncol."},{"key":"10.1016\/j.colsurfb.2025.114918_bib8","article-title":"Overcoming cancer chemotherapy resistance by the induction of ferroptosis","volume":"66","author":"Wang","year":"2022","journal-title":"Drug Resist Updat"},{"issue":"7664","key":"10.1016\/j.colsurfb.2025.114918_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nature23007","article-title":"Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway","volume":"547","author":"Viswanathan","year":"2017","journal-title":"Nature"},{"issue":"7679","key":"10.1016\/j.colsurfb.2025.114918_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature24297","article-title":"Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition","volume":"551","author":"Hangauer","year":"2017","journal-title":"Nature"},{"issue":"30","key":"10.1016\/j.colsurfb.2025.114918_bib11","doi-asserted-by":"crossref","first-page":"26722","DOI":"10.1021\/acsami.9b09784","article-title":"Ambidextrous approach to disrupt redox balance in tumor cells with increased ros production and decreased GSH synthesis for cancer therapy","volume":"11","author":"Kou","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"27","key":"10.1016\/j.colsurfb.2025.114918_bib12","doi-asserted-by":"crossref","first-page":"30031","DOI":"10.1021\/acsami.0c03564","article-title":"Tumor Microenvironment-responsive, multistaged liposome induces apoptosis and ferroptosis by amplifying oxidative stress for enhanced cancer therapy","volume":"12","author":"Kou","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"12","key":"10.1016\/j.colsurfb.2025.114918_bib13","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.neo.2017.10.005","article-title":"Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells","volume":"19","author":"Hao","year":"2017","journal-title":"Neoplasia"},{"key":"10.1016\/j.colsurfb.2025.114918_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7007933","article-title":"Comprehensive analysis of ferroptosis-related markers for the clinical and biological value in gastric cancer","author":"Shao","year":"2021","journal-title":"Oxid. Med Cell Longev. 2021"},{"issue":"11","key":"10.1016\/j.colsurfb.2025.114918_bib15","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1038\/s41418-022-01008-w","article-title":"Wnt\/beta-catenin signaling confers ferroptosis resistance by targeting GPX4 in gastric cancer","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114918_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-020-01168-8","article-title":"CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer","volume":"19","author":"Zhang","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.colsurfb.2025.114918_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102317","article-title":"Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer","volume":"52","author":"Ouyang","year":"2022","journal-title":"Redox Biol."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114918_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020603","article-title":"The multifaced role of STAT3 in cancer and its implication for anticancer therapy","volume":"22","author":"Tolomeo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2025.114918_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2020.111109","article-title":"Nanoparticle mediated codelivery of nifuratel and doxorubicin for synergistic anticancer therapy through STAT3 inhibition","volume":"193","author":"Zheng","year":"2020","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"138","key":"10.1016\/j.colsurfb.2025.114918_bib20","article-title":"Dual Targeting EGFR and STAT3 with erlotinib and alantolactone Co-loaded PLGA nanoparticles for pancreatic cancer treatment","volume":"12","author":"Bao","year":"2021","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.colsurfb.2025.114918_bib21","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4062\/biomolther.2022.017","article-title":"Modulation of reactive oxygen species to overcome 5-fluorouracil resistance","volume":"30","author":"Chun","year":"2022","journal-title":"Biomol. Ther."},{"key":"10.1016\/j.colsurfb.2025.114918_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109135","article-title":"Targeting STAT3 inhibition to reverse cisplatin resistance","volume":"117","author":"Sun","year":"2019","journal-title":"Biomed. Pharm."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.114918_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells9102202","article-title":"Perspectives regarding the intersections between STAT3 and oxidative metabolism in cancer","volume":"9","author":"Chun","year":"2020","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114918_bib24","first-page":"599","article-title":"Metabolomics combined with network pharmacology reveals anti-asthmatic effects of Nepeta bracteata on allergic asthma rats","volume":"16","author":"Abulaiti","year":"2024","journal-title":"Chin. Herb. Med."},{"issue":"7","key":"10.1016\/j.colsurfb.2025.114918_bib25","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41419-022-05082-3","article-title":"Thiostrepton induces ferroptosis in pancreatic cancer cells through STAT3\/GPX4 signalling","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis."},{"issue":"11","key":"10.1016\/j.colsurfb.2025.114918_bib26","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/cbin.11121","article-title":"The induction of ferroptosis by impairing STAT3\/Nrf2\/GPx4 signaling enhances the sensitivity of osteosarcoma cells to cisplatin","volume":"43","author":"Liu","year":"2019","journal-title":"Cell Biol. Int"},{"issue":"10","key":"10.1016\/j.colsurfb.2025.114918_bib27","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.tibs.2018.05.003","article-title":"Amino acid transporters revisited: New views in health and disease","volume":"43","author":"Kandasamy","year":"2018","journal-title":"Trends Biochem Sci."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.114918_bib28","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1158\/0008-5472.CAN-14-3745","article-title":"Amino Acid transporters in cancer and their relevance to \"glutamine addiction\": novel targets for the design of a new class of anticancer drugs","volume":"75","author":"Bhutia","year":"2015","journal-title":"Cancer Res"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114918_bib29","first-page":"145","article-title":"The role of transporters in cancer redox homeostasis and cross-talk with nanomedicines","volume":"15","author":"Kou","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.114918_bib30","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1080\/17425247.2020.1723544","article-title":"Endocytosis of ATB(0,+)(SLC6A14)-targeted liposomes for drug delivery and its therapeutic application for pancreatic cancer","volume":"17","author":"Kou","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2025.114918_bib31","first-page":"15","article-title":"Resetting amino acid metabolism of cancer cells by ATB(0,+)-targeted nanoparticles for enhanced anticancer therapy","volume":"9","author":"Kou","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2025.114918_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123082","article-title":"ATB(0,+)-targeted nanoparticles initiate autophagy suppression to overcome chemoresistance for enhanced colorectal cancer therapy","volume":"641","author":"Chen","year":"2023","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114918_bib33","article-title":"SLC6A14 depletion contributes to amino acid starvation to suppress emt-induced metastasis in gastric cancer by perturbing the PI3K\/AKT\/mTORC1 pathway","author":"Guo","year":"2022","journal-title":"Biomed. Res Int 2022"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114918_bib34","first-page":"3","article-title":"Consensus statement on research and application of Chinese herbal medicine derived extracellular vesicles-like particles (2023 edition)","volume":"16","author":"Zhao","year":"2024","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.colsurfb.2025.114918_bib35","article-title":"Nanomedicine-based disulfiram and metal ion co-delivery strategies for cancer treatment","volume":"7","author":"Shen","year":"2024","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.colsurfb.2025.114918_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114268","article-title":"Photothermal nanocomposite reactivate \u201cimmune-hot\u201d for triple-negative breast cancer treatment via glutamine metabolism reprograming","volume":"245","author":"Cheng","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"10","key":"10.1016\/j.colsurfb.2025.114918_bib37","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/17435889.2025.2493037","article-title":"Exosome-based nanomedicines for digestive system tumors therapy","volume":"20","author":"Song","year":"2025","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2025.114918_bib38","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jconrel.2016.10.031","article-title":"Transporter occluded-state conformation-induced endocytosis: amino acid transporter ATB(0,+)-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy","volume":"243","author":"Luo","year":"2016","journal-title":"J. Control Release"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114918_bib39","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1177\/0300060516685513","article-title":"Cryptotanshinone potentiates the antitumor effects of doxorubicin on gastric cancer cells via inhibition of STAT3 activity","volume":"45","author":"Wang","year":"2017","journal-title":"J. Int. Med. Res."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.114918_bib40","first-page":"251","article-title":"Preparation of tanshinone II(A) self-soluble microneedles and its inhibition on proliferation of human skin fibroblasts","volume":"15","author":"Zhan","year":"2023","journal-title":"Chin. Herb. Med."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114918_bib41","first-page":"622","article-title":"Compound Danshen Dripping Pills combined with isosorbide mononitrate for angina pectoris: a systematic review and a Meta-analysis","volume":"16","author":"Wang","year":"2024","journal-title":"Chin. Herb. Med"},{"issue":"17","key":"10.1016\/j.colsurfb.2025.114918_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201700165","article-title":"Cotransporting ion is a trigger for cellular endocytosis of transporter-targeting nanoparticles: a case study of high-efficiency Slc22a5 (Octn2)-mediated carnitine-conjugated nanoparticles for oral delivery of therapeutic drugs","volume":"6","author":"Kou","year":"2017","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2025.114918_bib43","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.jconrel.2025.02.005","article-title":"Metabolic reprogramming of macrophages by a nano-sized opsonization strategy to restore M1\/M2 balance for osteoarthritis therapy","volume":"380","author":"Chen","year":"2025","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.colsurfb.2025.114918_bib44","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jconrel.2024.12.024","article-title":"Chondrocyte-targeted bilirubin\/rapamycin carrier-free nanoparticles alleviate oxidative stress and modulate autophagy for osteoarthritis therapy","volume":"378","author":"Huang","year":"2025","journal-title":"J. Control. Release Off. J. Control. Release Soc."},{"key":"10.1016\/j.colsurfb.2025.114918_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.03.027","article-title":"Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy","author":"Kou","year":"2025","journal-title":"J. Adv. Res"},{"issue":"6","key":"10.1016\/j.colsurfb.2025.114918_bib46","first-page":"293","article-title":"The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy","volume":"9","author":"Bhutia","year":"2014","journal-title":"Asian J. Pharm. Sci."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.114918_bib47","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41568-021-00435-0","article-title":"The role of ROS in tumour development and progression","volume":"22","author":"Cheung","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2025.114918_bib48","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/5080843","article-title":"Reactive oxygen species-induced lipid peroxidation in apoptosis, autophagy, and ferroptosis","author":"Su","year":"2019","journal-title":"Oxid. Med Cell Longev. 2019"},{"key":"10.1016\/j.colsurfb.2025.114918_bib49","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2020.08.035","article-title":"Hypoxia-activated ROS burst liposomes boosted by local mild hyperthermia for photo\/chemodynamic therapy","volume":"328","author":"Tang","year":"2020","journal-title":"J. Control Release"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.114918_bib50","first-page":"637","article-title":"Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy","volume":"15","author":"Yang","year":"2020","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.114918_bib51","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.cbi.2017.06.003","article-title":"Cryptotanshinone induces ROS-dependent autophagy in multidrug-resistant colon cancer cells","volume":"273","author":"Xu","year":"2017","journal-title":"Chem. Biol. Inter."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.114918_bib52","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2022.5398","article-title":"Cryptotanshinone suppresses tumorigenesis by inhibiting lipogenesis and promoting reactive oxygen species production in KRAS\u2011activated pancreatic cancer cells","volume":"61","author":"Terado","year":"2022","journal-title":"Int J. Oncol."},{"key":"10.1016\/j.colsurfb.2025.114918_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114918_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129539","article-title":"Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy","volume":"1864","author":"Wei","year":"2020","journal-title":"Biochim Biophys. Acta Gen. Subj."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.114918_bib55","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","article-title":"The chemical basis of ferroptosis","volume":"15","author":"Conrad","year":"2019","journal-title":"Nat. Chem. Biol."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.114918_bib56","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41591-018-0262-9","article-title":"Wiskott-Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma","volume":"25","author":"Menotti","year":"2019","journal-title":"Nat. Med"},{"issue":"7545","key":"10.1016\/j.colsurfb.2025.114918_bib57","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14344","article-title":"Ferroptosis as a p53-mediated activity during tumour suppression","volume":"520","author":"Jiang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2025.114918_bib58","doi-asserted-by":"crossref","first-page":"6031","DOI":"10.2147\/DDDT.S494555","article-title":"Pharmacological mechanisms of cryptotanshinone: recent advances in cardiovascular, cancer, and neurological disease applications","volume":"18","author":"Zheng","year":"2024","journal-title":"Drug Des. Devel Ther."},{"key":"10.1016\/j.colsurfb.2025.114918_bib59","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/1783485","article-title":"Bavachin Induces Ferroptosis through the STAT3\/P53\/SLC7A11 axis in osteosarcoma cells","author":"Luo","year":"2021","journal-title":"Oxid. Med. Cell Longev. 2021"},{"key":"10.1016\/j.colsurfb.2025.114918_bib60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2017.11.011","article-title":"Splenomegaly: pathophysiological bases and therapeutic options","volume":"94","author":"McKenzie","year":"2018","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.114918_bib61","doi-asserted-by":"crossref","first-page":"990","DOI":"10.4143\/crt.2015.296","article-title":"Splenomegaly and its associations with genetic polymorphisms and treatment outcome in colorectal cancer patients treated with adjuvant FOLFOX","volume":"48","author":"Kim","year":"2016","journal-title":"Cancer Res. Treat."},{"issue":"28","key":"10.1016\/j.colsurfb.2025.114918_bib62","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026651","article-title":"Successful management of thrombocytopenia by partial splenic embolization in patients with advanced gastric cancer and invasion of the splenic vein","volume":"100","author":"Nakatsubo","year":"2021","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.114918_bib63","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/dna.2021.0936","article-title":"Gastric cancer cell-derived kynurenines hyperactive regulatory t cells to promote chemoresistance via the IL-10\/STAT3\/BCL2 signaling pathway","volume":"41","author":"Wu","year":"2022","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.colsurfb.2025.114918_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111332","article-title":"A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen","volume":"137","author":"Li","year":"2021","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.colsurfb.2025.114918_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/9896148","article-title":"Cryptotanshinone ameliorates radiation-induced lung injury in rats","volume":"2019","author":"Jiang","year":"2019","journal-title":"Evid. Based Complement. Altern. Med."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525004254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525004254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T13:16:18Z","timestamp":1757337378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525004254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":65,"alternative-id":["S0927776525004254"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114918","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATB0,+-targeted nanoparticles trigger STAT3-ferroptosis regulatory axis for enhanced gastric cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114918"}}