{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:25:58Z","timestamp":1783625158056,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20513"],"award-info":[{"award-number":["U22A20513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["24NSFSC0279"],"award-info":[{"award-number":["24NSFSC0279"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.colsurfb.2025.114960","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:31:42Z","timestamp":1752679902000},"page":"114960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Nanozyme-synbiotics to improve iron-deficiency anemia"],"prefix":"10.1016","volume":"255","author":[{"given":"Aimin","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zean","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-2231","authenticated-orcid":false,"given":"Xianxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.114960_bib1","series-title":"Nutritional Anaemias: Tools for Effective Prevention and Control","year":"2017"},{"key":"10.1016\/j.colsurfb.2025.114960_bib2","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1182\/blood-2012-09-453522","article-title":"Control of iron deficiency anemia in low- and middle-income countries","volume":"121","author":"Pasricha","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.colsurfb.2025.114960_bib3","doi-asserted-by":"crossref","unstructured":"J. Freeland-Graves, M.J. ProffittInorganic Biochemistry of Iron Metabolism:\u2009From Molecular Mechanisms to Clinical Consequences. Second Edition By Robert Crichton (Universit\u00e9 Catholique De Louvain, Belgium). J. Wiley & Sons:\u2009Chichester. 2001. xxi + 326 pp. $165.00. ISBN:0-471-49223-X, Journal of the American Chemical Society, 124 (2002) 7636-7636..","DOI":"10.1021\/ja015379j"},{"key":"10.1016\/j.colsurfb.2025.114960_bib4","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2019-129544","article-title":"Exploring Aanemia's impact on brain microstructure, volume, functional connectivity, iron and cognitive performance","volume":"134","author":"Choi","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.colsurfb.2025.114960_bib5","unstructured":"WHO Global Anaemia estimates. The Global Health Observatory 2021.."},{"key":"10.1016\/j.colsurfb.2025.114960_bib6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/bcmd.2002.0564","article-title":"Pathways of iron absorption","volume":"29","author":"Conrad","year":"2002","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.colsurfb.2025.114960_bib7","unstructured":"R.J. Stoltzfus, M.L. DreyfussGuidelines for the use of iron supplements to prevent and treat iron deficiency anemia, 1998.."},{"key":"10.1016\/j.colsurfb.2025.114960_bib8","doi-asserted-by":"crossref","first-page":"813S","DOI":"10.1093\/jn\/132.4.813S","article-title":"Iron supplements: scientific issues concerning efficacy and implications for research and programs","volume":"132","author":"Allen","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.colsurfb.2025.114960_bib9","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/MIB.0000000000001089","article-title":"Iron supplements modulate colon microbiota composition and potentiate the protective effects of probiotics in dextran sodium sulfate-induced colitis","volume":"23","author":"Constante","year":"2017","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.colsurfb.2025.114960_bib10","doi-asserted-by":"crossref","unstructured":"K.M. Tun, J. Aponte-Pieras, Y. Naga, D. Lankarani, M. JayarajS3113Gastric Siderosis: An Under-Recognized Side Effect of Oral Ferrous Sulfate Supplements, 116 (2021) S1285.","DOI":"10.14309\/01.ajg.0000785984.13399.6a"},{"key":"10.1016\/j.colsurfb.2025.114960_bib11","first-page":"103","article-title":"Iron oxide nanoparticles versus ferrous sulfate in treatment of iron deficiency anemia in rats","volume":"49","author":"Elshemy","year":"2018","journal-title":"Egypt. J. Vet. Sci."},{"key":"10.1016\/j.colsurfb.2025.114960_bib12","doi-asserted-by":"crossref","unstructured":"D. Paganini, M.A. Uyoga, G.A.M. Kortman, C.I. Cercamondi, D. Moretti, T. Barth-Jaeggi, C. Schwab, J. Boekhorst, H.M. Timmerman, C. Lacroix, S. Karanja, M.B. ZimmermannPrebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants, 66 (2017) 1956-1967..","DOI":"10.1136\/gutjnl-2017-314418"},{"key":"10.1016\/j.colsurfb.2025.114960_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201903793","article-title":"A probiotic spore-based oral autonomous nanoparticles generator for cancer therapy","volume":"31","author":"Song","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.114960_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-023-01880-9","article-title":"Iron oxide nanoparticles carried by probiotics for iron absorption: a systematic review","volume":"21","author":"Ciont","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2025.114960_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10071330","article-title":"Prebiotics, probiotics, and postbiotics in the prevention and treatment of anemia","volume":"10","author":"Zakrzewska","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/j.colsurfb.2025.114960_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nrgastro.2017.75","article-title":"Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics","volume":"14","author":"Gibson","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.colsurfb.2025.114960_bib17","doi-asserted-by":"crossref","unstructured":"D. Davani-Davari, M. Negahdaripour, I. Karimzadeh, M. Seifan, M. Mohkam, S.J. Masoumi, A. Berenjian, Y. GhasemiPrebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications, 8 (2019) 92.","DOI":"10.3390\/foods8030092"},{"key":"10.1016\/j.colsurfb.2025.114960_bib18","doi-asserted-by":"crossref","unstructured":"A. Durazzo, A. Nazhand, M. Lucarini, A.G. Atanasov, E.B. Souto, E. Novellino, R. Capasso, A. SantiniAn Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics, 21 (2020) 2285.","DOI":"10.3390\/ijms21072285"},{"key":"10.1016\/j.colsurfb.2025.114960_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1182\/blood-2015-06-654194","article-title":"Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors","volume":"127","author":"Canli","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.colsurfb.2025.114960_bib20","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/acs.jmedchem.4c02426","article-title":"Synthesis and application of a novel multifunctional nanoprodrug for synergistic chemotherapy and phototherapy with hydrogen sulfide gas","volume":"68","author":"Yang","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2025.114960_bib21","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1021\/acs.nanolett.9b02832","article-title":"Micromotors for active delivery of minerals toward the treatment of iron deficiency anemia","volume":"19","author":"Karshalev","year":"2019","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2025.114960_bib22","doi-asserted-by":"crossref","first-page":"13612","DOI":"10.1073\/pnas.0606424103","article-title":"Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells","volume":"103","author":"Liuzzi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.colsurfb.2025.114960_bib23","doi-asserted-by":"crossref","first-page":"S-311","DOI":"10.1016\/S0016-5085(11)61252-3","article-title":"H. pylori infection induced internalization of duodenal cellular iron exporter FPN1","volume":"140","author":"Hirata","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.colsurfb.2025.114960_bib24","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cmet.2015.05.002","article-title":"SLC39A14 is required for the development of hepatocellular iron overload in murine models of hereditary hemochromatosis","volume":"22","author":"Jenkitkasemwong","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.colsurfb.2025.114960_bib25","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1053\/j.gastro.2011.04.012","article-title":"Reduced expression of ferroportin-1 mediates hyporesponsiveness of suckling rats to stimuli that reduce iron absorption","volume":"141","author":"Darshan","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1016\/j.colsurfb.2025.114960_bib26","doi-asserted-by":"crossref","first-page":"e1476","DOI":"10.1016\/S2214-109X(19)30414-0","article-title":"Iron-deficiency anaemia in pregnancy: the role of hepcidin","volume":"7","author":"Lewkowitz","year":"2019","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.colsurfb.2025.114960_bib27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng1150","article-title":"Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis","volume":"34","author":"Nicolas","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.colsurfb.2025.114960_bib28","doi-asserted-by":"crossref","first-page":"A-147","DOI":"10.1016\/S0016-5085(08)60684-8","article-title":"984 suppression of LPS and IL-6 signaling by iron deficiency alters expression of the intestinal iron absorption regulator hepcidin","volume":"134","author":"Darshan","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.colsurfb.2025.114960_bib29","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1021\/acs.nanolett.1c04260","article-title":"Palladium nanoplate-based IL-6 receptor antagonists ameliorate cancer-related anemia and simultaneously inhibit cancer progression","volume":"22","author":"Zhu","year":"2022","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2025.114960_bib30","doi-asserted-by":"crossref","unstructured":"A.V. Nguyen, M. Yaghoobi, S. Zhang, P. Li, Q. Li, B. Dogan, G.P. Ahnrud, G. Flock, P. Marek, K.W. Simpson, A. AbbaspourradAdaptive Laboratory Evolution of Probiotics toward Oxidative Stress Using a Microfluidic-Based Platform, 20 (2024) 2306974.","DOI":"10.1002\/smll.202306974"},{"key":"10.1016\/j.colsurfb.2025.114960_bib31","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1038\/s41401-024-01305-9","article-title":"A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis","volume":"45","author":"Wang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.colsurfb.2025.114960_bib32","doi-asserted-by":"crossref","first-page":"S952","DOI":"10.1016\/j.annonc.2020.08.2044","article-title":"1561P Anemia and iron deficiency (ID) in association with tissue iron regulators - Hepcidin, ferroportin and ZIP14 expression in patients with pancreatic cancer (PC)","volume":"31","author":"Osmola","year":"2020","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.colsurfb.2025.114960_bib33","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0168-8278(02)80603-1","article-title":"Regulation of hepatic iron transporter (DMT1 and FPN1) expression by dietary iron: analysis by real-time quantitative PCR","volume":"36","author":"Cheung","year":"2002","journal-title":"J. Hepatol."},{"key":"10.1016\/j.colsurfb.2025.114960_bib34","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/s41418-022-01089-7","article-title":"SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1","volume":"30","author":"Wang","year":"2023","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.colsurfb.2025.114960_bib35","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-086323","article-title":"Comparison of the efficacy and safety of low-dose antihypertensive combinations in patients with hypertension: protocol for a systematic review and network meta-analysis","volume":"14","author":"Zhao","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.colsurfb.2025.114960_bib36","doi-asserted-by":"crossref","first-page":"4374","DOI":"10.1109\/JBHI.2025.3540712","article-title":"Fast Virtual Stenting for Thoracic Endovascular Aortic Repair of Aortic Dissection Using Graph Deep Learning","volume":"29","author":"Zhang","year":"2025","journal-title":"IEEE J. Biomed. Health Inform."},{"key":"10.1016\/j.colsurfb.2025.114960_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116337","article-title":"The Janus face of mitophagy in myocardial ischemia\/reperfusion injury and recovery","volume":"173","author":"Deng","year":"2024","journal-title":"Biomed. Pharmacother."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525004679?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525004679?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T08:20:11Z","timestamp":1762330811000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525004679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"alternative-id":["S0927776525004679"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114960","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanozyme-synbiotics to improve iron-deficiency anemia","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.114960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114960"}}