{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:30:31Z","timestamp":1792031431009,"version":"4.4.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006397","name":"National Taiwan Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109\\u20132221-E-011\\u2013037"],"award-info":[{"award-number":["109\\u20132221-E-011\\u2013037"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.colsurfb.2025.115024","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T15:08:05Z","timestamp":1754665685000},"page":"115024","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"P1","title":["Development of temperature and reactive oxygen species dual-responsive gelatin-PNIPAM-based hydrogels containing ferulic acid for peripheral arterial disease treatment"],"prefix":"10.1016","volume":"256","author":[{"given":"Hsin-Ho","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruy-Yu","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Hsin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.colsurfb.2025.115024_bib1","article-title":"Effectiveness of revascularisation for the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review","volume":"40","author":"Chuter","year":"2024","journal-title":"Diabetes\/Metab. Res. Rev."},{"key":"10.1016\/j.colsurfb.2025.115024_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2024.104713","article-title":"Oxidative stress and vascular dysfunction: potential therapeutic targets and therapies in peripheral artery disease","author":"Allen","year":"2024","journal-title":"Microvasc. Res."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115024_bib3","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/antiox8090367","article-title":"Oxidative stress in peripheral arterial disease (PAD) mechanism and biomarkers","volume":"8","author":"Signorelli","year":"2019","journal-title":"Antioxidants"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115024_bib4","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/CIRCRESAHA.116.309045","article-title":"Autologous cell therapy for peripheral arterial disease: systematic review and meta-analysis of randomized, nonrandomized, and noncontrolled studies","volume":"120","author":"Rigato","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.colsurfb.2025.115024_bib5","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/VHRM.S125065","article-title":"Critical limb ischemia: current challenges and future prospects","author":"Uccioli","year":"2018","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.colsurfb.2025.115024_bib6","article-title":"Injectable thermosensitive selenium-containing hydrogel as mesenchymal stem cell carrier to improve treatment efficiency in limb ischemia","volume":"25","author":"Tian","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115024_bib7","doi-asserted-by":"crossref","first-page":"9955","DOI":"10.3390\/ijms24129955","article-title":"Clinical potential of hydrogen sulfide in peripheral arterial disease","volume":"24","author":"Bechelli","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2025.115024_bib8","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.avsg.2024.01.031","article-title":"Advancements in omics and breakthrough gene therapies: a glimpse into the future of peripheral artery disease","volume":"107","author":"Brennan","year":"2024","journal-title":"Ann. Vasc. Surg."},{"key":"10.1016\/j.colsurfb.2025.115024_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111291","article-title":"Potential utilization of ferulic acid and its derivatives in the management of metabolic diseases and disorders: an insight into mechanisms","volume":"121","author":"Khatun","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.colsurfb.2025.115024_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119921","article-title":"Ferulic acid: a review of its pharmacology, pharmacokinetics and derivatives","volume":"284","author":"Li","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.colsurfb.2025.115024_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153652","article-title":"Overview of therapeutic potentiality of angelica sinensis for ischemic stroke","volume":"90","author":"Han","year":"2021","journal-title":"Phytomedicine"},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115024_bib12","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jnutbio.2009.04.001","article-title":"Ferulic acid augments angiogenesis via VEGF, PDGF and HIF-1\u03b1","volume":"21","author":"Lin","year":"2010","journal-title":"J. Nutr. Biochem."},{"issue":"03","key":"10.1016\/j.colsurfb.2025.115024_bib13","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1142\/S0192415X08005965","article-title":"Angiogenic effects of the extracts from Chinese herbs: angelica and chuanxiong","volume":"36","author":"Meng","year":"2008","journal-title":"Am. J. Chin. Med."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115024_bib14","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.clnu.2020.07.026","article-title":"Increased bioavailability of phenolic acids and enhanced vascular function following intake of feruloyl esterase-processed high fibre bread: a randomized, controlled, single blind, crossover human intervention trial","volume":"40","author":"Turner","year":"2021","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.colsurfb.2025.115024_bib15","first-page":"1","article-title":"Ferulic acid: therapeutic potential due to its antioxidant properties, role in plant growth, and stress tolerance","author":"Khan","year":"2024","journal-title":"Plant Growth Regul."},{"key":"10.1016\/j.colsurfb.2025.115024_bib16","article-title":"Ferulic acid-loaded drug delivery systems for biomedical applications","volume":"75","author":"Shukla","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"20","key":"10.1016\/j.colsurfb.2025.115024_bib17","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.2174\/1381612828666220705113514","article-title":"Role of drug delivery system in improving the bioavailability of resveratrol","volume":"28","author":"Saleem","year":"2022","journal-title":"Curr. Pharm. Des."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115024_bib18","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1002\/ptr.7737","article-title":"Curcumin-piperine co-supplementation and human health: a comprehensive review of preclinical and clinical studies","volume":"37","author":"Heidari","year":"2023","journal-title":"Phytother. Res."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115024_bib19","article-title":"Recent progress in thermosensitive hydrogels and their applications in drug delivery area","volume":"2","author":"Khan","year":"2023","journal-title":"MedCommBiomater. Appl."},{"issue":"37","key":"10.1016\/j.colsurfb.2025.115024_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202402432","article-title":"Poly (N-isopropylacrylamide) and its copolymers: a review on recent advances in the areas of sensing and biosensing","volume":"34","author":"Das","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115024_bib21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1039\/C9TB02052G","article-title":"Thermoresponsive polymers and their biomedical application in tissue engineering\u2013a review","volume":"8","author":"Doberenz","year":"2020","journal-title":"J. Mater. Chem. B"},{"issue":"18","key":"10.1016\/j.colsurfb.2025.115024_bib22","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.3390\/polym13183154","article-title":"Tuning the properties of PNIPAm-based hydrogel scaffolds for cartilage tissue engineering","volume":"13","author":"Rana","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2025.115024_bib23","article-title":"Engineered cell-laden thermosensitive poly (N-isopropylacrylamide)-immobilized gelatin microspheres as 3D cell carriers for regenerative Medicine","volume":"15","author":"Yang","year":"2022","journal-title":"Mater. Today Bio"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115024_bib24","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00380-015-0677-x","article-title":"Safety and efficacy of sustained release of basic fibroblast growth factor using gelatin hydrogel in patients with critical limb ischemia","volume":"31","author":"Kumagai","year":"2016","journal-title":"Heart Vessels"},{"key":"10.1016\/j.colsurfb.2025.115024_bib25","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jconrel.2014.04.014","article-title":"Gelatin carriers for drug and cell delivery in tissue engineering","volume":"190","author":"Santoro","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2025.115024_bib26","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fchem.2021.649048","article-title":"Reactive oxygen species responsive polymers for drug delivery systems","volume":"9","author":"Gao","year":"2021","journal-title":"Front. Chem."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115024_bib27","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/btm2.10014","article-title":"ROS-responsive drug delivery systems","volume":"1","author":"Liang","year":"2016","journal-title":"Bioeng. Transl. Med."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115024_bib28","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1039\/D1BM01179K","article-title":"Injectable thioketal-containing hydrogel dressing accelerates skin wound healing with the incorporation of reactive oxygen species scavenging and growth factor release","volume":"10","author":"An","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2025.115024_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.129549","article-title":"NIR-responsive carboxymethyl-cellulose hydrogels containing thioketal-linkages for on-demand drug delivery system","volume":"260","author":"Ali","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115024_bib30","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.carbpol.2011.09.048","article-title":"Thermo-sensitive alginate-based injectable hydrogel for tissue engineering","volume":"87","author":"Tan","year":"2012","journal-title":"Carbohydr. Polym."},{"issue":"32","key":"10.1016\/j.colsurfb.2025.115024_bib31","doi-asserted-by":"crossref","first-page":"13628","DOI":"10.1002\/ange.202004180","article-title":"Self-boosting catalytic nanoreactors integrated with triggerable crosslinking membrane networks for initiation of immunogenic cell death by pyroptosis","volume":"132","author":"Li","year":"2020","journal-title":"Angew. Chem."},{"key":"10.1016\/j.colsurfb.2025.115024_bib32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.actbio.2015.12.021","article-title":"A prosurvival and proangiogenic stem cell delivery system to promote ischemic limb regeneration","volume":"31","author":"Xu","year":"2016","journal-title":"Acta Biomater."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115024_bib33","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.ijpharm.2016.08.014","article-title":"H 2 o 2-responsive antioxidant polymeric nanoparticles as therapeutic agents for peripheral arterial disease","volume":"511","author":"Kwon","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115024_bib34","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/term.3109","article-title":"Injectable thermosensitive chitosan-based hydrogel containing ferulic acid for treating peripheral arterial disease","volume":"14","author":"Wang","year":"2020","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.colsurfb.2025.115024_bib35","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.apsusc.2018.10.269","article-title":"Thermosensitive PNIPAM grafted alginate\/chitosan PEC","author":"Conzatti","year":"2019","journal-title":"Appl. Surf. Sci. 467"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115024_bib36","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1021\/acsabm.1c00569","article-title":"pH\/ROS Dual-Responsive Polymer\u2013Drug-Based nanocarriers: Click-Reaction preparation and fluorescence Imaging-Guided chemotherapy and photodynamic therapy","volume":"4","author":"Zhang","year":"2021","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.colsurfb.2025.115024_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121656","article-title":"An injectable mitochondria-targeted nanodrug loaded-hydrogel for restoring mitochondrial function and hierarchically attenuating oxidative stress to reduce myocardial ischemia-reperfusion injury","volume":"287","author":"Zhang","year":"2022","journal-title":"Biomaterials"},{"issue":"34","key":"10.1016\/j.colsurfb.2025.115024_bib38","doi-asserted-by":"crossref","first-page":"19006","DOI":"10.1021\/acsami.5b02821","article-title":"Effective bone regeneration using thermosensitive poly (N-isopropylacrylamide) grafted gelatin as injectable carrier for bone mesenchymal stem cells","volume":"7","author":"Ren","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115024_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.bioconjchem.3c00476","article-title":"Cleavage and noncleavage chemistry in reactive oxygen species (ROS)-Responsive materials for smart drug delivery","volume":"35","author":"Chi","year":"2023","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.colsurfb.2025.115024_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108619","article-title":"Comparison of structures, physicochemical properties and in vitro bioactivity between ferulic acid-\u03b2-cyclodextrin conjugate and the corresponding inclusion complex","volume":"125","author":"Han","year":"2019","journal-title":"Food Res. Int."},{"key":"10.1016\/j.colsurfb.2025.115024_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113392","article-title":"Encapsulation of lutein in gelatin type A\/B-chitosan systems via tunable chains and bonds from tweens: thermal stability, rheologic property and food 2D\/3D printability","volume":"173","author":"Wang","year":"2023","journal-title":"Food Res. Int."},{"issue":"19","key":"10.1016\/j.colsurfb.2025.115024_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/app.52119","article-title":"Effect of gelatin type on the structure and properties of microfibrillated cellulose reinforced gelatin edible films","volume":"139","author":"Liu","year":"2022","journal-title":"J. Appl. Polym. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115024_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.polymer.2008.10.045","article-title":"Preparation and evaluation of thermo-reversible copolymer hydrogels containing chitosan and hyaluronic acid as injectable cell carriers","volume":"50","author":"Chen","year":"2009","journal-title":"Polymer"},{"issue":"32","key":"10.1016\/j.colsurfb.2025.115024_bib44","doi-asserted-by":"crossref","first-page":"19982","DOI":"10.1039\/C6RA27848E","article-title":"Thermoresponsive electrospun membrane with enhanced wettability","volume":"7","author":"Ranganath","year":"2017","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2025.115024_bib45","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.jcis.2023.08.152","article-title":"Effect of temperature on the conformation and functionality of poly (N-isopropylacrylamide)(PNIPAM)-grafted nanocellulose hydrogels","volume":"652","author":"Raghuwanshi","year":"2023","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115024_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69521-x","article-title":"Properties enhancement of carboxymethyl cellulose with thermo-responsive polymer as solid polymer electrolyte for zinc ion battery","volume":"10","author":"Dueramae","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115024_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adem.202201303","article-title":"Recent advances in poly (N-isopropylacrylamide) hydrogels and derivatives as promising materials for biomedical and engineering emerging applications","volume":"25","author":"Lanzalaco","year":"2023","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.colsurfb.2025.115024_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.116967","article-title":"Biomimetic hydrogel by enzymatic crosslinking of pullulan grafted with ferulic acid","volume":"250","author":"Hadrich","year":"2020","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115024_bib49","first-page":"217","article-title":"Kinetic modeling on drug release from controlled drug delivery systems","volume":"67","author":"Dash","year":"2010","journal-title":"Acta Pol. Pharm."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115024_bib50","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/pharmaceutics12121188","article-title":"Hydrogels as drug delivery systems: a review of current characterization and evaluation techniques","volume":"12","author":"Vigata","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.115024_bib51","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1590\/S1984-82502013000300002","article-title":"Ferulic acid and derivatives: molecules with potential application in the pharmaceutical field","volume":"49","author":"Paiva","year":"2013","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115024_bib52","article-title":"Development and biological evaluation of pNIPAM-based nanogels as vaccine carriers","volume":"630","author":"P\u00e9rez","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115024_bib53","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/gels8070454","article-title":"Poly (N-isopropylacrylamide)-based hydrogels for biomedical applications: a review of the state-of-the-art","volume":"8","author":"Ansari","year":"2022","journal-title":"Gels"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115024_bib54","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41467-020-14480-0","article-title":"Microchannel network hydrogel induced ischemic blood perfusion connection","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2025.115024_bib55","article-title":"Novel synthesis of trans-ferulic acid loaded tragacanth-chitosan nanoformulations and evaluation of their biological activities","volume":"11","author":"Rani","year":"2024","journal-title":"Eur. J. Med. Chem. Rep."},{"key":"10.1016\/j.colsurfb.2025.115024_bib56","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.avsg.2022.07.009","article-title":"Inflammation and loss of skeletal muscle mass in chronic limb threatening ischemia","volume":"88","author":"Ferreira","year":"2023","journal-title":"Ann. Vasc. Surg."},{"key":"10.1016\/j.colsurfb.2025.115024_bib57","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.2147\/JIR.S275595","article-title":"Reactive oxygen species: drivers of physiological and pathological processes","author":"Checa","year":"2020","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.colsurfb.2025.115024_bib58","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jff.2018.06.024","article-title":"Ferulic acid inhibits advanced glycation end products (AGEs) formation and mitigates the AGEs-induced inflammatory response in HUVEC cells","volume":"48","author":"Liu","year":"2018","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.colsurfb.2025.115024_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.112035","article-title":"A review of hydrogel systems based on poly (N-isopropyl acrylamide) for use in the engineering of bone tissues","volume":"208","author":"Khiabani","year":"2021","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.115024_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2023.111846","article-title":"Thermoresponsive nanocomposite hydrogels based on gelatin\/poly (N\u2013isopropylacrylamide)(PNIPAM) for controlled drug delivery","volume":"186","author":"Gheysoori","year":"2023","journal-title":"Eur. Polym. J."},{"key":"10.1016\/j.colsurfb.2025.115024_bib61","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.actbio.2022.08.061","article-title":"Thermosensitive hydrogel microneedles for controlled transdermal drug delivery","volume":"153","author":"Li","year":"2022","journal-title":"Acta Biomater."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.115024_bib62","doi-asserted-by":"crossref","first-page":"8285","DOI":"10.1111\/jcmm.16778","article-title":"Network analysis and the impact of aflibercept on specific mediators of angiogenesis in HUVEC cells","volume":"25","author":"Latifi-Navid","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.colsurfb.2025.115024_bib63","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.trsl.2024.03.011","article-title":"Endothelial ELABELA improves post-ischemic angiogenesis by upregulating VEGFR2 expression","volume":"270","author":"Peng","year":"2024","journal-title":"Transl. Res."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115024_bib64","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/ddr.21954","article-title":"Chrysin promotes angiogenesis in rat hindlimb ischemia: impact on PI3K\/Akt\/mTOR signaling pathway and autophagy","volume":"83","author":"Kamel","year":"2022","journal-title":"Drug Dev. Res."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525005314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525005314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T18:30:50Z","timestamp":1772821850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525005314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":64,"alternative-id":["S0927776525005314"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115024","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of temperature and reactive oxygen species dual-responsive gelatin-PNIPAM-based hydrogels containing ferulic acid for peripheral arterial disease treatment","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115024"}}