{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:19:50Z","timestamp":1786987190392,"version":"build-2736575974"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012528","name":"Kazan Federal University","doi-asserted-by":"publisher","award":["PRIORITY-2030"],"award-info":[{"award-number":["PRIORITY-2030"]}],"id":[{"id":"10.13039\/501100012528","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002674","name":"Russian Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003443","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003443","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.colsurfb.2025.115127","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T16:25:13Z","timestamp":1757348713000},"page":"115127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["TPP-alantolactone conjugates and their nanotherapeutic forms for antitumor application"],"prefix":"10.1016","volume":"257","author":[{"given":"Andrey V.","family":"Nemtarev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariya E.","family":"Shemakhina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana N.","family":"Pashirova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra D.","family":"Voloshina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana B.","family":"Souto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P.","family":"Lyubina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syumbelya K.","family":"Amerkhanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leysan R.","family":"Idrisova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexey V.","family":"Semakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir F.","family":"Mironov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.115127_bib1","series-title":"Terpenes","author":"Breitmaier","year":"2006"},{"key":"10.1016\/j.colsurfb.2025.115127_bib2","doi-asserted-by":"crossref","first-page":"10207","DOI":"10.3389\/fgene.2020.01027","article-title":"Diversity of insect sesquiterpenoid regulation","volume":"11","author":"Tsang","year":"2020","journal-title":"Front. Genet."},{"key":"10.1016\/j.colsurfb.2025.115127_bib3","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/07352689.2016.1145956","article-title":"Sesquiterpene lactones: more than protective plant compounds with high toxicity","volume":"35","author":"Padilla-Gonzalez","year":"2016","journal-title":"CRC Crit. Rev. Plant Sci."},{"key":"10.1016\/j.colsurfb.2025.115127_bib4","series-title":"Sesquiterpene lactones","year":"2018"},{"key":"10.1016\/j.colsurfb.2025.115127_bib5","unstructured":"M.S.N. Hohmann, D.T. Longhi-Balbinot, C.F.S. Guazelli, S.A. Navarro, A.C. Zarpelon, R. Casagrande, N.S. Arakawa, W.A. VerriSesquiterpene lactones, in: 2016: pp. 243\u2013264. https:\/\/doi.org\/10.1016\/B978-0-444-63601-0.00007-7.."},{"key":"10.1016\/j.colsurfb.2025.115127_bib6","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3390\/app10093001","article-title":"Applications of sesquiterpene lactones: a review of some potential success cases","volume":"10","author":"Moujir","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.colsurfb.2025.115127_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02919190","article-title":"Sesquiterpene lactones as taxonomic characters in the asteraceae","volume":"48","author":"Seaman","year":"1982","journal-title":"Bot. Rev."},{"key":"10.1016\/j.colsurfb.2025.115127_bib8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0305-1978(86)90101-8","article-title":"Biological activities of sesquiterpene lactones","volume":"14","author":"Picman","year":"1986","journal-title":"Biochem. Syst. Ecol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2021.114613","article-title":"Ethnopharmacology, phytochemistry, agrotechnology, and conservation of inula racemosa hook f. \u2013 A critically endangered medicinal plant of the Western himalaya","volume":"283","author":"Rathore","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib10","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s12039-012-0347-9","article-title":"Chemistry and antifungal potential of alantolides from inula racemosa h","volume":"125","author":"Kataria","year":"2013","journal-title":"J. Chem. Sci."},{"key":"10.1016\/j.colsurfb.2025.115127_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.7897\/2277-4343.09120","article-title":"Ethnopharmacology, phytochemistry and biological activity of inula racemosa hook. F: a review","volume":"9","author":"Firdous","year":"2018","journal-title":"Int. J. Res. Ayurved Pharm."},{"key":"10.1016\/j.colsurfb.2025.115127_bib12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1055\/s-1999-14001","article-title":"Antimycobacterial eudesmanolides from inula helenium and rudbeckia subtomentosa","volume":"65","author":"Cantrell","year":"1999","journal-title":"Planta Med"},{"key":"10.1016\/j.colsurfb.2025.115127_bib13","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s10096-011-1400-1","article-title":"Antistaphylococcal activity of inula helenium l. Root essential oil: eudesmane sesquiterpene lactones induce cell membrane damage","volume":"31","author":"Stojanovi\u0107-Radi\u0107","year":"2012","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.colsurfb.2025.115127_bib14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.intimp.2012.08.011","article-title":"Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-\u03baB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells","volume":"14","author":"Chun","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib15","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0960-894X(00)00686-7","article-title":"Cytotoxic michael-type amine adducts of \u03b1-methylene lactones alantolactone and isoalantolactone","volume":"11","author":"Lawrence","year":"2001","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.colsurfb.2025.115127_bib16","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1021\/np300742d","article-title":"Structural investigation and biological activity of sesquiterpene lactones from the traditional Chinese herb inula racemosa","volume":"76","author":"Ma","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.colsurfb.2025.115127_bib17","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1248\/bpb.25.1370","article-title":"Antiproliferative sesquiterpene lactones from the roots of inula helenium.","volume":"25","author":"Konishi","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.colsurfb.2025.115127_bib18","first-page":"1599","article-title":"Activation of caspases and poly (ADP-ribose) polymerase cleavage to induce apoptosis in leukemia HL-60 cells by inula racemosa","volume":"Vitr. 24","author":"Pal","year":"2010","journal-title":"Toxicol"},{"key":"10.1016\/j.colsurfb.2025.115127_bib19","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.canlet.2014.11.049","article-title":"Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells","volume":"357","author":"Chun","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.colsurfb.2025.115127_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/jfbc.12972","article-title":"Antitumor activity of alantolactone in lung cancer cell lines NCI-H1299 and Anip973","volume":"43","author":"Liu","year":"2019","journal-title":"J. Food Biochem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111231","article-title":"A comprehensive review of anticancer mechanisms of action of alantolactone","volume":"136","author":"Babaei","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2025.115127_bib22","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/248532","article-title":"Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone","volume":"2013","author":"Rasul","year":"2013","journal-title":"Sci. World J."},{"key":"10.1016\/j.colsurfb.2025.115127_bib23","doi-asserted-by":"crossref","first-page":"3313","DOI":"10.1016\/j.fct.2012.06.014","article-title":"Alantolactone induces activation of apoptosis in human hepatoma cells","volume":"50","author":"Lei","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib24","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/iub.1068","article-title":"Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction","volume":"64","author":"Khan","year":"2012","journal-title":"IUBMB Life"},{"key":"10.1016\/j.colsurfb.2025.115127_bib25","first-page":"1","article-title":"Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction","volume":"2013","author":"Khan","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.colsurfb.2025.115127_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bcp.2015.12.004","article-title":"Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells","volume":"102","author":"Zhang","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib27","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1038\/s41598-017-06535-y","article-title":"Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress","volume":"7","author":"Maryam","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2025.115127_bib28","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.lfs.2019.04.034","article-title":"Targeting non-oncogene ROS pathway by alantolactone in b cell acute lymphoblastic leukemia cells","volume":"227","author":"Xu","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.colsurfb.2025.115127_bib29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/iub.1141","article-title":"Alantolactone inhibits growth of K562\/adriamycin cells by downregulating Bcr\/Abl and P-glycoprotein expression","volume":"65","author":"Yang","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/j.colsurfb.2025.115127_bib30","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1111\/jcmm.14139","article-title":"Alantolactone promotes ER stress-mediated apoptosis by inhibition of TrxR1 in triple-negative breast cancer cell lines and in a mouse model","volume":"23","author":"Yin","year":"2019","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.colsurfb.2025.115127_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.taap.2018.08.003","article-title":"Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB","volume":"356","author":"He","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib32","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1186\/s12935-020-01537-9","article-title":"Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia","volume":"20","author":"Shi","year":"2020","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.colsurfb.2025.115127_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/jbt.21685","article-title":"Alantolactone induces apoptosis and cell cycle arrest on lung squamous cancer SK-MES-1 cells","volume":"29","author":"Zhao","year":"2015","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib34","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2019.10882","article-title":"Alantolactone suppresses human osteosarcoma through the PI3K\/AKT signaling pathway","author":"Zhang","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.colsurfb.2025.115127_bib35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13045-016-0327-5","article-title":"Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells","volume":"9","author":"Ding","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib36","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1080\/10715762.2018.1558448","article-title":"Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway","volume":"53","author":"He","year":"2019","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.colsurfb.2025.115127_bib37","doi-asserted-by":"crossref","first-page":"6644","DOI":"10.1021\/acsnano.5b03569","article-title":"Accelerating the translation of nanomaterials in biomedicine","volume":"9","author":"Mitragotri","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.115127_bib38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejpb.2016.08.001","article-title":"Preclinical safety of solid lipid nanoparticles and nanostructured lipid carriers: current evidence from in vitro and in vivo evaluation","volume":"108","author":"Doktorovov\u00e1","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2025.115127_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1080\/10408444.2020.1719974","article-title":"Toxicological profile of lipid-based nanostructures: are they considered as completely safe nanocarriers?","volume":"50","author":"Azarnezhad","year":"2020","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2022.114416","article-title":"The role of lipid components in lipid nanoparticles for vaccines and gene therapy","volume":"188","author":"Hald Albertsen","year":"2022","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2025.115127_bib41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ejps.2018.11.022","article-title":"Surface-tailored anti-HER2\/neu-solid lipid nanoparticles for site-specific targeting MCF-7 and BT-474 breast cancer cells","volume":"128","author":"Souto","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115127_bib42","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/pharmaceutics14010106","article-title":"Development of pharmaceutical nanomedicines: from the bench to the market","volume":"14","author":"Halwani","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.115127_bib43","doi-asserted-by":"crossref","first-page":"831","DOI":"10.3390\/pharmaceutics15030831","article-title":"Solid lipid nanoparticles: multitasking nano-carriers for cancer treatment","volume":"15","author":"German-Cort\u00e9s","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.115127_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.semcancer.2019.09.025","article-title":"Challenges and pitfalls in the development of liposomal delivery systems for cancer therapy","volume":"69","author":"Moosavian","year":"2021","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib45","doi-asserted-by":"crossref","DOI":"10.59761\/RCR5095","article-title":"Triarylphosphonium compounds \u2014 effective vectors for mitochondrial-directed delivery systems: decoration strategies and prospects for clinical application","volume":"92","author":"Pashirova","year":"2023","journal-title":"Russ. Chem. Rev."},{"key":"10.1016\/j.colsurfb.2025.115127_bib46","first-page":"268","article-title":"Alantolactone-loaded chitosan\/hyaluronic acid nanoparticles suppress psoriasis by deactivating STAT3 pathway and restricting immune cell recruitment","volume":"17","author":"Chen","year":"2022","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115127_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfoodeng.2023.111664","article-title":"Development of alantolactone-loaded zein and shellac nanoparticles for controlled release in simulated gastrointestinal digestion","volume":"358","author":"Yu","year":"2023","journal-title":"J. Food Eng."},{"key":"10.1016\/j.colsurfb.2025.115127_bib48","doi-asserted-by":"crossref","first-page":"12511","DOI":"10.1021\/acsnano.9b02875","article-title":"Nanoformulated codelivery of quercetin and alantolactone promotes an antitumor response through synergistic immunogenic cell death for microsatellite-stable colorectal cancer","volume":"13","author":"Zhang","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.115127_bib49","doi-asserted-by":"crossref","first-page":"10043","DOI":"10.1021\/acs.chemrev.7b00042","article-title":"Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications","volume":"117","author":"Zielonka","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2025.115127_bib50","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1021\/acs.jmedchem.0c01671","article-title":"A novel triphenylphosphonium carrier to target mitochondria without uncoupling oxidative phosphorylation","volume":"64","author":"Kulkarni","year":"2021","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib51","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.mencom.2020.11.003","article-title":"Reaction of R-pulegone with P\u2013H phosphonium salts","volume":"30","author":"Shemakhina","year":"2020","journal-title":"Mendeleev Commun."},{"key":"10.1016\/j.colsurfb.2025.115127_bib52","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1134\/S1070428017040212","article-title":"Reaction of methyl 2-methylidene-3-oxolup-20(29)-en-28-oate with triphenylphosphonium trifluoromethanesulfonate","volume":"53","author":"Tsepaeva","year":"2017","journal-title":"Russ. J. Org. Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib53","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1134\/S1070363218090335","article-title":"Reaction of methyl (2-Methylidene)-3-oxolup-20(29)-en-28-oate with dimethyl trimethylsilyl phosphite","volume":"88","author":"Tsepaeva","year":"2018","journal-title":"Russ. J. Gen. Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib54","doi-asserted-by":"crossref","first-page":"145","DOI":"10.14258\/jcprm.2020034681","article-title":"Methods of preparative isolation of isoalantholactone and alantholactone from ele-campane root","author":"Semakov","year":"2020","journal-title":"Chem. Plant Raw Mater."},{"key":"10.1016\/j.colsurfb.2025.115127_bib55","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1021\/acs.orglett.7b02710","article-title":"Ir(III)-Catalyzed direct C\u2013H functionalization of arylphosphine oxides: a strategy for MOP-type ligands synthesis","volume":"19","author":"Liu","year":"2017","journal-title":"Org. Lett."},{"key":"10.1016\/j.colsurfb.2025.115127_bib56","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1016\/j.tetlet.2016.06.088","article-title":"Palladium-catalyzed C\u2013P(III) bond formation reaction with acylphosphines as phosphorus source","volume":"57","author":"Yu","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.colsurfb.2025.115127_bib57","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.molcata.2006.05.062","article-title":"Efficient suzuki cross-coupling reactions using bulky phosphines","volume":"259","author":"Joshaghani","year":"2006","journal-title":"J. Mol. Catal. A Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib58","unstructured":"C.-C. CorpSEA627Hu 96 Tests: Enzyme-linked Immunosorbent Assay Kit For Caspase 9 (CASP9). https:\/\/\u0431\u0435\u043b\u043a\u0438\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430.\u0440\u0444\/upload\/files\/SEA627Hu_MANUAL.pdf (accessed on 15th May 2023) 2023, (n.d.).."},{"key":"10.1016\/j.colsurfb.2025.115127_bib59","unstructured":"C.-C. CorpSEA853Ra 96 Tests: Enzyme-linked Immunosorbent Assay Kit For Caspase 8 (CASP8). https:\/\/\u0431\u0435\u043b\u043a\u0438\u0430\u043d\u0442\u0438\u0442\u0435\u043b\u0430.\u0440\u0444\/upload\/files\/sea853ra_MANUAL.pdf (accessed on 15th May 2023) 2023, (n.d.).."},{"key":"10.1016\/j.colsurfb.2025.115127_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105328","article-title":"Synthesis, antimicrobial activity and cytotoxicity of triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues","volume":"116","author":"Yu. Strobykina","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib61","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.colsurfb.2018.07.049","article-title":"Mixed cationic liposomes for brain delivery of drugs by the intranasal route: the acetylcholinesterase reactivator 2-PAM as encapsulated drug model","volume":"171","author":"Pashirova","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.115127_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108753","article-title":"Delivery nanosystems based on sterically hindered phenol derivatives containing a quaternary ammonium moiety: synthesis, cholinesterase inhibition and antioxidant activity","volume":"310","author":"Pashirova","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.colsurfb.2025.115127_bib63","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1039\/D2MD00363E","article-title":"Novel triphenylphosphonium amphiphilic conjugates of glycerolipid type: synthesis, cytotoxic and antibacterial activity, and targeted cancer cell delivery","volume":"14","author":"Tsepaeva","year":"2023","journal-title":"RSC Med. Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib64","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1039\/b920629a","article-title":"Effect of cholesterol on the rigidity of saturated and unsaturated membranes: fluctuation and electrodeformation analysis of giant vesicles","volume":"6","author":"Graci\u00e0","year":"2010","journal-title":"Soft Matter"},{"key":"10.1016\/j.colsurfb.2025.115127_bib65","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0005-2736(79)90349-3","article-title":"The importance of the phospholipid bilayer and the length of the cholesterol molecule in membrane structure","volume":"551","author":"Suckling","year":"1979","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.colsurfb.2025.115127_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118953","article-title":"Synthesis, structure-activity relationship and biological evaluation of tetracationic gemini Dabco-surfactants for transdermal liposomal formulations","volume":"575","author":"Pashirova","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115127_bib67","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0005-2736(91)90268-D","article-title":"Uptake of liposomes by cultured mouse bone marrow macrophages: influence of liposome composition and size","volume":"1061","author":"Allen","year":"1991","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.colsurfb.2025.115127_bib68","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.3390\/molecules21081013","article-title":"Cytotoxicity, Post-treatment recovery, and selectivity analysis of naturally occurring podophyllotoxins from bursera fagaroides var. fagaroides on breast cancer cell lines","volume":"21","author":"Pe\u00f1a-Mor\u00e1n","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2025.115127_bib69","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.bbamcr.2010.10.008","article-title":"Mitochondrial involvement in cell death of non-mammalian eukaryotes","volume":"1813","author":"Abdelwahid","year":"2011","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.colsurfb.2025.115127_bib70","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev.pharmtox.47.120505.105122","article-title":"Mitochondrial oxidative stress: implications for cell death","volume":"47","author":"Orrenius","year":"2007","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib71","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1093\/jac\/dku057","article-title":"An unusual class of anthracyclines potentiate Gram-positive antibiotics in intrinsically resistant Gram-negative bacteria","volume":"69","author":"Cox","year":"2014","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.colsurfb.2025.115127_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/wnan.1771","article-title":"Bacterial infections in cancer: a bilateral relationship","volume":"14","author":"Basu","year":"2022","journal-title":"WIREs Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1089\/wound.2023.0097","article-title":"Chemotherapy-mediated complications of wound healing: an understudied side effect","volume":"13","author":"S\u0142onimska","year":"2024","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.colsurfb.2025.115127_bib74","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S1470-2045(03)01218-X","article-title":"Infections in patients with cancer undergoing chemotherapy: aetiology, prevention, and treatment","volume":"4","author":"Vento","year":"2003","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib75","doi-asserted-by":"crossref","unstructured":"T.R. ZembowerEpidemiology of infections in cancer patients. In: \u201cInfectious complications in cancer patients\u201d. V.Stosor and T.R.Zembower (eds.), (2014) 43\u201389. https:\/\/doi.org\/10.1007\/978-3-319-04220-6_2..","DOI":"10.1007\/978-3-319-04220-6_2"},{"key":"10.1016\/j.colsurfb.2025.115127_bib76","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41568-024-00708-4","article-title":"Why do patients with cancer die?","volume":"24","author":"Boire","year":"2024","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2025.115127_bib77","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/s41571-020-0413-z","article-title":"Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors","volume":"17","author":"Galluzzi","year":"2020","journal-title":"Nat. Rev. Clean. Oncol."},{"key":"10.1016\/j.colsurfb.2025.115127_bib78","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fchem.2017.00005","article-title":"Peptides with dual antimicrobial and anticancer activities","volume":"5","author":"Fel\u00edcio","year":"2017","journal-title":"Front. Chem."},{"key":"10.1016\/j.colsurfb.2025.115127_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2022.960693","article-title":"Common themes in antimicrobial and anticancer drug resistance","volume":"13","author":"Chifiriuc","year":"2022","journal-title":"Front. Microbiol."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525006344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525006344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:09:58Z","timestamp":1763327398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525006344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":79,"alternative-id":["S0927776525006344"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115127","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TPP-alantolactone conjugates and their nanotherapeutic forms for antitumor application","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115127","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115127"}}