{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:06:32Z","timestamp":1763327192978,"version":"3.45.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960648"],"award-info":[{"award-number":["81960648"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009967","name":"Xinjiang Production and Construction Corps","doi-asserted-by":"publisher","award":["2024ZD029","2023AB054"],"award-info":[{"award-number":["2024ZD029","2023AB054"]}],"id":[{"id":"10.13039\/501100009967","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017520","name":"Chengdu Medical College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.colsurfb.2025.115144","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T22:26:27Z","timestamp":1758061587000},"page":"115144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Construction and evaluation of a long-circulating thermosensitive liposomal black phosphorus quantum dot delivery system for osteosarcoma therapy"],"prefix":"10.1016","volume":"257","author":[{"given":"Zhou","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia-han","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-sheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.115144_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1200\/JCO.2008.14.0095","article-title":"Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival\u2014a report from the children's oncology group","volume":"26","author":"Meyers","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.colsurfb.2025.115144_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.blo.0000223978.36831.39","article-title":"Endoprosthetic reconstruction in 250 patients with sarcoma","volume":"450","author":"Gosheger","year":"2006","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.colsurfb.2025.115144_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1586\/era.10.172","article-title":"Palliative therapy for osteosarcoma","volume":"11","author":"Errani","year":"2011","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.colsurfb.2025.115144_bib4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.ctrv.2013.11.006","article-title":"Osteosarcoma treatment - where do we stand? A state of the art review","volume":"40","author":"Luetke","year":"2014","journal-title":"Cancer Treat. Rev."},{"key":"10.1016\/j.colsurfb.2025.115144_bib5","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejca.2017.09.036","article-title":"Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006\/sarcome-09 study","volume":"88","author":"Gaspar","year":"2018","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.colsurfb.2025.115144_bib6","doi-asserted-by":"crossref","first-page":"5149","DOI":"10.1158\/1078-0432.CCR-16-3186","article-title":"Trabectedin overrides osteosarcoma differentiative block and reprograms the tumor immune environment enabling effective combination with immune checkpoint inhibitors","volume":"23","author":"Ratti","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.colsurfb.2025.115144_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.nano.2015.08.006","article-title":"Nanomedicine applied to translational oncology: a future perspective on cancer treatment","volume":"12","author":"Bregoli","year":"2016","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.colsurfb.2025.115144_bib8","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1360\/SSC-2019-0026","article-title":"Design and challenge of cancer nanomedicine","volume":"49","author":"Liu","year":"2019","journal-title":"Sci. Sin. Chim."},{"key":"10.1016\/j.colsurfb.2025.115144_bib9","doi-asserted-by":"crossref","first-page":"11147","DOI":"10.1021\/acs.chemrev.5b00116","article-title":"Clinical translation of nanomedicine","volume":"115","author":"Min","year":"2015","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2025.115144_bib10","doi-asserted-by":"crossref","first-page":"7615","DOI":"10.1002\/adma.201401554","article-title":"Dual-pH-sensitive mesoporous silica nanoparticle-based drug delivery system for tumor-triggered intracellular drug release","volume":"26","author":"Sun","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib11","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1039\/C9CC09716C","article-title":"Small-sized copolymeric nanoparticles for tumor penetration and intracellular drug release","volume":"56","author":"Zhu","year":"2020","journal-title":"Chem. Commun."},{"key":"10.1016\/j.colsurfb.2025.115144_bib12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.jconrel.2011.06.001","article-title":"K. Park, targeted drug delivery to tumors: myths, reality and possibility","volume":"153","author":"Bae","year":"2011","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2025.115144_bib13","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1126\/science.1226338","article-title":"Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities","volume":"338","author":"Cheng","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2025.115144_bib14","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s11095-021-03045-5","article-title":"A liposomal gemcitabine, FF-10832, improves plasma stability, tumor targeting, and antitumor efficacy of gemcitabine in pancreatic cancer xenograft models","volume":"38","author":"Matsumoto","year":"2021","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2025.115144_bib15","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1039\/C7NR09083H","article-title":"Comparative effect of wrapping solid gold nanoparticles and hollow gold nanoparticles with doxorubicin-loaded thermosensitive liposomes for cancer thermo-chemotherapy","volume":"10","author":"Li","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2025.115144_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tibtech.2013.09.007","article-title":"Ligand-targeted liposome design: challenges and fundamental considerations","volume":"32","author":"Noble","year":"2014","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.colsurfb.2025.115144_bib17","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nnano.2014.35","article-title":"Black phosphorus field-effect transistors","volume":"9","author":"Li","year":"2014","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2025.115144_bib18","doi-asserted-by":"crossref","first-page":"4033","DOI":"10.1021\/nn501226z","article-title":"Phosphorene: an unexplored 2D semiconductor with a high hole mobility","volume":"8","author":"Liu","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.115144_bib19","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1038\/ncomms5458","article-title":"Rediscovering black phosphorus as an anisotropic layered material for optoelectronics and electronics","volume":"5","author":"Xia","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2025.115144_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12967","article-title":"Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy","volume":"7","author":"Shao","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2025.115144_bib21","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1021\/acsnano.8b03740","article-title":"Products of degradation of black phosphorus in protic solvents","volume":"12","author":"Plutnar","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.115144_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/admi.201600121","article-title":"Nanoscopy of black phosphorus degradation","volume":"3","author":"Gamage","year":"2016","journal-title":"Adv. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2025.115144_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120623","article-title":"Implantable multifunctional black phosphorus nanoformulation-deposited biodegradable scaffold for combinational photothermal\/ chemotherapy and wound healing","volume":"269","author":"Xue","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2025.115144_bib24","article-title":"2D-Black-Phosphorus-Reinforced 3D-Printed scaffolds: a stepwise countermeasure for osteosarcoma","volume":"30","author":"Yang","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib25","doi-asserted-by":"crossref","first-page":"44065","DOI":"10.1021\/acsami.2c10772","article-title":"Developing a versatile multiscale therapeutic platform for osteosarcoma synergistic Photothermo-Chemotherapy with effective osteogenicity and antibacterial capability","volume":"14","author":"Ma","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2025.115144_bib26","article-title":"Multifunctional nanoengineered hydrogels consisting of black phosphorus nanosheets upregulate bone formation","volume":"15","author":"Wang","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2025.115144_bib27","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1039\/c2cs35387c","article-title":"Metal dichalcogenide nanosheets: preparation, properties and applications","volume":"42","author":"Huang","year":"2013","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2025.115144_bib28","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1002\/anie.200906623","article-title":"Luminescent carbon nanodots: emergent nanolights","volume":"49","author":"Baker","year":"2010","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.colsurfb.2025.115144_bib29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/adma.201003819","article-title":"An electrochemical avenue to Green-luminescent graphene quantum dots as potential electron-acceptors for photovoltaics","volume":"23","author":"Li","year":"2011","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib30","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nnano.2012.60","article-title":"Hybrid graphene-quantum dot phototransistors with ultrahigh gain","volume":"7","author":"Konstantatos","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2025.115144_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12967","article-title":"Biodegradable black phosphorus-based nanospheres for in vivo photothermal cancer therapy","volume":"7","author":"Shao","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2025.115144_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201603276","article-title":"Black phosphorus nanosheets as a robust delivery platform for cancer theranostics","volume":"29","author":"Tao","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib33","article-title":"Black phosphorus nanosheet-based drug delivery system for synergistic photodynamic\/photothermal\/chemotherapy of cancer","volume":"29","author":"Chen","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib34","article-title":"Black phosphorus Nanosheet-Based drug delivery system for synergistic Photodynamic\/Photothermal\/Chemotherapy of cancer","volume":"29","author":"Chen","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib35","doi-asserted-by":"crossref","first-page":"35495","DOI":"10.1021\/acsami.8b12523","article-title":"Water-Based black phosphorus hybrid nanosheets as a moldable platform for wound healing applications","volume":"10","author":"Huang","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2025.115144_bib36","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/adma.201405150","article-title":"High-quality black phosphorus atomic layers by liquid-phase exfoliation","volume":"27","author":"Yasaei","year":"2015","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib37","doi-asserted-by":"crossref","first-page":"6060","DOI":"10.1039\/C8CC03423K","article-title":"Synthesis of lipid-black phosphorus quantum dot bilayer vesicles for near-infrared-controlled drug release","volume":"54","author":"Geng","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.colsurfb.2025.115144_bib38","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1124\/pr.58.3.10","article-title":"Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies","volume":"58","author":"Chou","year":"2006","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.colsurfb.2025.115144_bib39","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/anie.201810878","article-title":"Black phosphorus: bioactive nanomaterials with inherent and selective chemotherapeutic effects","volume":"58","author":"Zhou","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.colsurfb.2025.115144_bib40","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1021\/acs.nanolett.0c01098","article-title":"ROS-mediated selective killing effect of black phosphorus: mechanistic understanding and its guidance for safe biomedical applications","volume":"20","author":"Kong","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2025.115144_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201701210","article-title":"Size effect on the cytotoxicity of layered black phosphorus and underlying mechanisms","volume":"13","author":"Zhang","year":"2017","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2025.115144_bib42","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.msec.2019.03.040","article-title":"Fabrication and characterization of hydroxyapatite\/sodium alginate\/chitosan composite microspheres for drug delivery and bone tissue engineering","volume":"100","author":"Bi","year":"2019","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"key":"10.1016\/j.colsurfb.2025.115144_bib43","article-title":"Engineering platelet-rich plasma based dual-network hydrogel as a bioactive wound dressing with potential clinical translational value","volume":"31","author":"Zhang","year":"2021","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2025.115144_bib44","doi-asserted-by":"crossref","first-page":"4720","DOI":"10.7150\/thno.43092","article-title":"Bioactive phospho-therapy with black phosphorus for in vivo tumor suppression","volume":"10","author":"Geng","year":"2020","journal-title":"Theranostics"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525006514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525006514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:02:36Z","timestamp":1763326956000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525006514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0927776525006514"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115144","relation":{},"ISSN":["0927-7765"],"issn-type":[{"type":"print","value":"0927-7765"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Construction and evaluation of a long-circulating thermosensitive liposomal black phosphorus quantum dot delivery system for osteosarcoma therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115144","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115144"}}