{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:18:13Z","timestamp":1786987093584,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015499","name":"Jeonbuk National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015499","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.colsurfb.2025.115164","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T04:31:04Z","timestamp":1758947464000},"page":"115164","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Protective and immunostimulatory roles of yeast-derived vacuoles in immune suppression"],"prefix":"10.1016","volume":"257","author":[{"given":"Su-Min","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra-Mi","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bit-Na","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6025-7746","authenticated-orcid":false,"given":"Jiho","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.115164_bib1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1056\/NEJM200008033430506","article-title":"Jr, innate immunity","volume":"343","author":"Medzhitov","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.colsurfb.2025.115164_bib2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0065-2776(04)86004-8","article-title":"Innate autoimmunity","volume":"86","author":"Carroll","year":"2005","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.111889","article-title":"Cyclophosphamide induced physiological and biochemical changes in mice with an emphasis on sensitivity analysis","volume":"211","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.colsurfb.2025.115164_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2025.102728","article-title":"Resveratrol attenuates cyclophosphamide-induced hepatic apoptosis in association with the inhibition of oxidative stress and inflammation in a rat model of acute liver injury","volume":"93","author":"Alshehri","year":"2025","journal-title":"Tissue Cell"},{"key":"10.1016\/j.colsurfb.2025.115164_bib5","first-page":"1","article-title":"Effects of limosilactobacillus fermentum KBL375 on immune enhancement and gut microbiota composition in Cyclophosphamide-Induced immunosuppressed mice","author":"Song","year":"2025","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.colsurfb.2025.115164_bib6","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.intimp.2011.04.011","article-title":"Immunosuppressive effect of cyclophosphamide on White blood cells and lymphocyte subpopulations from peripheral blood of balb\/c mice","volume":"11","author":"Huyan","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/sji.12442","article-title":"Investigation on immunomodulatory activity of calf spleen extractive injection in cyclophosphamide-induced immunosuppressed mice and underlying mechanisms","volume":"84","author":"Jia","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1469-0691.2010.03285.x","article-title":"Inflammation, immunological reaction and role of infection in pulmonary hypertension","volume":"17","author":"Pullamsetti","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.colsurfb.2025.115164_bib9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jaut.2014.04.001","article-title":"The immune potential and immunopathology of cytokine-producing b cell subsets: a comprehensive review","volume":"55","author":"Bao","year":"2014","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.colsurfb.2025.115164_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.beha.2025.101628","article-title":"Cytokines and immune effector cell therapy","author":"Haugh","year":"2025","journal-title":"Best. Pract. Res. Clin. Haematol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib11","doi-asserted-by":"crossref","first-page":"13552","DOI":"10.3390\/ijms222413552","article-title":"The role of the inflammatory response in mediating functional recovery following composite tissue injuries","volume":"22","author":"Janakiram","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2025.115164_bib12","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbamcr.2008.08.003","article-title":"The yeast lysosome-like vacuole: endpoint and crossroads","volume":"1793","author":"Li","year":"2009","journal-title":"Biochimica et Biophysica Acta (BBA) Mol. Cell Res."},{"key":"10.1016\/j.colsurfb.2025.115164_bib13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1128\/mr.59.2.304-322.1995","article-title":"The plasma membrane of saccharomyces cerevisiae: structure, function, and biogenesis","volume":"59","author":"Van Der Rest","year":"1995","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.colsurfb.2025.115164_bib14","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20211158","article-title":"Enhanced immune response by vacuoles isolated from saccharomyces cerevisiae in RAW 264.7 macrophages","volume":"41","author":"Lee","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.colsurfb.2025.115164_bib15","doi-asserted-by":"crossref","first-page":"e01466","DOI":"10.1128\/spectrum.01466-23","article-title":"Anti-inflammatory effects of yeast-derived vacuoles on LPS-induced murine macrophage activation","volume":"11","author":"Lee","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.colsurfb.2025.115164_bib16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.arcmed.2009.04.003","article-title":"Role of the spleen in cyclophosphamide-induced hematosuppression and extramedullary hematopoiesis in mice","volume":"40","author":"Wang","year":"2009","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.colsurfb.2025.115164_bib17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.autrev.2017.10.014","article-title":"Genetic risk factors in thrombotic primary antiphospholipid syndrome: a systematic review with bioinformatic analyses","volume":"17","author":"Islam","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.colsurfb.2025.115164_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jcb.30342","article-title":"Identification of TLR2\/4-mediated phagocytosis and immune response activation pathways by vacuoles isolated from saccharomyces cerevisiae","volume":"124","author":"Lee","year":"2023","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.colsurfb.2025.115164_bib19","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1097\/MS9.0000000000002019","article-title":"Role of cytokines in immunomodulation during malaria clearance","volume":"86","author":"Obeagu","year":"2024","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.colsurfb.2025.115164_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ejphar.2011.06.044","article-title":"Artemisinins and immune system","volume":"668","author":"Shakir","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.dci.2015.12.003","article-title":"Progress in the use of swine in developmental immunology of b and t lymphocytes","volume":"58","author":"Sinkora","year":"2016","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib22","article-title":"Shengxian decoction alleviates cyclophosphamide-induced immunosuppression via improving b cell-mediated immune responses","volume":"16","author":"Yang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib23","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jep.2016.08.046","article-title":"Immuno-enhancement effects of yifei tongluo granules on cyclophosphamide-induced immunosuppression in balb\/c mice","volume":"194","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s11671-018-2728-6","article-title":"Insight into cellular uptake and intracellular trafficking of nanoparticles","volume":"13","author":"Foroozandeh","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.colsurfb.2025.115164_bib25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micres.2014.11.002","article-title":"Effects of cyclophosphamide on immune system and gut microbiota in mice","volume":"171","author":"Xu","year":"2015","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.colsurfb.2025.115164_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41523-020-0171-1","article-title":"Immunostimulatory and anti-tumor metronomic cyclophosphamide regimens assessed in primary orthotopic and metastatic murine breast cancer","volume":"6","author":"Khan","year":"2020","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.colsurfb.2025.115164_bib27","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1158\/1078-0432.CCR-17-0895","article-title":"Low-dose cyclophosphamide induces antitumor T-cell responses, which associate with survival in metastatic colorectal cancer","volume":"23","author":"Scurr","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.colsurfb.2025.115164_bib28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/imm.12913","article-title":"T-cell modulation by cyclophosphamide for tumour therapy","volume":"154","author":"Hughes","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.colsurfb.2025.115164_bib29","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.bcp.2006.07.010","article-title":"Toll-like receptors: from the discovery of NF\u03baB to new insights into transcriptional regulations in innate immunity","volume":"72","author":"Doyle","year":"2006","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41392-021-00687-0","article-title":"Pattern recognition receptors in health and diseases","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.colsurfb.2025.115164_bib31","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41541-025-01185-y","article-title":"Self-assembling TLR2 agonists promote mucosal immune responses without pulmonary immunopathologic injuries in mice","volume":"10","author":"Huang","year":"2025","journal-title":"Npj Vaccin."},{"key":"10.1016\/j.colsurfb.2025.115164_bib32","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.colsurfb.2025.115164_bib33","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ni.2703","article-title":"Innate and adaptive immune cells in the tumor microenvironment","volume":"14","author":"Gajewski","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.colsurfb.2025.115164_bib34","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1016\/j.immuni.2013.10.010","article-title":"The spleen in local and systemic regulation of immunity","volume":"39","author":"Bronte","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.colsurfb.2025.115164_bib35","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6495793","article-title":"The role of IL-1 family members and kupffer cells in liver regeneration","volume":"2016","author":"Tan","year":"2016","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.colsurfb.2025.115164_bib36","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.immuni.2016.10.024","article-title":"Local cellular and cytokine cues in the spleen regulate in situ t cell receptor affinity, function, and fate of CD8+ t cells","volume":"45","author":"Seo","year":"2016","journal-title":"Immunity"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652500671X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652500671X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:20:26Z","timestamp":1773138026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777652500671X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":36,"alternative-id":["S092777652500671X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115164","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective and immunostimulatory roles of yeast-derived vacuoles in immune suppression","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115164"}}