{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T04:19:22Z","timestamp":1793420362376,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31860264"],"award-info":[{"award-number":["31860264"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008871","name":"Yunnan Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["202403AC100003"],"award-info":[{"award-number":["202403AC100003"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.colsurfb.2025.115234","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:08:06Z","timestamp":1761930486000},"page":"115234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Fabrication and characterization of ZnO\/HA scaffolds via spark plasma sintering at different temperatures for bone repair"],"prefix":"10.1016","volume":"258","author":[{"given":"Bin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenda","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangxiaozhi","family":"Zha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengdong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"37","key":"10.1016\/j.colsurfb.2025.115234_bib1","article-title":"Harnessing nucleic acids nanotechnology for bone\/cartilage regeneration","volume":"19","author":"Han","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2025.115234_bib2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4248\/BR201303002","article-title":"Bone regeneration based on tissue engineering conceptions - a 21st century perspective","volume":"1","author":"Henkel","year":"2013","journal-title":"Bone Res"},{"key":"10.1016\/j.colsurfb.2025.115234_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2018.09.031","article-title":"Current state of fabrication technologies and materials for bone tissue engineering","volume":"80","author":"Wubneh","year":"2018","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2025.115234_bib4","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-9-66","article-title":"Bone regeneration: current concepts and future directions","volume":"9","author":"Dimitriou","year":"2011","journal-title":"BMC Med"},{"key":"10.1016\/j.colsurfb.2025.115234_bib5","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.injury.2021.01.043","article-title":"Autologous bone graft: is it still the gold standard? *","volume":"52","author":"Schmidt","year":"2021","journal-title":"Injury"},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115234_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00590-017-2063-0","article-title":"Treatment of critical-sized bone defects: clinical and tissue engineering perspectives","volume":"28","author":"Roddy","year":"2018","journal-title":"Eur. J. Orthop. Surg. Trauma."},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115234_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ph15070879","article-title":"Bone tissue engineering in the treatment of bone defects","volume":"15","author":"Xue","year":"2022","journal-title":"Pharmaceuticals"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115234_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202301283","article-title":"Application of bioactive materials for osteogenic function in bone tissue engineering","volume":"8","author":"Bai","year":"2024","journal-title":"Small Methods"},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115234_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202302132","article-title":"Metallic materials for bone repair","volume":"13","author":"Fan","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"23","key":"10.1016\/j.colsurfb.2025.115234_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202214726","article-title":"Structural and functional adaptive artificial bone: materials, fabrications, and properties","volume":"33","author":"Feng","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115234_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.202300032","article-title":"Research and application of medical polyetheretherketone as bone repair material","volume":"23","author":"Pu","year":"2023","journal-title":"Macromol. Biosci."},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115234_bib12","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.actbio.2011.03.027","article-title":"Bioinorganics and biomaterials: bone repair","volume":"7","author":"Habibovic","year":"2011","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2025.115234_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fmats.2019.00313","article-title":"Additive manufacturing methods for producing hydroxyapatite and hydroxyapatite-based composite scaffolds: a review","volume":"6","author":"Kumar","year":"2019","journal-title":"Front. Mater."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115234_bib14","first-page":"1","article-title":"An overview of graphene-based hydroxyapatite composites for orthopedic applications","volume":"3","author":"Li","year":"2018","journal-title":"Bioact. Mater."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115234_bib15","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/adcbd7","article-title":"Review of 3D-printed bioceramic\/biopolymer composites for bone regeneration: fabrication methods, technologies and functionalized applications","volume":"17","author":"Tang","year":"2025","journal-title":"Biofabrication"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115234_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/polym17081090","article-title":"Biomaterial-based additive manufactured composite\/scaffolds for tissue engineering and regenerative medicine: a comprehensive review","volume":"17","author":"Vyas","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2025.115234_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2025.101518","article-title":"Surface biofunctionalised porous materials: advances, challenges, and future prospects","volume":"154","author":"Zhang","year":"2025","journal-title":"Prog. Mater. Sci."},{"issue":"23","key":"10.1016\/j.colsurfb.2025.115234_bib18","doi-asserted-by":"crossref","first-page":"48891","DOI":"10.1016\/j.ceramint.2024.09.294","article-title":"Applications and progress of 3D printed bioceramic scaffolds in bone tissue repair and immune regulation","volume":"50","author":"Chen","year":"2024","journal-title":"Ceram. Int."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115234_bib19","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jeurceramsoc.2023.09.003","article-title":"Review on the strategies to improve the mechanical strength of highly porous bone bioceramic scaffolds","volume":"44","author":"Miri","year":"2024","journal-title":"J. Eur. Ceram. Soc."},{"key":"10.1016\/j.colsurfb.2025.115234_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.actbio.2023.06.001","article-title":"Angiogenic and immunomodulation role of ions for initial stages of bone tissue regeneration","author":"Bosch-Rue","year":"2023","journal-title":"Acta Biomater. 166"},{"issue":"6","key":"10.1016\/j.colsurfb.2025.115234_bib21","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1021\/acsbiomaterials.2c00368","article-title":"Effects of zinc, magnesium, and iron ions on bone tissue engineering","volume":"8","author":"Chen","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"22","key":"10.1016\/j.colsurfb.2025.115234_bib22","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.1039\/D3BM01146A","article-title":"Metal ions: the unfading stars of bone regeneration-from bone metabolism regulation to biomaterial applications","volume":"11","author":"Luo","year":"2023","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2025.115234_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.reactfunctpolym.2021.105151","article-title":"Hyaluronic acid-based materials for bone regeneration: a review","volume":"171","author":"Zheng","year":"2022","journal-title":"React. Funct. Polym."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115234_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00774-012-0409-6","article-title":"Zinc signal: a new player in osteobiology","volume":"31","author":"Fukada","year":"2013","journal-title":"J. Bone Miner. Metab."},{"key":"10.1016\/j.colsurfb.2025.115234_bib25","article-title":"Zinc based biodegradable metals for bone repair and regeneration: Bioactivity and molecular mechanisms","volume":"25","author":"Li","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"48","key":"10.1016\/j.colsurfb.2025.115234_bib26","doi-asserted-by":"crossref","first-page":"11405","DOI":"10.1039\/D3TB01874A","article-title":"Zinc-based biomaterials for bone repair and regeneration: mechanism and applications","volume":"11","author":"Wen","year":"2023","journal-title":"Mater. Chem. B"},{"issue":"15","key":"10.1016\/j.colsurfb.2025.115234_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/app10155194","article-title":"Doped zinc oxide nanoparticles: synthesis, characterization and potential use in nanomedicine","volume":"10","author":"Carofiglio","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.colsurfb.2025.115234_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1062562","article-title":"The advancing of zinc oxide nanoparticles for biomedical applications","volume":"2018","author":"Jiang","year":"2018","journal-title":"Bioinorg. Chem. Appl."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.115234_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/nano12173066","article-title":"Current research on zinc oxide nanoparticles: synthesis, characterization, and biomedical applications","volume":"12","author":"Mandal","year":"2022","journal-title":"Nanomaterials"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115234_bib30","doi-asserted-by":"crossref","DOI":"10.3892\/br.2024.1849","article-title":"Advances in antibacterial activity of zinc oxide nanoparticles against Staphylococcus aureus (Review)","volume":"21","author":"Hao","year":"2024","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.colsurfb.2025.115234_bib31","article-title":"The CuO and AgO co-modified ZnO nanocomposites for promoting wound healing in Staphylococcus aureus infection","volume":"18","author":"Ye","year":"2023","journal-title":"Mater. Today Bio"},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115234_bib32","doi-asserted-by":"crossref","first-page":"13039","DOI":"10.1016\/j.ceramint.2025.01.150","article-title":"Spark plasma sintered porous zinc oxide\/hydroxyapatite scaffolds for enhancing osteogenic functions via synergetic angiogenesis and osteogenesis as large-sized bone defect repair","volume":"51","author":"Zhu","year":"2025","journal-title":"Ceram. Int."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115234_bib33","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2174\/156802608783790956","article-title":"A cellular perspective to bioceramic scaffolds for bone tissue engineering: the state of the art","volume":"8","author":"Guda","year":"2008","journal-title":"Curr. Trends Med. Chem."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115234_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ma14092393","article-title":"Copper-doped biphasic calcium phosphate powders: dopant release, cytotoxicity and antibacterial properties","volume":"14","author":"Jacobs","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.colsurfb.2025.115234_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.jeurceramsoc.2024.116856","article-title":"Fabrication, physicochemical properties, and cytocompatibility of 3D-printed Sr2MgSi2O7 bioceramic scaffolds calcined at different temperature for bone repair","author":"Gan","year":"2025","journal-title":"J. Eur. Ceram. Soc. 45(1)"},{"key":"10.1016\/j.colsurfb.2025.115234_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113472","article-title":"Fabrication of 3D printed Ca3Mg3(PO4)4-based bioceramic scaffolds with tailorable high mechanical strength and osteostimulation effect","volume":"229","author":"He","year":"2023","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2025.115234_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2020.108662","article-title":"A review of multi-physical fields induced phenomena and effects in spark plasma sintering: Fundamentals and applications","volume":"191","author":"Hu","year":"2020","journal-title":"Mater. Des."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115234_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/min11121310","article-title":"A study of thermal stability of hydroxyapatite","volume":"11","author":"Bulina","year":"2021","journal-title":"Minerals"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115234_bib39","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1007\/s11837-019-03806-z","article-title":"Effect of heating mode on thermal stability of nanocrystalline hydroxyapatite","volume":"72","author":"Peng","year":"2020","journal-title":"Jom"},{"key":"10.1016\/j.colsurfb.2025.115234_bib40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.msec.2015.12.087","article-title":"Role of pore size and morphology in musculo-skeletal tissue regeneration","volume":"61","author":"Perez","year":"2016","journal-title":"Mater. Sci. Eng. C."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.115234_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/adem.202201743","article-title":"Glass, ceramic, polymeric, and composite scaffolds with multiscale porosity for bone tissue engineering","volume":"25","author":"Jeyachandran","year":"2023","journal-title":"Adv. Eng. Mater."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115234_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cben.202200043","article-title":"Definition of pore size in 3D-printed porous implants: a review","volume":"10","author":"Liu","year":"2023","journal-title":"ChemBioEng Rev."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115234_bib43","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jbiomech.2004.03.003","article-title":"Tensile and compressive stress yield criteria for cancellous bone","volume":"8","author":"Cowin","year":"2005","journal-title":"J. Biomech."},{"issue":"11","key":"10.1016\/j.colsurfb.2025.115234_bib44","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1016\/j.biomaterials.2003.09.001","article-title":"Osteoblast response to hydroxyapatite doped with divalent and trivalent cations","volume":"25","author":"Webster","year":"2004","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115234_bib45","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/jcb.10622","article-title":"Inorganic phosphate as a signaling molecule in osteoblast differentiation","volume":"90","author":"Beck","year":"2003","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115234_bib46","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jcb.20675","article-title":"Calcium\/calmodulin signaling controls osteoblast growth and differentiation","volume":"97","author":"Zayzafoon","year":"2006","journal-title":"J. Cell. Biochem."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115234_bib47","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1007\/s12011-023-03631-1","article-title":"The Role of Zinc in Bone Tissue Health and Regeneration-a Review","volume":"201","author":"Molenda","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115234_bib48","doi-asserted-by":"crossref","first-page":"350","DOI":"10.2174\/0113894501359782241216082049","article-title":"Signaling dynamics in osteogenesis: unraveling therapeutic targets for bone generation","volume":"26","author":"Yang","year":"2025","journal-title":"Curr. Drug Targets"},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115234_bib49","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.tibtech.2012.06.004","article-title":"Antibacterial properties of nanoparticles","volume":"30","author":"Hajipour","year":"2012","journal-title":"Trends Biotechnol."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115234_bib50","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.ceramint.2016.10.051","article-title":"Zinc oxide nanoparticles: Biological synthesis and biomedical applications","volume":"43","author":"Mirzaei","year":"2017","journal-title":"Ceram. Int."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115234_bib51","first-page":"219","article-title":"Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism","volume":"7","author":"Sirelkhatim","year":"2015","journal-title":"NanoMicro Lett."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115234_bib52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1166\/sam.2012.1269","article-title":"ZnO nanoparticles as an antibacterial agent against E.coli,","volume":"4","author":"Joshi","year":"2012","journal-title":"Sci. Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115234_bib53","first-page":"479","article-title":"3D-printed zinc oxide nanoparticles modified barium titanate\/ hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects","volume":"45","author":"Chen","year":"2025","journal-title":"Bioact. Mater."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007416?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007416?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:56:05Z","timestamp":1773273365000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525007416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"alternative-id":["S0927776525007416"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115234","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fabrication and characterization of ZnO\/HA scaffolds via spark plasma sintering at different temperatures for bone repair","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115234","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115234"}}