{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:46:09Z","timestamp":1793148369895,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473787"],"award-info":[{"award-number":["82473787"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.colsurfb.2025.115238","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T17:08:26Z","timestamp":1761930506000},"page":"115238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["pH-Responsive multifunction antibacterial hydrogel with remodeling the wound microenvironment for treating diabetic wound"],"prefix":"10.1016","volume":"258","author":[{"given":"Lina","family":"Du","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.colsurfb.2025.115238_bib1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/17435889.2025.2466414","article-title":"Smart self-healing hydrogel wound dressings for diabetic wound treatment","volume":"20","author":"Hu","year":"2025","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115238_bib2","doi-asserted-by":"crossref","DOI":"10.2174\/0122150838277241231206051011","article-title":"Hydrogel for the treatment of diabetic wounds: a comprehensive review","volume":"11","author":"Bhattacharyya","year":"2025","journal-title":"Curr. Tradit. Med."},{"key":"10.1016\/j.colsurfb.2025.115238_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115199","article-title":"Recent advances in strategies to target the behavior of macrophages in wound healing","volume":"165","author":"Zheng","year":"2023","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115238_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404255","article-title":"Hyaluronic acid-based self-healing hydrogels for diabetic wound healing","volume":"14","author":"Chhillar","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2025.115238_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eurpolymj.2017.12.046","article-title":"Hydrogel wound dressings for bioactive treatment of acute and chronic wounds","volume":"100","author":"Koehler","year":"2018","journal-title":"Eur. Polym. J."},{"issue":"03","key":"10.1016\/j.colsurfb.2025.115238_bib6","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1055\/s-0041-1731460","article-title":"Updates in diabetic wound healing, inflammation, and scarring","volume":"35","author":"Dasari","year":"2021","journal-title":"Semin. Plast. Surg."},{"key":"10.1016\/j.colsurfb.2025.115238_bib7","doi-asserted-by":"crossref","DOI":"10.1177\/20417314241253290","article-title":"Microenvironmental dynamics of diabetic wounds and insights for hydrogel-based therapeutics","volume":"15","author":"Zhao","year":"2024","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.colsurfb.2025.115238_bib8","article-title":"Modulation of macrophages by a paeoniflorin-loaded hyaluronic acid-based hydrogel promotes diabetic wound healing","volume":"12","author":"Yang","year":"2021","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.115238_bib9","article-title":"A chlorogenic acid-loaded hyaluronic acid-based hydrogel facilitates anti-inflammatory and pro-healing effects for diabetic wounds","volume":"70","author":"Song","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115238_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.114650","article-title":"Engineering anti-inflammatory magnesium-mangiferin hydrogel for diabetic wound healing","volume":"258","author":"Yao","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.colsurfb.2025.115238_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.133859","article-title":"An M2 macrophage-polarized anti-inflammatory hydrogel combined with mild heat stimulation for regulating chronic inflammation and impaired angiogenesis of diabetic wounds","volume":"433","author":"Yuan","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2025.115238_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145118","article-title":"Hyaluronan-based hydrogel achieves in situ administration of protocatechualdehyde to polarize macrophages to M2 phenotype for diabetic wound therapy","volume":"318","author":"Song","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"issue":"29","key":"10.1016\/j.colsurfb.2025.115238_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202215116","article-title":"Glycopeptide-based multifunctional hydrogels promote diabetic wound healing through pH regulation of microenvironment","volume":"33","author":"Xia","year":"2023","journal-title":"Adv. Funct. Mater."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115238_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404966","article-title":"A Smart MMP-9-responsive hydrogel releasing M2 macrophage-derived exosomes for diabetic wound healing","volume":"14","author":"Meng","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2025.115238_bib15","article-title":"Peptide loaded self-healing hydrogel promotes diabetic skin wound healing through macrophage orchestration and inflammation inhibition","volume":"32","author":"Lu","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.115238_bib16","article-title":"A fabric-reinforced polysaccharide-based hydrogel with conductive, adhesive, antibacterial and anti-inflammatory for monitoring and treatment of diabetic wounds","volume":"44","author":"Shen","year":"2025","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.colsurfb.2025.115238_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113354","article-title":"Tannic acid-based dual-network homogeneous hydrogel with antimicrobial and pro-healing properties for infected wound healing","volume":"227","author":"Cheng","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.115238_bib18","article-title":"Harnessing a biopolymer hydrogel reinforced by copper\/tannic acid nanosheets for treating bacteria-infected diabetic wounds","volume":"15","author":"You","year":"2022","journal-title":"Mater. Today Adv."},{"issue":"19","key":"10.1016\/j.colsurfb.2025.115238_bib19","article-title":"A versatile chitosan-based hydrogel accelerates infected wound healing via bacterial elimination, antioxidation, immunoregulation, and angiogenesis","volume":"13","author":"Zhang","year":"2024","journal-title":"Adv. Healthc. Mater."},{"issue":"35","key":"10.1016\/j.colsurfb.2025.115238_bib20","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1039\/D1TB00156F","article-title":"Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties","volume":"9","author":"Shi","year":"2021","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115238_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201700527","article-title":"Antibacterial hydrogels","volume":"5","author":"Li","year":"2018","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2025.115238_bib22","article-title":"Recent trends in hydrogel-based formulation for the treatment of diabetic wounds: a review","volume":"107","author":"Bhattacharjee","year":"2025","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115238_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137163","article-title":"Physically crosslinked chitosan\/\u03b1\u03b2\u2013glycerophosphate hydrogels enhanced by surface-modified cyclodextrin: an efficient strategy for controlled drug release","volume":"283","author":"Tong","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"21","key":"10.1016\/j.colsurfb.2025.115238_bib24","doi-asserted-by":"crossref","first-page":"17162","DOI":"10.1039\/C8NJ03482F","article-title":"The chitosan hydrogels: from structure to function","volume":"42","author":"Fu","year":"2018","journal-title":"N. J. Chem."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115238_bib25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.3390\/gels10090605","article-title":"Composite polysaccharide hydrogel loaded with scutellaria baicalensis extract for diabetic wound treatment","volume":"10","author":"Zhu","year":"2024","journal-title":"Gels"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115238_bib26","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/acs.biomac.5c00112","article-title":"Ganoderma lucidum polysaccharide\/carboxymethyl chitosan hydrogels modulate macrophage polarization for wound healing","volume":"26","author":"Zou","year":"2025","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2025.115238_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114346","article-title":"Multifunctional injectable oxidized sodium alginate\/carboxymethyl chitosan hydrogel for rapid hemostasis","volume":"245","author":"Liu","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"34","key":"10.1016\/j.colsurfb.2025.115238_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/app.54304","article-title":"Self-healing injectable stimuli responsive polysaccharide hydrogel constructed with dynamic covalent bonds","volume":"140","author":"Sun","year":"2023","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.colsurfb.2025.115238_bib29","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.actbio.2022.08.030","article-title":"Self-healing, injectable hydrogel based on dual dynamic covalent cross-linking against postoperative abdominal cavity adhesion","volume":"151","author":"Zeng","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2025.115238_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123322","article-title":"pH-responsive and self-adaptive injectable sodium alginate\/carboxymethyl chitosan hydrogel accelerates infected wound healing by bacteriostasis and immunomodulation","volume":"354","author":"Zhang","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2025.115238_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.114128","article-title":"Chinese herb-crosslinked polysaccharide hydrogel loading DFO accelerates diabetes wound healing","volume":"254","author":"Li","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.colsurfb.2025.115238_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.eurpolymj.2023.112425","article-title":"Tannic acid-inspired antibacterial hydrogel with antioxidant and anti-inflammatory properties for staphylococcus aureus-infected wound healing","volume":"198","author":"Zeng","year":"2023","journal-title":"Eur. Polym. J."},{"issue":"28","key":"10.1016\/j.colsurfb.2025.115238_bib33","doi-asserted-by":"crossref","first-page":"6856","DOI":"10.1039\/D4TB01000K","article-title":"Microenvironment-responsive release of Mg2+from tannic acid decorated and multilevel crosslinked hydrogels accelerates infected wound healing","volume":"12","author":"Li","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115238_bib34","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3390\/pharmaceutics17050644","article-title":"Construction of pH-sensitive multifunctional hydrogel with synergistic anti-inflammatory effect for treatment of diabetic wounds","volume":"17","author":"Sun","year":"2025","journal-title":"Pharmaceutics"},{"issue":"48","key":"10.1016\/j.colsurfb.2025.115238_bib35","doi-asserted-by":"crossref","first-page":"55392","DOI":"10.1021\/acsami.3c12672","article-title":"pH-Responsive injectable multifunctional pluronic F127\/gelatin-based hydrogels with hydrogen production for treating diabetic wounds","volume":"15","author":"Zhang","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"28","key":"10.1016\/j.colsurfb.2025.115238_bib36","doi-asserted-by":"crossref","first-page":"33584","DOI":"10.1021\/acsami.1c09889","article-title":"Inflammation-responsive drug-loaded hydrogels with sequential hemostasis, antibacterial, and anti-inflammatory behavior for chronically infected diabetic wound treatment","volume":"13","author":"Wang","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115238_bib37","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1021\/acsbiomaterials.2c00997","article-title":"Carboxymethyl chitosan\/tannic acid hydrogel with antibacterial, hemostasis, and antioxidant properties promoting skin wound repair","volume":"9","author":"Zhou","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.colsurfb.2025.115238_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120286","article-title":"ROS-scavenging hydrogel to promote healing of bacteria infected diabetic wounds","volume":"258","author":"Zhao","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2025.115238_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113528","article-title":"Dual-network hydrogels based on dynamic imine and borate ester bonds with antibacterial and self-healing properties","volume":"230","author":"Liu","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"11","key":"10.1016\/j.colsurfb.2025.115238_bib40","doi-asserted-by":"crossref","first-page":"9574","DOI":"10.1021\/acsapm.3c02022","article-title":"Biomass-based ferric tannate hydrogel with a photothermal conversion function for solar water evaporation","volume":"5","author":"Zhang","year":"2023","journal-title":"ACS Appl. Polym. Mater."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115238_bib41","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1586\/erd.11.27","article-title":"Design properties of hydrogel tissue-engineering scaffolds","volume":"8","author":"Zhu","year":"2011","journal-title":"Expert Rev. Med. Devices"},{"issue":"24","key":"10.1016\/j.colsurfb.2025.115238_bib42","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0142-9612(03)00340-5","article-title":"Hydrogels for tissue engineering: scaffold design variables and applications","volume":"24","author":"Drury","year":"2003","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115238_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e23223","article-title":"CD163 protein inhibits lipopolysaccharide-induced macrophage transformation from M2 to M1 involved in disruption of the TWEAK\u2013Fn14 interaction","volume":"10","author":"Chen","year":"2024","journal-title":"Heliyon"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:08:03Z","timestamp":1773810483000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525007453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":43,"alternative-id":["S0927776525007453"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115238","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"pH-Responsive multifunction antibacterial hydrogel with remodeling the wound microenvironment for treating diabetic wound","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115238","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115238"}}