{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:10:29Z","timestamp":1784092229946,"version":"3.55.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["23JCZDJC00720"],"award-info":[{"award-number":["23JCZDJC00720"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.colsurfb.2025.115257","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T02:50:32Z","timestamp":1762829432000},"page":"115257","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Design and optimization of indomethacin-loaded solid dispersion orally dissolving films: Machine learning and molecular dynamics study"],"prefix":"10.1016","volume":"258","author":[{"given":"Jianlu","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhao","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7961-7975","authenticated-orcid":false,"given":"Wenlong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2025.115257_bib1","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.ijbiomac.2020.03.030","article-title":"Nanocellulose hyperfine network achieves sustained release of berberine hydrochloride solubilized with beta-cyclodextrin for potential anti-infection oral administration","volume":"153","author":"Xiao","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115257_bib2","first-page":"473","article-title":"Role of borneol as enhancer in drug formulation: a review","volume":"17","author":"Tang","year":"2025","journal-title":"Chin. Herb. Med."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115257_bib3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/HM9.0000000000000083","article-title":"Metal ions as effectual tools for cancer with traditional Chinese medicine","volume":"3","author":"Wang","year":"2023","journal-title":"Acupunct. Herb. Med."},{"issue":"13","key":"10.1016\/j.colsurfb.2025.115257_bib4","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.1021\/jm2003427","article-title":"Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents","volume":"54","author":"Lu","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.colsurfb.2025.115257_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118832","article-title":"Design of Coenzyme Q10 solid dispersion for improved solubilization and stability","volume":"572","author":"Choi","year":"2019","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115257_bib6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijpharm.2017.07.010","article-title":"Improving the solubility of nilotinib through novel spray-dried solid dispersions","volume":"529","author":"Herbrink","year":"2017","journal-title":"Int. J. Pharm."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115257_bib7","first-page":"292","article-title":"Modernization of charcoal drugs: integrating research paradigms of carbon dots to gain new perspectives","volume":"17","author":"Tian","year":"2025","journal-title":"Chin. Herb. Med."},{"key":"10.1016\/j.colsurfb.2025.115257_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123139","article-title":"Enteric coating of tablets containing an amorphous solid dispersion of an enteric polymer and a weakly basic drug: a strategy to enhance in vitro release","volume":"642","author":"Nguyen","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124769","article-title":"Crystallization and intermolecular hydrogen bonding in carbamazepine-polyvinyl pyrrolidone solid dispersions: an experiment and molecular simulation study on drug content variation","volume":"666","author":"Wang","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ejpb.2020.12.001","article-title":"An integrated computational methodology with data-driven machine learning, molecular modeling and PBPK modeling to accelerate solid dispersion formulation design","volume":"158","author":"Gao","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2025.115257_bib11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.ijpharm.2017.02.029","article-title":"Patients' appropriateness, acceptability, usability and preferences for pharmaceutical preparations: results from a literature review on clinical evidence","volume":"521","author":"Drumond","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.colsurfb.2017.12.015","article-title":"Orally-dissolving film for sublingual and buccal delivery of ropinirole","volume":"163","author":"Lai","year":"2018","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.115257_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113526","article-title":"Loratadine oral bioavailability enhancement via solid dispersion loaded oro-dispersible films: Formulation, characterization and pharmacokinetics","volume":"230","author":"Islam","year":"2023","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.115257_bib14","article-title":"Quality by design (QbD) in the formulation and optimization of liquid crystalline nanoparticles (LCNPs): a risk based industrial approach","volume":"141","author":"Waghule","year":"2021","journal-title":"Biomed. Pharmacother. = Biomedecine Pharmacother."},{"key":"10.1016\/j.colsurfb.2025.115257_bib15","article-title":"Development and evaluation of novel famotidine-loaded fast dissolving sublingual film using the quality-by-design approach","volume":"85","author":"Tapre","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115257_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122620","article-title":"Interpretable artificial neural networks for retrospective QbD of pharmaceutical tablet manufacturing based on a pilot-scale developmental dataset","volume":"633","author":"Nagy","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120554","article-title":"Industry 4.0 for pharmaceutical manufacturing: Preparing for the smart factories of the future","volume":"602","author":"Arden","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123012","article-title":"Comparative study of lipid nanoparticle-based mRNA vaccine bioprocess with machine learning and combinatorial artificial neural network-design of experiment approach","volume":"640","author":"Maharjan","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.135123","article-title":"Development of fucoidan\/polyethyleneimine based sorafenib-loaded self-assembled nanoparticles with machine learning and DoE-ANN implementation: optimization, characterization, and in-vitro assessment for the anticancer drug delivery","author":"Chaurawal","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2025.115257_bib20","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejpb.2019.03.020","article-title":"Exploring the use of spray congealing to produce solid dispersions with enhanced indomethacin bioavailability: In vitro characterization and in vivo study","volume":"139","author":"Bertoni","year":"2019","journal-title":"Eur. J. Pharm. Biopharm. Off. J. Arb. Fur Pharm. Verfahr. eV"},{"key":"10.1016\/j.colsurfb.2025.115257_bib21","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jnutbio.2015.09.016","article-title":"Molecular mechanisms of gastrointestinal protection by quercetin against indomethacin-induced damage: role of NF-\u03baB and Nrf2","volume":"27","author":"Carrasco-Pozo","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.colsurfb.2025.115257_bib22","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.powtec.2015.02.001","article-title":"Polymeric microparticles containing indomethacin for inhalatory administration","volume":"285","author":"Ceschan","year":"2015","journal-title":"Powder Technol."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115257_bib23","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1021\/acs.molpharmaceut.8b00637","article-title":"In silico screening for solid dispersions: the trouble with solubility parameters and \u03c7FH","volume":"15","author":"Turpin","year":"2018","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115257_bib24","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejpb.2012.12.018","article-title":"Preparation of carbamazepine\u2013Soluplus\u00ae solid dispersions by hot-melt extrusion, and prediction of drug\u2013polymer miscibility by thermodynamic model fitting","volume":"84","author":"Djuris","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2025.115257_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpharm.2011.01.030","article-title":"Hansen solubility parameter as a tool to predict cocrystal formation","volume":"407","author":"Mohammad","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib26","article-title":"An investigation of the inter-molecular interaction, solid-state properties and dissolution properties of mixed copovidone hot-melt extruded solid dispersions","volume":"53","author":"Hurley","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115257_bib27","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1208\/s12249-024-02844-4","article-title":"Multivariate analysis of solubility parameters for drug-polymer miscibility assessment in preparing raloxifene hydrochloride amorphous solid dispersions","volume":"25","author":"Moreira","year":"2024","journal-title":"AAPS PharmSciTech"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115257_bib28","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3390\/polym12040864","article-title":"Novel mixed matrix sodium alginate\u2013fullerenol membranes: development, characterization, and study in pervaporation dehydration of isopropanol","volume":"12","author":"Dmitrenko","year":"2020","journal-title":"Polymers"},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115257_bib29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3390\/pharmaceutics11120625","article-title":"A novel rheological method to assess drug-polymer interactions regarding miscibility and crystallization of drug in amorphous solid dispersions for oral drug delivery","volume":"11","author":"Tsakiridou","year":"2019","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115257_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1248\/cpb.48.179","article-title":"Partial solubility parameters of lactose, mannitol and saccharose using the modified extended Hansen method and evaporation light scattering detection","volume":"48","author":"PE\u00f1A","year":"2000","journal-title":"Chem. Pharm. Bull."},{"key":"10.1016\/j.colsurfb.2025.115257_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.fbio.2022.101868","article-title":"Solid dispersions of quercetin-PEG matrices: miscibility prediction, preparation and characterization","volume":"49","author":"Van Hecke","year":"2022","journal-title":"Food Biosci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115257_bib32","first-page":"39","article-title":"Solid lipid dispersion of calcitriol with enhanced dissolution and stability","volume":"8","author":"Yuan","year":"2013","journal-title":"Asian J. Pharm. Sci."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115257_bib33","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3390\/polym12040854","article-title":"Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling","volume":"12","author":"Chen","year":"2020","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115257_bib34","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijpharm.2011.07.012","article-title":"A quality by design (QbD) case study on liposomes containing hydrophilic API: I. Formulation, processing design and risk assessment","volume":"419","author":"Xu","year":"2011","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119876","article-title":"Mechanical characteristics of orally disintegrating films_ Comparison of folding endurance and tensile properties","author":"Takeuchi","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"1-2","key":"10.1016\/j.colsurfb.2025.115257_bib36","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ijpharm.2017.05.048","article-title":"Quality by design approach for studying the impact of formulation and process variables on product quality of oral disintegrating films","volume":"527","author":"Mazumder","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2024.119610","article-title":"Development and optimization of a cocoa extraction treatment by means of the response surface methodology (RSM) and artificial neural networks (ANN)","volume":"222","author":"Beeler","year":"2024","journal-title":"Ind. Crops Prod."},{"key":"10.1016\/j.colsurfb.2025.115257_bib38","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.ejpb.2018.09.005","article-title":"Comparative study on disintegration methods for oral film preparations","volume":"132","author":"Speer","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115257_bib39","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1021\/jf010371e","article-title":"Effect of salivary components on volatile partitioning from solutions","volume":"49","author":"Friel","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2025.115257_bib40","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ejpb.2021.01.017","article-title":"Development and optimisation of simulated salivary fluid for biorelevant oral cavity dissolution","volume":"160","author":"Ali","year":"2021","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115257_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/17425247.2020.1699913","article-title":"In vivo, ex vivo and in vitro assessment of buccal permeation of drugs from delivery systems","volume":"17","author":"Pinto","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"issue":"20","key":"10.1016\/j.colsurfb.2025.115257_bib42","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.3390\/polym16202919","article-title":"Sublingual fast-dissolving thin films of loratadine: characterization, in vitro and ex vivo evaluation","volume":"16","author":"Alhamhoom","year":"2024","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2025.115257_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124672","article-title":"Manifesting the Dasatinib-gallic acid co-amorphous system to augment anticancer potential: Physicochemical characterization, in silico molecular simulation, ex vivo permeability, and in vitro efficacy","volume":"665","author":"Kanp","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115257_bib44","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ijbiomac.2021.02.180","article-title":"A review on orally disintegrating films (ODFs) made from natural polymers such as pullulan, maltodextrin, starch, and others","volume":"178","author":"Pacheco","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2025.115257_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114337","article-title":"Development of an innovative eugenol and borax-based orodispersible film for enhanced treatment of mouth ulcers","volume":"200","author":"Liu","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115257_bib46","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.3390\/pharmaceutics13101727","article-title":"Development, evaluation, and molecular docking of oral dissolving film of atenolol","volume":"13","author":"Rani","year":"2021","journal-title":"Pharmaceutics"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115257_bib47","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ijpharm.2016.07.058","article-title":"Efficient production of nanoparticle-loaded orodispersible films by process integration in a stirred media mill","volume":"511","author":"Steiner","year":"2016","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115257_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.foodhyd.2005.02.004","article-title":"Interactive plasticizing\u2013antiplasticizing effects of water and glycerol on the tensile properties of tapioca starch films","volume":"20","author":"Chang","year":"2006","journal-title":"Food Hydrocoll."},{"key":"10.1016\/j.colsurfb.2025.115257_bib49","article-title":"Oral fast dissolving films for co-administration of breviscapine and matrine: formulation optimization and in vitro characterization","volume":"95","author":"Yin","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115257_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemosphere.2021.131702","article-title":"Degradation of Bisphenol A by ozonation in a rotating packed bed: modeling by response surface methodology and artificial neural network","volume":"286","author":"Wang","year":"2022","journal-title":"Chemosphere"},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115257_bib51","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1208\/s12249-018-0954-y","article-title":"Formulation and characterization of fast-dissolving sublingual film of iloperidone using box\u2013behnken design for enhancement of oral bioavailability","volume":"19","author":"Londhe","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2025.115257_bib52","article-title":"Development, optimization and in-vivo evaluation of cyanocobalamin loaded orodispersible films using hot-melt extrusion technology: a quality by design (QbD) approach","volume":"63","author":"Suryawanshi","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115257_bib53","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.3390\/molecules29092070","article-title":"Molecular dynamics study of the green solvent polyethylene glycol with water impurities","volume":"29","author":"Hoffmann","year":"2024","journal-title":"Molecules"},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115257_bib54","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s11095-025-03873-9","article-title":"Development of alogliptin oral-dissolving films with optimized therapeutic outcomes","volume":"42","author":"Pathade","year":"2025","journal-title":"Pharm. Res."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007647?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007647?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:42:50Z","timestamp":1766076170000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525007647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":54,"alternative-id":["S0927776525007647"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115257","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design and optimization of indomethacin-loaded solid dispersion orally dissolving films: Machine learning and molecular dynamics study","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115257","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115257"}}