{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:49:03Z","timestamp":1793155743603,"version":"4.5.0"},"reference-count":210,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.colsurfb.2025.115289","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:04:01Z","timestamp":1763647441000},"page":"115289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Nanotechnology-driven targeted pulmonary drug delivery: Innovations, insights, and clinical horizons"],"prefix":"10.1016","volume":"259","author":[{"given":"Abeer Elmustafa","family":"Elrufaie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed Ahmad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutasem","family":"Rawas-Qalaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman Saad","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.4155\/tde-2017-0037","article-title":"Drug delivery to the lungs: challenges and opportunities","volume":"8","author":"Newman","year":"2017","journal-title":"Ther. Deliv."},{"issue":"6","key":"10.1016\/j.colsurfb.2025.115289_bib2","first-page":"772","article-title":"Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19","volume":"16","author":"Li","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115289_bib3","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1016\/j.xphs.2021.08.012","article-title":"Improved bioavailability with dry powder cannabidiol inhalation: a phase 1 clinical study","volume":"110","author":"Devinsky","year":"2021","journal-title":"J. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib4","article-title":"Therapeutic activity of an inhaled potent SARS-CoV-2 neutralizing human monoclonal antibody in hamsters","volume":"2","author":"Piepenbrink","year":"2021","journal-title":"Cell Rep. Med"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib5","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/jamp.2024.0025","article-title":"Comparison of systemic exposure between epinephrine delivered via metered-dose inhalation and intramuscular injection","volume":"38","author":"Zhang","year":"2025","journal-title":"J. Aerosol Med Pulm. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2025.115289_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2020.101938","article-title":"Inhaled nintedanib is well-tolerated and delivers key pharmacokinetic parameters required to treat bleomycin-induced pulmonary fibrosis","volume":"63","author":"Surber","year":"2020","journal-title":"Pulm. Pharm. Ther."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib7","doi-asserted-by":"crossref","first-page":"6684","DOI":"10.1021\/acsnano.0c10040","article-title":"Controlled pulmonary delivery of carrier-free budesonide dry powder by atomic layer deposition","volume":"15","author":"La Zara","year":"2021","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib8","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1124\/pharmrev.120.000108","article-title":"Inhaled medicines: past, present, and future","volume":"74","author":"Anderson","year":"2022","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.colsurfb.2025.115289_bib9","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jconrel.2014.05.058","article-title":"Controlled delivery of inhaled therapeutic agents","volume":"190","author":"Hickey","year":"2014","journal-title":"J. Control Release"},{"key":"10.1016\/j.colsurfb.2025.115289_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaerosci.2020.105649","article-title":"The effect of oral and nasal breathing on the deposition of inhaled particles in upper and tracheobronchial airways","volume":"150","author":"Lizal","year":"2020","journal-title":"J. Aerosol Sci."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib11","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/ppul.22999","article-title":"Nasal versus oral aerosol delivery to the \"lungs\" in infants and toddlers","volume":"50","author":"Amirav","year":"2015","journal-title":"Pedia Pulmonol."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1089\/jamp.2022.0006","article-title":"Relative lung and systemic bioavailability along with oropharyngeal deposition of salbutamol post-inhalation: a pharmacokinetic evaluation of novel inhaler technique training gadgets","volume":"35","author":"Ammari","year":"2022","journal-title":"J. Aerosol Med Pulm. Drug Deliv."},{"key":"10.1016\/j.colsurfb.2025.115289_bib13","first-page":"55","article-title":"Nanotechnology-based inhalation treatments for lung cancer: state of the art","volume":"8","author":"Ahmad","year":"2015","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.colsurfb.2025.115289_bib14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.addr.2020.07.006","article-title":"Emerging trends in inhaled drug delivery","volume":"157","author":"Hickey","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1080\/10717544.2017.1333172","article-title":"Toxicity of orally inhaled drug formulations at the alveolar barrier: parameters for initial biological screening","volume":"24","author":"Fr\u00f6hlich","year":"2017","journal-title":"Drug Deliv."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.22159\/ajpcr.2018.v11i4.24117","article-title":"INHALATION THERAPY - APPROACHES AND CHALLENGES","volume":"11","author":"Bhattacharyya","year":"2018","journal-title":"Asian J. Pharm. Clin. Res."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1208\/s12249-023-02559-y","article-title":"Inhalable nanoparticle-based dry powder formulations for respiratory diseases: challenges and strategies for translational research","volume":"24","author":"Chan","year":"2023","journal-title":"AAPS PharmSciTech"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/jamp.2020.29029.cd","article-title":"Deposition mechanisms","volume":"33","author":"Darquenne","year":"2020","journal-title":"J. Aerosol Med Pulm. Drug Deliv."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib19","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/microorganisms12040665","article-title":"Nontuberculous mycobacteria, mucociliary clearance, and bronchiectasis","volume":"12","author":"Retuerto-Guerrero","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.colsurfb.2025.115289_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101942","article-title":"Inhaled drug delivery: past, present, and future","volume":"Volume 52","author":"Yue","year":"2023","journal-title":"Nano Today"},{"issue":"174","key":"10.1016\/j.colsurfb.2025.115289_bib21","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0053-2024","article-title":"Macrophages and the microbiome in chronic obstructive pulmonary disease","volume":"33","author":"Sandhu","year":"2024","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.colsurfb.2025.115289_bib22","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.congress-2024.PA4764","article-title":"Inter-patient variability of inhaled medication lung deposition using Functional Respiratory Imaging (FRI)","author":"Sadafi","year":"2024","journal-title":"Airw. Pharmacol. Treat."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12989-023-00551-9","article-title":"An experimental study on lung deposition of inhaled 2 \u03bcm particles in relation to lung characteristics and deposition models","volume":"20","author":"Rissler","year":"2023","journal-title":"Part Fibre Toxicol."},{"issue":"6","key":"10.1016\/j.colsurfb.2025.115289_bib24","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4187\/respcare.06290","article-title":"Aerosol delivery devices for obstructive lung diseases","volume":"63","author":"Pleasants","year":"2018","journal-title":"Respir. Care"},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib25","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1517\/17425247.2014.873402","article-title":"Improving inhaler technique, adherence to therapy and the precision of dosing: major challenges for pulmonary drug delivery","volume":"11","author":"Newman","year":"2014","journal-title":"Expert Opin. Drug Deliv."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.4187\/respcare.04293","article-title":"Diverse inhaler devices: a big challenge for health-care professionals","volume":"61","author":"Alismail","year":"2016","journal-title":"Respir. Care"},{"key":"10.1016\/j.colsurfb.2025.115289_bib27","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pupt.2017.08.005","article-title":"Video instruction is more effective than written instruction in improving inhaler technique","volume":"46","author":"Shah","year":"2017","journal-title":"Pulm. Pharm. Ther."},{"key":"10.1016\/j.colsurfb.2025.115289_bib28","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2147\/COPD.S117196","article-title":"The use of multiple respiratory inhalers requiring different inhalation techniques has an adverse effect on COPD outcomes","volume":"12","author":"Bosnic-Anticevich","year":"2016","journal-title":"Int J. Chron. Obstruct Pulmon Dis."},{"key":"10.1016\/j.colsurfb.2025.115289_bib29","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.jconrel.2015.07.024","article-title":"Nanotechnology approaches for inhalation treatment of lung diseases","volume":"219","author":"Kuzmov","year":"2015","journal-title":"J. Control Release"},{"key":"10.1016\/j.colsurfb.2025.115289_bib30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.addr.2014.05.008","article-title":"Improving the efficacy of inhaled drugs in cystic fibrosis: challenges and emerging drug delivery strategies","volume":"75","author":"d'Angelo","year":"2014","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib31","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/MOO.0000000000000153","article-title":"Dysphonia associated with the use of inhaled corticosteroids","volume":"23","author":"Chmielewska","year":"2015","journal-title":"Curr. Opin. Otolaryngol. Head. Neck Surg."},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115289_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12968\/hmed.2020.0556","article-title":"An update on interstitial lung disease","volume":"82","author":"Mudawi","year":"2021","journal-title":"Br. J. Hosp. Med (Lond. )"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib33","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.iac.2023.01.009","article-title":"Drug-induced interstitial lung diseases","volume":"43","author":"Ng","year":"2023","journal-title":"Immunol. Allergy Clin. North Am."},{"key":"10.1016\/j.colsurfb.2025.115289_bib34","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.2147\/IDR.S427544","article-title":"Diagnosis and management of drug-induced interstitial lung disease associated with amikacin liposome inhalation suspension in refractory Mycobacterium Avium complex pulmonary disease: a case report","volume":"16","author":"Hashimoto","year":"2023","journal-title":"Infect. Drug Resist"},{"key":"10.1016\/j.colsurfb.2025.115289_bib35","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.jconrel.2014.03.012","article-title":"Pulmonary administration of a doxorubicin-conjugated dendrimer enhances drug exposure to lung metastases and improves cancer therapy","volume":"183","author":"Kaminskas","year":"2014","journal-title":"J. Control Release"},{"key":"10.1016\/j.colsurfb.2025.115289_bib36","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.addr.2019.07.006","article-title":"Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications","volume":"144","author":"Mohammadpour","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib37","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1021\/acsnano.6b08551","article-title":"Inhaled nanoparticles accumulate at sites of vascular disease","volume":"11","author":"Miller","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.115289_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110302","article-title":"Grand challenges in nanomedicine","volume":"106","author":"Wu","year":"2020","journal-title":"Mater. Sci. Eng. C. Mater. Biol. Appl."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib39","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1208\/s12248-014-9598-3","article-title":"Understanding pharmaceutical quality by design","volume":"16","author":"Yu","year":"2014","journal-title":"AAPS J."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib40","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12967-019-1945-9","article-title":"Translational formulation of nanoparticle therapeutics from laboratory discovery to clinical scale","volume":"17","author":"Feng","year":"2019","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.colsurfb.2025.115289_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119566","article-title":"Rapid scale-up and production of active-loaded PEGylated liposomes","volume":"586","author":"Roces","year":"2020","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115289_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119955","article-title":"Microfluidic production of protein loaded chimeric stealth liposomes","volume":"590","author":"Hussain","year":"2020","journal-title":"Int J. Pharm."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115289_bib43","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/jphp.13329","article-title":"Scalable solvent-free production of liposomes","volume":"72","author":"Khadke","year":"2020","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115289_bib44","article-title":"Mild and large-scale synthesis of nanoscale metal-organic framework used as a potential adenine-based drug nanocarrier","volume":"Volume 61","author":"Nguyen","year":"2021","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113952","article-title":"In vitro-in vivo correlation of cascade impactor data for orally inhaled pharmaceutical aerosols","volume":"177","author":"Chow","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2025.115289_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120307","article-title":"A 3D printed human upper respiratory tract model for particulate deposition profiling","volume":"597","author":"Lim","year":"2021","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115289_bib47","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.addr.2020.09.007","article-title":"Role of CFD based in silico modelling in establishing an in vitro-in vivo correlation of aerosol deposition in the respiratory tract","volume":"170","author":"Huang","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib48","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.xphs.2021.09.042","article-title":"In-Vitro In-Vivo Correlation (IVIVC) of Inhaled Products Using Twin Stage Impinger","volume":"111","author":"Al Ayoub","year":"2022","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115289_bib49","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.actbio.2019.06.056","article-title":"In vitro-in vivo correlation of inhalable budesonide-loaded large porous particles for sustained treatment regimen of asthma","volume":"96","author":"Li","year":"2019","journal-title":"Acta Biomater."},{"issue":"Issue 6","key":"10.1016\/j.colsurfb.2025.115289_bib50","first-page":"490","article-title":"Practical, regulatory and clinical considerations for development of inhalation drug products","volume":"Volume 10","author":"Hou","year":"2015","journal-title":"Asian J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib51","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1021\/acs.molpharmaceut.3c00685","article-title":"iBCS: 3. A biopharmaceutics classification system for orally inhaled drug products","volume":"21","author":"Hastedt","year":"2024","journal-title":"Mol. Pharm."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.115289_bib52","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1039\/D0BM00558D","article-title":"The regulation of nanomaterials and nanomedicines for clinical application: current and future perspectives","volume":"8","author":"Foulkes","year":"2020","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2025.115289_bib53","article-title":"The Global Bioequivalence Harmonisation Initiative (GBHI): Report of EUFEPS\/AAPS fourth conference","volume":"167","author":"B","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3390\/pharmaceutics16020161","article-title":"Nano-formulations for pulmonary delivery: past, present, and future perspectives","volume":"16","author":"Peng","year":"2024","journal-title":"Pharmaceutics"},{"issue":"26","key":"10.1016\/j.colsurfb.2025.115289_bib55","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.7150\/thno.39816","article-title":"Strategy to enhance lung cancer treatment by five essential elements: inhalation delivery, nanotechnology, tumor-receptor targeting, chemo- and gene therapy","volume":"9","author":"Garbuzenko","year":"2019","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115289_bib56","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00011-016-0959-5","article-title":"In vivo proinflammatory activity of generations 0-3 (G0-G3) polyamidoamine (PAMAM) nanoparticles","volume":"65","author":"Durocher","year":"2016","journal-title":"Inflamm. Res"},{"issue":"1-2","key":"10.1016\/j.colsurfb.2025.115289_bib57","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijpharm.2017.05.046","article-title":"TPP-dendrimer nanocarriers for siRNA delivery to the pulmonary epithelium and their dry powder and metered-dose inhaler formulations","volume":"527","author":"Bielski","year":"2017","journal-title":"Int J. Pharm."},{"issue":"41","key":"10.1016\/j.colsurfb.2025.115289_bib58","doi-asserted-by":"crossref","first-page":"23735","DOI":"10.1021\/acs.jpcc.5b06037","article-title":"Synthesis of water-dispersible Gd2O3\/GO nanocomposites with enhanced MRI T1 relaxivity","volume":"119","author":"Wang","year":"2015","journal-title":"J. Phys. Chem. C."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib59","doi-asserted-by":"crossref","first-page":"447","DOI":"10.17219\/acem\/186846","article-title":"Advantages and limitations of nanostructures for biomedical applications","volume":"34","author":"Roszkowski","year":"2025","journal-title":"Adv. Clin. Exp. Med."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115289_bib60","doi-asserted-by":"crossref","first-page":"4203","DOI":"10.1007\/s10904-020-01572-z","article-title":"Aluminum nanoparticles acting as a pulmonary vaccine adjuvant-delivery system (VADS) able to safely elicit robust systemic and mucosal immunity","volume":"30","author":"Wang","year":"2020","journal-title":"J. Inorg. Organomet Polym. Mater."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib61","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1208\/s12249-024-02754-5","article-title":"Drug nanocrystals: a delivery channel for antiviral therapies","volume":"25","author":"Chaturvedi","year":"2024","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib62","article-title":"Recent developments in the use of nanocrystals to improve bioavailability of APIs","volume":"16","author":"Ding","year":"2024","journal-title":"Wiley Inter. Rev. Nanomed. Nanobiotechnol"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib63","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1080\/10408347.2020.1805293","article-title":"Liposomes: preparation, characteristics, and application strategies in analytical chemistry","volume":"52","author":"Liu","year":"2022","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.colsurfb.2025.115289_bib64","unstructured":"Abbasi H, Kouchak M, Mirveis Z, Hajipour F, Khodarahmi M, Rahbar N, Handali S. What We Need to Know about Liposomes as Drug Nanocarriers: An Updated Review. Adv Pharm Bull, 2023 Jan;13(1):7-23. 10.34172\/apb.2023.009. Epub 2022 Apr 4. PMID: 36721822; PMCID: PMC9871273."},{"issue":"24","key":"10.1016\/j.colsurfb.2025.115289_bib65","doi-asserted-by":"crossref","first-page":"15909","DOI":"10.3390\/ijms232415909","article-title":"Development of inhalable chitosan-coated oxymatrine liposomes to alleviate RSV-Infected Mice","volume":"23","author":"Peng","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib66","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13205-020-2144-3","article-title":"Recent strategies towards the surface modification of liposomes: an innovative approach for different clinical applications","volume":"10","author":"Khan","year":"2020","journal-title":"3 Biotech"},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib67","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3390\/pharmaceutics17030329","article-title":"Effects of Surface Charge of Inhaled Liposomes on Drug Efficacy and Biocompatibility","volume":"17","author":"Zhang","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.115289_bib68","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ejpb.2022.01.009","article-title":"Elucidating inhaled liposome surface charge on its interaction with biological barriers in the lung","volume":"172","author":"Zhao","year":"2022","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"13","key":"10.1016\/j.colsurfb.2025.115289_bib69","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s40265-020-01359-z","article-title":"Inhaled Liposomal Antimicrobial Delivery in Lung Infections","volume":"80","author":"Bassetti","year":"2020","journal-title":"Drugs"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib70","doi-asserted-by":"crossref","first-page":"331","DOI":"10.4103\/0970-2113.159559","article-title":"A novel approach for lung delivery of rifampicin-loaded liposomes in dry powder form for the treatment of tuberculosis","volume":"32","author":"Patil","year":"2015","journal-title":"Lung India"},{"key":"10.1016\/j.colsurfb.2025.115289_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.106081","article-title":"Design and evaluation of folate-modified liposomes for pulmonary administration in lung cancer therapy","volume":"168","author":"Onodera","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115289_bib72","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1002\/ejlt.201300368","article-title":"Phospholipids in pulmonary drug delivery","volume":"116","author":"Wauthoz","year":"2014","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib73","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jconrel.2019.04.025","article-title":"Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization","volume":"303","author":"Wang","year":"2019","journal-title":"J. Control Release"},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115289_bib74","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3390\/pharmaceutics13071023","article-title":"Post-processing techniques for the improvement of liposome stability","volume":"13","author":"Yu","year":"2021","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib75","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/08982104.2021.2019762","article-title":"A drift on liposomes to proliposomes: recent advances and promising approaches","volume":"32","author":"Dhiman","year":"2022","journal-title":"J. Liposome Res"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib76","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1208\/s12249-018-1058-4","article-title":"Spray-dried proliposome microparticles for high-performance aerosol delivery using a monodose powder inhaler","volume":"19","author":"Omer","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2025.115289_bib77","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.2147\/IJN.S306831","article-title":"Design and characterization of spray-dried proliposomes for the pulmonary delivery of curcumin","volume":"16","author":"Adel","year":"2021","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.colsurfb.2025.115289_bib78","unstructured":"Tekade AR, au1> PS, Pisal CS. Nanostructured Lipid Carriers for Nose to Brain Delivery Targeting CNS: Diversified Role of Liquid Lipids for Synergistic Action. Adv Pharm Bull. 2022 Aug;12(4):763-771. 10.34172\/apb.2022.078. Epub 2021 Oct 4. PMID: 36415627; PMCID: PMC9675932."},{"key":"10.1016\/j.colsurfb.2025.115289_bib79","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2021.05.003","article-title":"Methods for preparation of nanostructured lipid carriers","volume":"199","author":"Gomaa","year":"2022","journal-title":"Methods"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib80","doi-asserted-by":"crossref","first-page":"2859","DOI":"10.1016\/j.xphs.2021.04.012","article-title":"The Effects of Solid and Liquid Lipids on the Physicochemical Properties of Nanostructured Lipid Carriers","volume":"110","author":"Apostolou","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115289_bib81","article-title":"Formulation development of itraconazole PEGylated nano-lipid carriers for pulmonary aspergillosis using hot-melt extrusion technology","author":"Shadambikar","year":"2021","journal-title":"Int J. Pharm. X"},{"key":"10.1016\/j.colsurfb.2025.115289_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124495","article-title":"Pulmonary delivery of magnolol-loaded nanostructured lipid carriers for COPD treatment","volume":"662","author":"Jia","year":"2024","journal-title":"Int J. Pharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-90910-7","article-title":"Design, development, and preclinical evaluation of pirfenidone-loaded nanostructured lipid carriers for pulmonary delivery","volume":"15","author":"Chettupalli","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2025.115289_bib84","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2147\/IJN.S489133","article-title":"Development and evaluation of aloperine-loaded nanostructured lipid carriers for the treatment of pulmonary arterial hypertension","volume":"20","author":"Liu","year":"2025","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.colsurfb.2025.115289_bib85","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jconrel.2020.07.011","article-title":"Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery","volume":"326","author":"Shen","year":"2020","journal-title":"J. Control Release"},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115289_bib86","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/jcm5090082","article-title":"Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery","volume":"5","author":"Yhee","year":"2016","journal-title":"J. Clin. Med"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib87","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3892\/mmr.2021.11964","article-title":"Application of nanotechnology in drug delivery systems for respiratory diseases (Review)","volume":"23","author":"Luo","year":"2021","journal-title":"Mol. Med Rep."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.115289_bib88","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.3390\/molecules25173982","article-title":"Applications and limitations of dendrimers in biomedicine","volume":"25","author":"Chis","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2025.115289_bib89","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.cbi.2019.05.028","article-title":"Oligonucleotide therapy: an emerging focus area for drug delivery in chronic inflammatory respiratory diseases","volume":"308","author":"Mehta","year":"2019","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.colsurfb.2025.115289_bib90","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ejpb.2020.08.009","article-title":"Treatment of acute lung inflammation by pulmonary delivery of anti-TNF-\u03b1 siRNA with PAMAM dendrimers in a murine model","volume":"156","author":"Bohr","year":"2020","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115289_bib91","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1021\/acs.molpharmaceut.6b00126","article-title":"Conjugation to Poly(amidoamine) dendrimers and pulmonary delivery reduce cardiac accumulation and enhance antitumor activity of doxorubicin in lung metastasis","volume":"13","author":"Zhong","year":"2016","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115289_bib92","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.ejpb.2017.07.005","article-title":"Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers","volume":"119","author":"Haque","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib93","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1038\/s41467-025-56448-y","article-title":"Targeted delivery of TGF-\u03b2 mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers","volume":"16","author":"Meshanni","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2025.115289_bib94","article-title":"Inhaled PAMAM-based nano-formulation prolonged lung retention for alleviating pulmonary inflammation of COPD","volume":"32","author":"Wang","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2025.115289_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbiomech.2021.110279","article-title":"Focused targeting of inhaled magnetic aerosols in reconstructed in vitro airway models","volume":"118","author":"Ostrovski","year":"2021","journal-title":"J. Biomech."},{"key":"10.1016\/j.colsurfb.2025.115289_bib96","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121318","article-title":"Respirable spray dried vancomycin coated magnetic nanoparticles for localized lung delivery","volume":"611","author":"Abdelaziz","year":"2022","journal-title":"Int J. Pharm."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115289_bib97","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3390\/jcm5090082","article-title":"Advanced Therapeutic Strategies for Chronic Lung Disease Using Nanoparticle-Based Drug Delivery","volume":"5","author":"Yhee","year":"2016","journal-title":"J. Clin. Med"},{"key":"10.1016\/j.colsurfb.2025.115289_bib98","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/magnetochemistry6020025","article-title":"Successes and challenges: inhaled treatment approaches using magnetic nanoparticles in cystic fibrosis","volume":"6","author":"Tan","year":"2020","journal-title":"Magnetochemistry"},{"key":"10.1016\/j.colsurfb.2025.115289_bib99","first-page":"55","article-title":"Nanotechnology-based inhalation treatments for lung cancer: state of the art","volume":"8","author":"Ahmad","year":"2015","journal-title":"Nanotechnol. Sci. Appl."},{"key":"10.1016\/j.colsurfb.2025.115289_bib100","series-title":"Drug Delivery Nanosystems for Biomedical Applications","first-page":"181","article-title":"Chapter 9 - Nanocomposites used for drug delivery applications, Editor(s): Chandra Prakash Sharma, In Micro and Nano Technologies","author":"Jayalekshmi","year":"2018"},{"key":"10.1016\/j.colsurfb.2025.115289_bib101","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.jconrel.2017.11.036","article-title":"Inhalable particulate drug delivery systems for lung cancer therapy: Nanoparticles, microparticles, nanocomposites and nanoaggregates","volume":"269","author":"Abdelaziz","year":"2018","journal-title":"J. Control Release"},{"key":"10.1016\/j.colsurfb.2025.115289_bib102","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ejps.2019.04.001","article-title":"Tadalafil nanocomposites as a dry powder formulation for inhalation, a new strategy for pulmonary arterial hypertension treatment","volume":"133","author":"Teymouri Rad","year":"2019","journal-title":"Eur. J. Pharm. Sci."},{"issue":"51","key":"10.1016\/j.colsurfb.2025.115289_bib103","doi-asserted-by":"crossref","first-page":"56498","DOI":"10.1021\/acsami.2c15204","article-title":"Supramolecular Peptide Nanofiber\/PLGA Nanocomposites for Enhancing Pulmonary Drug Delivery","volume":"14","author":"Chintapula","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"Pt 1","key":"10.1016\/j.colsurfb.2025.115289_bib104","article-title":"A novel synergistic enzyme-antibiotic therapy with immobilization of mycobacteriophage Lysin B enzyme onto Rif@UiO-66 nanocomposite for enhanced inhaled anti-TB therapy; Nanoenzybiotics approach","volume":"262","author":"Eldin","year":"2024","journal-title":"Int J. Biol. Macromol."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib105","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1021\/acs.molpharmaceut.0c00692","article-title":"Exploring the toxicity, lung distribution, and cellular uptake of rifampicin and ascorbic acid-loaded alginate nanoparticles as therapeutic treatment of lung intracellular infections","volume":"18","author":"Scolari","year":"2020","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.colsurfb.2025.115289_bib106","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jddst.2019.05.025","article-title":"Alginate modified-PLGA nanoparticles entrapping amikacin and moxifloxacin as a novel host-directed therapy for multidrug-resistant tuberculosis","volume":"Volume 52","author":"Abdelghany","year":"2019","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"19","key":"10.1016\/j.colsurfb.2025.115289_bib107","doi-asserted-by":"crossref","first-page":"10480","DOI":"10.3390\/ijms221910480","article-title":"Hyaluronic acid-dexamethasone nanoparticles for local adjunct therapy of lung inflammation","volume":"22","author":"Camara","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2025.115289_bib108","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3389\/fphar.2020.01199","article-title":"Attenuation of Radiation-Induced Lung Injury by Hyaluronic Acid Nanoparticles","volume":"11","author":"Lierova","year":"2020","journal-title":"Front Pharm."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib109","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/10837450.2020.1852570","article-title":"Dry powder inhalation formulation of chitosan nanoparticles for co-administration of isoniazid and pyrazinamide","volume":"26","author":"Changsan","year":"2021","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s43094-022-00419-3","article-title":"Preparation and evaluation of pirfenidone loaded chitosan nanoparticles pulmonary delivery for idiopathic pulmonary fibrosis","volume":"8","author":"Dudhat","year":"2022","journal-title":"Futur J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2025.115289_bib111","article-title":"Development and characterization of inhaled nintedanib-loaded PLGA nanoparticles using scalable high-pressure homogenization technique","volume":"91","author":"Wang","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib112","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/bcpt.13771","article-title":"A dose-related positive effect of inhaled simvastatin-loaded PLGA nanoparticles on paraquat-induced pulmonary fibrosis in rats","volume":"131","author":"Shahabadi","year":"2022","journal-title":"Basic Clin. Pharm. Toxicol."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib113","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.drudis.2014.09.020","article-title":"Recent advances in controlled pulmonary drug delivery","volume":"20","author":"Liang","year":"2015","journal-title":"Drug Discov. Today"},{"issue":"16","key":"10.1016\/j.colsurfb.2025.115289_bib114","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.3390\/molecules25163731","article-title":"Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology","volume":"25","author":"Zieli\u0144ska","year":"2020","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib115","article-title":"Inhaled nanoformulated mRNA polyplexes for protein production in lung epithelium","volume":"31","author":"Patel","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2025.115289_bib116","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.biopha.2016.01.027","article-title":"Treatment of bleomycin-induced pulmonary fibrosis by inhaled tacrolimus-loaded chitosan-coated poly(lactic-co-glycolic acid) nanoparticles","volume":"78","author":"Lee","year":"2016","journal-title":"Biomed. Pharm."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib117","doi-asserted-by":"crossref","first-page":"2522","DOI":"10.1016\/j.apsb.2021.10.027","article-title":"Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis","volume":"12","author":"Chen","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib118","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3892\/mmr.2021.11964","article-title":"Application of nanotechnology in drug delivery systems for respiratory diseases (Review)","volume":"23","author":"Luo","year":"2021","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.colsurfb.2025.115289_bib119","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1134\/S0003683820020088","article-title":"Antibacterial and immunomodulating activity of silver nanoparticles on mice experimental tuberculosis model","volume":"56","author":"Kalmantaeva","year":"2020","journal-title":"Appl. Biochem Microbiol"},{"issue":"7","key":"10.1016\/j.colsurfb.2025.115289_bib120","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/antibiotics13070630","article-title":"In vitro evaluation of colistin conjugated with chitosan-capped gold nanoparticles as a possible formulation applied in a metered-dose inhaler","volume":"13","author":"Changsan","year":"2024","journal-title":"Antibiot. (Basel)"},{"key":"10.1016\/j.colsurfb.2025.115289_bib121","article-title":"Formulation and optimization of ivermectin nanocrystals for enhanced topical delivery","volume":"6","author":"Awad","year":"2023","journal-title":"Int. J. Pharm. X"},{"key":"10.1016\/j.colsurfb.2025.115289_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106251","article-title":"Optimization, characterization and in vivo evaluation of mupirocin nanocrystals for topical administration","volume":"176","author":"Najm","year":"2022","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib123","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1080\/10717544.2022.2039809","article-title":"Nanocrystals based pulmonary inhalation delivery system: advance and challenge","volume":"29","author":"Yue","year":"2022","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2025.115289_bib124","article-title":"PEGylated mucus-penetrating nanocrystals for lung delivery of a new FtsZ inhibitor against Burkholderia cenocepacia infection","volume":"23","author":"Costabile","year":"2020","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2025.115289_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.113865","article-title":"Lipid-coated nanocrystals of paclitaxel as dry powder for inhalation: Characterization, in-vitro performance, and pharmacokinetic assessment","volume":"237","author":"Kumar","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2025.115289_bib126","doi-asserted-by":"crossref","first-page":"141","DOI":"10.25004\/IJPSDR.2022.140119","article-title":"Influence of particle size and particle deposition of inhaled medication in lung disease: a comrehensive review","volume":"14","author":"Dudhat","year":"2022","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115289_bib127","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.3390\/pharmaceutics15122777","article-title":"Inhaled medicines for targeting non-small cell lung cancer","volume":"15","author":"Al Khatib","year":"2023","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.colsurfb.2025.115289_bib128","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1021\/acsnano.2c10830","article-title":"Inhalable biomineralized liposomes for cyclic Ca2+-Burst-centered endoplasmic reticulum stress enhanced lung cancer ferroptosis therapy","volume":"17","author":"Fu","year":"2023","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib129","first-page":"725","article-title":"Pulmonary Delivery of Anticancer Drugs via Lipid-Based Nanocarriers for the Treatment of Lung Cancer: An Update","volume":"14","author":"Abdulbaqi","year":"2021","journal-title":"Pharm. (Basel)"},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib130","first-page":"44","article-title":"Inhalation treatment of lung cancer: the influence of composition, size and shape of nanocarriers on their lung accumulation and retention","volume":"11","author":"Garbuzenko","year":"2014","journal-title":"Cancer Biol. Med"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib131","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/jama.2019.11058","article-title":"Systemic therapy for locally advanced and metastatic non-small cell lung cancer: a review","volume":"322","author":"Arbour","year":"2019","journal-title":"JAMA"},{"key":"10.1016\/j.colsurfb.2025.115289_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118995","article-title":"Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: Repurposing quinacrine for lung cancer therapeutics","volume":"577","author":"Vaidya","year":"2020","journal-title":"Int J. Pharm."},{"issue":"14","key":"10.1016\/j.colsurfb.2025.115289_bib133","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.7150\/thno.61085","article-title":"Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2025.115289_bib134","article-title":"Dual barrier-penetrating inhaled nanoparticles for enhanced idiopathic pulmonary fibrosis therapy","volume":"34","author":"Yang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2025.115289_bib135","article-title":"Inhaled nintedanib nanoparticles for enhanced efficacy in idiopathic pulmonary fibrosis (IPF) treatment \u2013 Evidence in disease-relevant in-vitro models","volume":"95","author":"Wang","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib136","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jconrel.2024.01.032","article-title":"Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling","volume":"366","author":"Han","year":"2024","journal-title":"J. Control Release"},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib137","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/smll.201401284","article-title":"Nebulized gadolinium-based nanoparticles: a theranostic approach for lung tumor imaging and radiosensitization","volume":"11","author":"Dufort","year":"2015","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2025.115289_bib138","article-title":"Inhalable spray dried lipidnanoparticles for the co-delivery of paclitaxel and doxorubicin in lung cancer","volume":"56","author":"Kaur","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib139","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/17425247.2022.2076833","article-title":"Simultaneous pulmonary administration of celecoxib and naringin using a nebulization-friendly nanoemulsion: A device-targeted delivery for treatment of lung cancer","volume":"19","author":"Said-Elbahr","year":"2022","journal-title":"Expert Opin. Drug Deliv."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib140","doi-asserted-by":"crossref","first-page":"5300","DOI":"10.1007\/s12274-022-5205-6","article-title":"Aerosolized immunotherapeutic nanoparticle inhalation potentiates PD-L1 blockade for locally advanced lung cancer","volume":"16","author":"Liu","year":"2023","journal-title":"Nano Res"},{"key":"10.1016\/j.colsurfb.2025.115289_bib141","article-title":"DOE supported optimization of biodegradable polymeric nanoparticles based dry powder inhaler for targeted delivery of afatinib in non-small cell lung cancer","volume":"84","author":"Vanza","year":"2023","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"10","key":"10.1016\/j.colsurfb.2025.115289_bib142","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1007\/s13346-021-01088-0","article-title":"Pulmonary delivery of osimertinib liposomes for non-small cell lung cancer treatment: formulation development and in vitro evaluation","volume":"12","author":"Sawant","year":"2022","journal-title":"Drug Deliv. Transl. Res"},{"key":"10.1016\/j.colsurfb.2025.115289_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120504","article-title":"Encapsulation of a CpG oligonucleotide in cationic liposomes enhances its local antitumor activity following pulmonary delivery in a murine model of metastatic lung cancer","volume":"600","author":"Loira-Pastoriza","year":"2021","journal-title":"Int J. Pharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib144","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1021\/acsbiomaterials.0c01126","article-title":"Aerosol Delivery of Paclitaxel-Containing Self-Assembled Nanocochleates for Treating Pulmonary Metastasis: An Approach Supporting Pulmonary Mechanics","volume":"7","author":"Shanmugam","year":"2021","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib145","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1186\/s12967-024-05711-9","article-title":"Innovative nebulization delivery of lipid nanoparticle-encapsulated siRNA: a therapeutic advance for Staphylococcus aureus-induced pneumonia","volume":"22","author":"Meng","year":"2024","journal-title":"J. Transl. Med"},{"key":"10.1016\/j.colsurfb.2025.115289_bib146","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2147\/IJN.S218966","article-title":"AntimicrobiaL Peptide-loaded Nanoparticles as Inhalation Therapy for Pseudomonas Aeruginosa Infections","volume":"15","author":"Falciani","year":"2020","journal-title":"Int J. Nanomed."},{"key":"10.1016\/j.colsurfb.2025.115289_bib147","article-title":"Inhaled penindolone-loaded nanoparticles outperform oseltamivir for suppression of influenza A virus infection","volume":"98","author":"Li","year":"2024","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115289_bib148","doi-asserted-by":"crossref","first-page":"11147","DOI":"10.1021\/acsami.3c13677","article-title":"Inhalation delivery of interferon-\u03bb-loaded pulmonary surfactant nanoparticles induces rapid antiviral immune responses in the lung","volume":"16","author":"Gil","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib149","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s13205-020-2144-3","article-title":"Recent strategies towards the surface modification of liposomes: an innovative approach for different clinical applications","volume":"10","author":"Khan","year":"2020","journal-title":"3 Biotech"},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115289_bib150","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1080\/17425247.2018.1547280","article-title":"Lung cancer: active therapeutic targeting and inhalational nanoproduct design","volume":"15","author":"Alhajj","year":"2018","journal-title":"Expert Opin. Drug Deliv."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib151","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jconrel.2013.04.018","article-title":"Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA","volume":"171","author":"Taratula","year":"2013","journal-title":"J. Control Release"},{"issue":"44","key":"10.1016\/j.colsurfb.2025.115289_bib152","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2304966120","article-title":"Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection","volume":"120","author":"Tang","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.colsurfb.2025.115289_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121038","article-title":"Development and characterization of inhalable transferrin functionalized amodiaquine nanoparticles - Efficacy in Non-Small Cell Lung Cancer (NSCLC) treatment","volume":"608","author":"Parvathaneni","year":"2021","journal-title":"Int J. Pharm."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115289_bib154","doi-asserted-by":"crossref","first-page":"10353","DOI":"10.1021\/acsomega.3c07954","article-title":"Formulation of Folate Receptor-Targeted Silibinin-Loaded Inhalable Chitosan Nanoparticles by the QbD Approach for Lung Cancer Targeted Delivery","volume":"9","author":"Patel","year":"2024","journal-title":"ACS Omega"},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib155","first-page":"1108","article-title":"Mannose-functionalized isoniazid-loaded nanostructured lipid carriers for pulmonary delivery: in vitro prospects and in vivo therapeutic efficacy assessment","volume":"16","author":"Ahalwat","year":"2023","journal-title":"Pharm. (Basel)"},{"key":"10.1016\/j.colsurfb.2025.115289_bib156","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12951-020-00593-7","article-title":"Manipulation of macrophage polarization by peptide-coated gold nanoparticles and its protective effects on acute lung injury","volume":"18","author":"Wang","year":"2020","journal-title":"J. Nanobiotechnol"},{"key":"10.1016\/j.colsurfb.2025.115289_bib157","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.actbio.2024.01.032","article-title":"Pulmonary RNA interference against acute lung injury mediated by mucus- and cell-penetrating nanocomplexes","volume":"177","author":"Zhang","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2025.115289_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejpb.2024.114511","article-title":"Intratracheal delivery of macrophage targeted Celastrol-loaded PLGA nanoparticles for enhanced anti-inflammatory efficacy in acute lung injury mice","volume":"204","author":"Yao","year":"2024","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"2","key":"10.1016\/j.colsurfb.2025.115289_bib159","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1021\/acsbiomaterials.9b01639","article-title":"Inhalable lactoferrin\/chondroitin-functionalized monoolein nanocomposites for localized lung cancer targeting","volume":"6","author":"Abdelaziz","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"1","key":"10.1016\/j.colsurfb.2025.115289_bib160","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1515\/ntrev-2022-0021","article-title":"Octreotide-conjugated silver nanoparticles for active targeting of somatostatin receptors and their application in a nebulized rat model","volume":"11","author":"Abdellatif","year":"2022","journal-title":"Nanotechnol. Rev."},{"issue":"21","key":"10.1016\/j.colsurfb.2025.115289_bib161","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1016\/j.biomaterials.2013.03.061","article-title":"Inhalable magnetic nanoparticles for targeted hyperthermia in lung cancer therapy","volume":"34","author":"Sadhukha","year":"2013","journal-title":"Biomaterials"},{"issue":"26","key":"10.1016\/j.colsurfb.2025.115289_bib162","doi-asserted-by":"crossref","first-page":"31273","DOI":"10.1021\/acsami.3c05007","article-title":"Inhalable siRNA nanoparticles for enhanced tumor-targeting treatment of KRAS-mutant non-small-cell lung cancer","volume":"15","author":"Zhao","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"24","key":"10.1016\/j.colsurfb.2025.115289_bib163","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg3277","article-title":"Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates","volume":"9","author":"Meng","year":"2023","journal-title":"Sci. Adv."},{"issue":"13","key":"10.1016\/j.colsurfb.2025.115289_bib164","article-title":"Stimuli-Responsive Antibacterial Materials: Molecular Structures, Design Principles, and Biomedical Applications","volume":"9","author":"Wang","year":"2022","journal-title":"Adv. Sci. (Weinh. )"},{"issue":"23","key":"10.1016\/j.colsurfb.2025.115289_bib165","doi-asserted-by":"crossref","first-page":"23223","DOI":"10.1021\/acsnano.3c06019","article-title":"Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics","volume":"17","author":"Wei","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2025.115289_bib166","article-title":"Research progress of nano-based drug delivery systems based on stimuli-responsive materials for the treatment of lung diseases","volume":"13","author":"Li","year":"2025","journal-title":"Front Bioeng. Biotechnol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib167","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.actbio.2022.06.024","article-title":"ROS-responsive polymer nanoparticles with enhanced loading of dexamethasone effectively modulate the lung injury microenvironment","volume":"148","author":"Muhammad","year":"2022","journal-title":"Acta Biomater."},{"issue":"8","key":"10.1016\/j.colsurfb.2025.115289_bib168","doi-asserted-by":"crossref","first-page":"12590","DOI":"10.1021\/acsnano.2c04159","article-title":"An osimertinib-perfluorocarbon nanoemulsion with excellent targeted therapeutic efficacy in non-small cell lung cancer: achieving intratracheal and intravenous administration","volume":"16","author":"Yang","year":"2022","journal-title":"ACS Nano"},{"issue":"Pt 1","key":"10.1016\/j.colsurfb.2025.115289_bib169","article-title":"Inhalable pH-responsive core-shell nanocarriers with PEGylated chitosan\/alginate layer-by-layer coating for sequential drug release in lung cancer therapy","volume":"307","author":"Eldin","year":"2025","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib170","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123004","article-title":"Redox-activatable inhalable mucoadhesive proteinic nanotherapeutics for targeted treatment of lung cancer","volume":"316","author":"Jeong","year":"2025","journal-title":"Biomaterials"},{"issue":"15","key":"10.1016\/j.colsurfb.2025.115289_bib171","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800124","article-title":"Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery","volume":"7","author":"Miranda","year":"2018","journal-title":"Adv. Health Mater."},{"key":"10.1016\/j.colsurfb.2025.115289_bib172","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2022.101489","article-title":"Inhalable responsive polysaccharide-based antibiotic delivery nanoparticles to overcome mucus barrier for lung infection treatment","volume":"44","author":"Ren","year":"2022","journal-title":"Nano Today"},{"key":"10.1016\/j.colsurfb.2025.115289_bib173","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202112145","article-title":"Inhalable MOF-derived nanoparticles for sonodynamic therapy of bacterial pneumonia","volume":"32","author":"Pan","year":"2022","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2025.115289_bib174","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.132514","article-title":"A sulfatase-activatable AIEgen nanoprobe for inhalation imaging-guided surgical excision of lung cancer","volume":"428","author":"Xu","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2025.115289_bib175","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121539","article-title":"Aerosol delivery of star polymer-siRNA nanoparticles as a therapeutic strategy to inhibit lung tumor growth","volume":"285","author":"Ma","year":"2022","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.colsurfb.2025.115289_bib176","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1002\/mrm.28041","article-title":"Three-dimensional quantitative MRI of aerosolized gadolinium-based nanoparticles and contrast agents in isolated ventilated porcine lungs","volume":"83","author":"Cr\u00e9millieux","year":"2020","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.colsurfb.2025.115289_bib177","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4236\/ojmi.2015.52008","article-title":"Application of Magnetic Particle Imaging to Pulmonary Imaging Using Nebulized Magnetic Nanoparticles","volume":"5","author":"Nishimoto","year":"2015","journal-title":"Open J. Med. Imaging"},{"issue":"13","key":"10.1016\/j.colsurfb.2025.115289_bib178","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.7150\/thno.26608","article-title":"In vivo tracking and quantification of inhaled aerosol using magnetic particle imaging towards inhaled therapeutic monitoring","volume":"8","author":"Tay","year":"2018","journal-title":"Theranostics"},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115289_bib179","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3390\/pharmaceutics11120687","article-title":"An inhalable theranostic system for local tuberculosis treatment containing an isoniazid loaded metal organic framework Fe-MIL-101-NH2-From Raw MOF to drug delivery system","volume":"11","author":"Wyszogrodzka-Gawe\u0142","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2025.115289_bib180","doi-asserted-by":"crossref","DOI":"10.1111\/cpf.12517","article-title":"Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema: proof of concept for a novel diagnostic technique","author":"Aaltonen","year":"2018","journal-title":"Clin. Physiol. Funct. Imaging"},{"key":"10.1016\/j.colsurfb.2025.115289_bib181","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT02408874?term=NCT02408874&rank=1 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib182","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT04491240?term=inhaled%20nanoparticles&rank=9#study-plan (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib183","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/Clinicaltrials.gov\/study\/NCT04276987(Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib184","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT04602442 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib185","unstructured":"(2024) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT05668741."},{"issue":"12","key":"10.1016\/j.colsurfb.2025.115289_bib186","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1164\/rccm.202402-0389CI","article-title":"Lentiviral gene therapy for cystic fibrosis: a promising approach and first-in-human trial","volume":"210","author":"Davies","year":"2024","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.colsurfb.2025.115289_bib187","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/www.clinicaltrials.gov\/study\/NCT01621867 (Accessed: 17 August 2025)."},{"issue":"9","key":"10.1016\/j.colsurfb.2025.115289_bib188","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S2213-2600(15)00245-3","article-title":"UK Cystic Fibrosis Gene Therapy Consortium. Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial","volume":"3","author":"Alton","year":"2015","journal-title":"Lancet Respir. Med"},{"key":"10.1016\/j.colsurfb.2025.115289_bib189","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT03375047 (Accessed: 17 August 2025)."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib190","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.jcf.2023.04.008","article-title":"Inhaled mRNA therapy for treatment of cystic fibrosis: Interim results of a randomized, double-blind, placebo-controlled phase 1\/2 clinical study","volume":"22","author":"Rowe","year":"2023","journal-title":"J. Cyst. Fibros."},{"key":"10.1016\/j.colsurfb.2025.115289_bib191","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT01515007 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib192","unstructured":"Linhaliq | European Medicines Agency (EMA) (2019) European Medicines Agency (EMA). Available at: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/linhaliq (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib193","unstructured":"European Medicines Agency. (2019). Withdrawal assessment report for Linhaliq\u00ae (liposomal ciprofloxacin). Retrieved from https:\/\/www.ema.europa.eu\/en\/documents\/withdrawal-report\/withdrawal-assessment-report-linhaliq_en.pdf."},{"key":"10.1016\/j.colsurfb.2025.115289_bib194","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT02104245 (Accessed: 17 August 2025)."},{"issue":"3","key":"10.1016\/j.colsurfb.2025.115289_bib195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2213-2600(18)30427-2","article-title":"Inhaled liposomal ciprofloxacin in patients with non-cystic fibrosis bronchiectasis and chronic lung infection with Pseudomonas aeruginosa (ORBIT-3 and ORBIT-4): two phase 3, randomised controlled trials","volume":"7","author":"Haworth","year":"2019","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.colsurfb.2025.115289_bib196","unstructured":"Aradigm receives CRL for Linhaliq (2018) Oindpnews.com. Available at: https:\/\/www.oindpnews.com\/2018\/01\/aradigm-receives-crl-for-linhaliq\/ (Accessed: 4 November 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib197","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT01315236 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib198","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT01315678 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib199","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT01316276 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib200","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT02344004."},{"key":"10.1016\/j.colsurfb.2025.115289_bib201","unstructured":"U.S. Food and Drug Administration. (2020, October 19). ARIKAYCE (amikacin liposome inhalation suspension) Approval letter (NDA 207356\/S-003). https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/appletter\/2020\/207356Orig1s003ltr.pdf."},{"key":"10.1016\/j.colsurfb.2025.115289_bib202","unstructured":"European Medicines Agency. (2020, November 18). Arikayce liposomal: EPAR \u2013 Medicine overview. https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/arikayce-liposomal."},{"key":"10.1016\/j.colsurfb.2025.115289_bib203","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.131345","article-title":"Pushing nanomaterials up to the kilogram scale \u2013 An accelerated approach for synthesizing antimicrobial ZnO with high shear reactors, machine learning and high-throughput analysis","volume":"426","author":"Jose","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"17","key":"10.1016\/j.colsurfb.2025.115289_bib204","doi-asserted-by":"crossref","first-page":"7232","DOI":"10.1021\/acs.jpclett.0c02115","article-title":"Causal Inference Machine Learning Leads Original Experimental Discovery in CdSe\/CdS Core\/Shell Nanoparticles","volume":"11","author":"Liu","year":"2020","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.colsurfb.2025.115289_bib205","doi-asserted-by":"crossref","DOI":"10.1016\/j.powtec.2025.120924","article-title":"Evaluation of multi-output machine learning models for predicting inhaled particle deposition in the human upper and central airway","volume":"458","author":"Li","year":"2025","journal-title":"Powder Technol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib206","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT05938946?term=NCT05938946&rank=1 (Accessed: 17 August 2025)."},{"key":"10.1016\/j.colsurfb.2025.115289_bib207","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/www.clinicaltrials.gov\/study\/NCT04993443 (Accessed: 17 August 2025)."},{"issue":"4","key":"10.1016\/j.colsurfb.2025.115289_bib208","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.jaci.2024.05.027","article-title":"A novel inhalable nanobody targeting IL-4R\u03b1 for the treatment of asthma","volume":"154","author":"Zhu","year":"2024","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.colsurfb.2025.115289_bib209","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/clinicaltrials.gov\/study\/NCT06747858."},{"key":"10.1016\/j.colsurfb.2025.115289_bib210","unstructured":"(2025) Clinicaltrials.gov. Available at: https:\/\/www.clinicaltrials.gov\/study\/NCT04480333 (Accessed: 17 August 2025)."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776525007969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:57:34Z","timestamp":1779105454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776525007969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":210,"alternative-id":["S0927776525007969"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115289","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanotechnology-driven targeted pulmonary drug delivery: Innovations, insights, and clinical horizons","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2025.115289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115289"}}