{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:26:08Z","timestamp":1773977168164,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100024591","name":"National Institute of Pharmaceutical Education and Research, Kolkata","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024591","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.colsurfb.2026.115452","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:17:16Z","timestamp":1768493836000},"page":"115452","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Design, characterization, and in vitro evaluation of Eudragit-coated aminated mesoporous silica nanoparticles loaded with pterostilbene for colon delivery"],"prefix":"10.1016","volume":"261","author":[{"given":"Nikhil","family":"Raut","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manasa","family":"N.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swornahuti","family":"Panda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Hmingthangsanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2189-2234","authenticated-orcid":false,"given":"Subramanian","family":"Natesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115452_bib1","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s11739-024-03623-6","article-title":"Ulcerative colitis and nephrotic syndrome: a two-sample Mendelian randomization study","volume":"19","author":"Zhan","year":"2024","journal-title":"Intern Emerg. Med."},{"key":"10.1016\/j.colsurfb.2026.115452_bib2","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0016-5085(98)70381-6","article-title":"Inflammatory bowel disease: etiology and pathogenesis","volume":"115","author":"Fiocchi","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.colsurfb.2026.115452_bib3","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.apsb.2022.09.006","article-title":"The role of phosphatidylcholine 34:1 in the occurrence, development and treatment of ulcerative colitis","volume":"13","author":"Yu","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.colsurfb.2026.115452_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104442","article-title":"Can molecular stratification improve the treatment of inflammatory bowel disease?","volume":"148","author":"Wang","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.colsurfb.2026.115452_bib5","doi-asserted-by":"crossref","DOI":"10.1177\/17562848221138160","article-title":"A review of the therapeutic management of ulcerative colitis","volume":"15","author":"Aslam","year":"2022","journal-title":"Ther. Adv. Gastroenterol."},{"key":"10.1016\/j.colsurfb.2026.115452_bib6","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/ajg.2011.44","article-title":"Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature","volume":"106","author":"Hou","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.colsurfb.2026.115452_bib7","doi-asserted-by":"crossref","first-page":"14810","DOI":"10.1096\/fj.202001502R","article-title":"Pterostilbene reduces colonic inflammation by suppressing dendritic cell activation and promoting regulatory T cell development","volume":"34","author":"Yashiro","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.colsurfb.2026.115452_bib8","article-title":"Prebiotic microcapsule-encapsulated pterostilbene alleviates ulcerative colitis by regulating the intestinal microenvironment and activating AHR\/IL-22 pathway","author":"Li","year":"2025","journal-title":"Engineering"},{"key":"10.1016\/j.colsurfb.2026.115452_bib9","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1158\/1940-6207.CAPR-08-0224","article-title":"Anti-inflammatory action of pterostilbene is mediated through the p38 mitogen-activated protein kinase pathway in colon cancer cells","volume":"2","author":"Paul","year":"2009","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.colsurfb.2026.115452_bib10","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3390\/antiox10101552","article-title":"Pterostilbene attenuates particulate matter-induced oxidative stress, inflammation and aging in keratinocytes","volume":"10","author":"Teng","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2026.115452_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115049","article-title":"Biosafety of mesoporous silica nanoparticles; towards clinical translation","volume":"201","author":"L\u00e9rida-Viso","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.115452_bib12","doi-asserted-by":"crossref","first-page":"e0181738","DOI":"10.1371\/journal.pone.0181738","article-title":"A modified vaccinia Ankara vaccine vector expressing a mosaic H5 hemagglutinin reduces viral shedding in rhesus macaques","volume":"12","author":"Florek","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.colsurfb.2026.115452_bib13","doi-asserted-by":"crossref","first-page":"720","DOI":"10.2741\/E652","article-title":"Effects of early endometriosis on IVF-ET outcomes","volume":"5","author":"Mekaru","year":"2013","journal-title":"Front Biosci. (Elite Ed. )"},{"key":"10.1016\/j.colsurfb.2026.115452_bib14","doi-asserted-by":"crossref","first-page":"16166","DOI":"10.1021\/acsnano.4c01245","article-title":"Multichiral mesoporous silica screws with chiral differential mucus penetration and mucosal adhesion for oral drug delivery","volume":"18","author":"Wang","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115452_bib15","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1016\/j.apsb.2021.08.014","article-title":"Chiral mesoporous silica nano-screws as an efficient biomimetic oral drug delivery platform through multiple topological mechanisms","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.colsurfb.2026.115452_bib16","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1016\/j.apsb.2024.09.015","article-title":"Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer","volume":"14","author":"Niu","year":"2024","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.colsurfb.2026.115452_bib17","doi-asserted-by":"crossref","first-page":"832","DOI":"10.3390\/ma8030832","article-title":"Eudragit S100 coated citrus pectin nanoparticles for colon targeting of 5-Fluorouracil","volume":"8","author":"Subudhi","year":"2015","journal-title":"Materials"},{"key":"10.1016\/j.colsurfb.2026.115452_bib18","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1208\/s12249-021-02099-3","article-title":"Eudragit S-100 Surface engineered nanostructured lipid carriers for colon targeting of 5-Fluorouracil: optimization and in vitro and in vivo characterization","volume":"22","author":"Borderwala","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2026.115452_bib19","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1007\/s10934-022-01259-5","article-title":"Synthesis and characterization of amine-functionalized Fe3O4\/Mesoporous Silica Nanoparticles (MSNs) as potential nanocarriers in drug delivery systems","volume":"29","author":"Tabasi","year":"2022","journal-title":"J. Porous Mater."},{"key":"10.1016\/j.colsurfb.2026.115452_bib20","unstructured":"Charge-Reversal APTES-Modified Mesoporous Silica Nanoparticles with High Drug Loading and Release ControllabilityACS Applied Materials & Interfacesn.d10.1021\/acsami.6b05370(accessed December 27, 2025).https:\/\/pubs.acs.org\/doi\/full\/."},{"key":"10.1016\/j.colsurfb.2026.115452_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/10717544.2011.595841","article-title":"Colon-targeted celecoxib-loaded Eudragit\u00ae S100-coated poly-\u03b5-caprolactone microparticles: preparation, characterization and in vivo evaluation in rats","volume":"18","author":"Ghorab","year":"2011","journal-title":"Drug Deliv."},{"key":"10.1016\/j.colsurfb.2026.115452_bib22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.msec.2015.08.031","article-title":"Control-release microcapsule of famotidine loaded biomimetic synthesized mesoporous silica nanoparticles: Controlled release effect and enhanced stomach adhesion in vitro","volume":"58","author":"Li","year":"2016","journal-title":"Materials Science Engineering C"},{"key":"10.1016\/j.colsurfb.2026.115452_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1208\/s12249-009-9188-3","article-title":"Optimization of budesonide compression-coated tablets for colonic delivery","volume":"10","author":"Yehia","year":"2009","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2026.115452_bib24","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jps.2600830425","article-title":"Improved oral absorption of enteric coprecipitates of a poorly soluble drug","volume":"83","author":"Kondo","year":"1994","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2026.115452_bib25","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2019.7736","article-title":"Anti\u2011inflammatory and anti\u2011apoptosis activity of taraxasterol in ulcerative colitis in vitro and in vivo","author":"Che","year":"2019","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.colsurfb.2026.115452_bib26","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3892\/etm.2020.8718","article-title":"Baicalin alleviates TNBS\u2011induced colitis by inhibiting PI3K\/AKT pathway activation","volume":"20","author":"Zhu","year":"2020","journal-title":"Exp. Ther. Med"},{"key":"10.1016\/j.colsurfb.2026.115452_bib27","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ymeth.2016.06.008","article-title":"Quantifying ROS levels using CM-H2DCFDA and HyPer","volume":"109","author":"Oparka","year":"2016","journal-title":"Methods"},{"key":"10.1016\/j.colsurfb.2026.115452_bib28","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1399-3054.2009.01243.x","article-title":"Monitoring reactive oxygen species formation and localisation in living cells by use of the fluorescent probe CM-H(2)DCFDA and confocal laser microscopy","volume":"136","author":"Kristiansen","year":"2009","journal-title":"Physiol. Plant"},{"key":"10.1016\/j.colsurfb.2026.115452_bib29","article-title":"One-pot synthesis of pH-responsive eudragit-mesoporous silica nanocomposites enable colonic delivery of glucocorticoids for the treatment of inflammatory bowel disease","volume":"4","author":"Qu","year":"2021","journal-title":"Adv. Ther."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526000408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526000408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T02:17:28Z","timestamp":1773973048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526000408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":29,"alternative-id":["S0927776526000408"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115452","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Design, characterization, and in vitro evaluation of Eudragit-coated aminated mesoporous silica nanoparticles loaded with pterostilbene for colon delivery","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115452","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115452"}}