{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:38:53Z","timestamp":1787067533160,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["24NSFSC0279"],"award-info":[{"award-number":["24NSFSC0279"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20513"],"award-info":[{"award-number":["U22A20513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.colsurfb.2026.115456","type":"journal-article","created":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T02:58:24Z","timestamp":1768705104000},"page":"115456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Zinc oxide quantum dots enhanced growth performance and zinc metabolism in weaned piglets"],"prefix":"10.1016","volume":"261","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenshuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6234-2231","authenticated-orcid":false,"given":"Xianxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115456_bib1","article-title":"Fecal microbiota transplantation alleviates intestinal inflammatory diarrhea caused by oxidative stress and pyroptosis via reducing gut microbiota-derived lipopolysaccharides","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.115456_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetmic.2024.110090","article-title":"Macleaya cordata extract improves growth performance, immune responses and anti-inflammatory capacity in neonatal piglets","author":"Han","year":"2024","journal-title":"Vet. Microbiol."},{"issue":"7541","key":"10.1016\/j.colsurfb.2026.115456_bib3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14228","article-title":"A gp130-Src-YAP module links inflammation to epithelial regeneration","author":"Taniguchi","year":"2015","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115456_bib4","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/j.bbrc.2017.09.165","article-title":"Nano and bulk ZnO trigger diverse Zn-transport-related gene transcription in distinct regions of the small intestine in mice after oral exposure","author":"Yang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.colsurfb.2026.115456_bib5","article-title":"An alternative ZnO with large specific surface area: preparation, physicochemical characterization and effects on growth performance, diarrhea, zinc metabolism and gut barrier function of weaning piglets","author":"Su","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.colsurfb.2026.115456_bib6","first-page":"487","article-title":"Alternatives of zinc oxide in piglet diets Literature review","volume":"8","author":"Hetenyi","year":"2023","journal-title":"Magy. Allatorvosok Lapja"},{"key":"10.1016\/j.colsurfb.2026.115456_bib7","article-title":"The antioxidant, antibacterial, and infected wound healing effects of ZnO quantum dots-chitosan biocomposite","author":"Shu","year":"2023","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.colsurfb.2026.115456_bib8","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skae018","article-title":"Zinc status and indicators of intestinal health in enterotoxigenic Escherichia coli F18 challenged newly weaned pigs fed diets with different levels of zinc","author":"Hansen","year":"2024","journal-title":"J. Anim. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115456_bib9","doi-asserted-by":"crossref","DOI":"10.1186\/s40104-020-00458-x","article-title":"Zinc phosphate-based nanoparticles as alternatives to zinc oxide in diet of weaned piglets","author":"Kociova","year":"2020","journal-title":"J. Anim. Sci. Biotechnol."},{"issue":"23","key":"10.1016\/j.colsurfb.2026.115456_bib10","first-page":"8778","article-title":"pH-triggered controlled drug release from mesoporous silica nanoparticles via intracelluar dissolution of ZnO nanolids","author":"Muharnmad","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2026.115456_bib11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.apcatb.2016.06.016","article-title":"ZnO quantum dots decorated 3DOM TiO2 nanocomposites: symbiose of quantum size effects and photonic structure for highly enhanced photocatalytic degradation of organic pollutants","author":"Zalfani","year":"2016","journal-title":"Appl. Catal. BEnviron."},{"issue":"50","key":"10.1016\/j.colsurfb.2026.115456_bib12","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6528\/ac2846","article-title":"Antibacterial activity of ZnO quantum dots and its protective effects of chicks infected with Salmonella pullorum","author":"Li","year":"2021","journal-title":"Nanotechnology"},{"issue":"12","key":"10.1016\/j.colsurfb.2026.115456_bib13","doi-asserted-by":"crossref","first-page":"3871","DOI":"10.2527\/jas.2009-2771","article-title":"Chito-oligosaccharide reduces diarrhea incidence and attenuates the immune response of weaned pigs challenged with Escherichia coli K88","author":"Liu","year":"2010","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.colsurfb.2026.115456_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.plana.2024.100069","article-title":"Terminalia bellirica (Gaertn.) Roxb. extract-mediated green synthesis of magnesium oxide nanoparticles for multifunctional applications","author":"Patil","year":"2024","journal-title":"Plant Nano Biol."},{"key":"10.1016\/j.colsurfb.2026.115456_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2019.122043","article-title":"Facile synthesis of ZnO QDs@GO-CS hydrogel for synergetic antibacterial applications and enhanced wound healing","author":"Liang","year":"2019","journal-title":"Chem. Eng. J."},{"issue":"17","key":"10.1016\/j.colsurfb.2026.115456_bib16","doi-asserted-by":"crossref","first-page":"21431","DOI":"10.1007\/s13399-023-04252-3","article-title":"Biocompatible synthesis of magnesium oxide nanoparticles with effective antioxidant, antibacterial, and anti-inflammatory activities using Magnolia champaca extract","volume":"S","author":"Ali","year":"2024","journal-title":"Biomass. Convers. Biorefinery"},{"key":"10.1016\/j.colsurfb.2026.115456_bib17","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1007\/s44174-023-00139-z","article-title":"Comparative analysis of magnesium oxide nanoparticles biosynthesized from rubber seed shell and rubber leaf extracts","volume":"2","author":"Ikhuoria","year":"2024","journal-title":"Biomed. Mater. Devices"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115456_bib18","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41590-018-0295-8","article-title":"An essential role for the Zn(2+) transporter ZIP7 in B cell development","author":"Anzilotti","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.colsurfb.2026.115456_bib19","doi-asserted-by":"crossref","first-page":"e72543","DOI":"10.1371\/journal.pone.0072543","article-title":"Clioquinol synergistically augments rescue by zinc supplementation in a mouse model of Acrodermatitis Enteropathica","volume":"8","author":"Geiser","year":"2013","journal-title":"Plos One"},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115456_bib20","doi-asserted-by":"crossref","DOI":"10.3345\/cep.2023.01340","article-title":"Effect of probiotics plus zinc supplementation on clinical outcomes of infants and children with acute infectious diarrhea: a randomized controlled trial","author":"Abdulah","year":"2024","journal-title":"Clin. Exp. Pediatr."},{"key":"10.1016\/j.colsurfb.2026.115456_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.livsci.2021.104610","article-title":"Zinc oxide nanoparticles improve gut health and reduce faecal zinc excretion in piglets","author":"Cui","year":"2021","journal-title":"Livest. Sci."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115456_bib22","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.3945\/jn.113.177881","article-title":"A high amount of dietary zinc changes the expression of zinc transporters and metallothionein in jejunal epithelial cells in vitro and in vivo but does not prevent zinc accumulation in jejunal tissue of piglets","author":"Martin","year":"2013","journal-title":"J. Nutr."},{"key":"10.1016\/j.colsurfb.2026.115456_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2020.114399","article-title":"Evaluation of coated zinc oxide in young pigs challenged with enterotoxigenic Escherichia coli K88","author":"Lei","year":"2020","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.colsurfb.2026.115456_bib24","unstructured":"Y. , S.W. Kim, Intestinal challenge with enterotoxigenic Escherichia coli in pigs,and nutritional intervention to prevent postweaning diarrhea, \u52a8\u7269\u8425\u517b\uff1a\u82f1\u6587\u7248 (004) (2017) 000."},{"issue":"18","key":"10.1016\/j.colsurfb.2026.115456_bib25","doi-asserted-by":"crossref","DOI":"10.3390\/ijms251810040","article-title":"The mechanism of zinc oxide in alleviating diarrhea in piglets after weaning: a review from the perspective of intestinal barrier function","author":"Tang","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2026.115456_bib26","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.aninu.2024.03.006","article-title":"Nutrition strategies to control post-weaning diarrhea of piglets: from the perspective of feeds","author":"Tang","year":"2024","journal-title":"Anim. Nutr."},{"key":"10.1016\/j.colsurfb.2026.115456_bib27","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.aninu.2023.12.010","article-title":"Dietary nutrition, intestinal microbiota dysbiosis and post-weaning diarrhea in piglets","author":"Han","year":"2024","journal-title":"Anim. Nutr."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115456_bib28","first-page":"219","article-title":"Review on zinc oxide nanoparticles: antibacterial activity and toxicity mechanism","author":"Sirelkhatim","year":"2015","journal-title":"NanoMicro Lett."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115456_bib29","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1021\/am4053317","article-title":"Superior antibacterial activity of zinc oxide\/graphene oxide composites originating from high zinc concentration localized around bacteria","author":"Wang","year":"2014","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115456_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182550","article-title":"Comparison of porous and nano zinc oxide for replacing high-dose dietary regular zinc oxide in weaning piglets","author":"Long","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.colsurfb.2026.115456_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.852085","article-title":"Importance of zinc nanoparticles for the intestinal microbiome of weaned piglets","author":"Baholet","year":"2022","journal-title":"Front. Vet. Sci."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115456_bib32","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/iub.291","article-title":"Dietary zinc absorption: a play of Zips and ZnTs in the gut","author":"Wang","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.colsurfb.2026.115456_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.livsci.2020.104181","article-title":"Effects of different zinc sources on growth performance, antioxidant capacity and zinc storage of weaned piglets","author":"Liu","year":"2020","journal-title":"Livest. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115456_bib34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.livprodsci.2003.09.011","article-title":"Dietary means to better control the environmental impact of copper and zinc by pigs from weaning to slaughter","author":"Jondreville","year":"2003","journal-title":"Livest. Prod. Sci."},{"key":"10.1016\/j.colsurfb.2026.115456_bib35","article-title":"Weaning induced hepatic oxidative stress, apoptosis, and aminotransferases through MAPK signaling pathways in piglets","author":"Zhen","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.colsurfb.2026.115456_bib36","article-title":"An alternative ZnO with large specific surface area: preparation, physicochemical characterization and effects on growth performance, diarrhea, zinc metabolism and gut barrier function of weaning piglets","author":"Su","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.colsurfb.2026.115456_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.anifeedsci.2019.114312","article-title":"Effects of nano zinc oxide as an alternative to pharmacological dose of zinc oxide on growth performance, diarrhea, immune responses, and intestinal microflora profile in weaned piglets","author":"Sun","year":"2019","journal-title":"Anim. Feed Sci. Technol."},{"key":"10.1016\/j.colsurfb.2026.115456_bib38","article-title":"Dietary palygorskite clay-adsorbed Nano-ZnO supplementation improves the intestinal barrier function of weanling pigs","volume":"L","author":"Yu","year":"2022","journal-title":"Front. Nutr."},{"issue":"23","key":"10.1016\/j.colsurfb.2026.115456_bib39","doi-asserted-by":"crossref","first-page":"12303","DOI":"10.1039\/D2FO02243E","article-title":"Molecular actions of different functional oligosaccharides on intestinal integrity, immune function and microbial community in weanling pigs","author":"Gao","year":"2022","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115456_bib40","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3177\/jnsv.66.311","article-title":"The effects of dietary porous zinc oxide supplementation on growth performance, inflammatory cytokines and tight junction\u2019s gene expression in early-weaned piglets","author":"Peng","year":"2020","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"10.1016\/j.colsurfb.2026.115456_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.153927","article-title":"Effect of Coptis chinensis franch and Magnolia officinalis on intestinal flora and intestinal barrier in a TNBS-induced ulcerative colitis rats model","author":"Xie","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.colsurfb.2026.115456_bib42","doi-asserted-by":"crossref","DOI":"10.1093\/jas\/skae321","article-title":"Lactation-related dynamics of bacterial and fungal microbiomes in feces of sows and gut colonization in suckling and newly weaned piglets","author":"Yosi","year":"2024","journal-title":"J. Anim. Sci."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526000445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526000445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:59:55Z","timestamp":1770883195000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526000445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":42,"alternative-id":["S0927776526000445"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115456","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Zinc oxide quantum dots enhanced growth performance and zinc metabolism in weaned piglets","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115456"}}