{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:17:04Z","timestamp":1778807824626,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.colsurfb.2026.115475","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:34:07Z","timestamp":1769560447000},"page":"115475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Copper-infused 13\u201393 bioactive glass inhibiting postoperative osteosarcoma recurrence and enhancing bone regeneration"],"prefix":"10.1016","volume":"262","author":[{"given":"Hao","family":"Gong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengfeng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suming","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjun","family":"Rui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.colsurfb.2026.115475_bib1","first-page":"405","article-title":"The diagnosis and treatment of osteosarcoma and ewing's sarcoma in children and adolescents","volume":"120","author":"Zarghooni","year":"2023","journal-title":"Dtsch Arztebl Int."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115475_bib2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2217\/fon-2016-0261","article-title":"Novel insights and therapeutic interventions for pediatric osteosarcoma","volume":"13","author":"Kager","year":"2017","journal-title":"Future Oncol."},{"issue":"11","key":"10.1016\/j.colsurfb.2026.115475_bib3","doi-asserted-by":"crossref","first-page":"e0225242","DOI":"10.1371\/journal.pone.0225242","article-title":"Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: a multivariable radiomics model","volume":"14","author":"Sheen","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115475_bib4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/03008916211053048","article-title":"Lung metastasectomy for osteosarcoma in children, adolescents, and young adults: proof of permanent cure","volume":"109","author":"Pastorino","year":"2023","journal-title":"Tumori"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115475_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2024.189171","article-title":"Unraveling molecular aberrations and pioneering therapeutic strategies in osteosarcoma","volume":"1879","author":"Yan","year":"2024","journal-title":"Biochim. Biophys. Acta Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2026.115475_bib6","first-page":"474","article-title":"Regulated macrophage immune microenvironment in 3D printed scaffolds for bone tumor postoperative treatment","volume":"19","author":"Li","year":"2022","journal-title":"Bioact. Mater."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115475_bib7","doi-asserted-by":"crossref","first-page":"e008755","DOI":"10.1136\/jitc-2023-008755","article-title":"CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma","volume":"13","author":"Cho","year":"2025","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.colsurfb.2026.115475_bib8","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.knee.2021.01.016","article-title":"Distal femoral impaction bone grafting in revision for tumor endoprosthesis","volume":"29","author":"Kito","year":"2021","journal-title":"Knee"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115475_bib9","doi-asserted-by":"crossref","first-page":"853","DOI":"10.4055\/cios22254","article-title":"Proximal femur salvage in revision knee arthroplasty due to oncologic indications: long-term results of onlay and overlapping allograft in revision surgeries","volume":"15","author":"Cho","year":"2023","journal-title":"Clin. Orthop. Surg."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115475_bib10","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1007\/s11999-009-1117-y","article-title":"Staged lengthening arthroplasty for pediatric osteosarcoma around the knee","volume":"468","author":"Kong","year":"2010","journal-title":"Clin. Orthop. Relat. Res"},{"issue":"11","key":"10.1016\/j.colsurfb.2026.115475_bib11","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.2106\/JBJS.18.00842","article-title":"Bone repair using the masquelet technique","volume":"101","author":"Masquelet","year":"2019","journal-title":"J. Bone Jt. Surg. Am."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115475_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/term.1681","article-title":"Spatial distribution and survival of human and goat mesenchymal stromal cells on hydroxyapatite and \u03b2-tricalcium phosphate","volume":"10","author":"Prins","year":"2016","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.colsurfb.2026.115475_bib13","article-title":"Bioactive glasses and glass-ceramics for hyperthermia treatment of cancer: state-of-art, challenges, and future perspectives","volume":"S","author":"Danewalia","year":"2021","journal-title":"Mater. Today Bio. 10"},{"issue":"34","key":"10.1016\/j.colsurfb.2026.115475_bib14","article-title":"Time-sequential and multi-functional 3D printed MgO2\/PLGA scaffold developed as a novel biodegradable and bioactive bone substitute for challenging postsurgical osteosarcoma treatment","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.115475_bib15","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1093\/nar\/gkr1041","article-title":"Identification of tumor-specific Salmonella Typhimurium promoters and their regulatory logic","volume":"40","author":"Leschner","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115475_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1053\/j.gastro.2017.03.008","article-title":"Increased serotonin signaling contributes to the warburg effect in pancreatic tumor cells under metabolic stress and promotes growth of pancreatic tumors in mice","volume":"153","author":"Jiang","year":"2017","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115475_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41392-020-00280-x","article-title":"The updated landscape of tumor microenvironment and drug repurposing","volume":"5","author":"Jin","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115475_bib18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.ccell.2024.03.013","article-title":"Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization","volume":"42","author":"Wang","year":"2024","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115475_bib19","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/s12943-018-0913-y","article-title":"Effects of tumor metabolic microenvironment on regulatory T cells","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.colsurfb.2026.115475_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117466","article-title":"Extracellular pH is a critical regulator of osteoclast fusion, size and activation","volume":"195","author":"Davies","year":"2025","journal-title":"Bone"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115475_bib21","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2010.03.015","article-title":"Matrix metalloproteinases: regulators of the tumor microenvironment","volume":"141","author":"Kessenbrock","year":"2010","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115475_bib22","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1021\/mp200292c","article-title":"Drug resistance and cellular adaptation to tumor acidic pH microenvironment","volume":"8","author":"Wojtkowiak","year":"2011","journal-title":"Mol. Pharm."},{"issue":"11","key":"10.1016\/j.colsurfb.2026.115475_bib23","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s10856-006-0432-z","article-title":"The story of Bioglass","volume":"17","author":"Hench","year":"2006","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"10.1016\/j.colsurfb.2026.115475_bib24","article-title":"Beyond bioactive glass composition: using morphology to improve in vitro and in vivo performance","volume":"16","author":"Su","year":"2025","journal-title":"Adv. Health Mater."},{"issue":"26","key":"10.1016\/j.colsurfb.2026.115475_bib25","article-title":"A composite hydrogel functionalized by borosilicate bioactive glasses and VEGF for critical-size bone regeneration","volume":"11","author":"Huang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.colsurfb.2026.115475_bib26","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jmbbm.2012.04.001","article-title":"Effect of material, process parameters, and simulated body fluids on mechanical properties of 13-93 bioactive glass porous constructs made by selective laser sintering","volume":"13","author":"Kolan","year":"2012","journal-title":"J. Mech. Behav. Biomed. Mater."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.115475_bib27","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1016\/j.dental.2021.06.004","article-title":"Structural and elemental characterization of glass and ceramic particles for bone surgery","volume":"37","author":"Sirki\u00e4","year":"2021","journal-title":"Dent. Mater."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115475_bib28","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.actbio.2011.07.034","article-title":"Porous and strong bioactive glass (13-93) scaffolds prepared by unidirectional freezing of camphene-based suspensions","volume":"8","author":"Liu","year":"2012","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115475_bib29","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.ccell.2025.03.031","article-title":"Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance","volume":"43","author":"Lei","year":"2025","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.115475_bib30","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1039\/D4RA06081D","article-title":"Glasses for bone regeneration: structural features controlling physical properties and ion release of bioactive glasses 45S5, S53P4 and 13-93","volume":"15","author":"Jin","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2026.115475_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmbbm.2023.105719","article-title":"The influencing mechanism of phosphorus component on network structure and bioactivity of bioactive glass","volume":"140","author":"Wang","year":"2023","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"10.1016\/j.colsurfb.2026.115475_bib32","article-title":"Photocatalytic, antiproliferative and antimicrobial properties of copper nanoparticles synthesized using Manilkara zapota leaf extract: a photodynamic approach","volume":"32","author":"Kiriyanthan","year":"2020","journal-title":"Photo Photo Ther."},{"issue":"14","key":"10.1016\/j.colsurfb.2026.115475_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202204637","article-title":"Injectable bone cement reinforced with gold nanodots decorated rGO-hydroxyapatite nanocomposites, augment bone regeneration","volume":"19","author":"Chopra","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.115475_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2023.213524","article-title":"Synergistic effect of drug\/antibiotic-impregnated micro\/nanohybrid mesoporous bioactive glass\/calcium phosphate composite bone cement on antibacterial and osteoconductive activities","volume":"152","author":"Huang","year":"2023","journal-title":"Biomater. Adv."},{"issue":"48","key":"10.1016\/j.colsurfb.2026.115475_bib35","doi-asserted-by":"crossref","first-page":"55533","DOI":"10.1021\/acsami.3c14491","article-title":"Dual-setting bone cement based on magnesium phosphate modified with glycol methacrylate designed for biomedical applications","volume":"15","author":"Wekwejt","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115475_bib36","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.21037\/atm.2017.11.17","article-title":"Does a simple syringe applicator enhance bone cement set up time in knee arthroplasty?","volume":"5","author":"Sodhi","year":"2017","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.colsurfb.2026.115475_bib37","article-title":"Enhanced physicochemical properties and mineral precipitation in experimental glass ionomer cements containing fluoride-doped calcium phosphates and zinc-polycarboxylate bioactive glass","volume":"13","author":"Tsuchiya","year":"2025","journal-title":"Dent. Mater."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115475_bib38","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.drudis.2018.05.027","article-title":"Bioactive glasses entering the mainstream","volume":"23","author":"Kargozar","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.colsurfb.2026.115475_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121506","article-title":"Injectable adhesive hemostatic gel with tumor acidity neutralizer and neutrophil extracellular traps lyase for enhancing adoptive NK cell therapy prevents post-resection recurrence of hepatocellular carcinoma","volume":"284","author":"Cheng","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115475_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.actbio.2019.04.039","article-title":"Calcium carbonate: adored and ignored in bioactivity assessment","volume":"91","author":"Mozafari","year":"2019","journal-title":"Acta Biomater."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115475_bib41","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3892\/mmr.2024.13334","article-title":"Copper ions: the invisible killer of cardiovascular disease (Review)","volume":"30","author":"Wang","year":"2024","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.colsurfb.2026.115475_bib42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.actbio.2024.12.010","article-title":"A metal-organic framework functionalized CaO2-based cascade nanoreactor induces synergistic cuproptosis\/ferroptosis and Ca2+ overload-mediated mitochondrial damage for enhanced sono-chemodynamic immunotherapy","volume":"193","author":"Tang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.115475_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107988","article-title":"Copper homeostasis and cuproptosis represent emerging targets for therapeutic intervention in inflammatory diseases","volume":"221","author":"Yang","year":"2025","journal-title":"Pharm. Res"},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115475_bib44","doi-asserted-by":"crossref","first-page":"516","DOI":"10.7150\/ijbs.84399","article-title":"p32 regulates glycometabolism and TCA cycle to inhibit ccRCC progression via copper-induced DLAT lipoylation oligomerization","volume":"20","author":"Tian","year":"2024","journal-title":"Int J. Biol. Sci."},{"key":"10.1016\/j.colsurfb.2026.115475_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111702","article-title":"Calycosin-7-O-\u03b2-D-glucoside modulates copper homeostasis through SLC31A1 to mitigate cuproptosis in cerebral ischemia\/reperfusion injury","volume":"420","author":"Lou","year":"2025","journal-title":"Chem. Biol. Inter."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115475_bib46","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.biomaterials.2012.09.066","article-title":"Copper-containing mesoporous bioactive glass scaffolds with multifunctional properties of angiogenesis capacity, osteostimulation and antibacterial activity","volume":"34","author":"Wu","year":"2013","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115475_bib47","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"13-14","key":"10.1016\/j.colsurfb.2026.115475_bib48","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/scd.2023.0295","article-title":"Lysyl oxidase production by murine C3H10T1\/2 mesenchymal stem cells is increased by TGF\u03b2s and differentially modulated by mechanical stimuli","author":"Pancheri","year":"2024","journal-title":"Stem Cells Dev."},{"issue":"18","key":"10.1016\/j.colsurfb.2026.115475_bib49","article-title":"Silk fibroin nanoparticles for enhanced cuproptosis and immunotherapy in pancreatic cancer treatment","volume":"12","author":"Gao","year":"2025","journal-title":"Adv. Sci. (Weinh. )"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526000639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526000639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:32:35Z","timestamp":1774020755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526000639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":49,"alternative-id":["S0927776526000639"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115475","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Copper-infused 13\u201393 bioactive glass inhibiting postoperative osteosarcoma recurrence and enhancing bone regeneration","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115475"}}