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Mol. Sci."},{"key":"10.1016\/j.colsurfb.2026.115558_bib215","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202405930","article-title":"High-lactate-metabolizing photosynthetic bacteria reprogram tumor immune microenvironment","volume":"36","author":"Ma","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.115558_bib216","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jconrel.2016.12.012","article-title":"CD73 specific siRNA loaded chitosan lactate nanoparticles potentiate the antitumor effect of a dendritic cell vaccine in 4T1 breast cancer bearing mice","volume":"246","author":"Jadidi-Niaragh","year":"2017","journal-title":"J. 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