{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T01:52:31Z","timestamp":1789264351139,"version":"build-2803163510"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006407","name":"Henan Province Natural Science Foundation","doi-asserted-by":"publisher","award":["242300420426"],"award-info":[{"award-number":["242300420426"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.colsurfb.2026.115585","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T20:35:27Z","timestamp":1772483727000},"page":"115585","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Inflammation-targeted nanoaggregates encapsulated triptolide and hyperoside for M2 macrophage repolarization and oxidative stress reversal in rheumatoid arthritis therapy"],"prefix":"10.1016","volume":"263","author":[{"given":"Zhonghui","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingru","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-1161","authenticated-orcid":false,"given":"Xiangxiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huahui","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115585_bib1","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.colsurfb.2026.115585_bib2","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41584-022-00790-8","article-title":"Synovial tissue macrophages in joint homeostasis, rheumatoid arthritis and disease remission","volume":"18","author":"Kurowska-Stolarska","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.colsurfb.2026.115585_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102397","article-title":"Macrophage M1\/M2 polarization and rheumatoid arthritis: a systematic review","volume":"18","author":"Tardito","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.colsurfb.2026.115585_bib4","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3390\/antiox11061153","article-title":"The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2026.115585_bib5","doi-asserted-by":"crossref","first-page":"e070856","DOI":"10.1136\/bmj-2022-070856","article-title":"Therapeutic advances in rheumatoid arthritis","author":"Brown","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.colsurfb.2026.115585_bib6","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41584-023-00966-w","article-title":"Matrix metalloproteinases in arthritis: towards precision medicine","volume":"19","author":"Grillet","year":"2023","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.colsurfb.2026.115585_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102643","article-title":"The role and mechanism of triptolide, a potential new DMARD, in the treatment of rheumatoid arthritis","volume":"104","author":"Wang","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.colsurfb.2026.115585_bib8","article-title":"Disulfide bond-based oxidation-responsive triptolide-loaded nanodrug for inflammation-targeted treatment of collagen-induced arthritis","volume":"40","author":"Zeng","year":"2024","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.colsurfb.2026.115585_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.114618","article-title":"PEGylated retinoate prodrug self-assembled nanomicelles loaded with triptolide for targeting treatment of rheumatoid arthritis and side effect attenuation","volume":"251","author":"Zhu","year":"2025","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2026.115585_bib10","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1002\/ptr.7478","article-title":"Hyperoside: a review on its sources, biological activities, and molecular mechanisms","volume":"36","author":"Wang","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.colsurfb.2026.115585_bib11","doi-asserted-by":"crossref","first-page":"8657","DOI":"10.1080\/21655979.2022.2054499","article-title":"Hyperoside exerts osteoprotective effect on dexamethasone-induced osteoblasts by targeting NADPH Oxidase 4 (NOX4) to inhibit the reactive oxygen species (ROS) accumulation and activate c-Jun N-terminal kinase (JNK) pathway","volume":"13","author":"Fan","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/j.colsurfb.2026.115585_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jconrel.2019.12.025","article-title":"Synergistic effect of all-trans-retinal and triptolide encapsulated in an inflammation-targeted nanoparticle on collagen-induced arthritis in mice","volume":"319","author":"Li","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.115585_bib13","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.3390\/antiox11081437","article-title":"Hyperoside as a potential natural product targeting oxidative stress in liver diseases","volume":"11","author":"Jang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2026.115585_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144044","article-title":"Investigating the differences in \u03b2-Cyclodextrin derivatives \/ Hyperoside inclusion complexes: dissolution properties, thermal stability, and antioxidant activity","volume":"481","author":"Liu","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.colsurfb.2026.115585_bib15","doi-asserted-by":"crossref","first-page":"18100","DOI":"10.1021\/acsnano.1c06707","article-title":"Precise Delivery of Nanomedicines to M2 Macrophages by Combining \u201cEat Me\/Don\u2019t Eat Me\u201d Signals and Its Anticancer Application","volume":"15","author":"Tang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115585_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1394108","article-title":"Macrophage polarization in rheumatoid arthritis: signaling pathways, metabolic reprogramming, and crosstalk with synovial fibroblasts","volume":"15","author":"Zheng","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.colsurfb.2026.115585_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113056","article-title":"The role of macrophage polarization in rheumatoid arthritis and osteoarthritis: Pathogenesis and therapeutic strategies","volume":"142","author":"Chang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.colsurfb.2026.115585_bib18","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3390\/antiox11061151","article-title":"Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis","volume":"11","author":"L\u00f3pez-Armada","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2026.115585_bib19","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.7150\/ijbs.97362","article-title":"Catalpol attenuates hepatic glucose metabolism disorder and oxidative stress in triptolide-induced liver injury by regulating the SIRT1\/HIF-1\u03b1 pathway","volume":"20","author":"Nie","year":"2024","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.colsurfb.2026.115585_bib20","article-title":"A dual dynamically cross-linked hydrogel promotes rheumatoid arthritis repair through ROS initiative regulation and microenvironment modulation-independent triptolide release","volume":"26","author":"Wang","year":"2024","journal-title":"Mater. Today Bio"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526001736?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526001736?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:18:12Z","timestamp":1778775492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526001736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":20,"alternative-id":["S0927776526001736"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115585","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation-targeted nanoaggregates encapsulated triptolide and hyperoside for M2 macrophage repolarization and oxidative stress reversal in rheumatoid arthritis therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115585","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115585"}}