{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:32:48Z","timestamp":1793046768326,"version":"4.5.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["S202510571069"],"award-info":[{"award-number":["S202510571069"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017534","name":"Inner Mongolia Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017534","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.colsurfb.2026.115595","type":"journal-article","created":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:58:27Z","timestamp":1772837907000},"page":"115595","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Metal-phenolic nanoparticles with ROS\/pH dual-responsiveness for liver fibrosis therapy via synergistic microenvironment remodeling and metabolic reprogramming"],"prefix":"10.1016","volume":"263","author":[{"given":"Guangyang","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenen","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musi","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peier","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maierhaba","family":"Aihaiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinting","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0633-1264","authenticated-orcid":false,"given":"Xiaohua","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayaer","family":"Nashun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115595_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113997","article-title":"Reactive oxygen species-responsive micelles targeting activated hepatic stellate cells for treating liver fibrosis","volume":"385","author":"Liu","year":"2025","journal-title":"J. Control. Release"},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115595_bib2","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.drudis.2021.12.012","article-title":"Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis","volume":"27","author":"Baghaei","year":"2022","journal-title":"Drug Discov. Today"},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115595_bib3","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1111\/liv.14940","article-title":"Hepatic macrophages: Key players in the development and progression of liver fibrosis","volume":"41","author":"Cheng","year":"2021","journal-title":"Liver Int."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115595_bib4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41575-023-00807-x","article-title":"Hepatic inflammatory responses in liver fibrosis","volume":"20","author":"Hammerich","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115595_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12081567","article-title":"Novel therapeutic approaches to liver fibrosis based on targeting oxidative stress","volume":"12","author":"Blas-Garc\u00eda","year":"2023","journal-title":"Antioxidants"},{"issue":"19","key":"10.1016\/j.colsurfb.2026.115595_bib6","article-title":"Inflammation-responsive cell membrane-camouflaged nanoparticles against liver fibrosis via regulating endoplasmic reticulum stress and oxidative stress","volume":"36","author":"Bai","year":"2024","journal-title":"Adv. Mater."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115595_bib7","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/hep.28442","article-title":"Shutting off inflammation: a novel switch on hepatic stellate cells","volume":"63","author":"Cubero","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115595_bib8","first-page":"47","article-title":"Progress in drug delivery system for fibrosis therapy","volume":"16","author":"Xing","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2026.115595_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122887","article-title":"ROS-responsive injectable hydrogels loaded with exosomes carrying miR-4500 reverse liver fibrosis","volume":"314","author":"Yang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115595_bib10","first-page":"187","article-title":"From liver fibrosis to hepatocarcinogenesis: Role of excessive liver H2O2 and targeting nanotherapeutics","volume":"23","author":"Shao","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2026.115595_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122028","article-title":"Remodeling liver microenvironment by L-arginine loaded hollow polydopamine nanoparticles for liver cirrhosis treatment","volume":"295","author":"Wang","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115595_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.05.026","article-title":"Role of extracellular vesicles in liver diseases and their therapeutic potential","volume":"175","author":"Kostallari","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.115595_bib13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.addr.2017.05.007","article-title":"Hepatic stellate cells as key target in liver fibrosis","volume":"121","author":"Higashi","year":"2017","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.115595_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120180","article-title":"Injectable and tissue adhesive EGCG-laden hyaluronic acid hydrogel depot for treating oxidative stress and inflammation","volume":"299","author":"He","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"19","key":"10.1016\/j.colsurfb.2026.115595_bib15","doi-asserted-by":"crossref","first-page":"5437","DOI":"10.1021\/acs.jafc.8b05179","article-title":"Green tea catechins effectively altered hepatic fibrogenesis in rats by inhibiting ERK and Smad1\/2 phosphorylation","volume":"67","author":"Wang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.colsurfb.2026.115595_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.113870","article-title":"Multifaceted role of phyto-derived polyphenols in nanodrug delivery systems","volume":"176","author":"Chen","year":"2021","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.115595_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.actbio.2023.07.035","article-title":"Selective inhibition of glycolysis in hepatic stellate cells and suppression of liver fibrogenesis with vitamin A-derivative decorated camptothecin micelles","volume":"168","author":"Xiang","year":"2023","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.115595_bib18","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.jconrel.2023.05.002","article-title":"Delivery of hydroxycamptothecin via sonoporation: An effective therapy for liver fibrosis","volume":"358","author":"Chen","year":"2023","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115595_bib19","doi-asserted-by":"crossref","DOI":"10.1021\/acsami.2c16616","article-title":"Folate decoration supports the targeting of camptothecin micelles against activated hepatic stellate cells and the suppression of fibrogenesis","volume":"15","author":"Xiang","year":"2023","journal-title":"ACS Appl. Mater. & Interfaces"},{"key":"10.1016\/j.colsurfb.2026.115595_bib20","doi-asserted-by":"crossref","first-page":"8033","DOI":"10.2147\/IJN.S217898","article-title":"Conjugation of EGCG and chitosan NPs as A novel nano-drug delivery system","volume":"14","author":"Safer","year":"2019","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2026.115595_bib21","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.jconrel.2024.10.012","article-title":"Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis","volume":"376","author":"Yuan","year":"2024","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115595_bib22","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1039\/D3TB02790B","article-title":"Liver fibrosis: pathological features, clinical treatment and application of therapeutic nanoagents","volume":"12","author":"Chen","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.colsurfb.2026.115595_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135661","article-title":"Engineering polyphenol-based polymeric nanoparticles for drug delivery and bioimaging","volume":"439","author":"Wang","year":"2022","journal-title":"Chem. Eng. J."},{"issue":"35","key":"10.1016\/j.colsurfb.2026.115595_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202501438","article-title":"Polyphenol-regulated bimetallic artificial metalloproteinases with broad-spectrum RONS scavenging activities for diabetic wound repair","volume":"35","author":"Ou","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"22","key":"10.1016\/j.colsurfb.2026.115595_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202007356","article-title":"Polyphenol-containing nanoparticles: synthesis, properties, and therapeutic delivery","volume":"33","author":"Guo","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.115595_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113862","article-title":"M2 macrophage-targeted metal-polyphenol networks (MPNs) for OPN siRNA delivery and idiopathic pulmonary fibrosis therapy","volume":"383","author":"Zheng","year":"2025","journal-title":"J. Control. Release"},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115595_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202414740","article-title":"Injured myocardium-targeted theranostic nanoplatform for multi-dimensional immune-inflammation regulation in acute myocardial infarction","volume":"12","author":"Zheng","year":"2025","journal-title":"Adv. Sci."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115595_bib28","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.ymthe.2004.08.011","article-title":"Metallothionein gene therapy for chemical-induced liver fibrosis in mice","volume":"10","author":"Jiang","year":"2004","journal-title":"Mol. Ther."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.115595_bib29","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1016\/j.apsb.2025.07.008","article-title":"Intercellular communication interference through energy metabolism-related exosome secretion inhibition for liver fibrosis treatment","volume":"15","author":"Zhang","year":"2025","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115595_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2025.111237","article-title":"A c(RGDyK)-modified ROS-responsive polymeric micelle for hepatic stellate cell targeting","volume":"37","author":"Liu","year":"2026","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.colsurfb.2026.115595_bib31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.jcis.2025.01.081","article-title":"Metal-based mesoporous polydopamine with dual enzyme-like activity as biomimetic nanodrug for alleviating liver fibrosis","volume":"684","author":"Liu","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.115595_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117663","article-title":"Injectable DMEM-induced phenylboronic acid-modified hyaluronic acid self-crosslinking hydrogel for potential applications in tissue repair","volume":"258","author":"Gao","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2026.115595_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113798","article-title":"Metal-phenolic epigallocatechin gallate-zinc antioxidant nanoparticles for cataract treatment","volume":"383","author":"Wang","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.115595_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbae122","article-title":"Curcumin-incorporated EGCG-based nano-antioxidants alleviate colon and kidney inflammation via antioxidant and anti-inflammatory therapy","volume":"11","author":"Pan","year":"2024","journal-title":"Regen. Biomater."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115595_bib35","doi-asserted-by":"crossref","first-page":"4704","DOI":"10.1021\/acsnano.3c06107","article-title":"Antioxidative hyaluronic acid-bilirubin nanomedicine targeting activated hepatic stellate cells for anti-hepatic-fibrosis therapy","volume":"18","author":"Shinn","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115595_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153294","article-title":"Physalin D attenuates hepatic stellate cell activation and liver fibrosis by blocking TGF-\u03b2\/Smad and YAP signaling","volume":"78","author":"Xiang","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.colsurfb.2026.115595_bib37","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.actbio.2023.12.027","article-title":"Collagenase type I and probucol-loaded nanoparticles penetrate the extracellular matrix to target hepatic stellate cells for hepatic fibrosis therapy","volume":"175","author":"Wang","year":"2024","journal-title":"Acta Biomater."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526001839?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526001839?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T11:14:49Z","timestamp":1775819689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526001839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":37,"alternative-id":["S0927776526001839"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115595","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal-phenolic nanoparticles with ROS\/pH dual-responsiveness for liver fibrosis therapy via synergistic microenvironment remodeling and metabolic reprogramming","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115595","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115595"}}