{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T11:58:54Z","timestamp":1793793534435,"version":"4.6.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515010499"],"award-info":[{"award-number":["2024A1515010499"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["SEZYY2025QB03"],"award-info":[{"award-number":["SEZYY2025QB03"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.colsurfb.2026.115638","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T17:17:42Z","timestamp":1774372662000},"page":"115638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["ROS-triggered smart nanoplatform promotes osteoarthritis repair by modulating macrophage polarization and mitochondrial homeostasis"],"prefix":"10.1016","volume":"264","author":[{"given":"Weijian","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiasheng","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yizhe","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Weiyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanxi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-8429","authenticated-orcid":false,"given":"Wengang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115638_bib1","article-title":"PdZn\/CoSA-NC nanozymes with highly efficient SOD\/CAT activities for treatment of osteoarthritis via regulating immune microenvironment","volume":"34","author":"Yang","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2026.115638_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156948","article-title":"Phenotypic screening identified polydatin alleviating cartilage degeneration by modulating SIRT3-dependent mitochondrial dysfunction","volume":"144","author":"Mao","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.colsurfb.2026.115638_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.114326","article-title":"Engineered self-assembly of plant proteins into \u03b1-ketoglutarate-loaded nanoplatforms for osteoarthritis treatment","volume":"388","author":"Xue","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.115638_bib4","article-title":"Application and progress of smart hydrogels in regulating oxidative stress and improving the immune microenvironment in osteoarthritis","volume":"522","author":"Wang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115638_bib5","first-page":"38","article-title":"Immunoregulatory orchestrations in osteoarthritis and mesenchymal stromal cells for therapy","volume":"55","author":"Jiang","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"10.1016\/j.colsurfb.2026.115638_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102382","article-title":"Trends and cross-country inequalities in the global burden of osteoarthritis, 1990\u20132019: a population-based study","volume":"99","author":"Cao","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.colsurfb.2026.115638_bib7","article-title":"Cartilage-penetrating framework nucleic acid nanoparticles ameliorate osteoarthritis by promoting drug delivery and chondrocyte uptake","volume":"12","author":"Huang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.115638_bib8","doi-asserted-by":"crossref","first-page":"40440","DOI":"10.1021\/acsnano.5c12637","article-title":"A diselenide-linkage self-assembled nanoprodrug for enhanced osteoarthritis treatment","volume":"19","author":"Li","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115638_bib9","article-title":"Biomimetic Nanoplatform Integrating CeO\u2082 Nanozymes and Anti-Inflammatory Peptides for Osteoarthritis Therapy","volume":"21","author":"Yang","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.115638_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123239","article-title":"Hydrogen generators-protected mesenchymal stem cells reverse articular redox imbalance-induced immune dysfunction for osteoarthritis treatment","volume":"320","author":"Xu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115638_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113975","article-title":"Mitochondria-targeted NAD+\/O2 co-delivery interpenetrating network hydrogel for respiratory chain restoration and osteoarthritis therapy","volume":"385","author":"Shen","year":"2025","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.115638_bib12","article-title":"Lithospermic acid etched ZIF-8 nanoparticles delays osteoarthritis progression by inhibiting inflammatory signaling pathways and rescuing mitochondrial damage","volume":"31","author":"Zhang","year":"2025","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.colsurfb.2026.115638_bib13","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1186\/s12951-025-03716-0","article-title":"Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal","volume":"23","author":"Wang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.115638_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.167229","article-title":"Ultrasound-triggered piezocatalytic MOF(Hf)-Pt nanozymes for efficient ROS scavenging in the treatment of osteoarthritis","volume":"522","author":"Yao","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115638_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202419261","article-title":"A DNA nanomachine reverses mitochondrial dysfunction by cascaded drug release to treat osteoarthritis","volume":"35","author":"Xue","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2026.115638_bib16","doi-asserted-by":"crossref","first-page":"31828","DOI":"10.1021\/acsami.5c01679","article-title":"Cerium-organic framework and resveratrol composite hydrogel scaffold with dual antioxidant activity for enhanced bone regeneration","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.115638_bib17","doi-asserted-by":"crossref","first-page":"6144","DOI":"10.1021\/acsami.4c21260","article-title":"Facile Formulation of a Resveratrol-Mediated Multibond Network Hydrogel with Efficient Sustainable Antibacterial, Reactive Oxygen Species Scavenging, Pro-Angiogenesis, and Immunomodulation Activities for Accelerating Infected Wound Healing","volume":"17","author":"Feng","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.115638_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.146803","article-title":"Injectable resveratrol micelles loaded chitosan hydrogel for protecting myocardial cell from injure in oxidative stress microenvironment","volume":"322","author":"Gao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.115638_bib19","first-page":"2022","article-title":"Protective effect of resveratrol on knee osteoarthritis and its molecular mechanisms: a recent review in preclinical and clinical trials","volume":"Volume 13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.colsurfb.2026.115638_bib20","doi-asserted-by":"crossref","first-page":"e1004440","DOI":"10.1371\/journal.pmed.1004440","article-title":"Oral resveratrol in adults with knee osteoarthritis: A randomized placebo-controlled trial (ARTHROL)","volume":"21","author":"Nguyen","year":"2024","journal-title":"PLOS Med."},{"key":"10.1016\/j.colsurfb.2026.115638_bib21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1136\/annrheumdis-2016-eular.5934","article-title":"AB0108 resveratrol inhibits canonical wnt signaling and ameliorates experimental arthritis","volume":"75","author":"Koca","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.colsurfb.2026.115638_bib22","article-title":"Intra-articular administration of PLGA resveratrol sustained-release nanoparticles attenuates the development of rat osteoarthritis","volume":"24","author":"Wei","year":"2024","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.colsurfb.2026.115638_bib23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s42114-022-00576-2","article-title":"Resveratrol-silica aerogel nanodrug complex system enhances the treatment of sports osteoarthritis by activating SIRT-1","volume":"6","author":"Qin","year":"2022","journal-title":"Adv. Compos. Hybrid. Mater."},{"key":"10.1016\/j.colsurfb.2026.115638_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.164716","article-title":"Ginger exosome-covered mesoporous polydopamine nanoplatform ameliorates liver fibrosis via antioxidation and macrophage phenotypic transformation","volume":"518","author":"Zhou","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115638_bib25","article-title":"A mesoporous polydopamine-derived nanomedicine for targeted and synergistic treatment of inflammatory bowel disease by pH-Responsive drug release and ROS scavenging","volume":"19","author":"Guan","year":"2023","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.colsurfb.2026.115638_bib26","doi-asserted-by":"crossref","first-page":"29550","DOI":"10.1021\/acsami.3c03680","article-title":"Mussel-inspired polydopamine composite mesoporous bioactive glass nanoparticles: an exploration of potential metal-ion loading platform and in vitro bioactivity","volume":"15","author":"Sui","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.115638_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2023.112007","article-title":"Multifunctional mesoporous polydopamine near-infrared photothermal controlled release of kartogenin for cartilage repair","volume":"231","author":"Luo","year":"2023","journal-title":"Mater. & Des."},{"key":"10.1016\/j.colsurfb.2026.115638_bib28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.ijbiomac.2018.04.034","article-title":"Chitosan-based hydrogels: Preparation, properties and applications","volume":"115","author":"Shariatinia","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.115638_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.fochx.2023.101095","article-title":"Chitosan-based hydrogels: From preparation to applications, a review","volume":"21","author":"Hong","year":"2024","journal-title":"Food Chem. X"},{"key":"10.1016\/j.colsurfb.2026.115638_bib30","article-title":"A factor-free hydrogel with ROS scavenging and responsive degradation for enhanced diabetic bone healing","volume":"20","author":"Zhang","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.115638_bib31","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202470300","article-title":"Enhancing Endogenous Hyaluronic Acid in Osteoarthritic Joints with an Anti-Inflammatory Supramolecular Nanofiber Hydrogel Delivering HAS2 Lentivirus","volume":"20","author":"Zhou","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.115638_bib32","doi-asserted-by":"crossref","first-page":"31898","DOI":"10.1021\/acsami.5c04355","article-title":"Development of Injectable Aldehyde Hyaluronic Acid Hydrogels Loaded with CRISPRa Reprogrammed Elite Macrophages for the Treatment of Osteoarthritis","volume":"17","author":"Fu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.115638_bib33","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.actbio.2024.03.015","article-title":"An injectable cartilage-coating composite with long-term protection, effective lubrication and chondrocyte nourishment for osteoarthritis treatment","volume":"179","author":"Cao","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.115638_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.167490","article-title":"Cascade-targeting hydrogel microspheres with biomimetic nanoparticles enable multifaceted anti-inflammatory and antioxidant defense for osteoarthritis management","volume":"522","author":"Ma","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115638_bib35","article-title":"Using Cu-based metal\u2013organic framework as a comprehensive and powerful antioxidant nanozyme for efficient osteoarthritis treatment","volume":"11","author":"Yu","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.115638_bib36","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s42114-025-01219-y","article-title":"Intra-articular injection of MOF-based nanomaterials for the treatment of osteoarthritis by modulating the bone microenvironment","volume":"8","author":"Tan","year":"2025","journal-title":"Adv. Compos. Hybrid. Mater."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526002262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526002262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T11:55:48Z","timestamp":1779105348000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526002262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":36,"alternative-id":["S0927776526002262"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115638","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ROS-triggered smart nanoplatform promotes osteoarthritis repair by modulating macrophage polarization and mitochondrial homeostasis","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115638","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115638"}}