{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:37:29Z","timestamp":1787063849791,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012165","name":"Key Technologies Research and Development Program","doi-asserted-by":"publisher","award":["2023YFC2605002"],"award-info":[{"award-number":["2023YFC2605002"]}],"id":[{"id":"10.13039\/501100012165","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.colsurfb.2026.115720","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:45:37Z","timestamp":1776408337000},"page":"115720","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Reduction\/pH dual responsive micelle delivery system for cancer chemo\/photothermal \/photodynamic therapy"],"prefix":"10.1016","volume":"265","author":[{"given":"Hong-Ming","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Shuai","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-2752","authenticated-orcid":false,"given":"Tao","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.colsurfb.2026.115720_bib1","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/s41571-023-00776-9","article-title":"Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship","volume":"20","author":"Lustberg","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib2","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"Ca. Cancer J. Clin."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib3","article-title":"Advancements and limitations in traditional anti-cancer therapies: a comprehensive review of surgery, chemotherapy, radiation therapy, and hormonal therapy","volume":"16","author":"Zafar","year":"2025","journal-title":"Discov. Oncol."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib4","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/s41467-023-36296-4","article-title":"Single-cell RNA sequencing reveals the effects of chemotherapy on human pancreatic adenocarcinoma and its tumor microenvironment","volume":"14","author":"Werba","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib5","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1080\/10717544.2022.2094498","article-title":"Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review","volume":"29","author":"Li","year":"2022","journal-title":"Drug Deliv."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib6","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41392-023-01642-x","article-title":"Smart nanoparticles for cancer therapy","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.115720_bib7","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric nanoparticles for drug delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.115720_bib8","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.jconrel.2023.11.057","article-title":"Extracellular vesicles and their engineering strategies, delivery systems, and biomedical applications","volume":"365","author":"Yang","year":"2024","journal-title":"J. Control Release"},{"issue":"11","key":"10.1016\/j.colsurfb.2026.115720_bib9","doi-asserted-by":"crossref","first-page":"5440","DOI":"10.7150\/thno.112475","article-title":"Nano drug delivery systems for advanced immune checkpoint blockade therapy","volume":"15","author":"Guo","year":"2025","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib10","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-025-03252-x","article-title":"Metal-organic framework-based smart stimuli-responsive drug delivery systems for cancer therapy: advances, challenges, and future perspectives","volume":"23","author":"Guo","year":"2025","journal-title":"J. Nanobiotechnology"},{"issue":"31","key":"10.1016\/j.colsurfb.2026.115720_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202209799","article-title":"Biodegradable NIR-II pseudo conjugate polymeric nanoparticles amplify photodynamic immunotherapy via alleviation of tumor hypoxia and tumor-associated macrophage reprogramming","volume":"35","author":"Wan","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901223","article-title":"Size-dependent epr effect of polymeric nanoparticles on tumor targeting","volume":"9","author":"Kang","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.115720_bib13","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jconrel.2021.02.016","article-title":"Polymeric micelles in cancer therapy: State of the art","volume":"332","author":"Ghosh","year":"2021","journal-title":"J. Control Release"},{"issue":"11","key":"10.1016\/j.colsurfb.2026.115720_bib14","doi-asserted-by":"crossref","first-page":"10636","DOI":"10.1021\/acsnano.8b06104","article-title":"Stimuli-responsive nano-architecture drug-delivery systems to solid tumor micromilieu: past, present, and future perspectives","volume":"12","author":"El-Sawy","year":"2018","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115720_bib15","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.addr.2019.04.008","article-title":"Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine","volume":"143","author":"Donahue","year":"2019","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115720_bib16","doi-asserted-by":"crossref","first-page":"640","DOI":"10.3390\/cancers11050640","article-title":"Active targeting strategies using biological ligands for nanoparticle drug delivery systems","volume":"11","author":"Yoo","year":"2019","journal-title":"Cancers"},{"issue":"32","key":"10.1016\/j.colsurfb.2026.115720_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201701170","article-title":"Sequentially responsive shell-stacked nanoparticles for deep penetration into solid tumors","volume":"29","author":"Chen","year":"2017","journal-title":"Adv. Mater."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.115720_bib18","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1021\/acsnano.6b02326","article-title":"Smart superstructures with ultrahigh ph-sensitivity for targeting acidic tumor microenvironment: instantaneous size switching and improved tumor penetration","volume":"10","author":"Li","year":"2016","journal-title":"ACS Nano"},{"issue":"38","key":"10.1016\/j.colsurfb.2026.115720_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201803001","article-title":"Binary cooperative prodrug nanoparticles improve immunotherapy by synergistically modulating immune tumor microenvironment","volume":"30","author":"Feng","year":"2018","journal-title":"Adv. Mater."},{"issue":"17","key":"10.1016\/j.colsurfb.2026.115720_bib20","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1021\/ja071090b","article-title":"A protein nanocarrier from charge-conversion polymer in response to endosomal pH","volume":"129","author":"Lee","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2026.115720_bib21","doi-asserted-by":"crossref","first-page":"0148","DOI":"10.34133\/research.0148","article-title":"Advanced strategies for overcoming endosomal\/lysosomal barrier in nanodrug delivery","volume":"6","author":"Qiu","year":"2023","journal-title":"Res."},{"issue":"13","key":"10.1016\/j.colsurfb.2026.115720_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202306476","article-title":"Photo-triggered cascade therapy: a nir-ii aie luminogen collaborating with nitric oxide facilitates efficient collagen depletion for boosting pancreatic cancer phototheranostics","volume":"36","author":"Li","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.115720_bib23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.biomaterials.2016.01.061","article-title":"Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: a review","volume":"85","author":"Kanamala","year":"2016","journal-title":"Biomaterials"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115720_bib24","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1021\/acs.nanolett.8b00737","article-title":"Disulfide bond-driven oxidation- and reduction-responsive prodrug nanoassemblies for cancer therapy","volume":"18","author":"Sun","year":"2018","journal-title":"Nano Lett."},{"issue":"23","key":"10.1016\/j.colsurfb.2026.115720_bib25","doi-asserted-by":"crossref","first-page":"23223","DOI":"10.1021\/acsnano.3c06019","article-title":"Stimuli-responsive polymer-based nanosystems for cancer theranostics","volume":"17","author":"Wei","year":"2023","journal-title":"ACS Nano"},{"issue":"22","key":"10.1016\/j.colsurfb.2026.115720_bib26","doi-asserted-by":"crossref","first-page":"13566","DOI":"10.1021\/acs.chemrev.7b00258","article-title":"Nanotechnology for multimodal synergistic cancer therapy","volume":"117","author":"Fan","year":"2017","journal-title":"Chem. Rev."},{"issue":"27","key":"10.1016\/j.colsurfb.2026.115720_bib27","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1039\/D2TB00409G","article-title":"Tumor-triggered targeting ammonium bicarbonate liposomes for tumor multimodal therapy","volume":"10","author":"Chen","year":"2022","journal-title":"J. Mater. Chem. B"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115720_bib28","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1007\/s11426-024-2411-7","article-title":"Phototherapy: progress, challenges, and opportunities","volume":"68","author":"Yuan","year":"2025","journal-title":"Sci. China Chem."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115720_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/s41392-025-02140-y","article-title":"Phototherapy in cancer treatment: strategies and challenges","volume":"10","author":"Cai","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.colsurfb.2026.115720_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114076","article-title":"Pt(IV) complexes loaded hollow copper sulfide nanoparticles for tumor chemo\/photothermal\/photodynamic therapy","volume":"242","author":"Chen","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2026.115720_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214789","article-title":"Platinum(IV) complex-loaded nanoparticles with photosensitive activity for cancer therapy","volume":"472","author":"Chen","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.115720_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2024.114076","article-title":"Pt(IV) complexes loaded hollow copper sulfide nanoparticles for tumor chemo\/photothermal\/photodynamic therapy","volume":"242","author":"Chen","year":"2024","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2026.115720_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.145131","article-title":"Preparation and antitumor of hyaluronic acid-human serum albumin-indocyanine green-paclitaxel nanoparticles","volume":"318","author":"Li","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.115720_bib34","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jconrel.2021.01.033","article-title":"Hyaluronic acid and albumin based nanoparticles for drug delivery","volume":"331","author":"Lei","year":"2021","journal-title":"J. Control Release"},{"issue":"14","key":"10.1016\/j.colsurfb.2026.115720_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201606628","article-title":"Rational design of cancer nanomedicine: nanoproperty integration and synchronization","volume":"29","author":"Sun","year":"2017","journal-title":"Adv. Mater."},{"issue":"40","key":"10.1016\/j.colsurfb.2026.115720_bib36","doi-asserted-by":"crossref","first-page":"5476","DOI":"10.1002\/adma.201202296","article-title":"Surface charge switchable nanoparticles based on zwitterionic polymer for enhanced drug delivery to tumor","volume":"24","author":"Yuan","year":"2012","journal-title":"Adv. Mater."},{"issue":"31","key":"10.1016\/j.colsurfb.2026.115720_bib37","doi-asserted-by":"crossref","first-page":"6358","DOI":"10.1016\/j.biomaterials.2009.07.051","article-title":"Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin","volume":"30","author":"Sun","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115720_bib38","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jconrel.2015.03.018","article-title":"Selective redox-responsive drug release in tumor cells mediated by chitosan based glycolipid-like nanocarrier","volume":"206","author":"Hu","year":"2015","journal-title":"J. Control Release"},{"issue":"32","key":"10.1016\/j.colsurfb.2026.115720_bib39","doi-asserted-by":"crossref","first-page":"9350","DOI":"10.1002\/ange.201503863","article-title":"Hydrophobic cysteine poly(disulfide)-based redox-hypersensitive nanoparticle platform for cancer theranostics","volume":"127","author":"Wu","year":"2015","journal-title":"Angew. Chem."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115720_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201801486","article-title":"Water-responsive hybrid nanoparticles codelivering icg and dox effectively treat breast cancer via hyperthermia-aided dox functionality and drug penetration","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115720_bib41","doi-asserted-by":"crossref","first-page":"3217","DOI":"10.1021\/acsbiomaterials.0c00286","article-title":"Smart assembled human serum albumin nanocarrier enhanced breast cancer treatment and antitumor immunity by chemo-photothermal therapy","volume":"6","author":"Ma","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"10.1016\/j.colsurfb.2026.115720_bib42","doi-asserted-by":"crossref","first-page":"14770","DOI":"10.1021\/acsami.9b19373","article-title":"Novel chitosan derivatives with reversible cationization and hydrophobicization for tumor cytoplasm-specific burst co-delivery of siRNA and chemotherapeutics","volume":"12","author":"Yin","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526003085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526003085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T02:19:04Z","timestamp":1780798744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526003085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":42,"alternative-id":["S0927776526003085"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115720","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduction\/pH dual responsive micelle delivery system for cancer chemo\/photothermal \/photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115720","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115720"}}