{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:50:23Z","timestamp":1793757023046,"version":"4.6.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["20230204101YY"],"award-info":[{"award-number":["20230204101YY"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.colsurfb.2026.115765","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:43:05Z","timestamp":1777567385000},"page":"115765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Enhancing antitumor immunotherapy in head and neck cancer via ferroptosis-immune cascade activation by Fe-Shikonin nanomedicine"],"prefix":"10.1016","volume":"265","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1280-0738","authenticated-orcid":false,"given":"Shengrui","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2549-8217","authenticated-orcid":false,"given":"Wanzhong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115765_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.colsurfb.2026.115765_bib2","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ccell.2015.03.001","article-title":"Immune checkpoint blockade: a common denominator approach to cancer therapy","volume":"27","author":"Topalian","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.colsurfb.2026.115765_bib3","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.colsurfb.2026.115765_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41568-021-00347-z","article-title":"Systemic immunity in cancer","volume":"21","author":"Hiam-Galvez","year":"2021","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2026.115765_bib5","article-title":"Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy","volume":"6","author":"Tang","year":"2021","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.colsurfb.2026.115765_bib6","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib7","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001369","article-title":"Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity","volume":"8","author":"Efimova","year":"2020","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.colsurfb.2026.115765_bib8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1126\/science.1237265","article-title":"One-step assembly of coordination complexes for versatile film and particle engineering","volume":"341","author":"Ejima","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2026.115765_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121651","article-title":"Autophagy inhibition recovers deficient ICD-based cancer immunotherapy","volume":"287","author":"Li","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115765_bib10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.freeradbiomed.2014.02.016","article-title":"Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells","volume":"70","author":"Duan","year":"2014","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.colsurfb.2026.115765_bib11","doi-asserted-by":"crossref","first-page":"13889","DOI":"10.1021\/acsnano.4c17090","article-title":"Nanosized shikonin disrupts tumor-cell mismatch repair and synergizes with manganese to sensitize squamous carcinoma to immunotherapy","volume":"19","author":"Yu","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115765_bib12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.jconrel.2021.05.040","article-title":"Low dose shikonin and anthracyclines coloaded liposomes induce robust immunogenetic cell death for synergistic chemo-immunotherapy","volume":"335","author":"Li","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.115765_bib13","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2026.115765_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tcb.2015.10.014","article-title":"Ferroptosis: death by lipid peroxidation","volume":"26","author":"Yang","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib15","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.colsurfb.2026.115765_bib17","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.7150\/thno.81650","article-title":"Fe(III)-Shikonin supramolecular nanomedicines as immunogenic cell death stimulants and multifunctional immunoadjuvants for tumor vaccination","volume":"13","author":"Feng","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2026.115765_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2025.123939","article-title":"Sodium hyaluronate-modified Fe(III)-shikonin self-assembly nanoparticle for effective tumor therapy and reduced tumor metastasis","volume":"367","author":"Gao","year":"2025","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2026.115765_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/s41568-022-00531-9","article-title":"Improving head and neck cancer therapies by immunomodulation of the tumour microenvironment","volume":"23","author":"Ruffin","year":"2023","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2026.115765_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202204514","article-title":"Ferroptosis signature shapes the immune profiles to enhance the response to immune checkpoint inhibitors in head and neck cancer","volume":"10","author":"Chung","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.115765_bib21","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.1208347","article-title":"Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice","volume":"334","author":"Michaud","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2026.115765_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-31218-2","article-title":"Cancer cells dying from ferroptosis impede dendritic cell cross-presentation to reduce anti-tumor immunity","volume":"13","author":"Wiernicki","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.115765_bib23","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/nri.2016.107","article-title":"Immunogenic cell death in cancer and infectious disease","volume":"17","author":"Galluzzi","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-61239-6","article-title":"Biotechnological approaches and therapeutic potential of mitochondria transfer and transplantation","volume":"16","author":"Kubat","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.115765_bib25","doi-asserted-by":"crossref","first-page":"20825","DOI":"10.1021\/acsnano.3c05853","article-title":"Size-dependent in vivo transport of nanoparticles: implications for delivery, targeting, and clearance","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115765_bib26","doi-asserted-by":"crossref","first-page":"15344","DOI":"10.1073\/pnas.1411499111","article-title":"Investigating the optimal size of anticancer nanomedicine","volume":"111","author":"Tang","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.colsurfb.2026.115765_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.colsurfb.2026.115765_bib28","article-title":"Precise design strategies of nanomedicine for improving cancer therapeutic efficacy using subcellular targeting","volume":"5","author":"Fu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.colsurfb.2026.115765_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119280","article-title":"Multifunctional low-temperature photothermal nanodrug with in vivo clearance, ROS-Scavenging and anti-inflammatory abilities","volume":"216","author":"Yang","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115765_bib30","article-title":"Atomically dispersed janus nickel sites on red phosphorus for photocatalytic overall water splitting","volume":"61","author":"Wang","year":"2022","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.colsurfb.2026.115765_bib31","article-title":"Tumor microenvironment-responsive fenton nanocatalysts for intensified anticancer treatment","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib32","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02992-6","article-title":"FeS2@COF based nanocarrier for photothermal-enhanced chemodynamic\/thermodynamic tumor therapy and immunotherapy via reprograming tumor-associated macrophages","volume":"22","author":"Deng","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib33","article-title":"GOx-assisted synthesis of pillar[5]arene based supramolecular polymeric nanoparticles for targeted\/synergistic chemo-chemodynamic cancer therapy","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib34","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.jcis.2024.01.034","article-title":"Dual-Responsive hollow mesoporous organosilicon nanocarriers for photodynamic therapy","volume":"659","author":"Hao","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.115765_bib35","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.7150\/thno.75323","article-title":"Metal-fluorouracil networks with disruption of mitochondrion enhanced ferroptosis for synergistic immune activation","volume":"12","author":"Lei","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2026.115765_bib36","doi-asserted-by":"crossref","first-page":"6752","DOI":"10.1039\/D4SC01214C","article-title":"An iridium(iii)-based photosensitizer disrupting the mitochondrial respiratory chain induces ferritinophagy-mediated immunogenic cell death","volume":"15","author":"Feng","year":"2024","journal-title":"Chem. Sci."},{"key":"10.1016\/j.colsurfb.2026.115765_bib37","article-title":"Ultrasound-activated precise sono-immunotherapy for breast cancer with reduced pulmonary fibrosis","volume":"12","author":"Li","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.115765_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj8833","article-title":"A nonferrous ferroptosis-like strategy for antioxidant inhibition-synergized nanocatalytic tumor therapeutics","volume":"7","author":"Wu","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.colsurfb.2026.115765_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-021-01102-0","article-title":"Self-amplification of oxidative stress with tumour microenvironment-activatable iron-doped nanoplatform for targeting hepatocellular carcinoma synergistic cascade therapy and diagnosis","volume":"19","author":"Zhou","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.115765_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904197","article-title":"Recent progress in ferroptosis inducers for cancer therapy","volume":"31","author":"Liang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.115765_bib41","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41586-019-1426-6","article-title":"Intercellular interaction dictates cancer cell ferroptosis via NF2-YAP signalling","volume":"572","author":"Wu","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.colsurfb.2026.115765_bib42","first-page":"418","article-title":"Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy","volume":"16","author":"Wang","year":"2022","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2026.115765_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202404886","article-title":"Metal-coordinated NIR-II nanoadjuvants with nanobody conjugation for potentiating immunotherapy by tumor metabolism reprogramming","volume":"11","author":"Dai","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.115765_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18745-6","article-title":"Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death","volume":"11","author":"Deng","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.115765_bib45","first-page":"56","article-title":"Synergistic ferroptosis-immunotherapy nanoplatforms: multidimensional engineering for tumor microenvironment remodeling and therapeutic optimization","volume":"18","author":"Wei","year":"2025","journal-title":"Nanomicro Lett."},{"key":"10.1016\/j.colsurfb.2026.115765_bib46","doi-asserted-by":"crossref","first-page":"5386","DOI":"10.7150\/thno.87854","article-title":"Stimuli-activatable nanomedicine meets cancer theranostics","volume":"13","author":"Li","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.colsurfb.2026.115765_bib47","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.ccell.2025.02.026","article-title":"Distinct CD8(+) T cell dynamics associate with response to neoadjuvant cancer immunotherapies","volume":"43","author":"Li","year":"2025","journal-title":"Cancer Cell"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652600353X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652600353X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T07:34:47Z","timestamp":1783064087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777652600353X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":47,"alternative-id":["S092777652600353X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115765","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhancing antitumor immunotherapy in head and neck cancer via ferroptosis-immune cascade activation by Fe-Shikonin nanomedicine","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115765","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115765"}}