{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:51:36Z","timestamp":1786467096011,"version":"build-2736575974"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515012639"],"award-info":[{"award-number":["2024A1515012639"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2026A1515010589"],"award-info":[{"award-number":["2026A1515010589"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010096","name":"Southern Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572291"],"award-info":[{"award-number":["82572291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271374"],"award-info":[{"award-number":["32271374"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501164"],"award-info":[{"award-number":["32501164"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230067"],"award-info":[{"award-number":["82230067"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013068","name":"Key Technologies Research and Development Program of Guangzhou Municipality","doi-asserted-by":"publisher","award":["2025B01J3007"],"award-info":[{"award-number":["2025B01J3007"]}],"id":[{"id":"10.13039\/501100013068","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.colsurfb.2026.115949","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T15:37:37Z","timestamp":1782747457000},"page":"115949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Simultaneous disruption of glutathione and 7-dehydrocholesterol antioxidant armor drives lipid peroxidation cascade for robust ferroptotic tumor elimination"],"prefix":"10.1016","volume":"267","author":[{"given":"Zehui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanchao","family":"Que","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haobin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshui","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingshang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qindeng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0350-375X","authenticated-orcid":false,"given":"Zheyu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangrong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41392-024-01969-z","article-title":"Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects","volume":"9","author":"Ru","year":"2024","journal-title":"Signal. Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s12915-025-02378-6","article-title":"Iron metabolism and ferroptosis in human health and disease","volume":"23","author":"Zhong","year":"2025","journal-title":"BMC Biol."},{"issue":"14","key":"10.1016\/j.colsurfb.2026.115949_bib3","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib4","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cell.2010.06.028","article-title":"Two to Tango: Regulation of Mammalian Iron Metabolism","volume":"142","author":"Hentze","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib5","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.canlet.2015.07.008","article-title":"Reactive oxygen species in redox cancer therapy","volume":"367","author":"Tong","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12964-023-01398-5","article-title":"Interplay of oxidative stress, cellular communication and signaling pathways in cancer","volume":"22","author":"Iqbal","year":"2024","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.colsurfb.2026.115949_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103208","article-title":"Interactions between oxidative stress and senescence in cancer: Mechanisms, therapeutic implications, and future perspectives","volume":"73","author":"Li","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.colsurfb.2026.115949_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101753","article-title":"Adaptive redox homeostasis in cutaneous melanoma","volume":"37","author":"Arslanbaeva","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.colsurfb.2026.115949_bib9","article-title":"Copper\/iron-based intelligent nanoparticles self-amplify apoptosis\/ferroptosis\/cuproptosis in colorectal cancer","volume":"36","author":"Xue","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2026.115949_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121110","article-title":"Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy","volume":"277","author":"Niu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115949_bib11","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/biom10101429","article-title":"Role of Glutathione in Cancer: From Mechanisms to Therapies","author":"Kennedy","year":"2020","journal-title":"Biomolecules"},{"issue":"7998","key":"10.1016\/j.colsurfb.2026.115949_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41586-023-06878-9","article-title":"7-Dehydrocholesterol is an endogenous suppressor of ferroptosis","volume":"626","author":"Freitas","year":"2024","journal-title":"Nature"},{"issue":"7998","key":"10.1016\/j.colsurfb.2026.115949_bib13","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/s41586-023-06983-9","article-title":"7-Dehydrocholesterol dictates ferroptosis sensitivity","volume":"626","author":"Li","year":"2024","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.115949_bib14","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.molcel.2024.03.003","article-title":"7-Dehydrocholesterol: A sterol shield against an iron sword","volume":"84","author":"Cui","year":"2024","journal-title":"Mol. Cell."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12935-025-04146-6","article-title":"NSC777201 exhibits anticancer activity against colorectal cancer cells by inducing multiple types of cell death","volume":"26","author":"Ho","year":"2025","journal-title":"Cancer Cell. Int."},{"key":"10.1016\/j.colsurfb.2026.115949_bib16","first-page":"2026","article-title":"7-Dehydrocholesterol attenuates osteoarthritis by synergistically inhibiting oxidative stress, inflammation, and ferroptosis in macrophages","volume":"1","author":"Zhang","year":"2026","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib17","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/s42003-023-05477-8","article-title":"Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene","volume":"6","author":"Sun","year":"2023","journal-title":"Commun. Biol."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115949_bib18","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.cell.2024.01.030","article-title":"Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis","volume":"187","author":"Qiu","year":"2024","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.colsurfb.2026.115949_bib19","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2322935121","article-title":"Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle\u2013mRNA formulation","volume":"121","author":"Wang","year":"2024","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115949_bib20","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cell.2024.10.047","article-title":"ACSL4 and polyunsaturated lipids support metastatic extravasation and colonization","volume":"188","author":"Wang","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2026.115949_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jconrel.2024.08.006","article-title":"ROS-responsive nanoparticle delivery of obeticholic acid mitigate primary sclerosing cholangitis","volume":"374","author":"Yao","year":"2024","journal-title":"J. Control. Release"},{"issue":"22","key":"10.1016\/j.colsurfb.2026.115949_bib22","doi-asserted-by":"crossref","first-page":"27183","DOI":"10.1021\/acsami.3c03792","article-title":"Biomimetic Nanoparticle with Glutathione Depletion and Amplified ROS Generation Capabilities for Synergistic Chemo-Sonodynamic Therapy in Squamous Cell Carcinomas","volume":"15","author":"Fan","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115949_bib23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41573-024-00979-4","article-title":"Targeting ROS in cancer: rationale and strategies","volume":"23","author":"Glorieux","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115949_bib24","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.chembiol.2021.09.003","article-title":"Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor","volume":"29","author":"Hao","year":"2022","journal-title":"Cell. Chem. Biol."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.115949_bib25","doi-asserted-by":"crossref","first-page":"11492","DOI":"10.1021\/acsnano.3c01369","article-title":"Tumor-Generated Reactive Oxygen Species Storm for High-Performance Ferroptosis Therapy","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115949_bib26","first-page":"1","article-title":"Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis","author":"Ren","year":"2026","journal-title":"Cancer Sci."},{"key":"10.1016\/j.colsurfb.2026.115949_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202204830","article-title":"Back Cover: Glutathione Depletion-Induced Activation of Dimersomes for Potentiating the Ferroptosis and Immunotherapy of \u201cCold\u201d Tumor","volume":"61","author":"Zhou","year":"2022","journal-title":"Angew. Chem. Int. Ed."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115949_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202310158","article-title":"Self-Reliant Nanomedicine with Long-Lasting Glutathione Depletion Ability Disrupts Adaptive Redox Homeostasis and Suppresses Cancer Stem Cells","volume":"34","author":"Xiong","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"15","key":"10.1016\/j.colsurfb.2026.115949_bib29","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2174\/0113895575287242240129120002","article-title":"Targeting Lysosomes: A Strategy Against Chemoresistance in Cancer","volume":"24","author":"Ekta","year":"2024","journal-title":"Mini-Rev. Med. Chem."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115949_bib30","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41420-025-02608-4","article-title":"The role of hydroxyindoles in protecting neuronal cultures from ferroptosis","volume":"11","author":"Jakaria","year":"2025","journal-title":"Cell. Death Discov."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115949_bib31","first-page":"651","article-title":"Ferroptosis: when metabolism meets cell death","volume":"105","author":"Conrad","year":"2024","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.colsurfb.2026.115949_bib32","article-title":"CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis","author":"Zhou","year":"2026","journal-title":"Adv. Sci."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115949_bib33","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and Cancer","volume":"166","author":"Vyas","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.colsurfb.2026.115949_bib34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ab.2016.10.021","article-title":"Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: Analytical and biological challenges","volume":"524","author":"Tsikas","year":"2017","journal-title":"Anal. Biochem."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:04:40Z","timestamp":1786464280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526005370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"alternative-id":["S0927776526005370"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115949","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous disruption of glutathione and 7-dehydrocholesterol antioxidant armor drives lipid peroxidation cascade for robust ferroptotic tumor elimination","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115949"}}