{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:52:22Z","timestamp":1789588342591,"version":"build-2803163510"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.colsurfb.2026.115958","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:25:43Z","timestamp":1783009543000},"page":"115958","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Unmodified orientable osteoclastic cytomembrane bionic fluorescent magnetic nanocarbons as high-efficiency multifunctional platforms for antiresorptive compound discovery"],"prefix":"10.1016","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6173-9595","authenticated-orcid":false,"given":"Qiming","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangbo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lupin","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10514","key":"10.1016\/j.colsurfb.2026.115958_bib1","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1016\/S0140-6736(25)01385-6","article-title":"The osteoporosis","volume":"406","author":"Ye","year":"2025","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115958_bib2","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1001\/jama.2025.6003","article-title":"Osteoporosis: a review","volume":"334","author":"Morin","year":"2025","journal-title":"Jama-J. Am. Med. Assoc."},{"issue":"48","key":"10.1016\/j.colsurfb.2026.115958_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl6432","article-title":"Cytokine-scavenging nanodecoys reconstruct osteoclast\/osteoblast balance toward the treatment of postmenopausal osteoporosis","volume":"7","author":"Zhou","year":"2021","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115958_bib4","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1038\/s41467-025-59719-w","article-title":"FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice","volume":"16","author":"Xie","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.115958_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115654","article-title":"Recent advance of small-molecule drugs for clinical treatment of osteoporosis: A review","volume":"259","author":"Zhang","year":"2023","journal-title":"Eur. J. Med. Chem."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115958_bib6","article-title":"Food and medicine homology components ameliorate metabolic diseases via dual pathways: blood absorption and nonabsorptive pathways","volume":"3","author":"Zhai","year":"2026","journal-title":"Food Med. Homol."},{"issue":"05","key":"10.1016\/j.colsurfb.2026.115958_bib7","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1142\/S0192415X24500526","article-title":"Insight of Chinese Herbal Medicine in treating osteoporosis: achievements from 2013 to 2023","volume":"52","author":"Tan","year":"2024","journal-title":"Am. J. Chin. Med."},{"issue":"11","key":"10.1016\/j.colsurfb.2026.115958_bib8","doi-asserted-by":"crossref","DOI":"10.1055\/s-0032-1320562","article-title":"Anti-osteoporotic effects of multiple herbal components in Erxian decoction, a Chinese medicinal formula","volume":"78","author":"Tong","year":"2012","journal-title":"Planta Med."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115958_bib9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s11655-023-3751-8","article-title":"Q, protective effects of phellodendron species on bone health: a novel perspective on their potentials in treating osteoporosis and osteoarthritis","volume":"30","author":"Xin","year":"2024","journal-title":"Chin. J. Integr. Med."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115958_bib10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/13813455.2025.2465360","article-title":"Role of berberine in metabolic and bone changes in ovariectomized rats","volume":"131","author":"Eid","year":"2025","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.colsurfb.2026.115958_bib11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jchromb.2018.11.014","article-title":"Preparation of micro-cell membrane chromatographic columns with polyvinyl alcohol-modified polyether ether ketone tube as cellular Cheek tor membrane carrier","volume":"1104","author":"Wang","year":"2019","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.colsurfb.2026.115958_bib12","doi-asserted-by":"crossref","first-page":"6697","DOI":"10.1002\/anie.200502189","article-title":"Hydrogel stamping of arrays of supported lipid bilayers with various lipid compositions for the screening of drug-membrane and protein-membrane interactions","volume":"44","author":"Majd","year":"2005","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.colsurfb.2026.115958_bib13","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41573-021-00240-2","article-title":"Ligand binding at the protein\u2013lipid interface: strategic considerations for drug design","volume":"20","author":"Payandeh","year":"2021","journal-title":"Nat. Rev. Drug. Discov."},{"issue":"43","key":"10.1016\/j.colsurfb.2026.115958_bib14","doi-asserted-by":"crossref","first-page":"17353","DOI":"10.1021\/acs.analchem.4c04017","article-title":"Nondestructively assemble cell membrane-coated nanoparticles by host\u2212guest interactions for efficient capture of bioactive compounds","volume":"96","author":"Hu","year":"2024","journal-title":"Anal. Chem."},{"issue":"7571","key":"10.1016\/j.colsurfb.2026.115958_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature15373","article-title":"Nanoparticle biointerfacing by platelet membrane cloaking","volume":"526","author":"Hu","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115958_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2025.101515","article-title":"Synergistic cell membrane-coated ECL-DNA biosensor for specificity-enhanced drug lead evaluation","volume":"16","author":"Wu","year":"2026","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.colsurfb.2026.115958_bib17","first-page":"15277","article-title":"Cell membrane-camouflaged biomimetic magnetic fluorescent nanoparticles with enhanced stability for high-performance lead drug discovery","volume":"96","author":"Jiang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.colsurfb.2026.115958_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.129039","article-title":"A green, efficient and stable platform based on hyperbranched quaternized hydrothermal magnetic chitosan nanospheres integrated cytomembranes for screening drug candidates from natural products","volume":"258","author":"Sang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.115958_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2025.107493","article-title":"Sustainable stable extraction of anti-osteoporotic compounds from Cornus officinalis by osteoblast membrane bionic multifunctional carbonaceous microspheres composite column","volume":"142","author":"Zhao","year":"2025","journal-title":"J. Food Compos. Anal."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115958_bib20","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1016\/j.apsb.2020.01.019","article-title":"Development of 3-mercaptopropyltrimethox-ysilane (MPTS)-modified bone marrow mononuclear cell membrane chromatography for screening anti-osteoporosis components from Scutellariae Radix","volume":"10","author":"Gu","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115958_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1381612003401532","article-title":"Progress in the development of inhibitors of SH2 domains","volume":"6","author":"Cody","year":"2000","journal-title":"Curr. Pharm. Des."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115958_bib22","doi-asserted-by":"crossref","first-page":"11137","DOI":"10.1096\/fj.201900436RR","article-title":"The role of EGFR signaling in age-related osteoporosis in mouse cortical bone","volume":"33","author":"Liu","year":"2019","journal-title":"FASEB J."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.115958_bib23","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1038\/s41418-024-01368-5","article-title":"Inhibition of inflammatory osteoclasts accelerates callus remodeling in osteoporotic fractures by enhancing CGRP+TrkA+ signaling","volume":"31","author":"Shu","year":"2024","journal-title":"Cell. Death Differ."},{"key":"10.1016\/j.colsurfb.2026.115958_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117983","article-title":"Advancements in screening systems for active ingredients in traditional Chinese medicines using ligand fishing technique","volume":"180","author":"Qin","year":"2024","journal-title":"Trac. -Trend Anal. Chem."},{"key":"10.1016\/j.colsurfb.2026.115958_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103166","article-title":"Advances in surface design and biomedical applications of magnetic nanoparticles","volume":"328","author":"Ara\u00fajo","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"issue":"5512","key":"10.1016\/j.colsurfb.2026.115958_bib26","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1126\/science.291.5512.2370","article-title":"Glycosylation and the immune system","volume":"291","author":"Rudd","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2026.115958_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2026.129591","article-title":"A multi-ligand polymer-particle composite-based array chip for selective and simultaneous enrichment of phosphoproteins and glycoproteins","volume":"305","author":"Aparna","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.colsurfb.2026.115958_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2014.09.001","article-title":"Electrogenerated chemiluminescence biosensing for the detection of prostate PC-3 cancer cells incorporating antibody as capture probe and ruthenium complex-labelled wheat germ agglutinin as signal probe","volume":"863","author":"Yang","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.colsurfb.2026.115958_bib29","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/19373341251369772","article-title":"Human Recellularization for Xenoantigen-Free Decellularized Cardiac Xenografts","volume":"32","author":"Yoon","year":"2026","journal-title":"Tissue Eng. Pt. A"},{"issue":"27","key":"10.1016\/j.colsurfb.2026.115958_bib30","doi-asserted-by":"crossref","first-page":"24784","DOI":"10.1021\/acsnano.5c02254","article-title":"Direct reversible conjugation of an adenosine receptor antagonist to an axonal transport protein carrier","volume":"19","author":"Hakobyan","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.115958_bib31","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.apsb.2022.05.034","article-title":"Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.colsurfb.2026.115958_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2025.114211","article-title":"Covalent biofunctionalization of hydrothermal nanocarbons with inner-side-out directed cytomembrane by hydrazone bioconjugation for screening herbal active components","volume":"255","author":"Ye","year":"2025","journal-title":"Mater. Des."},{"key":"10.1016\/j.colsurfb.2026.115958_bib33","article-title":"Magnetic hydrothermal carbonaceous nanospheres bonded cell membranes as a stable and reusable platform for discovering natural bioactive components","volume":"454","author":"Liu","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115958_bib34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/bs.pmch.2021.01.004","article-title":"Use of molecular docking computational tools in drug discovery","volume":"60","author":"Stanzione","year":"2021","journal-title":"Prog. Med. Chem."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115958_bib35","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1021\/acsami.5c20200","article-title":"Facile label-free cytomembrane reversely coated strategy via membrane carbohydrate-lectin self-assembly for targeted discovery of natural drug candidates","volume":"18","author":"Yu","year":"2026","journal-title":"ACS Appl. Mater. Inter."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.115958_bib36","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1038\/s41596-018-0033-6","article-title":"Preparation of asymmetric phospholipid vesicles for use as cell membrane models","volume":"13","author":"Doktorova","year":"2018","journal-title":"Nat. Protoc."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115958_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.abb.2006.03.023","article-title":"Energetics of membrane protein folding and stability","volume":"453","author":"Minetti","year":"2006","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115958_bib38","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0962-8924(00)01906-1","article-title":"W.A. Frazier, Integrin-associated protein (CD47) and its ligands","volume":"11","author":"Brown","year":"2001","journal-title":"Trends Cell. Biol."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115958_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s10528-020-09961-2","article-title":"Zoledronate inhibits osteoclast differentiation via suppressing vascular endothelial growth factor receptor 2 expression","volume":"58","author":"Nakagawa","year":"2020","journal-title":"Biochem. Genet."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115958_bib40","first-page":"4832","article-title":"Chlorogenic acid prevents ovariectomized-induced bone loss by facilitating osteoblast functions and suppressing osteoclast formation","volume":"16","author":"Ho","year":"2024","journal-title":"Aging-Us"},{"key":"10.1016\/j.colsurfb.2026.115958_bib41","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.phymed.2008.09.001","article-title":"Citrus bioactive compounds improve bone quality and plasma antioxidant activity in orchidectomized rats","volume":"16","author":"Mandadi","year":"2009","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.colsurfb.2026.115958_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107696","article-title":"A neurotrophic mechanism directs sensory nerve transit in cranial bone","volume":"31","author":"Meyers","year":"2020","journal-title":"Cell. Rep."},{"key":"10.1016\/j.colsurfb.2026.115958_bib43","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2555687","article-title":"Ngf\/TrKA signal is associated with macrophage activation of acute kidney injury in mice","volume":"47","author":"Tang","year":"2025","journal-title":"Ren. Fail."},{"key":"10.1016\/j.colsurfb.2026.115958_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154739","article-title":"Safranal inhibits estrogen-deficiency osteoporosis by targeting Sirt1 to interfere with NF-\u03baB acetylation","volume":"114","author":"Sheng","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.colsurfb.2026.115958_bib45","article-title":"From neuromodulation to bone homeostasis: therapeutic targets of nerve growth factor in skeletal diseases","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.colsurfb.2026.115958_bib46","doi-asserted-by":"crossref","first-page":"16329","DOI":"10.1073\/pnas.0706662104","article-title":"Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death","volume":"104","author":"Jang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005461?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005461?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:07:31Z","timestamp":1786464451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526005461"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":46,"alternative-id":["S0927776526005461"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115958","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unmodified orientable osteoclastic cytomembrane bionic fluorescent magnetic nanocarbons as high-efficiency multifunctional platforms for antiresorptive compound discovery","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115958","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115958"}}