{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:50:56Z","timestamp":1786467056428,"version":"build-2736575974"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.colsurfb.2026.115960","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T16:25:50Z","timestamp":1783009550000},"page":"115960","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Manganese\u2011containing mesoporous bioactive glass with antioxidative and osteogenic activities for periodontitis treatment"],"prefix":"10.1016","volume":"267","author":[{"given":"Yandi","family":"Hao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhe","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quanchen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.115960_bib1","first-page":"459","article-title":"Metformin carbon dots-based osteogenic and protein delivery system to promote bone regeneration in periodontitis","volume":"53","author":"Wei","year":"2025","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2026.115960_bib2","article-title":"Preparation of NIR responsive resveratrol@Au nanocages using for regulating oxidative stress microenvironment of periodontitis","volume":"504","author":"Han","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115960_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2021.130207","article-title":"Constructing biocompatible MSN@Ce@PEG nanoplatform for enhancing regenerative capability of stem cell via ROS-scavenging in periodontitis","volume":"423","author":"Ren","year":"2021","journal-title":"Chem. Eng. J."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115960_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/prd.12342","article-title":"Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way","volume":"84","author":"Sczepanik","year":"2020","journal-title":"Periodontol 2000"},{"issue":"29","key":"10.1016\/j.colsurfb.2026.115960_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202507481","article-title":"Mitochondria-targeted ROS scavenging natural enzyme cascade nanogels for periodontitis treatment via hypoxia alleviation and immunomodulation","volume":"12","author":"Zheng","year":"2025","journal-title":"Adv. Sci."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115960_bib6","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1186\/s12951-025-03907-9","article-title":"Fisetin carbon dots alleviate periodontitis by enhancing mitophagy through regulation of sirtuin 3 sumoylation","volume":"23","author":"Deng","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.115960_bib7","article-title":"Multifunctional Fe-melatonin nanozyme facilitates osteoporotic bone regeneration based on a mitochondrial protection and microenvironment remodeling strategy","volume":"531","author":"Li","year":"2026","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115960_bib8","article-title":"Circular RNA-chimeric CeO\u2082 nanoplatform maintains protective autophagy in macrophages for periodontitis","volume":"503","author":"Han","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115960_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.166999","article-title":"Dual-functional natural drug-loaded responsive hydrogel for activating autophagy and regulating immune microenvironment in the treatment of diabetic periodontitis","volume":"521","author":"Ai","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115960_bib10","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.70039","article-title":"Melatonin increased autophagy level to facilitate osteogenesis of inflamed PDLSCs through TMEM110 signaling pathways","volume":"77","author":"Xu","year":"2025","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.colsurfb.2026.115960_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.167364","article-title":"Mitochondria-targeted nanoformulation inhibits periodontal ligament stem cells pyroptosis to promote periodontal tissue regeneration in periodontitis","volume":"522","author":"Shao","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"Pt 1","key":"10.1016\/j.colsurfb.2026.115960_bib12","article-title":"Antioxidant nanozymes as next-generation therapeutics to free radical-mediated inflammatory diseases: A comprehensive review","volume":"260","author":"Singh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115960_bib13","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1007\/s00204-024-03696-4","article-title":"Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants","volume":"98","author":"Jomova","year":"2024","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.colsurfb.2026.115960_bib14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.actbio.2021.08.023","article-title":"Immunomodulatory bioactive glasses for tissue regeneration","volume":"133","author":"Zheng","year":"2021","journal-title":"Acta Biomater."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115960_bib15","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1021\/acsbiomaterials.4c00107","article-title":"Gold nanoparticles confined in mesoporous bioactive glass for periodontitis therapy","volume":"10","author":"Zhou","year":"2024","journal-title":"ACS Biomater. Sci. Eng."},{"issue":"44","key":"10.1016\/j.colsurfb.2026.115960_bib16","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.1002\/anie.200460598","article-title":"Highly ordered mesoporous bioactive glasses with superior in vitro bone-forming bioactivities","volume":"43","author":"Yan","year":"2004","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.colsurfb.2026.115960_bib17","first-page":"200","article-title":"L-arginine modified mesoporous bioactive glass with ROS scavenging and NO release for periodontitis treatment","volume":"48","author":"Yao","year":"2025","journal-title":"Bioact. Mater."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115960_bib18","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1186\/s12951-024-02865-y","article-title":"From ROS scavenging to boosted osseointegration: Cerium-containing mesoporous bioactive glass nanoparticles functionalized implants in diabetes","volume":"22","author":"Jiang","year":"2024","journal-title":"J. Nanobiotechnol."},{"issue":"29","key":"10.1016\/j.colsurfb.2026.115960_bib19","doi-asserted-by":"crossref","first-page":"34378","DOI":"10.1021\/acsami.3c03446","article-title":"Selenium-doped mesoporous bioactive glass regulates macrophage metabolism and polarization by scavenging ROS and promotes bone regeneration in vivo","volume":"15","author":"Chen","year":"2023","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.115960_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.162671","article-title":"SOD\/CAT-biomimetic bioactive glass-ceramics nanozyme with intracellular oxygen supply and immunoregulation for MRSA-infected wound repair","volume":"513","author":"Tian","year":"2025","journal-title":"Chem. Eng. J."},{"issue":"21","key":"10.1016\/j.colsurfb.2026.115960_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201733","article-title":"Manganese-based nanozymes: Preparation, catalytic mechanisms, and biomedical applications","volume":"11","author":"Tang","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.115960_bib22","doi-asserted-by":"crossref","first-page":"848","DOI":"10.3390\/antiox14070848","article-title":"Manganese superoxide dismutase: Structure, function, and implications in human disease","volume":"14","author":"Grujicic","year":"2025","journal-title":"Antioxidants"},{"key":"10.1016\/j.colsurfb.2026.115960_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2025.105958","article-title":"Manganese-based nanozymes for the dynamic regulation of the osteogenic microenvironment","volume":"121","author":"Li","year":"2025","journal-title":"EBioMedicine"},{"key":"10.1016\/j.colsurfb.2026.115960_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.116404","article-title":"Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload","volume":"278","author":"Wang","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.colsurfb.2026.115960_bib25","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.jconrel.2021.05.043","article-title":"Bioactive glass: A multifunctional delivery system","volume":"335","author":"Gupta","year":"2021","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.115960_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnoncrysol.2023.122656","article-title":"Study of the manganese and calcium synergetic influence on mesoporous bioactive glass characteristic","volume":"622","author":"Queiroz","year":"2023","journal-title":"J. Non-Cryst. Solids"},{"key":"10.1016\/j.colsurfb.2026.115960_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.168205","article-title":"Restoration of periodontitis-induced bone defects with multifunctional barrier membranes by alleviating oxidative stress and remodelling macrophage metabolism","volume":"523","author":"Han","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.115960_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2024.134188","article-title":"Unlocking the potential of iron-containing mesoporous bioactive glasses: Orchestrating osteogenic differentiation in bone marrow mesenchymal stem cells and osteoblasts","volume":"694","author":"Zhou","year":"2024","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.115960_bib29","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jcis.2021.11.122","article-title":"Construction of tellurium-doped mesoporous bioactive glass nanoparticles for bone cancer therapy by promoting ROS-mediated apoptosis and antibacterial activity","volume":"610","author":"Zhang","year":"2021","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.115960_bib30","article-title":"Antioxidant mesoporous Ce-doped bioactive glass nanoparticles with anti-inflammatory and pro-osteogenic activities","volume":"5","author":"Zheng","year":"2020","journal-title":"Mater. Today Bio"},{"issue":"25","key":"10.1016\/j.colsurfb.2026.115960_bib31","article-title":"Zinc-cobalt bimetallic organic frameworks with antioxidative and osteogenic activities for periodontitis treatment","volume":"21","author":"Tang","year":"2025","journal-title":"Small"},{"issue":"19","key":"10.1016\/j.colsurfb.2026.115960_bib32","doi-asserted-by":"crossref","first-page":"18732","DOI":"10.1021\/acsnano.3c01940","article-title":"Microenvironment-responsive metal-phenolic nanozyme release platform with antibacterial, ROS scavenging, and osteogenesis for periodontitis","volume":"17","author":"Xu","year":"2023","journal-title":"ACS Nano"},{"issue":"2","key":"10.1016\/j.colsurfb.2026.115960_bib33","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.ceramint.2023.10.091","article-title":"Assessing Mn as an antioxidant agent in bioactive glasses by quantification of catalase and superoxide dismutase enzymatic mimetic activities","volume":"50","author":"Abati","year":"2023","journal-title":"Ceram. Int."},{"key":"10.1016\/j.colsurfb.2026.115960_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123179","article-title":"Manganese dioxide coupled metal-organic framework as mitophagy regulator alleviates periodontitis through SIRT1-FOXO3-BNIP3 signaling axis","volume":"319","author":"Zhu","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.115960_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103859","article-title":"Mitochondrial membrane potential and compartmentalized signaling: Calcium, ROS, and beyond","volume":"86","author":"Ahmed Selim","year":"2025","journal-title":"Redox Biol."},{"key":"10.1016\/j.colsurfb.2026.115960_bib36","article-title":"Bifunctional mesoporous HMUiO-66-NH2 nanoparticles for bone remodeling and ROS scavenging in periodontitis therapy","volume":"314","author":"Lam","year":"2024","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115960_bib37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12951-025-03270-9","article-title":"Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy","volume":"23","author":"Lin","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115960_bib38","doi-asserted-by":"crossref","DOI":"10.26599\/NR.2025.94907375","article-title":"Mitochondria replenishment enhances senescent periodontal ligament stem cell osteogenesis and facilitates bone repair","volume":"18","author":"Nuerlan","year":"2025","journal-title":"Nano Res."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115960_bib39","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s12964-019-0414-7","article-title":"Autophagy drives osteogenic differentiation of human gingival mesenchymal stem cells","volume":"17","author":"Vidoni","year":"2019","journal-title":"Cell. Commun. Signal."},{"key":"10.1016\/j.colsurfb.2026.115960_bib40","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.freeradbiomed.2025.12.057","article-title":"Spermidine promotes osteogenic differentiation of BMSCs via the m6A methylation-autophagy axis under inflammatory stress","volume":"245","author":"Hao","year":"2026","journal-title":"Free. Radic. Biol. Med."},{"key":"10.1016\/j.colsurfb.2026.115960_bib41","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jcis.2020.06.122","article-title":"Design and evaluation a kind of functional biomaterial for bone tissue engineering: Selenium\/mesoporous bioactive glass nanospheres","volume":"579","author":"Hu","year":"2020","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.115960_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.150546","article-title":"Gold capped mesoporous bioactive glass guides bone regeneration via BMSCs recruitment and drug adaptive release","volume":"487","author":"Zhou","year":"2024","journal-title":"Chem. Eng. J."},{"issue":"15","key":"10.1016\/j.colsurfb.2026.115960_bib43","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1007\/s10853-017-0944-6","article-title":"Sol\u2013gel-derived manganese-releasing bioactive glass as a therapeutic approach for bone tissue engineering","volume":"52","author":"Barrioni","year":"2017","journal-title":"J. Mater. Sci."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115960_bib44","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s10856-018-6070-4","article-title":"Synthesis and characterization of manganese containing mesoporous bioactive glass nanoparticles for biomedical applications","volume":"29","author":"Nawaz","year":"2018","journal-title":"J. Mater. Sci. Mater. Med."},{"issue":"36","key":"10.1016\/j.colsurfb.2026.115960_bib45","doi-asserted-by":"crossref","first-page":"32482","DOI":"10.1021\/acsnano.5c08885","article-title":"Natural polyphenol-functionalized Schwann cell-derived exosomes as a temporal neuromodulation strategy for diabetic periodontitis therapy","volume":"19","author":"Fan","year":"2025","journal-title":"ACS Nano"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T16:02:27Z","timestamp":1786464147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526005485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":45,"alternative-id":["S0927776526005485"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115960","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Manganese\u2011containing mesoporous bioactive glass with antioxidative and osteogenic activities for periodontitis treatment","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115960","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115960"}}