{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:20:07Z","timestamp":1788531607452,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504678"],"award-info":[{"award-number":["82504678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024CXA034"],"award-info":[{"award-number":["2024CXA034"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011065"],"award-info":[{"award-number":["2024J011065"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J08265"],"award-info":[{"award-number":["2025J08265"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.colsurfb.2026.115975","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:20:25Z","timestamp":1784042425000},"page":"115975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Dual-targeted pH-responsive nanoliposome (M5\/NMN\/DEAP\/iRGD-Lip): Immunostimulatory-photodynamic synergy for breast cancer therapy"],"prefix":"10.1016","volume":"268","author":[{"given":"Junwei","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingming","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaukat Semm Ally","family":"Basinda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.colsurfb.2026.115975_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmr.2025.100087","article-title":"Metal-based antibody, nanobody, and peptide conjugates: potential for breast cancer therapy","volume":"77","author":"Kaya","year":"2025","journal-title":"Pharmacol. Rev."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41392-024-02108-4","article-title":"Breast cancer: pathogenesis and treatments","volume":"10","author":"Xiong","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.colsurfb.2026.115975_bib3","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-pathol-042420-093238","article-title":"Pathogenesis of triple-negative breast cancer","volume":"17","author":"Derakhshan","year":"2022","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.colsurfb.2026.115975_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-025-03502-3","article-title":"Global patterns and trends in breast cancer incidence and mortality across 185 countries","author":"Kim","year":"2025","journal-title":"Nat. Med."},{"issue":"15","key":"10.1016\/j.colsurfb.2026.115975_bib5","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1039\/D1CS01079D","article-title":"New guidelines and definitions for type I photodynamic therapy","volume":"54","author":"Li","year":"2025","journal-title":"Chem. Soc. Rev."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.7150\/thno.67300","article-title":"Recent advances in nanomedicines for photodynamic therapy (PDT)-driven cancer immunotherapy","volume":"12","author":"Ji","year":"2022","journal-title":"Theranostics"},{"issue":"17","key":"10.1016\/j.colsurfb.2026.115975_bib7","doi-asserted-by":"crossref","first-page":"7749","DOI":"10.1039\/D5CS00054H","article-title":"Enhancing biosafety in photodynamic therapy: progress and perspectives","volume":"54","author":"Zhao","year":"2025","journal-title":"Chem. Soc. Rev."},{"issue":"18","key":"10.1016\/j.colsurfb.2026.115975_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202207546","article-title":"BODIPY as a multifunctional theranostic reagent in biomedicine: self-assembly, properties, and applications","volume":"35","author":"Cheng","year":"2023","journal-title":"Adv. Mater."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115975_bib9","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1039\/D2CS00673A","article-title":"The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy","volume":"52","author":"Han","year":"2023","journal-title":"Chem. Soc. Rev."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115975_bib10","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1021\/acs.accounts.2c00699","article-title":"Light conversion nanomaterials for wireless phototherapy","volume":"56","author":"Sun","year":"2023","journal-title":"Acc. Chem. Res."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115975_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202204413","article-title":"Photoresponsive supramolecular polymers: from light-controlled small molecules to smart materials","volume":"35","author":"Xu","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.115975_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122570","article-title":"Nanocarriers based novel and effective drug delivery system","volume":"632","author":"Khizar","year":"2023","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.115975_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202305300","article-title":"Lipid nanoparticles optimized for targeting and release of nucleic acid","volume":"36","author":"Jia","year":"2024","journal-title":"Adv. Mater."},{"issue":"30","key":"10.1016\/j.colsurfb.2026.115975_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202402720","article-title":"Expanded ROS generation and hypoxia reversal: excipient-free self-assembled nanotheranostics for enhanced cancer photodynamic immunotherapy","volume":"36","author":"Yang","year":"2024","journal-title":"Adv. Mater."},{"issue":"14","key":"10.1016\/j.colsurfb.2026.115975_bib15","article-title":"Engineered neutrophil nanovesicles for inhibiting corneal neovascularization by synergistic anti-inflammatory, anti-VEGF, and chemoexcited photodynamic therapy","volume":"37","author":"Liu","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.115975_bib16","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ejpb.2015.03.018","article-title":"Advanced targeted therapies in cancer: Drug nanocarriers, the future of chemotherapy","volume":"93","author":"P\u00e9rez-Herrero","year":"2015","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib17","doi-asserted-by":"crossref","first-page":"e000337","DOI":"10.1136\/jitc-2019-000337","article-title":"Consensus guidelines for the definition, detection and interpretation of immunogenic cell death","volume":"8","author":"Galluzzi","year":"2020","journal-title":"J. Immunother. Cancer"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.115975_bib18","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1021\/acs.nanolett.9b05210","article-title":"Endoplasmic reticulum targeting to amplify immunogenic cell death for cancer immunotherapy","volume":"20","author":"Deng","year":"2020","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib19","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1186\/s12951-021-01075-0","article-title":"Unsymmetrical cyanine dye via in vivo hitchhiking endogenous albumin affords high-performance NIR-II\/photoacoustic imaging and photothermal therapy","volume":"19","author":"Xu","year":"2021","journal-title":"J. Nanobiotechnology"},{"issue":"12","key":"10.1016\/j.colsurfb.2026.115975_bib20","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/s41556-023-01280-z","article-title":"NAD+ regulates nucleotide metabolism and genomic DNA replication","volume":"25","author":"Munk","year":"2023","journal-title":"Nat. Cell. Biol."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.115975_bib21","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.3390\/cells12091329","article-title":"Cellular and mitochondrial NAD homeostasis in health and disease","volume":"12","author":"Waddell","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115975_bib22","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.advnut.2023.08.008","article-title":"The safety and antiaging effects of nicotinamide mononucleotide in human clinical trials: an update","volume":"14","author":"Song","year":"2023","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.colsurfb.2026.115975_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.116842","article-title":"Quantitative dynamics of intracellular NMN by genetically encoded biosensor","volume":"267","author":"Chen","year":"2025","journal-title":"Biosens. Bioelectron."},{"issue":"A","key":"10.1016\/j.colsurfb.2026.115975_bib24","article-title":"Application of multifunctional BODIPY in photodynamic therapy","volume":"185","author":"Zhang","year":"2021","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.colsurfb.2026.115975_bib25","article-title":"Liposome-mediated biomimetic delivery of PLK3 inhibitor with NIR II-triggered release prevents renal ischemia-reperfusion injury","volume":"5","author":"Zhu","year":"2022","journal-title":"Adv. Ther."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-73266-2","article-title":"Spectroscopic insights into BSA-mediated deaggregation of m-THPC","volume":"14","author":"Kolman","year":"2024","journal-title":"Sci. Rep."},{"issue":"33","key":"10.1016\/j.colsurfb.2026.115975_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201900309","article-title":"A gold nanocage\/cluster hybrid structure for whole-body multispectral optoacoustic tomography imaging, EGFR inhibitor delivery, and photothermal therapy","volume":"15","author":"Zhan","year":"2019","journal-title":"Small"},{"issue":"43","key":"10.1016\/j.colsurfb.2026.115975_bib28","doi-asserted-by":"crossref","first-page":"70100","DOI":"10.18632\/oncotarget.12149","article-title":"Secondary nuclear targeting of mesoporous silica nano-particles for cancer-specific drug delivery based on charge inversion","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115975_bib29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3390\/ph18060805","article-title":"DFT and molecular docking study of HA-conjugated SWCNTs for CD44-targeted delivery of platinum-based chemotherapeutics","volume":"18","author":"Khan","year":"2025","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s10020-024-00827-6","article-title":"Extracellular matrix marker LAMC2 targets ZEB1 to promote TNBC malignancy via up-regulating CD44\/STAT3 signaling pathway","volume":"30","author":"Wang","year":"2024","journal-title":"Mol. Med."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib31","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41467-019-09296-6","article-title":"iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer","volume":"10","author":"Ding","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.115975_bib32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jconrel.2022.05.063","article-title":"Strategies for persistent retention of macromolecules and nanoparticles in the blood circulation","volume":"350","author":"Takakura","year":"2022","journal-title":"J. Control. Release"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.115975_bib33","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.7150\/thno.18557","article-title":"Design of tumor acidity-responsive sheddable nanoparticles for fluorescence\/magnetic resonance imaging-guided photodynamic therapy","volume":"7","author":"Fan","year":"2017","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.115975_bib34","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12951-021-00862-z","article-title":"Persistent luminescence nanoparticles for cancer theranostics application","volume":"19","author":"Liu","year":"2021","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.colsurfb.2026.115975_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123116","article-title":"Inhibition of PDT-induced PGE2 surge for enhanced photo-immunotherapy","volume":"317","author":"Liu","year":"2025","journal-title":"Biomaterials"},{"issue":"10","key":"10.1016\/j.colsurfb.2026.115975_bib36","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s43630-024-00638-y","article-title":"Recent development of nanomaterials-based PDT to improve immunogenic cell death","volume":"23","author":"Ain","year":"2024","journal-title":"Photochem. Photobiol. Sci."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.115975_bib37","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.3390\/pharmaceutics15061693","article-title":"Overcoming resistance to immune checkpoint inhibitor therapy using calreticulin-inducing nanoparticle","volume":"15","author":"Chandrasekar","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2026.115975_bib38","doi-asserted-by":"crossref","DOI":"10.1177\/17588359251336627","article-title":"Comparison of immune checkpoint inhibitors in combination with chemotherapy versus chemotherapy alone in the first-line treatment of advanced gastric cancer patients with low PD-L1 expression: a systematic review and meta-analysis","volume":"17","author":"Wang","year":"2025","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"Pt A","key":"10.1016\/j.colsurfb.2026.115975_bib39","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.biocel.2016.09.009","article-title":"CD44: more than a mere stem cell marker","volume":"81","author":"Morath","year":"2016","journal-title":"Int. J. Biochem. Cell. Biol."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005631?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526005631?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:37:33Z","timestamp":1788529053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526005631"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":39,"alternative-id":["S0927776526005631"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115975","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-targeted pH-responsive nanoliposome (M5\/NMN\/DEAP\/iRGD-Lip): Immunostimulatory-photodynamic synergy for breast cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.115975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115975"}}