{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:18:51Z","timestamp":1788531531056,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202610444"],"award-info":[{"award-number":["202610444"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020205","name":"Health Commission of Jiangxi Province","doi-asserted-by":"publisher","award":["202610440"],"award-info":[{"award-number":["202610440"]}],"id":[{"id":"10.13039\/501100020205","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.colsurfb.2026.116030","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:07:10Z","timestamp":1785539230000},"page":"116030","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Smart nanoplatform targeting the mitochondria-P-gp axis to overcome chemoresistance for synergistic bladder cancer therapy"],"prefix":"10.1016","volume":"268","author":[{"given":"Zhihua","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxing","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.colsurfb.2026.116030_bib1","doi-asserted-by":"crossref","first-page":"e2408599","DOI":"10.1002\/advs.202408599","article-title":"Enhanced oxidative phosphorylation driven by TACO1 mitochondrial translocation promotes stemness and cisplatin resistance in bladder cancer","volume":"12","author":"Deng","year":"2025","journal-title":"Adv. Sci."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116030_bib2","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41565-023-01577-y","article-title":"Urease-powered nanobots for radionuclide bladder cancer therapy","volume":"19","author":"Sim\u00f3","year":"2024","journal-title":"Nat. Nanotechnol."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116030_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.hoc.2021.02.011","article-title":"Emerging targeted therapy for bladder cancer","volume":"35","author":"Thibault","year":"2021","journal-title":"Hematol. Oncol. Clin. North. Am."},{"key":"10.1016\/j.colsurfb.2026.116030_bib4","doi-asserted-by":"crossref","first-page":"100938","DOI":"10.1016\/j.drup.2023.100938","article-title":"Regulation of cisplatin resistance in bladder cancer by epigenetic mechanisms","volume":"68","author":"Li","year":"2023","journal-title":"Drug. Resist. Updat."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116030_bib5","first-page":"69","article-title":"Natural products as a means of overcoming cisplatin chemoresistance in bladder cancer","volume":"4","author":"Rajendran","year":"2021","journal-title":"Cancer Drug. Resist."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.116030_bib6","doi-asserted-by":"crossref","first-page":"8136","DOI":"10.3390\/ijms24098136","article-title":"MDR1 inhibition reverses doxorubicin-resistance in six doxorubicin-resistant canine prostate and bladder cancer cell lines","volume":"24","author":"Packeiser","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116030_bib7","doi-asserted-by":"crossref","first-page":"116941","DOI":"10.1016\/j.celrep.2026.116941","article-title":"Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer","volume":"45","author":"Xu","year":"2026","journal-title":"Cell. Rep."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116030_bib8","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.7150\/ijbs.63125","article-title":"Discovery and validation of nitroxoline as a novel STAT3 inhibitor in drug-resistant urothelial bladder cancer","volume":"17","author":"Lin","year":"2021","journal-title":"Int. J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116030_bib9","doi-asserted-by":"crossref","first-page":"bio041889","DOI":"10.1242\/bio.041889","article-title":"Intercellular transfer of P-glycoprotein mediates the formation of stable multi-drug resistance in human bladder cancer BIU-87 cells","volume":"8","author":"Cheng","year":"2019","journal-title":"Biol. Open."},{"issue":"46","key":"10.1016\/j.colsurfb.2026.116030_bib10","doi-asserted-by":"crossref","first-page":"e09075","DOI":"10.1002\/smll.202509075","article-title":"Innovative DCZCMC platform: dual regulation of cholesterol dynamics and the cGAS\/STING pathway activation to combat drug resistance in tumor therapy","volume":"21","author":"Wang","year":"2025","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116030_bib11","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00432-022-04387-2","article-title":"Role of natural P-gp inhibitor in the effective delivery for chemotherapeutic agents","volume":"149","author":"Shah","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"24","key":"10.1016\/j.colsurfb.2026.116030_bib12","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1042\/BCJ20190736","article-title":"ATP-dependent thermostabilization of human P-glycoprotein (ABCB1) is blocked by modulators","volume":"476","author":"Lusvarghi","year":"2019","journal-title":"Biochem. J."},{"issue":"13","key":"10.1016\/j.colsurfb.2026.116030_bib13","doi-asserted-by":"crossref","first-page":"e05701","DOI":"10.1002\/adhm.202505701","article-title":"Reversing multidrug resistance via efficient inhibition of drug efflux for enhanced cancer therapy","volume":"15","author":"Liu","year":"2026","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116030_bib14","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.21147\/j.issn.1000-9604.2025.06.13","article-title":"Curcumol overcomes cisplatin resistance and rewires glycolysis-H3K9la-ORC6 axis to trigger ferroptosis in bladder cancer","volume":"37","author":"Zhang","year":"2025","journal-title":"Chin. J. Cancer Res."},{"issue":"11","key":"10.1016\/j.colsurfb.2026.116030_bib15","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1021\/acsnano.5c21831","article-title":"A redox-responsive selenium-containing nanomedicine enables dual antioxidant system inhibition to overcome platinum resistance and enhance immunotherapy in bladder cancer","volume":"20","author":"Gao","year":"2026","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.116030_bib16","doi-asserted-by":"crossref","first-page":"101343","DOI":"10.1016\/j.drup.2025.101343","article-title":"Entinostat overcomes cisplatin resistance in bladder cancer by promoting H3K18la-mediated DHRS2 expression and nuclear translocation to suppress the AKR1C3-androgen axis","volume":"85","author":"Xu","year":"2026","journal-title":"Drug. Resist. Updat."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116030_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s13045-025-01722-1","article-title":"Application of single-cell and spatial omics in deciphering cellular hallmarks of cancer drug response and resistance","volume":"18","author":"Cheng","year":"2025","journal-title":"J. Hematol. Oncol."},{"issue":"19","key":"10.1016\/j.colsurfb.2026.116030_bib18","doi-asserted-by":"crossref","first-page":"18932","DOI":"10.1021\/acsnano.3c04175","article-title":"Elevating second near-infrared photothermal conversion efficiency of hollow gold nanorod for a precise theranostic of orthotopic bladder cancer","volume":"17","author":"Zhang","year":"2023","journal-title":"ACS Nano"},{"issue":"41","key":"10.1016\/j.colsurfb.2026.116030_bib19","doi-asserted-by":"crossref","first-page":"2402692","DOI":"10.1002\/adfm.202402692","article-title":"Homologous tumor targeting molybdenum-doped prussian blue for enhancing immunotherapy via PTT\/CDT and remodeled tumor immune microenvironment","volume":"34","author":"Ma","year":"2024","journal-title":"Adv. Funct. Mater."},{"issue":"18","key":"10.1016\/j.colsurfb.2026.116030_bib20","doi-asserted-by":"crossref","first-page":"e13913","DOI":"10.1002\/advs.202513913","article-title":"NIR-activatable domino cascade catalysis nanozyme reactor for multi-mechanism synergistic immunotherapy in bladder cancer","volume":"13","author":"Jiang","year":"2025","journal-title":"Adv. Sci."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116030_bib21","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1039\/C9SC05506A","article-title":"A H2O2 self-sufficient nanoplatform with domino effects for thermal-responsive enhanced chemodynamic therapy","volume":"11","author":"Zhang","year":"2020","journal-title":"Chem. Sci."},{"issue":"21","key":"10.1016\/j.colsurfb.2026.116030_bib22","doi-asserted-by":"crossref","first-page":"19599","DOI":"10.1021\/acsnano.4c17444","article-title":"Thermosensitive resiquimod-loaded lipid nanoparticles promote the polarization of tumor-associated macrophages to enhance bladder cancer immunotherapy","volume":"19","author":"Shang","year":"2025","journal-title":"ACS Nano"},{"issue":"21","key":"10.1016\/j.colsurfb.2026.116030_bib23","doi-asserted-by":"crossref","first-page":"10273","DOI":"10.1039\/D4NR01128G","article-title":"NIR-II light powered hydrogel nanomotor for intravesical instillation with enhanced bladder cancer therapy","volume":"16","author":"Chen","year":"2024","journal-title":"Nanoscale"},{"issue":"13","key":"10.1016\/j.colsurfb.2026.116030_bib24","doi-asserted-by":"crossref","first-page":"12544","DOI":"10.1021\/acsnano.3c02401","article-title":"Doxorubicin-Fe(III)-gossypol infinite coordination polymer@PDA:CuO2 composite nanoparticles for cost-effective programmed photothermal-chemodynamic-coordinated dual drug chemotherapy trimodal synergistic tumor therapy","volume":"17","author":"Zhu","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.116030_bib25","doi-asserted-by":"crossref","first-page":"123950","DOI":"10.1016\/j.biomaterials.2025.123950","article-title":"Plasmon-boosted titanium nitride-based nanoplatform for synergistic photothermal-chemodynamic cancer therapy with smart degradability","volume":"329","author":"Yang","year":"2026","journal-title":"Biomaterials"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116030_bib26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1039\/D3TB02491A","article-title":"Intelligent responsive copper-diethyldithiocarbamate-based multifunctional nanomedicine for photothermal-augmented synergistic cancer therapy","volume":"12","author":"Meng","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.colsurfb.2026.116030_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jcis.2021.12.172","article-title":"Mesoporous polydopamine-based multifunctional nanoparticles for enhanced cancer phototherapy","volume":"612","author":"Hu","year":"2022","journal-title":"J. Colloid Interface Sci."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116030_bib28","doi-asserted-by":"crossref","first-page":"112576","DOI":"10.1016\/j.isci.2025.112576","article-title":"Mesoporous polydopamine@CeO2 nanoparticles for photoacoustic-guided photothermal therapy in suppressing arthritis","volume":"28","author":"Liu","year":"2025","journal-title":"iScience"},{"key":"10.1016\/j.colsurfb.2026.116030_bib29","doi-asserted-by":"crossref","first-page":"rbad087","DOI":"10.1093\/rb\/rbad087","article-title":"Mesoporous polydopamine delivery system for intelligent drug release and photothermal-enhanced chemodynamic therapy using MnO2 as gatekeeper","volume":"10","author":"Wang","year":"2023","journal-title":"Regen. Biomater."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116030_bib30","doi-asserted-by":"crossref","first-page":"7350","DOI":"10.1021\/acsnano.4c18099","article-title":"Yeast-inspired orally-administered nanocomposite scavenges oxidative stress and restores gut immune homeostasis for inflammatory bowel disease treatment","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.116030_bib31","doi-asserted-by":"crossref","first-page":"115505","DOI":"10.1016\/j.colsurfb.2026.115505","article-title":"Multifunctional cisplatin-loaded polydopamine\/MnO2 nanomedicine circumvents drug resistant tumor microenvironment for enhanced chemo-photothermal therapy","volume":"262","author":"Cheng","year":"2026","journal-title":"Colloid Surf. B"},{"key":"10.1016\/j.colsurfb.2026.116030_bib32","doi-asserted-by":"crossref","first-page":"121609","DOI":"10.1016\/j.ijpharm.2022.121609","article-title":"Her3-specific affibody mediated tumor targeting delivery of ICG enhanced the photothermal therapy against Her3-positive tumors","volume":"617","author":"Liu","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116030_bib33","doi-asserted-by":"crossref","first-page":"2410630","DOI":"10.1002\/advs.202410630","article-title":"A mitochondria-targeted biomimetic nanomedicine capable of reversing drug resistance in colorectal cancer through mitochondrial dysfunction","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.116030_bib34","doi-asserted-by":"crossref","first-page":"117242","DOI":"10.1016\/j.jphotochem.2026.117242","article-title":"Photocatalytic hydrogen production performance of anatase and brookite TiO2 based on oxygen vacancies and noble metal Pt modification","volume":"479","author":"Liu","year":"2026","journal-title":"J. Photochem. Photobiol. A"},{"key":"10.1016\/j.colsurfb.2026.116030_bib35","doi-asserted-by":"crossref","first-page":"1540750","DOI":"10.1016\/j.ijhydene.2026.154075","article-title":"Heterojunction\/active site co-construction of Mn0.5Cd0.5S\/NiO photocatalyst for boosting H2 evolution and enhanced stability","volume":"218","author":"Wang","year":"2026","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.colsurfb.2026.116030_bib36","doi-asserted-by":"crossref","DOI":"10.31635\/ccschem.026.202607706","article-title":"Multi-phase catalysis for regulating Li2S nucleation and polysulfide dynamics in Li-S batteries","author":"Liu","year":"2026","journal-title":"CCS Chem."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116030_bib37","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3390\/catal16060527","article-title":"Synergistic Pt-Ni cocatalysis on dendritic CdS boosts photocatalytic H2 evolution by promoting charge separation and water dissociation","volume":"16","author":"Niu","year":"2026","journal-title":"Catalysts"},{"issue":"17","key":"10.1016\/j.colsurfb.2026.116030_bib38","doi-asserted-by":"crossref","first-page":"6786","DOI":"10.1039\/D4FO03280B","article-title":"Combination of resveratrol and epirubicin to overcome chemoresistance in lung adenocarcinoma organoids: synergistic effects and translational implications","volume":"16","author":"Liu","year":"2025","journal-title":"Food Funct."},{"key":"10.1016\/j.colsurfb.2026.116030_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/smll.73950","article-title":"Multifunctional manganese-based nanocomposites for enhanced immunotherapy by regulating lactate metabolism and activating the cGAS-STING pathway","author":"Meng","year":"2026","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.116030_bib40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jconrel.2017.03.038","article-title":"Mastocarcinoma therapy synergistically promoted by lysosome dependent apoptosis specifically evoked by 5-Fu@nanogel system with passive targeting and pH activatable dual function","volume":"254","author":"Zhu","year":"2017","journal-title":"J. Control. Release"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526006181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526006181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T13:31:59Z","timestamp":1788528719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526006181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":40,"alternative-id":["S0927776526006181"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116030","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smart nanoplatform targeting the mitochondria-P-gp axis to overcome chemoresistance for synergistic bladder cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116030"}}