{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:15:28Z","timestamp":1788552928741,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104106"],"award-info":[{"award-number":["82104106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073778"],"award-info":[{"award-number":["82073778"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["3332025063"],"award-info":[{"award-number":["3332025063"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"CAMS Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2021-I2M-1-026"],"award-info":[{"award-number":["2021-I2M-1-026"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.colsurfb.2026.116050","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:44:29Z","timestamp":1785944669000},"page":"116050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Moist heat sterilization-resistant hyaluronic acid hydrogels co-crosslinked by ternary metal ions for full-cycle wound care"],"prefix":"10.1016","volume":"268","author":[{"given":"Jinyu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ge","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangshuang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingji","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonggao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-6051","authenticated-orcid":false,"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.116050_bib1","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.actbio.2025.06.023","article-title":"Chitooligosaccharide endowed tunable adhesion to self-gelling powders for rapid hemostasis and sutureless skin wound closure","volume":"201","author":"Peng","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib2","article-title":"Recent development of ZiF-8 incorporated dressings for wound healing application: current insight and future perspective","volume":"46","author":"Zafar","year":"2025","journal-title":"Mater. Today Commun."},{"key":"10.1016\/j.colsurfb.2026.116050_bib3","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1007\/s10904-025-03954-7","article-title":"In vitro and in vivo evaluation of hyaluronic acid\/PVA\/Chitosan Incorporated ZiF-8 hydrogels for wound healing applications","volume":"36","author":"Yasin","year":"2026","journal-title":"J. Inorg. Organomet. Polym."},{"key":"10.1016\/j.colsurfb.2026.116050_bib4","article-title":"Triple cross-linked dynamic responsive hydrogel loaded with selenium nanoparticles for modulating the inflammatory microenvironment via PI3K\/akt\/NF-\u03baB and MAPK signaling pathways","volume":"10","author":"Wang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.116050_bib5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.actbio.2020.11.001","article-title":"Extracellular vesicle-based therapeutics for the regeneration of chronic wounds: current knowledge and future perspectives","volume":"119","author":"Lou","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib6","first-page":"71","article-title":"Trace element-dictated exosome modules and self-adaptive dual-network hydrogel orchestrate diabetic foot regeneration through complement-mitochondria-autophagy circuitry","volume":"12","author":"Wang","year":"2025","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.colsurfb.2026.116050_bib7","article-title":"Recent perspective of chitosan in wound healing approaches \u2013 A review","volume":"47","author":"Khan","year":"2025","journal-title":"Mater. Today Commun."},{"key":"10.1016\/j.colsurfb.2026.116050_bib8","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.actbio.2021.03.057","article-title":"Injectable adaptive self-healing hyaluronic acid\/poly (\u03b3-glutamic acid) hydrogel for cutaneous wound healing","volume":"127","author":"Yang","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib9","doi-asserted-by":"crossref","first-page":"13903","DOI":"10.1021\/jacs.4c01758","article-title":"Biocompatible tough ionogels with reversible supramolecular adhesion","volume":"146","author":"Xiong","year":"2024","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2026.116050_bib10","article-title":"Recent perspective of polymeric biomaterial in tissue engineering\u2013 a review","volume":"34","author":"Khan","year":"2023","journal-title":"Mater. Today Chem."},{"key":"10.1016\/j.colsurfb.2026.116050_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202213368","article-title":"Hybrid shear-thinning hydrogel integrating hyaluronic acid with ROS-responsive nanoparticles","volume":"33","author":"Bezold","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib12","doi-asserted-by":"crossref","DOI":"10.1088\/1758-5090\/ab0b7c","article-title":"Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl","volume":"11","author":"O\u2019Connell","year":"2019","journal-title":"Biofabrication"},{"key":"10.1016\/j.colsurfb.2026.116050_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.actbio.2026.04.018","article-title":"Antimicrobial hydrogels for oral infection management: From molecular design to clinical translation","author":"Mu","year":"2026","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib14","article-title":"Fabrication of gelatin-based and Zn2+-incorporated composite hydrogel for accelerated infected wound healing","volume":"13","author":"Tao","year":"2022","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2026.116050_bib15","article-title":"Facile general injectable gelatin\/metal\/tea polyphenol double nanonetworks remodel wound microenvironment and accelerate healing","volume":"11","author":"Zan","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.116050_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.122658","article-title":"Metal-ion-binding properties of glycyrrhiza polysaccharide extracted from Licorice: Structural characterization and potential application in drug delivery","volume":"346","author":"Yang","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.colsurfb.2026.116050_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3390\/biomedicines14010051","article-title":"ZIF-8 hydrogel-mediated regulation of macrophage phenotype accelerates frostbite wound healing","volume":"14","author":"Lou","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.colsurfb.2026.116050_bib18","article-title":"Environmentally activatable hydrogel for spatiotemporally programmed nitric oxide delivery for diabetic wound healing","volume":"37","author":"Chai","year":"2026","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.colsurfb.2026.116050_bib19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.actbio.2025.09.016","article-title":"Electrosprayed hydrogel microsphere dressing promotes vascularization and accelerates wound healing","volume":"206","author":"Wang","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib20","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1002\/jbm.b.33070","article-title":"Terminal sterilization of alginate hydrogels: efficacy and impact on mechanical properties","volume":"102","author":"Stoppel","year":"2014","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.colsurfb.2026.116050_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103267","article-title":"Chitosan-based self-healing hydrogel dressing for wound healing","volume":"332","author":"Zhang","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116050_bib22","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1080\/09205063.2025.2501094","article-title":"Antibacterial and bioactive composite hydrogels from carrageenan-PVA-chitosan incorporated ZiF-8@GO for wound healing: in vitro and in vivo evaluations","volume":"36","author":"Yasin","year":"2025","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.colsurfb.2026.116050_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.127882","article-title":"Fundamental properties of smart hydrogels for tissue engineering applications: a review","volume":"254","author":"Khan","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.116050_bib24","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1089\/wound.2020.1232","article-title":"Moist wound healing with commonly available dressings","volume":"10","author":"Nuutila","year":"2021","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.colsurfb.2026.116050_bib25","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.cej.2019.01.028","article-title":"Degradable conductive injectable hydrogels as novel antibacterial, anti-oxidant wound dressings for wound healing","volume":"362","author":"Qu","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.116050_bib26","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12951-025-03148-w","article-title":"An antibacterial, antioxidant and hemostatic hydrogel accelerates infectious wound healing","volume":"23","author":"Zhou","year":"2025","journal-title":"J. Nanobiotechnol"},{"key":"10.1016\/j.colsurfb.2026.116050_bib27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1055\/a-1497-9573","article-title":"Iron-driven alterations on red blood cell-derived microvesicles amplify coagulation during hemolysis via the intrinsic tenase complex","volume":"122","author":"Delvasto-N\u00fa\u00f1ez","year":"2022","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.colsurfb.2026.116050_bib28","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1186\/s12967-025-06913-5","article-title":"CD44 signaling in skin wound healing and regeneration","volume":"23","author":"Guan","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.colsurfb.2026.116050_bib29","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1039\/C9BM00155G","article-title":"Hyaluronic acid-based extracellular matrix triggers spontaneous M2-like polarity of monocyte\/macrophage","volume":"7","author":"Kim","year":"2019","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.colsurfb.2026.116050_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2024.112635","article-title":"Experimental and computational study on morin and its complexes with Mg2+, Mn2+, Zn2+, and Al3+: Coordination and antioxidant properties","volume":"258","author":"Abate","year":"2024","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.colsurfb.2026.116050_bib31","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1021\/acs.inorgchem.4c05111","article-title":"The coordination chemistry of two peptidic models of NFeoB and Core CFeoB Regions of FeoB Protein: Complexes of Fe(II), Mn(II), and Zn(II)","volume":"64","author":"Orzel","year":"2025","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.colsurfb.2026.116050_bib32","first-page":"203","article-title":"A Mg2+\/polydopamine composite hydrogel for the acceleration of infected wound healing","volume":"15","author":"Guo","year":"2021","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.colsurfb.2026.116050_bib33","doi-asserted-by":"crossref","first-page":"22355","DOI":"10.1021\/acsnano.3c04556","article-title":"Exudate absorbing and antimicrobial hydrogel integrated with multifunctional curcumin-loaded magnesium polyphenol network for facilitating burn wound healing","volume":"17","author":"Gong","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.116050_bib34","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1186\/s12951-022-01634-z","article-title":"A physicochemical double-cross-linked gelatin hydrogel with enhanced antibacterial and anti-inflammatory capabilities for improving wound healing","volume":"20","author":"Lu","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.116050_bib35","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s12010-019-03022-0","article-title":"Structural modifications and solution behavior of hyaluronic acid degraded with high pH and Temperature","volume":"189","author":"De Melo","year":"2019","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.colsurfb.2026.116050_bib36","article-title":"Tuning stiffness of hyaluronan-cholesterol nanogels by mussel-inspired dopamine-Fe3+ coordination: Preparation and properties evaluation","volume":"280","author":"Wang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.116050_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/mabi.201800047","article-title":"An extracellular matrix-mimicking hydrogel for full thickness wound healing in diabetic mice","volume":"18","author":"Qin","year":"2018","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.colsurfb.2026.116050_bib38","doi-asserted-by":"crossref","first-page":"NP402","DOI":"10.1093\/asj\/sjae032","article-title":"Comparison of hyaluronidase-mediated degradation kinetics of commercially available hyaluronic acid fillers in vitro","volume":"44","author":"Faivre","year":"2024","journal-title":"Aesthet. Surg. J."},{"key":"10.1016\/j.colsurfb.2026.116050_bib39","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1166\/jbn.2013.1637","article-title":"Hemostasis disorders caused by polymer coated iron oxide nanoparticles","volume":"9","author":"Ali","year":"2013","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2026.116050_bib40","doi-asserted-by":"crossref","first-page":"6509","DOI":"10.1166\/jnn.2015.10319","article-title":"Zinc Oxide Nanoparticles Suppress LPS-Induced NF-\u03baB Activation by Inducing A20, a Negative Regulator of NF-\u03baB, in RAW 264.7 Macrophages","volume":"15","author":"Kim","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.colsurfb.2026.116050_bib41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.celrep.2013.01.009","article-title":"ZIP8 regulates host defense through zinc-mediated inhibition of NF-\u03baB","volume":"3","author":"Liu","year":"2013","journal-title":"Cell. Rep."},{"key":"10.1016\/j.colsurfb.2026.116050_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116025","article-title":"An organic state trace element solution for rheumatoid arthritis treatment by modulating macrophage phenotypic from M1 to M2","volume":"170","author":"Wang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2026.116050_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118128","article-title":"Therapeutic effects of zinc oxide nanoparticles encapsulated within chitosan-camphor against hydatid cysts through suppressing oxidative stress, inflammation, and DNA damage","volume":"188","author":"Amirafshari","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2026.116050_bib44","article-title":"Copper Nanocluster-decorated magnesium silicate-based microneedle enhances antimicrobial effects and tissue remodeling for diabetic wounds","volume":"6","author":"Tan","year":"2025","journal-title":"Small Sci."},{"key":"10.1016\/j.colsurfb.2026.116050_bib45","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.actbio.2026.01.046","article-title":"Functionalized layered double hydroxide coatings on biodegradable Zn-Mg alloy enhance osteogenesis via the Wnt\/\u03b2-catenin and PI3K\/Akt signaling pathways","volume":"213","author":"Lu","year":"2026","journal-title":"Acta Biomater."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526006387?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526006387?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:49:07Z","timestamp":1788551347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526006387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":45,"alternative-id":["S0927776526006387"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116050","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Moist heat sterilization-resistant hyaluronic acid hydrogels co-crosslinked by ternary metal ions for full-cycle wound care","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116050"}}