{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:16:06Z","timestamp":1788552966784,"version":"build-2803163510"},"reference-count":153,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004434","name":"University of Florence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100024370","name":"Ministero dell'Istruzione dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.colsurfb.2026.116072","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:05:27Z","timestamp":1786633527000},"page":"116072","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Poly(allylamine)-based carriers for gene and drug delivery: Chemical functionalization, structure-function relationships, and biointerface interactions"],"prefix":"10.1016","volume":"268","author":[{"given":"Francesca","family":"Milano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofia","family":"Zuffi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanchai","family":"Boonla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Andreozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Enrique","family":"Moya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0831-6942","authenticated-orcid":false,"given":"Marco","family":"Marradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.116072_bib1","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1039\/c2cs35094g","article-title":"Cationic polymers and their therapeutic potential","volume":"41","author":"Samal","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib2","first-page":"1","article-title":"Significant role of cationic polymers in drug delivery systems","author":"Farshbaf","year":"2017","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.colsurfb.2026.116072_bib3","first-page":"296","article-title":"Cationic Polymers in Regenerative Medicine","author":"Karewicz","year":"2014"},{"key":"10.1016\/j.colsurfb.2026.116072_bib4","doi-asserted-by":"crossref","first-page":"11527","DOI":"10.1021\/acs.chemrev.0c00997","article-title":"Polymeric Delivery of Therapeutic Nucleic Acids","volume":"121","author":"Kumar","year":"2021","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib5","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.3390\/pharmaceutics15051502","article-title":"Cationic Polymers as Transfection Reagents for Nucleic Acid Delivery","volume":"15","author":"Cai","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2026.116072_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202500029","article-title":"Cationic Polymers for Gene Delivery: Properties and Functional Optimization","volume":"26","author":"Liu","year":"2025","journal-title":"ChemBioChem"},{"key":"10.1016\/j.colsurfb.2026.116072_bib7","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.3390\/nano10071403","article-title":"Polymeric Nanoparticles for Drug Delivery: Recent Developments and Future Prospects","volume":"10","author":"Begines","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.colsurfb.2026.116072_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2019.119358","article-title":"Polymers for cytosolic protein delivery","volume":"218","author":"Lv","year":"2019","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.116072_bib9","doi-asserted-by":"crossref","first-page":"11026","DOI":"10.1039\/C9RA00834A","article-title":"Spermine modified polymeric micelles with pH-sensitive drug release for targeted and enhanced antitumor therapy","volume":"9","author":"Chen","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2026.116072_bib10","doi-asserted-by":"crossref","first-page":"5491","DOI":"10.3390\/ijms20215491","article-title":"The Development of Functional Non-Viral Vectors for Gene Delivery","volume":"20","author":"Patil","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1208\/s12248-021-00608-7","article-title":"Non-viral Vectors in Gene Therapy: Recent Development, Challenges, and Prospects","volume":"23","author":"Zu","year":"2021","journal-title":"AAPS J."},{"key":"10.1016\/j.colsurfb.2026.116072_bib12","doi-asserted-by":"crossref","first-page":"8683","DOI":"10.1021\/la401166v","article-title":"Properties and Evaluation of Quaternized Chitosan\/Lipid Cation Polymeric Liposomes for Cancer-Targeted Gene Delivery","volume":"29","author":"Liang","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib13","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.1039\/C3TB21348J","article-title":"Mitochondrial targeting dendrimer allows efficient and safe gene delivery","volume":"2","author":"Wang","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.colsurfb.2026.116072_bib14","doi-asserted-by":"crossref","first-page":"5106","DOI":"10.1039\/C5NR06757J","article-title":"Low generation polyamine dendrimers bearing flexible tetraethylene glycol as nanocarriers for plasmids and siRNA","volume":"8","author":"Sharma","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.colsurfb.2026.116072_bib15","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1021\/mp5001263","article-title":"Versatile Reticular Polyethylenimine Derivative-Mediated Targeted Drug and Gene Codelivery for Tumor Therapy","volume":"11","author":"Ding","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.126501","article-title":"Advances in metal ion\u2013mediated macromolecular drug delivery","volume":"689","author":"Li","year":"2026","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib17","doi-asserted-by":"crossref","first-page":"16982","DOI":"10.1021\/acsnano.1c04996","article-title":"Lipid Nanoparticles\u2500From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement","volume":"15","author":"Tenchov","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.116072_bib18","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3390\/pharmaceutics16111366","article-title":"The Impact of COVID-19 on RNA Therapeutics: A Surge in Lipid Nanoparticles and Alternative Delivery Systems","volume":"16","author":"Parvin","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2026.116072_bib19","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1021\/acsmaterialsau.3c00032","article-title":"Lipid-Based Nanoparticles for Drug\/Gene Delivery: An Overview of the Production Techniques and Difficulties Encountered in Their Industrial Development","volume":"3","author":"Mehta","year":"2023","journal-title":"ACS Mater. Au"},{"key":"10.1016\/j.colsurfb.2026.116072_bib20","doi-asserted-by":"crossref","first-page":"5505","DOI":"10.1021\/acs.chemrev.3c00705","article-title":"Polymeric Nanoparticles for Drug Delivery","volume":"124","author":"Beach","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib21","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.addr.2006.03.007","article-title":"Current status of polymeric gene delivery systems","volume":"58","author":"Park","year":"2006","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib22","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jconrel.2021.12.030","article-title":"Evolution of drug delivery systems: From 1950 to 2020 and beyond","volume":"342","author":"Park","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib23","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nmat3765","article-title":"Delivery materials for siRNA therapeutics","volume":"12","author":"Kanasty","year":"2013","journal-title":"Nat. Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib24","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.msec.2016.07.066","article-title":"Polyethylenimine: A versatile, multifunctional non-viral vector for nucleic acid delivery","volume":"68","author":"Pandey","year":"2016","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.colsurfb.2026.116072_bib25","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jconrel.2023.09.001","article-title":"Polyethylenimine (PEI) in gene therapy: Current status and clinical applications","volume":"362","author":"Casper","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib26","doi-asserted-by":"crossref","unstructured":"C. Gallops, J. Ziebarth, Y. WangA Polymer Physics Perspective on Why PEI Is an Effective Nonviral Gene Delivery Vector Washington Polymers in Therapeutic Delivery T.FujiwaraX.M.LiuY.OhyaY.Wang2020, 112.","DOI":"10.1021\/bk-2020-1350.ch001"},{"key":"10.1016\/j.colsurfb.2026.116072_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s41061-017-0124-9","article-title":"Degradable Polyethylenimine-Based Gene Carriers for Cancer Therapy","volume":"375","author":"Jiang","year":"2017","journal-title":"Top. Curr. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103119","article-title":"PEI-based functional materials: Fabrication techniques, properties, and biomedical applications","volume":"325","author":"Fattahi","year":"2024","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib29","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3390\/polym17152150","article-title":"Polyethylenimine carriers for drug and gene delivery","volume":"17","author":"Ismail","year":"2025","journal-title":"Polymers"},{"key":"10.1016\/j.colsurfb.2026.116072_bib30","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1080\/10837450.2022.2107014","article-title":"An overview of polyallylamine applications in gene delivery","volume":"27","author":"Gholami","year":"2022","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.colsurfb.2026.116072_bib31","first-page":"1480","article-title":"Synthesis and Thermal Property of Poly(Allylamine Hydrochloride)","volume":"150\u2013151","author":"Zhao","year":"2010","journal-title":"Adv. Mat. Res."},{"key":"10.1016\/j.colsurfb.2026.116072_bib32","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.colsurfa.2015.10.015","article-title":"Determination of polyelectrolyte pKa values using surface-to-air tension measurements","volume":"488","author":"Dickhaus","year":"2016","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib33","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/00037028231213673","article-title":"Determination of the pK a Value of Protonated Mono and Polyamine in Solution Using Fourier Transform Infrared Titration","volume":"78","author":"M\u00fcller","year":"2024","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.colsurfb.2026.116072_bib34","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jcis.2019.02.040","article-title":"Mechanistic study of the nucleation and conformational changes of polyamines in presence of phosphate ions","volume":"543","author":"Andreozzi","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib35","doi-asserted-by":"crossref","first-page":"14300","DOI":"10.1021\/acs.langmuir.9b02636","article-title":"Polyphosphate Poly(amine) Nanoparticles: Self-Assembly, Thermodynamics, and Stability Studies","volume":"35","author":"Cuenca","year":"2019","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib36","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jcis.2024.04.185","article-title":"Supramolecular citrate poly allylamine hydrochloride nanoparticles for citrate delivery and calcium oxalate nanocrystal dissolution","volume":"669","author":"Gianvincenzo","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib37","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00396-010-2255-1","article-title":"Self-assembly of poly(allylamine hydrochloride) through electrostatic interaction with sodium dodecyl sulfate","volume":"288","author":"Yoshida","year":"2010","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib38","doi-asserted-by":"crossref","first-page":"6265","DOI":"10.1021\/la204782x","article-title":"Green Amorphous Nanoplex as a New Supersaturating Drug Delivery System","volume":"28","author":"Cheow","year":"2012","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib39","doi-asserted-by":"crossref","first-page":"4714","DOI":"10.1021\/acsabm.3c00489","article-title":"Poly(allylamine)-tripolyphosphate Ionic Assemblies as Nanocarriers: Friend or Foe?","volume":"6","author":"Apuzzo","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib40","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.jcis.2019.09.082","article-title":"Self-assembly of poly(allylamine)\/siRNA nanoparticles, their intracellular fate and siRNA delivery","volume":"557","author":"Di Silvio","year":"2019","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110550","article-title":"Preparation of curcumin-poly (allyl amine) hydrochloride based nanocapsules: Piperine in nanocapsules accelerates encapsulation and release of curcumin and effectiveness against colon cancer cells","volume":"109","author":"Slika","year":"2020","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.colsurfb.2026.116072_bib42","doi-asserted-by":"crossref","first-page":"8130","DOI":"10.1039\/C7RA12862B","article-title":"Novel morphologies of poly(allyamine hydrochloride)\u2013methotrexate nanoassemblies for methotrexate delivery","volume":"8","author":"Wang","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2026.116072_bib43","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1002\/pat.5230","article-title":"pH-sensitive polymers: Classification and some fine potential applications","volume":"32","author":"Ofridam","year":"2021","journal-title":"Polym. Adv. Technol."},{"key":"10.1016\/j.colsurfb.2026.116072_bib44","doi-asserted-by":"crossref","first-page":"38242","DOI":"10.1021\/acsami.7b11132","article-title":"Exploring the pH Sensitivity of Poly(allylamine) Phosphate Supramolecular Nanocarriers for Intracellular siRNA Delivery","volume":"9","author":"Andreozzi","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.116072_bib45","doi-asserted-by":"crossref","first-page":"9454","DOI":"10.1039\/c1jm10712g","article-title":"Polyamine\u2013salt aggregate assembly of capsules as responsive drug delivery vehicles","volume":"21","author":"Bagaria","year":"2011","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib46","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1021\/nl080877c","article-title":"Templated Synthesis of Single-Component Polymer Capsules and Their Application in Drug Delivery","volume":"8","author":"Wang","year":"2008","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2026.116072_bib47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.jcis.2017.02.029","article-title":"Non-covalent assembly of poly(allylamine hydrochloride)\/triethylamine microcapsules with ionic strength-responsiveness and auto-fluorescence","volume":"496","author":"Li","year":"2017","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib48","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.addr.2011.05.011","article-title":"Introduction to nanocoatings produced by layer-by-layer (LbL) self-assembly","volume":"63","author":"de Villiers","year":"2011","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib49","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jconrel.2012.12.033","article-title":"Stimuli-sensitive layer-by-layer (LbL) self-assembly systems: Targeting and biosensory applications","volume":"166","author":"Deshmukh","year":"2013","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib50","doi-asserted-by":"crossref","first-page":"14828","DOI":"10.1021\/acs.chemrev.6b00627","article-title":"Innovation in Layer-by-Layer Assembly","volume":"116","author":"Richardson","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib51","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1021\/acs.chemrev.5b00369","article-title":"Supramolecular Polymers in Aqueous Media","volume":"116","author":"Krieg","year":"2016","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib52","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1021\/acsabm.2c00845","article-title":"Self-Assembled Oleic Acid-Modified Polyallylamines for Improved siRNA Transfection Efficiency and Lower Cytotoxicity","volume":"6","author":"Salvador","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib53","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1021\/acsami.3c13121","article-title":"Enhancement of the Photosensitizing Properties of 6-Carboxypterin through Covalent Binding to the pH-Responsive and Biocompatible Poly(allylamine Hydrochloride)","volume":"16","author":"Armijos-Capa","year":"2024","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.116072_bib54","doi-asserted-by":"crossref","first-page":"4194","DOI":"10.1016\/j.biomaterials.2010.01.116","article-title":"Polycation\/DNA complexes coated with oligonucleotides for gene delivery","volume":"31","author":"Chung","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.116072_bib55","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1039\/c3md00374d","article-title":"New arginine substituted derivative of poly(allylamine hydrochloride) for heparin reversal","volume":"5","author":"Kami\u0144ski","year":"2014","journal-title":"Medchemcomm"},{"key":"10.1016\/j.colsurfb.2026.116072_bib56","doi-asserted-by":"crossref","first-page":"12569","DOI":"10.1021\/acsapm.5c02380","article-title":"Light-Controlled Release of Water-Soluble Photosensitizers from a Biocompatible Polymer Based on Polyallylamine Functionalized with Folic Acid","volume":"7","author":"Armijos-Capa","year":"2025","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib57","first-page":"111","article-title":"Preparation, characterization and transfection efficiency of nanoparticles composed of alkane-modified polyallylamine","volume":"2","author":"Oskuee","year":"2015","journal-title":"Nanomed. J."},{"key":"10.1016\/j.colsurfb.2026.116072_bib58","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.msec.2015.01.016","article-title":"A simple approach for producing highly efficient DNA carriers with reduced toxicity based on modified polyallylamine","volume":"49","author":"Oskuee","year":"2015","journal-title":"Mat. Sci. Eng. C."},{"key":"10.1016\/j.colsurfb.2026.116072_bib59","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.jcis.2024.12.074","article-title":"Supramolecular dextran\/polyamine phosphate nanocapsules with smart responsiveness for encapsulation of therapeutics","volume":"683","author":"Steff\u00e8","year":"2025","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib60","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/app.29440","article-title":"Guanidinylated poly(allyl amine) as a gene carrier","volume":"112","author":"Yu","year":"2009","journal-title":"J. Appl. Polym. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib61","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1163\/092050610X528543","article-title":"PEGylated Guanidinylated Polyallylamine as Gene-Delivery Carrier","volume":"22","author":"Chung","year":"2011","journal-title":"J. Biomater. Sci. Polym. Ed."},{"key":"10.1016\/j.colsurfb.2026.116072_bib62","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/pola.26017","article-title":"Tetramethylguanidinium-polyallylamine (Tmg-PA): A new class of nonviral vector for efficient gene transfection","volume":"50","author":"Mahato","year":"2012","journal-title":"J. Polym. Sci. A Polym. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib63","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1021\/bc9900439","article-title":"Synthesis of Polyallylamine Derivatives and Their Use as Gene Transfer Vectors in Vitro","volume":"10","author":"Boussif","year":"1999","journal-title":"Bioconjug. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib64","article-title":"Novel Core\u2013Shell Polyamine Phosphate Nanoparticles Self-Assembled from PEGylated Poly(allylamine hydrochloride) with Low Toxicity and Increased In Vivo Circulation Time","volume":"17","author":"Andreozzi","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.116072_bib65","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1007\/s11095-007-9259-7","article-title":"Engineered Polyallylamine Nanoparticles for Efficient In Vitro Transfection","volume":"24","author":"Pathak","year":"2007","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2026.116072_bib66","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1007\/s00396-008-1925-8","article-title":"The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine)","volume":"286","author":"Thompson","year":"2008","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib67","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/macp.201200130","article-title":"Superoxide Dismutase Binding and Release Behaviors of Dodecylated Poly(allylamine)s: Effects of Self-Aggregation and Organic Solvents","volume":"213","author":"Yan","year":"2012","journal-title":"Macromol. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2026.116072_bib68","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/btpr.1799","article-title":"Cholic acid modified 2 kDa polyethylenimine as efficient transfection agent","volume":"29","author":"Dube","year":"2013","journal-title":"Biotechnol. Prog."},{"key":"10.1016\/j.colsurfb.2026.116072_bib69","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902017000300140","article-title":"Cholesterol improves the transfection efficiency of polyallylamine as a non-viral gene delivery vector","volume":"53","author":"Oskuee","year":"2017","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib70","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.jconrel.2010.07.128","article-title":"In vitro and in vivo characterisation of a novel peptide delivery system: Amphiphilic polyelectrolyte\u2013salmon calcitonin nanocomplexes","volume":"147","author":"Cheng","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib71","doi-asserted-by":"crossref","first-page":"139","DOI":"10.15171\/bi.2017.17","article-title":"The effect of cell penetrating peptides on transfection activity and cytotoxicity of polyallylamine","volume":"7","author":"Sabouri-Rad","year":"2017","journal-title":"BioImpacts"},{"key":"10.1016\/j.colsurfb.2026.116072_bib72","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1021\/bm3004786","article-title":"Effect of Thiol Pendant Conjugates on Plasmid DNA Binding, Release, and Stability of Polymeric Delivery Vectors","volume":"13","author":"Bacalocostantis","year":"2012","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2026.116072_bib73","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1016\/j.xphs.2020.06.018","article-title":"Effect of Poly(allylamine) Molecular Weight on Drug Loading and Release Abilities of Nano-Aggregates for Potential in Cancer Nanomedicine","volume":"109","author":"Al Ameri","year":"2020","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib74","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1773-2247(09)50084-6","article-title":"The efflux pump inhibitory properties of (thiolated) polyallylamines","volume":"19","author":"Vigl","year":"2009","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2026.116072_bib75","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijpharm.2015.12.036","article-title":"Comparison of the mucoadhesive properties of thiolated polyacrylic acid to thiolated polyallylamine","volume":"498","author":"Duggan","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib76","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1007\/s00396-015-3561-4","article-title":"Synthesis, characterisation and in vitro evaluation of novel thiolated derivatives of polyallylamine and quaternised polyallylamine","volume":"293","author":"Ibie","year":"2015","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.213184","article-title":"Redox responsive poly(allylamine)\/eudragit S-100 nanoparticles for dual drug delivery in colorectal cancer","volume":"143","author":"Gupta","year":"2022","journal-title":"Biomater. Adv."},{"key":"10.1016\/j.colsurfb.2026.116072_bib78","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1021\/acs.analchem.7b04511","article-title":"Phasor\u2013Fluorescence Lifetime Imaging Microscopy Analysis to Monitor Intercellular Drug Release from a pH-Sensitive Polymeric Nanocarrier","volume":"90","author":"Zhou","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib79","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1021\/acs.biomac.8b01704","article-title":"Glycopolycation\u2013DNA Polyplex Formulation N\/P Ratio Affects Stability, Hemocompatibility, and in Vivo Biodistribution","volume":"20","author":"Phillips","year":"2019","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.colsurfb.2026.116072_bib80","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1006\/bioo.1994.1025","article-title":"Ionization of Poly(ethylenimine) and Poly(allylamine) at Various pH\u2032s","volume":"22","author":"Suh","year":"1994","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib81","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1002\/jgm.696","article-title":"Exploring polyethylenimine-mediated DNA transfection and the proton sponge hypothesis","volume":"7","author":"Akinc","year":"2005","journal-title":"J. Gene Med."},{"key":"10.1016\/j.colsurfb.2026.116072_bib82","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrd1775","article-title":"Design and development of polymers for gene delivery","volume":"4","author":"Pack","year":"2005","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.colsurfb.2026.116072_bib83","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13036-022-00298-5","article-title":"Dendrimer-based drug delivery systems: history, challenges, and latest developments","volume":"16","author":"Wang","year":"2022","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.colsurfb.2026.116072_bib84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.apmt.2018.05.002","article-title":"PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy","volume":"12","author":"Abedi-Gaballu","year":"2018","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.colsurfb.2026.116072_bib85","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.ymthe.2004.12.006","article-title":"Formation and Intracellular Trafficking of Lipoplexes and Polyplexes","volume":"11","author":"Elouahabi","year":"2005","journal-title":"Mol. Ther."},{"key":"10.1016\/j.colsurfb.2026.116072_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125424","article-title":"Exploring the promise of lipoplexes: From concept to clinical applications","volume":"674","author":"Al-Shihabi","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib87","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.ymthe.2017.03.013","article-title":"Lipid Nanoparticle Systems for Enabling Gene Therapies","volume":"25","author":"Cullis","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.colsurfb.2026.116072_bib88","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/s41573-024-00977-6","article-title":"The 60-year evolution of lipid nanoparticles for nucleic acid delivery","volume":"23","author":"Cullis","year":"2024","journal-title":"Nat. Rev. Drug. Discov."},{"key":"10.1016\/j.colsurfb.2026.116072_bib89","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib90","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1089\/nat.2018.0721","article-title":"Lipid Nanoparticles Enabling Gene Therapies: From Concepts to Clinical Utility","volume":"28","author":"Kulkarni","year":"2018","journal-title":"Nucleic Acid. Ther."},{"key":"10.1016\/j.colsurfb.2026.116072_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121806","article-title":"The influence of poly(allylamine hydrochloride) hydrogel crosslinking density on its thermal and phosphate binding properties","volume":"621","author":"Elsiddig","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib92","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/10717544.2017.1388451","article-title":"Cleavable PEGylation: a strategy for overcoming the \u201cPEG dilemma\u201d in efficient drug delivery","volume":"24","author":"Fang","year":"2017","journal-title":"Drug. Deliv."},{"key":"10.1016\/j.colsurfb.2026.116072_bib93","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jconrel.2022.09.031","article-title":"Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products","volume":"351","author":"Ibrahim","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib94","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/sj.gt.3300503","article-title":"ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo","volume":"4","author":"Ferrari","year":"1997","journal-title":"Gene Ther."},{"key":"10.1016\/j.colsurfb.2026.116072_bib95","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s11095-011-0602-7","article-title":"The Use of Nano Polymeric Self-Assemblies Based on Novel Amphiphilic Polymers for Oral Hydrophobic Drug Delivery","volume":"29","author":"Clare","year":"2012","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2026.116072_bib96","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ijpharm.2009.04.014","article-title":"The complexation between novel comb shaped amphiphilic polyallylamine and insulin\u2014Towards oral insulin delivery","volume":"376","author":"Thompson","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib97","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s11095-010-0345-x","article-title":"Uptake and Transport of Novel Amphiphilic Polyelectrolyte-Insulin Nanocomplexes by Caco-2 Cells\u2014Towards Oral Insulin","volume":"28","author":"Thompson","year":"2011","journal-title":"Pharm. Res."},{"key":"10.1016\/j.colsurfb.2026.116072_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2021.126592","article-title":"Mesoporous silica nanoparticles with surface transformation ability for prostate cancer treatment","volume":"621","author":"Liu","year":"2021","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib99","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1039\/C5CS00781J","article-title":"Layer-by-layer assembly of versatile nanoarchitectures with diverse dimensionality: a new perspective for rational construction of multilayer assemblies","volume":"45","author":"Xiao","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib100","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1039\/c2cs35088b","article-title":"Layer-by-layer assembly of microcapsules and their biomedical applications","volume":"41","author":"Tong","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib101","doi-asserted-by":"crossref","first-page":"8883","DOI":"10.1021\/cr400531v","article-title":"Molecular Interactions Driving the Layer-by-Layer Assembly of Multilayers","volume":"114","author":"Borges","year":"2014","journal-title":"Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cis.2018.11.003","article-title":"Layer-by-layer adsorption: Factors affecting the choice of substrates and polymers","volume":"262","author":"Elizarova","year":"2018","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib103","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0040-6090(92)90417-A","article-title":"Buildup of ultrathin multilayer films by a self-assembly process: III. Consecutively alternating adsorption of anionic and cationic polyelectrolytes on charged surfaces","author":"Decher","year":"1992","journal-title":"Thin Solid. Films"},{"key":"10.1016\/j.colsurfb.2026.116072_bib104","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1021\/la00026a020","article-title":"Assembly, structural characterization, and thermal behavior of layer-by-layer deposited ultrathin films of poly(vinyl sulfate) and poly(allylamine)","volume":"9","author":"Lvov","year":"1993","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib105","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1126\/science.277.5330.1232","article-title":"Fuzzy Nanoassemblies: Toward Layered Polymeric Multicomposites","volume":"277","author":"Decher","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.colsurfb.2026.116072_bib106","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/0040-6090(94)90569-X","article-title":"Proof of multilayer structural organization in self-assembled polycation-polyanion molecular films","volume":"244","author":"Decher","year":"1994","journal-title":"Thin Solid. Films"},{"key":"10.1016\/j.colsurfb.2026.116072_bib107","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1002\/adma.200600113","article-title":"Biomedical Applications of Layer-by-Layer Assembly: From Biomimetics to Tissue Engineering","volume":"18","author":"Tang","year":"2006","journal-title":"Adv. Mat."},{"key":"10.1016\/j.colsurfb.2026.116072_bib108","article-title":"Biomedical Applications of Layer-by-Layer Self-Assembly for Cell Encapsulation: Current Status and Future Perspectives","volume":"8","author":"Liu","year":"2019","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib109","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1002\/adma.201103698","article-title":"Layer-by-Layer Assembly Through Weak Interactions and Their Biomedical Applications","volume":"24","author":"Matsusaki","year":"2012","journal-title":"Adv. Mat."},{"key":"10.1016\/j.colsurfb.2026.116072_bib110","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/26\/42\/422001","article-title":"Layer-by-layer assembly for biomedical applications in the last decade","volume":"26","author":"Gentile","year":"2015","journal-title":"Nanotechnology"},{"key":"10.1016\/j.colsurfb.2026.116072_bib111","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.addr.2011.03.010","article-title":"Stimuli-responsive LbL capsules and nanoshells for drug delivery","volume":"63","author":"Delcea","year":"2011","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.colsurfb.2026.116072_bib112","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jconrel.2011.08.035","article-title":"Responsive layer-by-layer materials for drug delivery","volume":"158","author":"Wohl","year":"2012","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib113","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsadv.2021.100068","article-title":"Towards a new class of stimuli-responsive polymer-based materials \u2013 Recent advances and challenges","volume":"4","author":"Bratek-Skicki","year":"2021","journal-title":"Appl. Surf. Sci. Adv."},{"key":"10.1016\/j.colsurfb.2026.116072_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2020.102200","article-title":"Weak polyelectrolyte-based multilayers via layer-by-layer assembly: Approaches, properties, and applications","volume":"282","author":"Yuan","year":"2020","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib115","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1351\/pac200476071387","article-title":"Controlling the physicochemical properties of weak polyelectrolyte multilayer films through acid\/base equilibria","volume":"76","author":"Burke","year":"2004","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib116","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1021\/nl0490826","article-title":"From Functional Core\/Shell Nanoparticles Prepared via Layer-by-Layer Deposition to Empty Nanospheres","volume":"4","author":"Schneider","year":"2004","journal-title":"Nano Lett."},{"key":"10.1016\/j.colsurfb.2026.116072_bib117","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1021\/la047629q","article-title":"Magnetic Switch of Permeability for Polyelectrolyte Microcapsules Embedded with Co@Au Nanoparticles","volume":"21","author":"Lu","year":"2005","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib118","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.colsurfb.2011.01.029","article-title":"A facile route to synthesize silver nanoparticles in polyelectrolyte capsules","volume":"84","author":"Anandhakumar","year":"2011","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2026.116072_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123749","article-title":"Co-encapsulation and release of apigenin and ascorbic acid in polyelectrolyte multilayer capsules for targeted polycystic ovary syndrome","volume":"651","author":"Nehru","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2022.129385","article-title":"Biocompatible hydroxyapatite nanoparticles as templates for the preparation of thin film polyelectrolyte multilayer nanocapsules","volume":"648","author":"Kla\u010di\u0107","year":"2022","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib121","doi-asserted-by":"crossref","DOI":"10.1002\/cphc.202300758","article-title":"Physicochemical Features and Applicability of Newly Fabricated Phytopharmaceutical-Loaded Hydrogel Alginate Microcarriers with Viscoelastic Polyelectrolyte Coatings","volume":"25","author":"Szcz\u0119sna-G\u00f3rniak","year":"2024","journal-title":"ChemPhysChem"},{"key":"10.1016\/j.colsurfb.2026.116072_bib122","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.msec.2012.07.006","article-title":"Silver nanoparticles modified nanocapsules for ultrasonically activated drug delivery","volume":"32","author":"Anandhakumar","year":"2012","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.colsurfb.2026.116072_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124638","article-title":"Incorporation of CuS nanorods in polyelectrolyte multilayer microcapsules improved cancer cell cytotoxicity and signal intensity in ultrasound imaging","volume":"664","author":"Ramamoorthy","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib124","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2020.125461","article-title":"N6L-functionalized nanoparticles for targeted and inhibited pancreatic cancer cells","volume":"607","author":"Belbekhouche","year":"2020","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib125","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2019.110022","article-title":"Sonication-assisted Layer-by-Layer self-assembly nanoparticles for resveratrol delivery","volume":"105","author":"Santos","year":"2019","journal-title":"Mater. Sci. Eng. C."},{"key":"10.1016\/j.colsurfb.2026.116072_bib126","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijpharm.2006.03.050","article-title":"Novel polyallylamine\u2013dextran sulfate\u2013DNA nanoplexes: Highly efficient non-viral vector for gene delivery","volume":"320","author":"Nimesh","year":"2006","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib127","doi-asserted-by":"crossref","first-page":"9767","DOI":"10.1021\/la801274z","article-title":"Multilayer Assembly of Hyaluronic Acid\/Poly(allylamine): Control of the Buildup for the Production of Hollow Capsules","volume":"24","author":"Szarpak","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib128","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.colsurfb.2012.07.025","article-title":"Designing carboxymethyl cellulose based layer-by-layer capsules as a carrier for protein delivery","volume":"101","author":"Tripathy","year":"2013","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2026.116072_bib129","doi-asserted-by":"crossref","DOI":"10.1155\/sci5\/8259470","article-title":"Combating Methotrexate Resistance in Cancer Treatment: A Review on Navigating Pathways and Enhancing Its Efficacy With Fat-Soluble Vitamins","volume":"2025","author":"Kakkadath","year":"2025","journal-title":"Scientifica"},{"key":"10.1016\/j.colsurfb.2026.116072_bib130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/jbm.a.36526","article-title":"Poly-allylamine hydrochloride and fucoidan-based self-assembled polyelectrolyte complex nanoparticles for cancer therapeutics","volume":"107","author":"Wang","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2026.116072_bib131","doi-asserted-by":"crossref","first-page":"11972","DOI":"10.1021\/acsami.5b02002","article-title":"Sonication-Assisted Layer-by-Layer Assembly for Low Solubility Drug Nanoformulation","volume":"7","author":"Santos","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.116072_bib132","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.colsurfa.2005.05.017","article-title":"(PAH\/PSS)5 microcapsules templated on silica core: Encapsulation of anticancer drug DOX and controlled release study","volume":"264","author":"Yang","year":"2005","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib133","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00396-022-04969-z","article-title":"Preparation of polyelectrolyte complex nanoparticles with tunable and narrow size distributions by template polymerization","volume":"300","author":"Choudhuri","year":"2022","journal-title":"Colloid Polym. Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2021.126210","article-title":"Tailored gentamicin release from silica nanocarriers coated with polyelectrolyte multilayers","volume":"614","author":"Al Thaher","year":"2021","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2023.132671","article-title":"pH-responsive LBL coated silica nanocarriers for controlled release of chlorhexidine","volume":"680","author":"Al Thaher","year":"2024","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib136","doi-asserted-by":"crossref","first-page":"8328","DOI":"10.1021\/la401423d","article-title":"Robust and Flexible Free-Standing Films for Unidirectional Drug Delivery","volume":"29","author":"Chen","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib137","doi-asserted-by":"crossref","first-page":"7990","DOI":"10.1021\/la9004664","article-title":"Layer-by-Layer Deposition of Polymeric Microgel Films on Surgical Sutures for Loading and Release of Ibuprofen","volume":"25","author":"Wang","year":"2009","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib138","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1021\/la7031048","article-title":"Layer-by-Layer Assembled Microgel Films with High Loading Capacity: Reversible Loading and Release of Dyes and Nanoparticles","volume":"24","author":"Wang","year":"2008","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib139","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.ijbiomac.2014.08.003","article-title":"The crosslinking of polysaccharides with polyamines and dextran\u2013polyallylamine antibacterial hydrogels","volume":"72","author":"O\u2019Connor","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.116072_bib140","doi-asserted-by":"crossref","first-page":"8533","DOI":"10.1021\/acsapm.3c01663","article-title":"Exploring the Mechanical and Chemical Properties of Cross-Linked Poly(allylamine)-hyaluronic Acid Multilayer Films Using a Chemometric Unmixing Approach","volume":"5","author":"Ekrami","year":"2023","journal-title":"ACS Appl. Polym. Mater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib141","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2008.03.012","article-title":"Control of burst release from nanogels via layer by layer assembly","volume":"128","author":"Tan","year":"2008","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116072_bib142","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1016\/j.polymer.2013.06.002","article-title":"Layer-by-layer assembled highly adhesive microgel films","volume":"54","author":"Zhang","year":"2013","journal-title":"Polymer"},{"key":"10.1016\/j.colsurfb.2026.116072_bib143","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1039\/b807514j","article-title":"Poly(allylamine hydrochloride)\u2013dextran microgels functionalized with magnetic and luminescent nanoparticles","volume":"18","author":"Wang","year":"2008","journal-title":"J. Mater. Chem."},{"key":"10.1016\/j.colsurfb.2026.116072_bib144","doi-asserted-by":"crossref","first-page":"8864","DOI":"10.1016\/j.actbio.2013.06.012","article-title":"Polyelectrolyte\/silver nanocomposite multilayer films as multifunctional thin film platforms for remote activated protein and drug delivery","volume":"9","author":"Anandhakumar","year":"2013","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116072_bib145","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ijpharm.2013.09.036","article-title":"Laser receptive polyelectrolyte thin films doped with biosynthesized silver nanoparticles for antibacterial coatings and drug delivery applications","volume":"457","author":"Sripriya","year":"2013","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116072_bib146","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2021.112258","article-title":"Dextran-based polyelectrolyte multilayers: Effect of charge density on film build-up and morphology","volume":"210","author":"Delvart","year":"2022","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"10.1016\/j.colsurfb.2026.116072_bib147","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.3390\/ma14092361","article-title":"Tuning the Surface Properties of Poly(Allylamine Hydrochloride)-Based Multilayer Films","volume":"14","author":"Ciejka","year":"2021","journal-title":"Materials"},{"key":"10.1016\/j.colsurfb.2026.116072_bib148","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1016\/j.electacta.2008.02.036","article-title":"Covalently attached metalloporphyrins in LBL self-assembled redox polyelectrolyte thin films","volume":"53","author":"Carballo","year":"2008","journal-title":"Electrochim. Acta"},{"key":"10.1016\/j.colsurfb.2026.116072_bib149","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.colsurfa.2006.04.031","article-title":"Layer-by-layer assembly of PA-EDTA\/PAH multilayer films and their potential-switchable electrochemistry","volume":"289","author":"Zheng","year":"2006","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116072_bib150","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1208\/s12249-025-03323-0","article-title":"The PAH-AM-PEG-ApoE@siRNA Nanocarrier Delivery System for Polo-like Kinase 1 Inhibition Suppresses Glioma Progression","volume":"27","author":"Su","year":"2026","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.colsurfb.2026.116072_bib151","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jcis.2023.04.136","article-title":"Assembly and recognition mechanisms of glycosylated PEGylated polyallylamine phosphate nanoparticles: A fluorescence correlation spectroscopy and small angle X-ray scattering study","volume":"645","author":"Perez Schmidt","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116072_bib152","doi-asserted-by":"crossref","first-page":"7751","DOI":"10.1021\/acs.langmuir.7b01909","article-title":"Protein Adsorption to Charged Gold Nanospheres as a Function of Protein Deformability","volume":"33","author":"Dennison","year":"2017","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116072_bib153","doi-asserted-by":"crossref","first-page":"10514","DOI":"10.1021\/acs.chemmater.4c01767","article-title":"Synthesis and Evaluation of Polymer-Drug Conjugates as Potential Antioxidants and Cholinesterase Inhibitors for Neurodegenerative Diseases","volume":"36","author":"Mahadik","year":"2024","journal-title":"Chem. Mater."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526006600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526006600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:53:27Z","timestamp":1788551607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526006600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":153,"alternative-id":["S0927776526006600"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116072","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Poly(allylamine)-based carriers for gene and drug delivery: Chemical functionalization, structure-function relationships, and biointerface interactions","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116072","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116072"}}