{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:15:37Z","timestamp":1788552937825,"version":"build-2803163510"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004772","name":"Natural Science Foundation of Ningxia Province","doi-asserted-by":"publisher","award":["2024AAC03731"],"award-info":[{"award-number":["2024AAC03731"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.colsurfb.2026.116094","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:42:02Z","timestamp":1786981322000},"page":"116094","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Mannose-based VZV-gE protein self-adjuvanted hydrogel vaccine enhances immune response"],"prefix":"10.1016","volume":"268","author":[{"given":"Yuqin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5838-3257","authenticated-orcid":false,"given":"Jianhong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.colsurfb.2026.116094_bib1","article-title":"Vaccines for preventing herpes zoster in older adults","volume":"10","author":"de Oliveira Gomes","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.colsurfb.2026.116094_bib2","doi-asserted-by":"crossref","first-page":"k5095","DOI":"10.1136\/bmj.k5095","article-title":"Herpes zoster infection","volume":"364","author":"Le","year":"2019","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116094_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/papr.13423","article-title":"Herpes zoster and post herpetic neuralgia","volume":"25","author":"Adriaansen","year":"2024","journal-title":"Pain. Pract."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116094_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11916-016-0548-x","article-title":"Post-herpetic neuralgia: a review","volume":"20","author":"Hadley","year":"2016","journal-title":"Curr. Pain. Headache Rep."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.116094_bib5","doi-asserted-by":"crossref","first-page":"e3210","DOI":"10.1093\/cid\/ciaa1185","article-title":"Herpes zoster and postherpetic neuralgia: changing incidence rates From 1994 to 2018 in the United States","volume":"73","author":"Thompson","year":"2021","journal-title":"Clin. Infect. Dis."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116094_bib6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s40259-016-0180-7","article-title":"Shingles (herpes zoster) vaccine (Zostavax (R)): a review in the prevention of herpes zoster and postherpetic neuralgia","volume":"30","author":"Keating","year":"2016","journal-title":"BioDrugs"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116094_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.nwh.2018.07.004","article-title":"Recombinant zoster vaccine (Shingrix) to prevent herpes zoster","volume":"22","author":"Sly","year":"2018","journal-title":"Nurs. Women\u2019s. Health"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116094_bib8","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/1060028018758431","article-title":"Shingrix: the new adjuvanted recombinant herpes zoster vaccine","volume":"52","author":"James","year":"2018","journal-title":"Ann. Pharmacother."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116094_bib9","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s40266-018-0603-x","article-title":"Recombinant zoster vaccine (Shingrix (R)): a review in herpes zoster","volume":"35","author":"Syed","year":"2018","journal-title":"Drugs Aging"},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116094_bib10","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1039\/C7MD00158D","article-title":"Applications and perspectives of nanomaterials in novel vaccine development","volume":"9","author":"Shen","year":"2017","journal-title":"Medchemcomm"},{"issue":"8","key":"10.1016\/j.colsurfb.2026.116094_bib11","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1080\/21645515.2017.1321725","article-title":"Use of adjuvants for immunotherapy","volume":"13","author":"Circelli","year":"2017","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.colsurfb.2026.116094_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-0716-1892-9_8","article-title":"Developments in vaccine adjuvants","volume":"2412","author":"Firdaus","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"17","key":"10.1016\/j.colsurfb.2026.116094_bib13","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1039\/D3TB02861E","article-title":"Vaccine adjuvants: current status, research and development, licensing, and future opportunities","volume":"12","author":"Cui","year":"2024","journal-title":"J. Mater. Chem. B"},{"issue":"79","key":"10.1016\/j.colsurfb.2026.116094_bib14","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2012.0536","article-title":"Applications of polymeric adjuvants in studying autoimmune responses and vaccination against infectious diseases","volume":"10","author":"Shakya","year":"2013","journal-title":"J. R. Soc. Interface"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116094_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/gels3030025","article-title":"Polymeric hydrogels as technology platform for drug delivery applications","volume":"3","author":"Sosnik","year":"2017","journal-title":"Gels"},{"issue":"9-10","key":"10.1016\/j.colsurfb.2026.116094_bib16","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1002\/mabi.200700035","article-title":"Preparation and properties of novel hydrogels from oxidized konjac glucomannan cross-linked chitosan for in vitro drug delivery","volume":"7","author":"Yu","year":"2007","journal-title":"Macromol. Biosci."},{"key":"10.1016\/j.colsurfb.2026.116094_bib17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jconrel.2022.09.038","article-title":"Mannose in vaccine delivery","volume":"351","author":"Nahar","year":"2022","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116094_bib18","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3390\/ijms25031370","article-title":"Mannose ligands for mannose receptor targeting","volume":"25","author":"Paurevi\u0107","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116094_bib19","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1039\/D4RA08406C","article-title":"Chitosan immunomodulation: insights into mechanisms of action on immune cells and signaling pathways","volume":"15","author":"Ghattas","year":"2025","journal-title":"RSC Adv."},{"issue":"17","key":"10.1016\/j.colsurfb.2026.116094_bib20","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.2174\/1381612829666230524153002","article-title":"Biomedical application of chitosan and chitosan derivatives: a comprehensive review","volume":"29","author":"Kankariya","year":"2023","journal-title":"Curr. Pharm. Des."},{"issue":"11","key":"10.1016\/j.colsurfb.2026.116094_bib21","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/jbm.a.37203","article-title":"Modulation of injectable hydrogel properties for slow co-delivery of influenza subunit vaccine components enhance the potency of humoral immunity","volume":"109","author":"Saouaf","year":"2021","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.colsurfb.2026.116094_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123819","article-title":"In-situ gel: a smart carrier for drug delivery","volume":"652","author":"Garg","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.116094_bib23","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/vaccines12101111","article-title":"Structures of the varicella zoster virus glycoprotein e and epitope mapping of vaccine-elicited antibodies","volume":"12","author":"Harshbarger","year":"2024","journal-title":"Vaccin. (Basel)"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116094_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/rmv.362","article-title":"Varicella-zoster virus latency in human ganglia","volume":"12","author":"Kennedy","year":"2002","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.colsurfb.2026.116094_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1088130","article-title":"Subunit vaccines for Acinetobacter baumannii","volume":"13","author":"Yang","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116094_bib26","article-title":"Developing next-generation protein-based vaccines using high-affinity glycan ligand-decorated glyconanoparticles","volume":"10","author":"Gao","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116094_bib27","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1021\/acs.nanolett.9b00030","article-title":"Targeted codelivery of an antigen and dual agonists by hybrid nanoparticles for enhanced cancer immunotherapy","volume":"19","author":"Zhang","year":"2019","journal-title":"Nano Lett."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116094_bib28","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1038\/s41467-024-49546-w","article-title":"A cocktail nanovaccine targeting key entry glycoproteins elicits high neutralizing antibody levels against EBV infection","volume":"15","author":"Zhong","year":"2024","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116094_bib29","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1016\/j.biomaterials.2014.01.050","article-title":"Biodegradable and injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for postoperative adhesion prevention","volume":"35","author":"Li","year":"2014","journal-title":"Biomaterials"},{"issue":"33","key":"10.1016\/j.colsurfb.2026.116094_bib30","doi-asserted-by":"crossref","first-page":"16473","DOI":"10.1073\/pnas.1902179116","article-title":"Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination","volume":"116","author":"Boopathy","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.colsurfb.2026.116094_bib31","article-title":"In vitro bone marrow-derived dendritic cells (BMDC) generation for antigen presentation assay","volume":"15","author":"Singh","year":"2025","journal-title":"Bio Protoc."},{"issue":"20","key":"10.1016\/j.colsurfb.2026.116094_bib32","doi-asserted-by":"crossref","first-page":"11230","DOI":"10.1039\/C9RA00818G","article-title":"Properties of immature and mature dendritic cells: phenotype, morphology, phagocytosis, and migration","volume":"9","author":"Kim","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.colsurfb.2026.116094_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2024.109482","article-title":"The interaction between the costimulatory molecules CD80\/86 and CD28 contributed to CD4+ T lymphocyte activation in flounder (Paralichthys olivaceus)","volume":"148","author":"Xing","year":"2024","journal-title":"Fish. Shellfish. Immunol."},{"key":"10.1016\/j.colsurfb.2026.116094_bib34","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-immunol-120419-022408","article-title":"Germinal centers","volume":"40","author":"Victora","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.colsurfb.2026.116094_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2022.02.008","article-title":"T follicular cells: the regulators of germinal center homeostasis","volume":"244","author":"Ribeiro","year":"2022","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116094_bib36","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.it.2017.04.002","article-title":"Mechanisms and dynamics of T cell-mediated cytotoxicity in vivo","volume":"38","author":"Halle","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.colsurfb.2026.116094_bib37","doi-asserted-by":"crossref","first-page":"k5095","DOI":"10.1136\/bmj.k5095","article-title":"Herpes zoster infection","volume":"364","author":"Le","year":"2019","journal-title":"BMJ"},{"issue":"9","key":"10.1016\/j.colsurfb.2026.116094_bib38","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/vaccines11091475","article-title":"Evaluation of the immunological efficacy of an LNP-mRNA vaccine prepared from varicella zoster virus glycoprotein gE with a double-mutated carboxyl terminus in different untranslated regions in mice","volume":"11","author":"Wang","year":"2023","journal-title":"Vaccin. (Basel)"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652600682X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S092777652600682X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T19:50:43Z","timestamp":1788551443000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S092777652600682X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":38,"alternative-id":["S092777652600682X"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116094","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mannose-based VZV-gE protein self-adjuvanted hydrogel vaccine enhances immune response","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116094","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116094"}}