{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:28:28Z","timestamp":1793924908126,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003482","name":"Hebei Province Department of Education","doi-asserted-by":"publisher","award":["ZC2023061"],"award-info":[{"award-number":["ZC2023061"]}],"id":[{"id":"10.13039\/501100003482","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012505","name":"Hebei Medical University","doi-asserted-by":"publisher","award":["2022LCTD-B32"],"award-info":[{"award-number":["2022LCTD-B32"]}],"id":[{"id":"10.13039\/501100012505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008238","name":"Hebei Provincial Department of Science And Technology","doi-asserted-by":"publisher","award":["264Z2605G"],"award-info":[{"award-number":["264Z2605G"]}],"id":[{"id":"10.13039\/501100008238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.colsurfb.2026.116120","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:50:01Z","timestamp":1788331801000},"page":"116120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["NQO1\u2011activated self\u2011reinforcing bimetallic nanoplatform triggers ferroptosis and cuproptosis for osteosarcoma therapy"],"prefix":"10.1016","volume":"269","author":[{"given":"Ye","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjian","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8348-6768","authenticated-orcid":false,"given":"Meng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.116120_bib1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/nrc3838","article-title":"Translational biology of osteosarcoma","volume":"14","author":"Kansara","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.colsurfb.2026.116120_bib2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41572-022-00409-y","article-title":"Osteosarcoma","volume":"8","author":"Beird","year":"2022","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.colsurfb.2026.116120_bib3","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41571-021-00519-8","article-title":"Advancing therapy for osteosarcoma","volume":"18","author":"Gill","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.colsurfb.2026.116120_bib4","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra2103423","article-title":"New horizons in the treatment of osteosarcoma","volume":"385","author":"Meltzer","year":"2021","journal-title":"New. Engl. J. Med."},{"key":"10.1016\/j.colsurfb.2026.116120_bib5","article-title":"A forward vision for chemodynamic therapy: issues and opportunities","volume":"62","author":"Zhao","year":"2023","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.colsurfb.2026.116120_bib6","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/anie.201805664","article-title":"Chemodynamic therapy: tumour microenvironment-mediated fenton and fenton-like reactions","volume":"58","author":"Tang","year":"2019","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.colsurfb.2026.116120_bib7","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1039\/D1SC05482A","article-title":"Recent advances of cancer chemodynamic therapy based on fenton\/fenton-like chemistry","volume":"13","author":"Cao","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.colsurfb.2026.116120_bib8","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202400809","article-title":"Emerging chemodynamic nanotherapeutics for cancer treatment","volume":"13","author":"Sun","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib9","doi-asserted-by":"crossref","first-page":"30716","DOI":"10.1021\/acsami.5c05324","article-title":"Dendrimer-entrapped CuPt bimetallic nanozymes for tumor microenvironment-regulated photothermal\/catalytic therapy","volume":"17","author":"Lu","year":"2025","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.116120_bib10","article-title":"Porous Fe\/Cu nanoreactor with dual insurance design for precision chemotherapy and chemodynamic therapy","volume":"14","author":"Zhu","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib11","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.1039\/D3CS00356F","article-title":"Strategies to engineer various nanocarrier-based hybrid catalysts for enhanced chemodynamic cancer therapy","volume":"52","author":"Hao","year":"2023","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116120_bib12","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.colsurfb.2026.116120_bib13","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s41571-024-00876-0","article-title":"Targeting cuproplasia and cuproptosis in cancer","volume":"21","author":"Tang","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.colsurfb.2026.116120_bib14","article-title":"Emerging strategies of cancer therapy based on ferroptosis","volume":"30","author":"Shen","year":"2018","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib15","doi-asserted-by":"crossref","first-page":"6282","DOI":"10.1039\/D5CS00083A","article-title":"Cuproptosis: mechanisms and nanotherapeutic strategies in cancer and beyond","volume":"54","author":"Mao","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116120_bib16","article-title":"Charge and size-variable biodegradable nanocomposites for self-reinforcing CDT, PTT, and chemotherapy: augmented cuproptosis and ferroptosis against tumor hypoxia via glycolysis\/redox dual disruption","author":"Hu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib17","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1016\/j.apsb.2024.05.029","article-title":"CRISPR-Cas9 gene editing strengthens cuproptosis\/chemodynamic\/ferroptosis synergistic cancer therapy","volume":"14","author":"Wu","year":"2024","journal-title":"Acta Pharm. Sin. B."},{"key":"10.1016\/j.colsurfb.2026.116120_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.123075","article-title":"Bimetallic nanoreactor mediates cascade amplification of oxidative stress for complementary chemodynamic-immunotherapy of tumor","volume":"317","author":"Zhou","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.116120_bib19","article-title":"Glucose oxidase-powered nanocatalytic medicine: rewiring tumor metabolism for multimodal cancer therapy","volume":"36","author":"Wang","year":"2026","journal-title":"Mater. Today Bio."},{"key":"10.1016\/j.colsurfb.2026.116120_bib20","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.actbio.2024.01.041","article-title":"Dumbbell-shaped bimetallic AuPd nanoenzymes for NIR-II cascade catalysis-photothermal synergistic therapy","volume":"177","author":"Tang","year":"2024","journal-title":"Acta Biomate"},{"key":"10.1016\/j.colsurfb.2026.116120_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2025.102715","article-title":"Intracellular in-situ activated enzyme\/prodrug strategy based on tris(triazole)-Cu+ complex for cooperative catalytic cancer therapy","volume":"62","author":"Qiu","year":"2025","journal-title":"Nano Today"},{"key":"10.1016\/j.colsurfb.2026.116120_bib22","doi-asserted-by":"crossref","first-page":"18419","DOI":"10.1021\/jacs.2c06877","article-title":"Engineering poly(ethylene glycol) nanoparticles for accelerated blood clearance inhibition and targeted drug delivery","volume":"144","author":"Tian","year":"2022","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2026.116120_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312169","article-title":"Nanomedicine tumor targeting","volume":"36","author":"Lammers","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib24","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41467-020-20886-7","article-title":"Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets","volume":"12","author":"Vincent","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.116120_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41571-022-00699-x","article-title":"Targeting drugs to tumours using cell membrane-coated nanoparticles","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.colsurfb.2026.116120_bib26","article-title":"Multifunctional biomedical materials derived from biological membranes","volume":"34","author":"Wang","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib27","doi-asserted-by":"crossref","first-page":"11517","DOI":"10.1021\/acsnano.4c16280","article-title":"Engineered cell membrane coating technologies for biomedical applications: from nanoscale to macroscale","volume":"19","author":"An","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.colsurfb.2026.116120_bib28","doi-asserted-by":"crossref","first-page":"23843","DOI":"10.1021\/acsanm.5c03729","article-title":"Tumor microenvironment-mediated activation of oxidative stress storm for MRI-guided ferroptosis therapy","volume":"8","author":"Huang","year":"2025","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2024.103292","article-title":"DPP9 regulates NQO1 and ROS to promote resistance to chemotherapy in liver cancer cells","volume":"75","author":"Zhou","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.colsurfb.2026.116120_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202205414","article-title":"NIR responsive doxorubicin-loaded hollow copper ferrite@polydopamine for synergistic chemodynamic\/photothermal\/chemo-therapy","volume":"19","author":"Chu","year":"2023","journal-title":"Small"},{"key":"10.1016\/j.colsurfb.2026.116120_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbon.2024.119859","article-title":"Reduction-regulated ultralight CoFe2O4 nanofiber\/graphene composite aerogels as superior broadband electromagnetic wave absorber","volume":"234","author":"Xu","year":"2025","journal-title":"Carbon"},{"key":"10.1016\/j.colsurfb.2026.116120_bib32","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1021\/acsanm.9b02192","article-title":"Fe\/N-codoped hollow carbonaceous nanospheres anchored on reduced graphene oxide for microwave absorption","volume":"2","author":"Wang","year":"2019","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib33","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1039\/D4CS01061B","article-title":"Mixed-valence metal-organic frameworks: concepts, opportunities, and prospects","volume":"54","author":"Afshariazar","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116120_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202401893","article-title":"Peroxidase-mimicking iron-based single-atom upconversion photocatalyst for enhancing chemodynamic therapy","volume":"34","author":"Le","year":"2024","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib35","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/s41419-022-04660-9","article-title":"Plasma-activated medium induces ferroptosis by depleting FSP1 in human lung cancer cells","volume":"13","author":"Jo","year":"2022","journal-title":"Cell. Death Dis."},{"key":"10.1016\/j.colsurfb.2026.116120_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202104223","article-title":"Manipulating intratumoral fenton chemistry for enhanced chemodynamic and chemodynamic-synergized multimodal therapy","volume":"33","author":"Zhou","year":"2021","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.202400125","article-title":"Defect-engineered tin disulfide nanocarriers as \u201cPrecision-Guided Projectile\u201d for intensive synergistic therapy","volume":"8","author":"Zhu","year":"2024","journal-title":"Small Methods"},{"key":"10.1016\/j.colsurfb.2026.116120_bib38","doi-asserted-by":"crossref","first-page":"20682","DOI":"10.1021\/acsami.2c01782","article-title":"Open-source and reduced-expenditure nanosystem with ROS self-amplification and glutathione depletion for simultaneous augmented chemodynamic\/photodynamic therapy","volume":"14","author":"Chen","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.colsurfb.2026.116120_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202419673","article-title":"Engineered nanozymes with asymmetric Mn-O-Ce sites for intratumorally leveraged multimode therapy","volume":"37","author":"Ye","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201904836","article-title":"Plasmonic Pt superstructures with boosted near-infrared absorption and photothermal conversion efficiency in the second biowindow for cancer therapy","volume":"31","author":"Wang","year":"2019","journal-title":"Adv. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib41","article-title":"Copper sulfide engineered covalent organic frameworks for pH-responsive chemo\/photothermal\/chemodynamic synergistic therapy against cancer","volume":"451","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.116120_bib42","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jcis.2024.01.217","article-title":"Covalent organic frameworks-derived carbon nanospheres based nanoplatform for tumor specific synergistic therapy via oxidative stress amplification and calcium overload","volume":"661","author":"Pang","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116120_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202404184","article-title":"Hybrid cell membrane-coated nanoparticles for synergizing sonodynamic therapy and immunotherapy against triple-negative breast cancer","volume":"14","author":"Gong","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib44","article-title":"Membrane fusion-inspired nanomaterials: emerging strategies for infectious disease and cancer diagnostics","author":"Lee","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.116120_bib45","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jcis.2023.02.041","article-title":"Degradable iron-rich mesoporous dopamine as a dual-glutathione depletion nanoplatform for photothermal-enhanced ferroptosis and chemodynamic therapy","volume":"639","author":"Cheng","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.colsurfb.2026.116120_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.217519","article-title":"Cuproptosis and its cooperative role in cancer therapy: exploring new treatment strategies","volume":"552","author":"Xu","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.colsurfb.2026.116120_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202407196","article-title":"Tumor microenvironment activated Cu crosslinked near-infrared sonosensitizers for visualized cuproptosis-enhanced sonodynamic cancer immunotherapy","volume":"11","author":"Hu","year":"2024","journal-title":"Adv. Sci."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:01:52Z","timestamp":1793923312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526007083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":47,"alternative-id":["S0927776526007083"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116120","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NQO1\u2011activated self\u2011reinforcing bimetallic nanoplatform triggers ferroptosis and cuproptosis for osteosarcoma therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116120","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116120"}}