{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:25:42Z","timestamp":1788791142446,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020730","name":"Department of Natural Resources of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.colsurfb.2026.116142","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:04:25Z","timestamp":1788537865000},"page":"116142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Biohybrid microalgae living hydrogel with self-oxygenation and green-synthesized zinc nanoparticles to combat multidrug-resistant infections via transcriptional reprogramming"],"prefix":"10.1016","volume":"269","author":[{"given":"Zhiying","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lugang","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib1","doi-asserted-by":"crossref","first-page":"3738","DOI":"10.1038\/s41467-025-58987-w","article-title":"A dynamically phase-adaptive regulating hydrogel promotes ultrafast anti-fibrotic wound healing","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.116142_bib2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41579-024-01035-z","article-title":"The wound microbiota: microbial mechanisms of impaired wound healing and infection","volume":"22","author":"Uberoi","year":"2024","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib3","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/s41467-024-45101-9","article-title":"Programmed microalgae-gel promotes chronic wound healing in diabetes","volume":"15","author":"Kang","year":"2024","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116142_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jiph.2023.11.024","article-title":"Etiology, pathology, and host-impaired immunity in medical implant-associated infections","volume":"17","author":"Ul Haq","year":"2024","journal-title":"J. Infect. Public. Health"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116142_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41580-020-0227-y","article-title":"Cellular adaptation to hypoxia through hypoxia inducible factors and beyond","volume":"21","author":"Lee","year":"2020","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"issue":"32","key":"10.1016\/j.colsurfb.2026.116142_bib6","doi-asserted-by":"crossref","first-page":"13505","DOI":"10.1073\/pnas.0906670106","article-title":"The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues","volume":"106","author":"Thangarajah","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.colsurfb.2026.116142_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2023.122029","article-title":"All-in-one bioactive properties of photothermal nanofibers for accelerating diabetic wound healing","volume":"295","author":"Zhao","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.116142_bib8","unstructured":"X Qi, Y Li, Y Xiang, Y Chen, Y Shi, X Ge, B Zeng, J ShenHyperthermia-enhanced immunoregulation hydrogel for oxygenation and ROS neutralization in diabetic foot ulcers. Cell Biomaterials.."},{"issue":"9","key":"10.1016\/j.colsurfb.2026.116142_bib9","doi-asserted-by":"crossref","first-page":"11144","DOI":"10.1021\/acsami.1c25014","article-title":"Dendritic Hydrogels with Robust Inherent Antibacterial Properties for Promoting Bacteria-Infected Wound Healing","volume":"14","author":"Cheng","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116142_bib10","first-page":"397","article-title":"Implant infections: adhesion, biofilm formation and immune evasion, Nature reviews","volume":"16","author":"Arciola","year":"2018","journal-title":"Microbiology"},{"issue":"10","key":"10.1016\/j.colsurfb.2026.116142_bib11","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41579-022-00682-4","article-title":"Tolerance and resistance of microbial biofilms","volume":"20","author":"Ciofu","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.colsurfb.2026.116142_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121401","article-title":"Nano-oxygenated hydrogels for locally and permeably hypoxia relieving to heal chronic wounds","volume":"282","author":"Yang","year":"2022","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116142_bib13","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1021\/acsnano.1c08411","article-title":"Wound dressing: from nanomaterials to diagnostic dressings and healing evaluations","volume":"16","author":"Zeng","year":"2022","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib14","article-title":"Reactive-oxygen-species-responsive drug delivery systems: promises and challenges","volume":"4","author":"Saravanakumar","year":"2017","journal-title":"Adv. Sci. (Weinheim Baden-Wurttemberg Germany)"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116142_bib15","doi-asserted-by":"crossref","first-page":"5901","DOI":"10.1021\/acsnano.0c01059","article-title":"Black phosphorus-loaded separable microneedles as responsive oxygen delivery carriers for wound healing","volume":"14","author":"Zhang","year":"2020","journal-title":"ACS nano"},{"issue":"36","key":"10.1016\/j.colsurfb.2026.116142_bib16","doi-asserted-by":"crossref","first-page":"11522","DOI":"10.1002\/anie.201805138","article-title":"Innovative strategies for hypoxic-tumor photodynamic therapy","volume":"57","author":"Li","year":"2018","journal-title":"Angew. Chem. (Int. Ed. Engl. )"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116142_bib17","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1021\/acs.nanolett.0c00047","article-title":"Self-delivery nanomedicine for O(2)-economized photodynamic tumor therapy","volume":"20","author":"Zhao","year":"2020","journal-title":"Nano Lett."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116142_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41579-022-00686-0","article-title":"Skeletal infections: microbial pathogenesis, immunity and clinical management","volume":"20","author":"Masters","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"issue":"35","key":"10.1016\/j.colsurfb.2026.116142_bib19","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj0153","article-title":"Sustained oxygenation accelerates diabetic wound healing by promoting epithelialization and angiogenesis and decreasing inflammation","volume":"7","author":"Guan","year":"2021","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116142_bib20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2174\/1381612822666151112145226","article-title":"Chlorella vulgaris: a multifunctional dietary supplement with diverse medicinal properties","volume":"22","author":"Panahi","year":"2016","journal-title":"Curr. Pharm. Des."},{"issue":"15","key":"10.1016\/j.colsurfb.2026.116142_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202307585","article-title":"Chlorella-loaded antibacterial microneedles for microacupuncture oxygen therapy of diabetic bacterial infected wounds","volume":"36","author":"Gao","year":"2024","journal-title":"Adv. Mater. (Deerfield Beach Fla. )"},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116142_bib22","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.15537\/smj.2023.44.12.20230366","article-title":"Bacteriophage treatment as an alternative therapy for multidrug-resistant bacteria","volume":"44","author":"Alqahtani","year":"2023","journal-title":"Saudi Med. J."},{"issue":"Pt A","key":"10.1016\/j.colsurfb.2026.116142_bib23","article-title":"Prospects and environmental sustainability of phyconanotechnology: a review on algae-mediated metal nanoparticles synthesis and mechanism","volume":"212","author":"Chan","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.colsurfb.2026.116142_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.mimet.2019.105656","article-title":"Algae-based metallic nanoparticles: synthesis, characterization and applications","volume":"163","author":"Khanna","year":"2019","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.colsurfb.2026.116142_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.mimet.2019.105656","article-title":"Algae-based metallic nanoparticles: synthesis, characterization and applications","volume":"163","author":"Khanna","year":"2019","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.colsurfb.2026.116142_bib26","first-page":"112","article-title":"Screening of cyanobacteria and microalgae for their ability to synthesize silver nanoparticles with antibacterial activity","volume":"5","author":"Patel","year":"2015","journal-title":"Biotechnol. Rep. (Amst. Neth. )"},{"issue":"24","key":"10.1016\/j.colsurfb.2026.116142_bib27","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202312275","article-title":"Microalgae-Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression","volume":"36","author":"Zhong","year":"2024","journal-title":"Adv. Mater. (Deerfield Beach Fla. )"},{"issue":"48","key":"10.1016\/j.colsurfb.2026.116142_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abi9265","article-title":"Orally deliverable strategy based on microalgal biomass for intestinal disease treatment","volume":"7","author":"Zhong","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.colsurfb.2026.116142_bib29","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.ijbiomac.2022.11.156","article-title":"Carboxymethyl chitosan\/sodium alginate hydrogels with polydopamine coatings as promising dressings for eliminating biofilm and multidrug-resistant bacteria induced wound healing","volume":"225","author":"Liu","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.colsurfb.2026.116142_bib30","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.ijbiomac.2020.07.311","article-title":"Alginate hydrogel dressings for advanced wound management","volume":"162","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"26","key":"10.1016\/j.colsurfb.2026.116142_bib31","doi-asserted-by":"crossref","first-page":"17251","DOI":"10.1021\/acsnano.4c04816","article-title":"A Double Network Composite Hydrogel with Self-Regulating Cu(2+)\/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing","volume":"18","author":"Li","year":"2024","journal-title":"ACS nano"},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116142_bib32","doi-asserted-by":"crossref","first-page":"11253","DOI":"10.1021\/acsnano.2c10742","article-title":"NIR-II Responsive Nanohybrids Incorporating Thermosensitive Hydrogel as Sprayable Dressing for Multidrug-Resistant-Bacteria Infected Wound Management","volume":"17","author":"Pan","year":"2023","journal-title":"ACS nano"},{"key":"10.1016\/j.colsurfb.2026.116142_bib33","article-title":"Difluoroboron curcumin\/glycyrrhizic acid liposome-incorporated Mg2\u207a-chelated microgel for MRSA-infected wound photothermal therapy, Drug resistance updates: reviews and commentaries in antimicrobial and anticancer","volume":"85","author":"Zhu","year":"2026","journal-title":"chemotherapy"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116142_bib34","article-title":"Highly efficient self-healing multifunctional dressing with antibacterial activity for sutureless wound closure and infected wound monitoring","volume":"34","author":"Tang","year":"2022","journal-title":"Adv. Mater. (Deerfield Beach Fla. )"},{"issue":"42","key":"10.1016\/j.colsurfb.2026.116142_bib35","article-title":"Enzyme-Like Photocatalytic Octahedral Rh\/Ag(2)MoO(4) Accelerates Diabetic Wound Healing by Photo-Eradication of Pathogen and Relieving Wound Hypoxia","volume":"20","author":"Li","year":"2024","journal-title":"Small (Weinh. der Bergstr. Ger. )"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib36","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s12951-025-03509-5","article-title":"Zinc-doped curcumin carbon dots promote infected wound healing with photodynamic via the VEGF signaling pathway","volume":"23","author":"Zhao","year":"2025","journal-title":"J. nanobiotechnology"},{"issue":"48","key":"10.1016\/j.colsurfb.2026.116142_bib37","article-title":"Kill Two Birds with One Stone: Dual-Metal MOF-Nanozyme-Decorated Hydrogels with ROS-Scavenging, Oxygen-Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing","volume":"20","author":"Wei","year":"2024","journal-title":"Small (Weinh. der Bergstr. Ger. )"},{"issue":"21","key":"10.1016\/j.colsurfb.2026.116142_bib38","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg3478","article-title":"Living microecological hydrogels for wound healing","volume":"9","author":"Chen","year":"2023","journal-title":"Sci. Adv."},{"issue":"524","key":"10.1016\/j.colsurfb.2026.116142_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax6601","article-title":"A dual-action peptide-containing hydrogel targets wound infection and inflammation","volume":"12","author":"Puthia","year":"2020","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib40","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1038\/s41467-022-35050-6","article-title":"Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing","volume":"13","author":"Meng","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.colsurfb.2026.116142_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122548","article-title":"From hemostasis to proliferation: accelerating the infected wound healing through a comprehensive repair strategy based on GA\/OKGM hydrogel loaded with MXene@TiO(2) nanosheets","volume":"308","author":"Qiu","year":"2024","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib42","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1021\/acsnano.3c07638","article-title":"Engineering single-component antibacterial anti-inflammatory polyitaconate-based hydrogel for promoting methicillin-resistant staphylococcus aureus-infected wound healing and skin regeneration","volume":"18","author":"Wang","year":"2024","journal-title":"ACS nano"},{"key":"10.1016\/j.colsurfb.2026.116142_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2023.120575","article-title":"Synthesis and evaluation of water-soluble imidazolium salt chitin with broad-spectrum antimicrobial activity and excellent biocompatibility for infected wound healing","volume":"306","author":"Ma","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"17","key":"10.1016\/j.colsurfb.2026.116142_bib44","article-title":"Hyaluronidase-responsive bactericidal cryogel for promoting healing of infected wounds: inflammatory attenuation, ROS scavenging, and immune regulation","volume":"11","author":"Liu","year":"2024","journal-title":"Adv. Sci. (Weinheim Baden-Wurttemberg Germany)"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116142_bib45","article-title":"RADA16 and SAAP148 peptide-modified collagen self-assembled hydrogels for accelerated healing of infected wounds","volume":"13","author":"Liu","year":"2026","journal-title":"Adv. Sci. (Weinheim Baden-Wurttemberg Germany)"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116142_bib46","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s12951-025-03953-3","article-title":"Bioinspired smart catalytic microneedle patch with structural color for infected wound management","volume":"24","author":"Huang","year":"2025","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.colsurfb.2026.116142_bib47","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1251956","article-title":"Application of hypoxia-mesenchymal stem cells in treatment of anaerobic bacterial wound infection: wound healing and infection recovery","volume":"14","author":"Andalib","year":"2023","journal-title":"Front. Microbiol."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:27:52Z","timestamp":1788787672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526007307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":47,"alternative-id":["S0927776526007307"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116142","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biohybrid microalgae living hydrogel with self-oxygenation and green-synthesized zinc nanoparticles to combat multidrug-resistant infections via transcriptional reprogramming","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116142","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116142"}}