{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:12:49Z","timestamp":1789747969708,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS142"],"award-info":[{"award-number":["ZR2025MS142"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22307060"],"award-info":[{"award-number":["22307060"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.colsurfb.2026.116173","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:37:59Z","timestamp":1789054679000},"page":"116173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Baicalein-loaded rhamnolipid nanomicelles target mitochondrial dysfunction and activate the cGAS-STING pathway for triple-negative breast cancer therapy"],"prefix":"10.1016","volume":"269","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyu","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengshu","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanlong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.colsurfb.2026.116173_bib1","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1158\/1078-0432.CCR-24-2865","article-title":"Receptor CDCP1 Is a Potential Target for Personalized Imaging and Treatment of Poor Outcome HER2+, Triple-Negative, and Metastatic ER+\/HER2\u2212 Breast Cancers","volume":"31","author":"Gough","year":"2025","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.colsurfb.2026.116173_bib2","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.colsurfb.2026.116173_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2023.115545","article-title":"Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies","volume":"212","author":"Karim","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s13045-022-01341-0","article-title":"Recent advances in therapeutic strategies for triple-negative breast cancer","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/s41392-025-02337-1","article-title":"Exploratory phase II trial of an anti-PD-1 antibody camrelizumab combined with a VEGFR-2 inhibitor apatinib and chemotherapy as a neoadjuvant therapy for triple-negative breast cancer (NeoPanDa03): efficacy, safety and biomarker analysis","volume":"10","author":"Liu","year":"2025","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.colsurfb.2026.116173_bib6","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/s12885-025-13693-0","article-title":"Intraductal chemotherapy for triple-negative breast cancer: a pathway to minimally invasive clinical treatment","volume":"25","author":"Wu","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.colsurfb.2026.116173_bib7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12943-023-01850-7","article-title":"Advances in immunotherapy for triple-negative breast cancer","volume":"22","author":"Liu","year":"2023","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.colsurfb.2026.116173_bib8","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/s41577-024-01026-4","article-title":"Cancer cell metabolism and antitumour immunity","volume":"24","author":"De Martino","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123568","article-title":"Chrono-controlled hydrogel platform orchestrates metabolic reprogramming and cuproptosis-driven immune activation against triple-negative breast cancer","volume":"325","author":"Lu","year":"2026","journal-title":"Biomaterials"},{"key":"10.1016\/j.colsurfb.2026.116173_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202501871","article-title":"A Self-Adaptive Rhodium(I) Complex-Based Nanoplatform with Type II Immunogenic Cell Death for Near-Infrared Phosphorescence Imaging and Cancer Immunotherapy","volume":"14","author":"Xiang","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.colsurfb.2026.116173_bib11","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13045-020-00916-z","article-title":"cGAS-STING, an important pathway in cancer immunotherapy","volume":"13","author":"Jiang","year":"2020","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110972","article-title":"cGAS-STING signaling in cancer immunity and immunotherapy","volume":"133","author":"Du","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2026.116173_bib13","first-page":"45","article-title":"Emerging mechanisms and implications of cGAS-STING signaling in cancer immunotherapy strategies","volume":"21","author":"Zhang","year":"2024","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.colsurfb.2026.116173_bib14","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.immuni.2014.10.017","article-title":"STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors","volume":"41","author":"Woo","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.colsurfb.2026.116173_bib15","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41422-020-00395-4","article-title":"Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy","volume":"30","author":"Lv","year":"2020","journal-title":"Cell. Res."},{"key":"10.1016\/j.colsurfb.2026.116173_bib16","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1158\/2159-8290.CD-20-0387","article-title":"Metastasis and Immune Evasion from Extracellular cGAMP Hydrolysis","volume":"11","author":"Li","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/j.colsurfb.2026.116173_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2026.176643","article-title":"A full active pharmaceutical ingredients-based nanoplatform potentiates tumor immunotherapy via multidimensional cGAS-STING pathway activation","volume":"537","author":"Wang","year":"2026","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.colsurfb.2026.116173_bib18","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/mc.23436","article-title":"Targeting mitochondrial metabolism for metastatic cancer therapy","volume":"61","author":"Passaniti","year":"2022","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.colsurfb.2026.116173_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/cr.2017.155","article-title":"Mitochondrial metabolism and cancer","volume":"28","author":"Porporato","year":"2018","journal-title":"Cell. Res."},{"key":"10.1016\/j.colsurfb.2026.116173_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8324696","article-title":"Natural Products for the Management and Prevention of Breast Cancer","volume":"2018","author":"Mitra","year":"2018","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"10.1016\/j.colsurfb.2026.116173_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.577","article-title":"Baicalein resensitizes tamoxifen-resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia-inducible factor-1\u03b1","volume":"11","author":"Chen","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.colsurfb.2026.116173_bib22","doi-asserted-by":"crossref","first-page":"10749","DOI":"10.2147\/OTT.S222819","article-title":"Baicalein, as a Prooxidant, Triggers Mitochondrial Apoptosis in MCF-7 Human Breast Cancer Cells Through Mobilization of Intracellular Copper and Reactive Oxygen Species Generation","volume":"12","author":"Liu","year":"2019","journal-title":"Onco Targets Ther."},{"key":"10.1016\/j.colsurfb.2026.116173_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125694","article-title":"Precision medicine for acute kidney injury: Baicalein-nanodrug delivery system combat oxidative stress and repair mitochondrial dysfunction","volume":"678","author":"Zhou","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116173_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2024.04.010","article-title":"Regulatory insights into nanomedicine and gene vaccine innovation: Safety assessment, challenges, and regulatory perspectives","volume":"180","author":"Souto","year":"2024","journal-title":"Acta Biomater."},{"key":"10.1016\/j.colsurfb.2026.116173_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.121351","article-title":"Two birds with one stone: Copper metal-organic framework as a carrier of disulfiram prodrug for cancer therapy","volume":"612","author":"Pan","year":"2022","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116173_bib26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejpb.2016.12.013","article-title":"Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery","volume":"116","author":"M\u00fcller","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.colsurfb.2026.116173_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110460","article-title":"Improvement on stability, loading capacity and sustained release of rhamnolipids modified curcumin liposomes","volume":"183","author":"Cheng","year":"2019","journal-title":"Colloids Surf. B"},{"key":"10.1016\/j.colsurfb.2026.116173_bib28","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jconrel.2023.11.019","article-title":"Biomimetic hybrid nanovesicles improve infected diabetic wound via enhanced targeted delivery","volume":"365","author":"Jiang","year":"2024","journal-title":"J. Control. Release"},{"key":"10.1016\/j.colsurfb.2026.116173_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/1541-4337.13252","article-title":"Rhamnolipids: A biosurfactant for the development of lipid-based nanosystems for food applications","volume":"23","author":"Azevedo","year":"2024","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.colsurfb.2026.116173_bib30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.2147\/IJN.S283400","article-title":"Rhamnolipid-based liposomes as promising nano-carriers for enhancing the antibacterial activity of peptides derived from bacterial toxin-antitoxin systems","volume":"16","author":"Sanches","year":"2021","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.colsurfb.2026.116173_bib31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nano.2019.03.015","article-title":"Rhamnolipid nanoparticles for in vivo drug delivery and photodynamic therapy","volume":"19","author":"Yi","year":"2019","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"key":"10.1016\/j.colsurfb.2026.116173_bib32","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1007\/s43440-025-00784-9","article-title":"Log-probit accompanied with Tallarida and Chou-Talalay-Martin methods in an isobolographic analysis of interactions between two antiseizure medications - a comparative study","volume":"77","author":"\u0141uszczki","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.colsurfb.2026.116173_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115511","article-title":"Improved bioavailability and anticancer efficacy of Hesperetin on breast cancer via a self-assembled rebaudioside A nanomicelles system","volume":"419","author":"Wang","year":"2021","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202206737","article-title":"Raddeanin A enhances mitochondrial DNA-cGAS\/STING axis-mediated antitumor immunity by targeting transactive responsive DNA-binding protein 43","volume":"10","author":"Yin","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.colsurfb.2026.116173_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113591","article-title":"Manganese improves CD8+ T cell recruitment via cGAS-STING in hepatocellular carcinoma","volume":"143","author":"Fu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib36","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jhazmat.2018.10.050","article-title":"Biodegradability and toxicity of monorhamnolipid biosurfactant diastereomers","volume":"364","author":"Hogan","year":"2019","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.colsurfb.2026.116173_bib37","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3390\/pharmaceutics17070851","article-title":"Effect of hepatic impairment on the pharmacokinetics of baicalin in rats: critical roles of gut microbiota and hepatic transporters","author":"Li","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.colsurfb.2026.116173_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2025.118589","article-title":"Current status and future perspectives of drug delivery systems loaded with baicalein and baicalin in cancer therapy","volume":"192","author":"Nazemiyeh","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.colsurfb.2026.116173_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119546","article-title":"The effect of baicalein-loaded Y-shaped miktoarm copolymer on spatial memory and hippocampal expression of DHCR24, SELADIN and SIRT6 genes in rat model of Alzheimer","volume":"586","author":"Aghajanzadeh","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.colsurfb.2026.116173_bib40","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70823","article-title":"Construction of a rice glutelin-rhamnolipid-pectin nanoparticle delivery system for curcumin delivery: effect of pectin esterification on characterization, stability, and bioaccessibility","volume":"13","author":"Chen","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.colsurfb.2026.116173_bib41","article-title":"Rhamnolipids in advanced biomaterial engineering: applications in antimicrobial, wound healing, and drug delivery","volume":"110","author":"\u00c7olak","year":"2025","journal-title":"J. Drug. Deliv. Sci. Technol."},{"key":"10.1016\/j.colsurfb.2026.116173_bib42","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/jsde.70030","article-title":"Functional roles of microbial biosurfactants in pharmaceutical formulation and targeted drug delivery","volume":"29","author":"Gaur","year":"2026","journal-title":"J. Surfactants Deterg."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007617?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007617?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T15:46:11Z","timestamp":1789746371000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526007617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":42,"alternative-id":["S0927776526007617"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116173","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalein-loaded rhamnolipid nanomicelles target mitochondrial dysfunction and activate the cGAS-STING pathway for triple-negative breast cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116173"}}