{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:28:28Z","timestamp":1793924908286,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2026YFE0200700"],"award-info":[{"award-number":["2026YFE0200700"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474123"],"award-info":[{"award-number":["82474123"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.colsurfb.2026.116187","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:42:27Z","timestamp":1789688547000},"page":"116187","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["From biomass side-product to nano-therapeutics: Characterization and anti-colitis efficacy of carbon dots originating from Nelumbinis Rhizomatis Nodus Carbonisatus"],"prefix":"10.1016","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6945-845X","authenticated-orcid":false,"given":"Yijia","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zipeng","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengdi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10401","key":"10.1016\/j.colsurfb.2026.116187_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0140-6736(23)00966-2","article-title":"Ulcerative colitis","volume":"402","author":"Le Berre","year":"2023","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.colsurfb.2026.116187_bib2","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/s41577-024-01008-6","article-title":"Strategies for targeting cytokines in inflammatory bowel disease","volume":"24","author":"Neurath","year":"2024","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.colsurfb.2026.116187_bib3","first-page":"219","article-title":"Ulcerative Colitis: Advances in Pathogenesis, Biomarkers, and Therapeutic Strategies","author":"Bu","year":"2025","journal-title":"Pharmgenomics Pers. Med. 18"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41392-025-02345-1","article-title":"Ulcerative colitis: signaling pathways, therapeutic targets and interventional strategies","author":"Jia","year":"2026","journal-title":"Signal. Transduct. Target. Ther. 11"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116187_bib5","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1053\/j.gastro.2024.10.001","article-title":"clinicalpractice@gastro.org AGACGCEa. AGA Living clinical practice guideline on pharmacological management of moderate-to-severe ulcerative colitis","volume":"167","author":"Singh","year":"2024","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116187_bib6","doi-asserted-by":"crossref","DOI":"10.51894\/001c.123397","article-title":"Current Pharmacologic options and emerging therapeutic approaches for the management of ulcerative colitis: a narrative review","volume":"9","author":"Sebastian","year":"2024","journal-title":"Spartan Med. Res. J."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40364-024-00612-x","article-title":"Monocyte-macrophages modulate intestinal homeostasis in inflammatory bowel disease","volume":"12","author":"Lu","year":"2024","journal-title":"Biomark. Res."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116187_bib8","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41575-022-00658-y","article-title":"The metabolic nature of inflammatory bowel diseases","volume":"19","author":"Adolph","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116187_bib9","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41575-022-00593-y","article-title":"Multiomics to elucidate inflammatory bowel disease risk factors and pathways","volume":"19","author":"Agrawal","year":"2022","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.colsurfb.2026.116187_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2024.103182","article-title":"Biomass-derived carbon dots as significant biological tools in the medicinal field: a review","author":"Singh","year":"2024","journal-title":"Adv. Colloid Interface Sci. 328"},{"issue":"19","key":"10.1016\/j.colsurfb.2026.116187_bib11","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.scib.2024.08.011","article-title":"Biomass-derived carbon dots with pharmacological activity for biomedicine: Recent advances and future perspectives","volume":"69","author":"Liu","year":"2024","journal-title":"Sci. Bull."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib12","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1186\/s12951-021-01072-3","article-title":"Herbal medicine derived carbon dots: synthesis and applications in therapeutics, bioimaging and sensing","volume":"19","author":"Luo","year":"2021","journal-title":"J. Nanobiotechnology"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-026-04208-5","article-title":"Calcined lotus leaf-derived carbon dots: enhanced hemostasis, anti-inflammatory, immunomodulatory properties for ulcerative colitis management","volume":"24","author":"Zheng","year":"2026","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.colsurfb.2026.116187_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.mtbio.2025.101971","article-title":"Design of nano mume Fructus charcoal by reshaping inflammatory microenvironment as biofunctional wound nanomedicine","author":"Liang","year":"2025","journal-title":"Mater. Today Bio. 33"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/s12951-017-0296-z","article-title":"Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots","volume":"15","author":"Yan","year":"2017","journal-title":"J. Nanobiotechnology"},{"key":"10.1016\/j.colsurfb.2026.116187_bib16","unstructured":"Pharmacopoeia of the People\u2019s Republic of China China Medical Science Press Beijing 1 Part 12025, ed. ."},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116187_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26071855","article-title":"Comparative analysis of chemical constituents in different parts of lotus by UPLC and QToF-MS","volume":"26","author":"Pei","year":"2021","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116187_bib18","article-title":"Spatial metabolomics: Revolutionary transformation in food and medicinal homology research\u2014decoding the spatiotemporal map of food and medicinal substances in organisms","volume":"2","author":"Zhu","year":"2025","journal-title":"Food Med. Homol."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116187_bib19","article-title":"Co-assembly strategies of natural plant compounds for improving their bioavailability","volume":"2","author":"Miao","year":"2025","journal-title":"Food Med. Homol."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib20","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cclet.2023.108423","article-title":"State-of-the-art of biomass-derived carbon dots: preparation, properties, and applications","volume":"35","author":"Fang","year":"2024","journal-title":"Chin. Chem. Lett."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.116187_bib21","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.1021\/acsabm.3c00462","article-title":"Carbon Dots Derived from Traditional Chinese Medicines with Bioactivities: A Rising Star in Clinical Treatment","volume":"6","author":"Zhang","year":"2023","journal-title":"ACS Appl. Bio Mater."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15212\/bioi-2025-0212","article-title":"From Ambiguity to Precision: Carbon Dots Bridge Traditional Charcoal Medicine and Modern Nanomedicine","volume":"7","author":"Zhang","year":"2026","journal-title":"BIO Integr."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116187_bib23","article-title":"Refining the gut-microbiome axis: A triad of metabolites, targeted microbial delivery, and AI-assisted profiling for precision medicine-food intervention","volume":"2","author":"Zhu","year":"2025","journal-title":"Food Med. Homol."},{"issue":"11","key":"10.1016\/j.colsurfb.2026.116187_bib24","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.molmed.2020.06.006","article-title":"Oxidative Stress and redox-modulating therapeutics in inflammatory bowel disease","author":"Bourgonje","year":"2020","journal-title":"Trends Mol. Med. 26"},{"key":"10.1016\/j.colsurfb.2026.116187_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101837","article-title":"Carbon dots as oxidant-antioxidant nanomaterials, understanding the structure-properties relationship. A critical review","volume":"50","author":"Innocenzi","year":"2023","journal-title":"Nano Today"},{"issue":"7444","key":"10.1016\/j.colsurfb.2026.116187_bib26","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"20","key":"10.1016\/j.colsurfb.2026.116187_bib27","doi-asserted-by":"crossref","DOI":"10.1242\/dev.201135","article-title":"S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency","volume":"150","author":"Li","year":"2023","journal-title":"Development"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41392-020-00349-7","article-title":"Methionine metabolism in chronic liver diseases: an update on molecular mechanism and therapeutic implication","author":"Li","year":"2020","journal-title":"Signal. Transduct. Target. Ther. 5"},{"issue":"11","key":"10.1016\/j.colsurfb.2026.116187_bib29","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41568-019-0187-8","article-title":"Methionine metabolism in health and cancer: a nexus of diet and precision medicine","volume":"19","author":"Sanderson","year":"2019","journal-title":"Nat. Rev. Cancer"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116187_bib30","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.molcel.2019.06.039","article-title":"One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages","author":"Yu","year":"2019","journal-title":"Mol. Cell. 75"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66121-z","article-title":"MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages","volume":"16","author":"Du","year":"2025","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116187_bib32","article-title":"Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma","volume":"6","author":"Mu","year":"2025","journal-title":"Cell. Rep. Med."},{"key":"10.1016\/j.colsurfb.2026.116187_bib33","article-title":"Engineered carbon dots from a traditional herb pair orchestrate concurrent antioxidant and ap-1-mediated inflammation to attenuate renal ischemia-reperfusion injury","author":"Liu","year":"2026","journal-title":"Adv. Sci."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.116187_bib34","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.7150\/thno.126643","article-title":"Panax notoginseng-derived carbon dots herbzymes ameliorate renal ischemia-reperfusion injury via anti-inflammation, antioxidation and gut-kidney axis regulation","volume":"16","author":"Yang","year":"2026","journal-title":"Theranostics"},{"issue":"19","key":"10.1016\/j.colsurfb.2026.116187_bib35","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.2217\/nnm-2020-0472","article-title":"Gastroprotective effects of Nelumbinis Rhizomatis Nodus-derived carbon dots on ethanol-induced gastric ulcers in rats","volume":"16","author":"Luo","year":"2021","journal-title":"Nanomedicine"},{"key":"10.1016\/j.colsurfb.2026.116187_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2025.115651","article-title":"Harnessing carbon nanomaterials for reactive oxygen species regulation: insights into generation, scavenging, and sensing","volume":"224","author":"Liu","year":"2025","journal-title":"Adv. Drug. Deliv. Rev."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24010152","article-title":"Tuning the functional groups on carbon nanodots and antioxidant studies","volume":"24","author":"Ji","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116187_bib38","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1039\/C8CP06768F","article-title":"Optimizing oxygen functional groups in graphene quantum dots for improved antioxidant mechanism","volume":"21","author":"Wang","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.colsurfb.2026.116187_bib39","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.carbon.2017.01.090","article-title":"Tuning the antioxidant activity of graphene quantum dots: protective nanomaterials against dye decoloration","volume":"116","author":"Ruiz","year":"2017","journal-title":"Carbon"},{"key":"10.1016\/j.colsurfb.2026.116187_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.mser.2025.101024","article-title":"Carbon dots for reactive oxygen species modulation","volume":"166","author":"Xu","year":"2025","journal-title":"Materials Science Engineering R Reports"},{"issue":"33","key":"10.1016\/j.colsurfb.2026.116187_bib41","doi-asserted-by":"crossref","first-page":"22055","DOI":"10.1021\/acsnano.4c05266","article-title":"Structurally oriented carbon dots as ROS nanomodulators for dynamic chronic inflammation and infection elimination","volume":"18","author":"Nie","year":"2024","journal-title":"ACS Nano"},{"issue":"32","key":"10.1016\/j.colsurfb.2026.116187_bib42","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1080\/10408398.2025.2491638","article-title":"Methionine in embryonic development: metabolism, redox homeostasis, epigenetic modification and signaling pathway","author":"Yan","year":"2025","journal-title":"Crit. Rev. Food Sci. Nutr. 65"},{"key":"10.1016\/j.colsurfb.2026.116187_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.tem.2025.12.008","article-title":"Interplays and functional divergences of one-carbon metabolic shunts","author":"Wang","year":"2026","journal-title":"Trends Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116187_bib44","article-title":"Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis","author":"Manolakou","year":"2026","journal-title":"Signal. Transduct. Target. Ther. 11"},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116187_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.31083\/ph.2025.5008","article-title":"Formulation development and optimization of artemether-lumefantrine self-nanoemulsifying drug delivery systems","volume":"80","author":"Mudyahoto","year":"2025","journal-title":"Pharmazie"},{"issue":"24","key":"10.1016\/j.colsurfb.2026.116187_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202418683","article-title":"Honeysuckle-derived carbon dots with robust catalytic and pharmacological activities for mitigating lung inflammation by inhibition of caspase11\/GSDMD-dependent pyroptosis","volume":"35","author":"Deng","year":"2025","journal-title":"Adv. Funct. Mater."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116187_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/sstr.202500714","article-title":"Scutellaria baicalensis-derived carbon dots alleviate colitis by activating anti-inflammatory and barrier-protective cascades","volume":"7","author":"Zhang","year":"2026","journal-title":"Small Struct."}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:01:42Z","timestamp":1793923302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526007757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":47,"alternative-id":["S0927776526007757"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116187","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From biomass side-product to nano-therapeutics: Characterization and anti-colitis efficacy of carbon dots originating from Nelumbinis Rhizomatis Nodus Carbonisatus","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116187","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116187"}}