{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:28:05Z","timestamp":1793924885576,"version":"4.8.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Colloids and Surfaces B: Biointerfaces"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.colsurfb.2026.116209","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:01:44Z","timestamp":1790434904000},"page":"116209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["From model membranes to cell lines: Evaluating the safety of antifungal polycations using Langmuir monolayers"],"prefix":"10.1016","volume":"269","author":[{"given":"Monika","family":"Binkowska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil","family":"Kami\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"H\u0105c-Wydro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.colsurfb.2026.116209_bib1","doi-asserted-by":"crossref","first-page":"16952","DOI":"10.3390\/ijms242316952","article-title":"Biodegradable polymers in biomedical applications: a review\u2014developments, perspectives and future challenges","volume":"24","author":"Kurowiak","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.colsurfb.2026.116209_bib2","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.3390\/life13081673","article-title":"Bioinspired polymers: transformative applications in biomedicine and regenerative medicine","volume":"13","author":"Omidian","year":"2023","journal-title":"Life"},{"issue":"10","key":"10.1016\/j.colsurfb.2026.116209_bib3","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.3390\/pharmaceutics14102199","article-title":"Polymers Enhancing Bioavailability in Drug Delivery","volume":"14","author":"Fernandes","year":"2022","journal-title":"Pharmaceutics"},{"issue":"21","key":"10.1016\/j.colsurfb.2026.116209_bib4","doi-asserted-by":"crossref","first-page":"7147","DOI":"10.1039\/c2cs35094g","article-title":"Cationic polymers and their therapeutic potential","volume":"41","author":"Samal","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.colsurfb.2026.116209_bib5","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.3390\/pharmaceutics15072009","article-title":"K. Kami\u0144ski, The Use of a Barley-Based Well to Define Cationic Betaglucan to Study Mammalian Cell Toxicity Associated with Interactions with Biological Structures","volume":"15","author":"Tymecka","year":"2023","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116209_bib6","doi-asserted-by":"crossref","first-page":"983","DOI":"10.3390\/biom15070983","article-title":"Role of Charge Density of Polycations in DNA Complexation and Condensation","volume":"15","author":"Huang","year":"2025","journal-title":"Biomolecules"},{"issue":"16","key":"10.1016\/j.colsurfb.2026.116209_bib7","doi-asserted-by":"crossref","first-page":"5808","DOI":"10.1021\/jacs.6b12887","article-title":"Quantifying the Electrostatics of Polycation-Lipid Bilayer Interactions","volume":"139","author":"Troiano","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.colsurfb.2026.116209_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/pj.2017.72","article-title":"Antimicrobial cationic polymers: from structural design to functional control","volume":"50","author":"Yang","year":"2018","journal-title":"Polym. J."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116209_bib9","doi-asserted-by":"crossref","first-page":"9906","DOI":"10.3390\/ijms14059906","article-title":"Cationic Antimicrobial Polymers and Their Assemblies","volume":"14","author":"Carmona-Ribeiro","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116209_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1039\/D1SC05835E","article-title":"Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies","volume":"13","author":"Si","year":"2022","journal-title":"Chem. Sci."},{"issue":"12","key":"10.1016\/j.colsurfb.2026.116209_bib11","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1021\/acs.langmuir.5b04247","article-title":"Real-time observation of antimicrobial polycation effects on Escherichia coli: adapting the carpet model for membrane disruption to Quaternary copolyoxetanes","volume":"32","author":"Wang","year":"2016","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116209_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2026.110836","article-title":"Investigation of the effects of polycations on Candida albicans membrane models and fungal cells. The effect of polymer structure and molecular weight","volume":"781","author":"Binkowska","year":"2026","journal-title":"Arch. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116209_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00844-23","article-title":"Studies on antifungal properties of methacrylamido propyl trimethyl ammonium chloride polycations and their toxicity in vitro","volume":"11","author":"Sk\u00f3ra","year":"2023","journal-title":"Microbiol. Spectr."},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116209_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3390\/jof9060669","article-title":"Cutaneous Fungal Infections Caused by Dermatophytes and Non-Dermatophytes: An Updated Comprehensive Review of Epidemiology, Clinical Presentations, and Diagnostic Testing","volume":"9","author":"Chanyachailert","year":"2023","journal-title":"J. Fungi (Basel)"},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116209_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1439-0507.2008.01606.x","article-title":"Epidemiological trends in skin mycoses worldwide","volume":"51","author":"Havlickova","year":"2008","journal-title":"Mycoses"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116209_bib16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/s41579-019-0322-2","article-title":"Drug resistance and tolerance in fungi","volume":"18","author":"Berman","year":"2020","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116209_bib17","doi-asserted-by":"crossref","first-page":"437","DOI":"10.5423\/PPJ.RW.02.2025.0029","article-title":"Application of Nanocomposites-Based Polymers on Managing Fungal Diseases in Crop Production","volume":"41","author":"Hoang","year":"2025","journal-title":"Plant. Pathol. J."},{"issue":"10","key":"10.1016\/j.colsurfb.2026.116209_bib18","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3390\/biom9100521","article-title":"Antifungal agents in agriculture: friends and foes of public health","volume":"9","author":"Brauer","year":"2019","journal-title":"Biomolecules"},{"issue":"42","key":"10.1016\/j.colsurfb.2026.116209_bib19","doi-asserted-by":"crossref","first-page":"12435","DOI":"10.1021\/acs.langmuir.0c01062","article-title":"Polycation-anionic lipid membrane interactions","volume":"36","author":"Kopec","year":"2020","journal-title":"Langmuir"},{"key":"10.1016\/j.colsurfb.2026.116209_bib20","unstructured":"B.D. Monnery, M. Wright, R. Cavill, R. Hoogenboom, S. Shaunak, J.H.G. Steinke, M. ThanouCytotoxicity of polycations: Relationship of molecular weight and the hydrolytic theory of the mechanism of toxicityInternational Journal of Pharmaceutics5211-224925810.1016\/j.ijpharm.2017.02.048."},{"key":"10.1016\/j.colsurfb.2026.116209_bib21","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1039\/D1EN01156A","article-title":"Effect of polycation nanostructures on cell membrane permeability and toxicity","volume":"9","author":"Wytrwal-Sarna","year":"2022","journal-title":"Environ. Sci. Nano"},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116209_bib22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3390\/molecules27041267","article-title":"Research progress on typical Quaternary ammonium salt polymers","volume":"27","author":"Fu","year":"2022","journal-title":"Molecules"},{"issue":"14","key":"10.1016\/j.colsurfb.2026.116209_bib23","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.3390\/polym14142811","article-title":"Study on Hydrolysis Properties and Mechanism of Poly(3-Methacrylamido Propyl Trimethyl Ammonium Chloride) Solution","volume":"14","author":"Wang","year":"2022","journal-title":"Polymers"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116209_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-47026-7","article-title":"Dual pH- and temperature-responsive poly(dimethylaminoethyl methacrylate)-coated mesoporous silica nanoparticles as a smart drug delivery system","volume":"13","author":"Ramezanian","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.colsurfb.2026.116209_bib25","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1039\/D2PY01604D","article-title":"PDMAEMA from \u03b1 to \u03c9 chain ends: tools for elucidating the structure of poly(2-(dimethylamino)ethyl methacrylate)","volume":"14","author":"Leggieri","year":"2023","journal-title":"Polym. Chem."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116209_bib26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbalip.2013.11.007","article-title":"Role of lipids in the formation and maintenance of the cutaneous permeability barrier","volume":"1841","author":"Feingold","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Biology Lipids"},{"issue":"6","key":"10.1016\/j.colsurfb.2026.116209_bib27","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3390\/pharmaceutics16060807","article-title":"Lipid Biomimetic Models as Simple Yet Complex Tools to Predict Skin Permeation and Drug\u2013Membrane Biophysical Interactions","volume":"16","author":"Fernandes","year":"2024","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116209_bib28","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0304-4157(96)00009-3","article-title":"Lateral pressure in membranes","volume":"1286","author":"Marsh","year":"1996","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.colsurfb.2026.116209_bib29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tsf.2015.09.047","article-title":"Interactions of bioactive molecules & nanomaterials with Langmuir monolayers as cell membrane models","volume":"593","author":"Nobre","year":"2025","journal-title":"Thin Solid. Films"},{"key":"10.1016\/j.colsurfb.2026.116209_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/der2.70028","article-title":"The Role of Keratinocytes in Skin Health and Disease","volume":"6","author":"Al-Dhubaibi","year":"2025","journal-title":"Dermatol. Rev."},{"issue":"22","key":"10.1016\/j.colsurfb.2026.116209_bib31","doi-asserted-by":"crossref","first-page":"8790","DOI":"10.3390\/ijms21228790","article-title":"The Immune Functions of Keratinocytes in Skin Wound Healing","volume":"21","author":"Piipponen","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116209_bib32","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tcb.2014.10.001","article-title":"Understanding fibroblast heterogeneity in the skin","volume":"25","author":"Driskell","year":"2015","journal-title":"Trends Cell. Biol."},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116209_bib33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.3390\/molecules25030630","article-title":"Lipidomic Analysis Reveals Specific Differences between Fibroblast and Keratinocyte Ceramide Profile of Patients with Psoriasis Vulgaris","volume":"25","author":"\u0141uczaj","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.colsurfb.2026.116209_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.chemphyslip.2025.105511","article-title":"Lipid membrane composition modulates Hinokitiol\u2019s effects on keratinocytes and fibroblasts","volume":"270","author":"Wy\u017cga","year":"2025","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.colsurfb.2026.116209_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2024.135411","article-title":"The influence of blackcurrant extract\u2013based cosmetic antimicrobial agent on skin cells and skin model membranes","volume":"703","author":"Wy\u017cga","year":"2024","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.colsurfb.2026.116209_bib36","article-title":"Interfacial phenomena","author":"Davies","year":"1963"},{"issue":"2","key":"10.1016\/j.colsurfb.2026.116209_bib37","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.colsurfb.2006.09.005","article-title":"Comparison of paclitaxel penetration in normal and cancerous cervical model monolayer membranes","volume":"53","author":"Preetha","year":"2006","journal-title":"Colloids Surf. B Biointerfaces"},{"issue":"4","key":"10.1016\/j.colsurfb.2026.116209_bib38","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0006-291X(03)01505-5","article-title":"Surface film pressure of actin: interactions with lipids in mixed monolayers","volume":"308","author":"Gicquaud","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.colsurfb.2026.116209_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2026.152888","article-title":"Comparison of cationic beta-glucans with antifungal properties \u2014 Correlation between chemical structure and biological activity","volume":"370","author":"Sk\u00f3ra","year":"2026","journal-title":"Int. J. Biol. Macromol."},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116209_bib40","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1016\/S0006-3495(01)75892-4","article-title":"Insertion and pore formation driven by adsorption of proteins onto lipid bilayer membrane-water interfaces","volume":"81","author":"Zuckermann","year":"2001","journal-title":"Biophys. J."},{"issue":"14","key":"10.1016\/j.colsurfb.2026.116209_bib41","doi-asserted-by":"crossref","first-page":"6016","DOI":"10.1021\/la053276z","article-title":"Poly(dimethylamino)ethyl Methacrylate for use as a surfactant in the miniemulsion polymerization of styrene","volume":"22","author":"Ni","year":"2006","journal-title":"Langmuir"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116209_bib42","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1021\/jp109151s","article-title":"A discussion of the pH-Dependent protonation behaviors of Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) and Poly(ethylenimine-ran-2-ethyl-2-oxazoline) (P(EI-r-EOz))","volume":"115","author":"Lee","year":"2011","journal-title":"J. Phys. Chem. B."},{"issue":"18","key":"10.1016\/j.colsurfb.2026.116209_bib43","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.1021\/jp054533b","article-title":"Reversible Activation of Diblock Copolymer Monolayers at the Interface by pH Modulation, 2: Membrane Interactions at the Solid\/Liquid Interface","volume":"110","author":"Rehfeldt","year":"2006","journal-title":"J. Phys. Chem. B"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116209_bib44","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.jconrel.2010.05.002","article-title":"High content analysis of cytotoxic effects of pDMAEMA on human intestinal epithelial and monocyte cultures","volume":"146","author":"Rawlinson","year":"2010","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.colsurfb.2026.116209_bib45","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jconrel.2006.04.014","article-title":"Toxicity of cationic lipids and cationic polymers in gene delivery","volume":"114","author":"Lv","year":"2006","journal-title":"J. Control. Release"},{"issue":"3","key":"10.1016\/j.colsurfb.2026.116209_bib46","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jconrel.2004.02.011","article-title":"pDMAEMA is internalised by endocytosis but does not physically disrupt endosomes","volume":"96","author":"Jones","year":"2004","journal-title":"J. Control. Release"},{"issue":"7","key":"10.1016\/j.colsurfb.2026.116209_bib47","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1021\/ma102498g","article-title":"Effect of chain length on cytotoxicity and endocytosis of cationic polymers","volume":"44","author":"Cai","year":"2011","journal-title":"Macromolecules"},{"issue":"5","key":"10.1016\/j.colsurfb.2026.116209_bib48","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/bm061150q","article-title":"The chemistry and applications of antimicrobial polymers: a state-of-the-art review","volume":"8","author":"Kenawy","year":"2007","journal-title":"Biomacromolecules"}],"container-title":["Colloids and Surfaces B: Biointerfaces"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007976?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0927776526007976?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T23:58:37Z","timestamp":1793923117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0927776526007976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":48,"alternative-id":["S0927776526007976"],"URL":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116209","relation":{},"ISSN":["0927-7765"],"issn-type":[{"value":"0927-7765","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"From model membranes to cell lines: Evaluating the safety of antifungal polycations using Langmuir monolayers","name":"articletitle","label":"Article Title"},{"value":"Colloids and Surfaces B: Biointerfaces","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.colsurfb.2026.116209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116209"}}