{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T06:29:14Z","timestamp":1769581754174,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81202855"],"award-info":[{"award-number":["81202855"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Program for Liaoning Excellent Talents in University","award":["LJQ2015107"],"award-info":[{"award-number":["LJQ2015107"]}]},{"name":"Shenyang Pharmaceutical University","award":["ZQN2016013"],"award-info":[{"award-number":["ZQN2016013"]}]},{"name":"Shenyang Pharmaceutical University Medical College-Jingxin Cooperative Fund"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.compbiolchem.2018.04.007","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T12:35:55Z","timestamp":1523277355000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The role of the arginine residue in site RC for the analgesic activity of the recombinant Chinese scorpion Buthus martensii Karsch, BmK AGP-SYPU1"],"prefix":"10.1016","volume":"74","author":[{"given":"Yong","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuelin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinghai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongshan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.peptides.2013.10.021","volume":"51","author":"Almaaytah","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0010","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","volume":"25","author":"Altschul","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0015","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0020","doi-asserted-by":"crossref","first-page":"e0128578","DOI":"10.1371\/journal.pone.0128578","volume":"10","author":"Camargos","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0025","series-title":"Amber 12","author":"Case","year":"2012"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.toxicon.2006.09.022","volume":"49","author":"Catterall","year":"2007","journal-title":"Toxicon"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0035","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.4155\/fmc.14.108","volume":"6","author":"Daly","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0040","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1002\/jcc.10349","volume":"24","author":"Duan","year":"2003","journal-title":"J. Comp. Chem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0045","series-title":"Methods in Narcotics Research","first-page":"76","author":"Fennessy","year":"1975"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0050","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.2174\/138161207782023739","volume":"13","author":"Fox","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0055","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1074\/jbc.274.9.5769","volume":"274","author":"Froy","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0060","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/S0041-0101(02)00142-3","volume":"40","author":"Goudet","year":"2002","journal-title":"Toxicon"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0065","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1006\/jmbi.1999.3036","volume":"292","author":"He","year":"1999","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0378-1119(89)90358-2","volume":"77","author":"Ho","year":"1989","journal-title":"Gene"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0075","doi-asserted-by":"crossref","first-page":"31679","DOI":"10.1074\/jbc.M402048200","volume":"279","author":"Karbat","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0080","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1432-1033.1989.tb14735.x","volume":"181","author":"Kharrat","year":"1989","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0085","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1517\/14712598.2011.621940","volume":"11","author":"King","year":"2011","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0090","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd1197","volume":"2","author":"Lewis","year":"2003","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0095","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1046-5928(02)00609-5","volume":"27","author":"Liu","year":"2003","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0100","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.3390\/toxins6072137","volume":"6","author":"M.Goyffon","year":"2014","journal-title":"Toxins"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0105","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1021\/acs.biochem.5b00067","volume":"54","author":"Meng","year":"2015","journal-title":"Biochemistry"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0110","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ijbiomac.2017.01.020","volume":"99","author":"Meng","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0115","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.toxicon.2014.11.233","volume":"93","author":"Ortiz","year":"2015","journal-title":"Toxicon"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0120","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bcp.2017.03.005","volume":"134","author":"Perumal","year":"2017","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0125","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.3390\/toxins7072534","volume":"7","author":"Pucca","year":"2015","journal-title":"Toxins"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0130","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","volume":"23","author":"Rychaert","year":"1977","journal-title":"J. Comp. Phys."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0135","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1006\/jmbi.1993.1626","volume":"234","author":"Sali","year":"1993","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0140","doi-asserted-by":"crossref","first-page":"24125","DOI":"10.1074\/jbc.M211931200","volume":"278","author":"Sun","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0145","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.3390\/toxins5122456","volume":"5","author":"Sunagar","year":"2013","journal-title":"Toxins"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0150","doi-asserted-by":"crossref","first-page":"4699","DOI":"10.1021\/bi0270438","volume":"42","author":"Wang","year":"2003","journal-title":"Biochemistry"},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0155","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/bmc.1519","volume":"25","author":"Wang","year":"2011","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0160","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s12010-012-9768-7","volume":"168","author":"Wang","year":"2012","journal-title":"Appl. Biochem. Biotechnol."},{"key":"10.1016\/j.compbiolchem.2018.04.007_bib0165","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbrc.2009.11.110","volume":"391","author":"Zhu","year":"2010","journal-title":"Biochem. Biophys Res. Commun."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927118300100?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927118300100?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,21]],"date-time":"2019-09-21T13:38:00Z","timestamp":1569073080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927118300100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":33,"alternative-id":["S1476927118300100"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2018.04.007","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of the arginine residue in site RC for the analgesic activity of the recombinant Chinese scorpion Buthus martensii Karsch, BmK AGP-SYPU1","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2018.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}