{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:07:10Z","timestamp":1786241230570,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.compbiolchem.2024.108149","type":"journal-article","created":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T19:08:04Z","timestamp":1720984084000},"page":"108149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Comprehending the pharmacological mechanism of marine phenolic acids in bladder cancer therapy against matrix metalloproteinase 9 protein by integrated network pharmacology and in-silico approaches"],"prefix":"10.1016","volume":"112","author":[{"given":"Miah","family":"Roney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Nazim","family":"Uddin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Fadhlizil","family":"Fasihi Mohd Aluwi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib1","doi-asserted-by":"crossref","first-page":"34984","DOI":"10.1038\/srep34984","article-title":"Structural insights into conformational stability of both wild-type and mutant EZH2 receptor","volume":"6","author":"Aier","year":"2016","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.compbiolchem.2024.108149_bib2","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nrurol.2009.201","article-title":"The bladder extracellular matrix. Part I: architecture, development and disease","volume":"6","author":"Aitken","year":"2009","journal-title":"Nat. Rev. Urol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3390\/molecules27010155","article-title":"In vitro evaluation of the anti-diabetic potential of aqueous acetone Helichrysum petiolare Extract (AAHPE) with molecular docking relevance in diabetes mellitus","volume":"27","author":"Akinyede","year":"2021","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.eururo.2021.08.010","article-title":"European Association of Urology guidelines on non\u2013muscle-invasive bladder cancer (Ta, T1, and carcinoma in situ)","volume":"81","author":"Babjuk","year":"2022","journal-title":"Eur. Urol."},{"key":"10.1016\/j.compbiolchem.2024.108149_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.569377","article-title":"Proteoglycans as mediators of cancer tissue mechanics","volume":"8","author":"Barkovskaya","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2024.108149_bib6","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1039\/D0NP00089B","article-title":"Marine natural products","volume":"38","author":"Carroll","year":"2021","journal-title":"Nat. Prod. Rep."},{"issue":"4","key":"10.1016\/j.compbiolchem.2024.108149_bib7","first-page":"1","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib8","doi-asserted-by":"crossref","first-page":"25462","DOI":"10.1038\/srep25462","article-title":"In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database","volume":"6","author":"Dai","year":"2016","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.compbiolchem.2024.108149_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.3390\/md20120759","article-title":"Marine compounds and cancer: updates 2022","volume":"20","author":"Dyshlovoy","year":"2022","journal-title":"Mar. Drugs"},{"issue":"W1","key":"10.1016\/j.compbiolchem.2024.108149_bib10","doi-asserted-by":"crossref","first-page":"W726","DOI":"10.1093\/nar\/gkac297","article-title":"SuperPred 3.0: drug classification and target prediction\u2014a machine learning approach","volume":"50","author":"Gallo","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.compbiolchem.2024.108149_bib11","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3390\/md20060349","article-title":"Natural marine products: Anti-colorectal cancer in vitro and in vivo","volume":"20","author":"Han","year":"2022","journal-title":"Mar. Drugs"},{"issue":"2","key":"10.1016\/j.compbiolchem.2024.108149_bib12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3897\/pharmacia.70.e101989","article-title":"Molecular docking and dynamics analysis of halogenated imidazole chalcone as anticancer compounds","volume":"70","author":"Haryadi","year":"2023","journal-title":"Pharmacia"},{"issue":"5","key":"10.1016\/j.compbiolchem.2024.108149_bib13","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1582-4934.2010.01236.x","article-title":"Proteoglycans in cancer biology, tumour microenvironment and angiogenesis","volume":"15","author":"Iozzo","year":"2011","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.compbiolchem.2024.108149_bib14","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.eururo.2023.03.029","article-title":"Epidemiology of bladder cancer in 2023: a systematic review of risk factors","volume":"84","author":"Jubber","year":"2023","journal-title":"Eur. Urol."},{"issue":"24","key":"10.1016\/j.compbiolchem.2024.108149_bib15","doi-asserted-by":"crossref","first-page":"11644","DOI":"10.1158\/0008-5472.CAN-06-1212","article-title":"Matrix metalloproteinase polymorphisms and bladder cancer risk","volume":"66","author":"Kader","year":"2006","journal-title":"Cancer Res."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2024.108149_bib16","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"Kanehisa","year":"2017","journal-title":"Nucleic Acids Res."},{"issue":"16","key":"10.1016\/j.compbiolchem.2024.108149_bib17","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.3390\/jcm10163683","article-title":"Enhanced expression but decreased specific activity of matrix metalloproteinase 10 (MMP-10) in comparison with Matrix Metalloproteinase 3 (MMP-3) in human urinary bladder carcinoma","volume":"10","author":"Kudelski","year":"2021","journal-title":"J. Clin. Med."},{"issue":"3","key":"10.1016\/j.compbiolchem.2024.108149_bib18","doi-asserted-by":"crossref","first-page":"956","DOI":"10.3390\/biomedicines11030956","article-title":"The significance of matrix metalloproteinase 9 (MMP-9) and metalloproteinase 2 (MMP-2) in urinary bladder cancer","volume":"11","author":"Kudelski","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.compbiolchem.2024.108149_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.730288","article-title":"Identification of natural inhibitors against SARS-CoV-2 drugable targets using molecular docking, molecular dynamics simulation, and MM-PBSA approach","volume":"11","author":"Kushwaha","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2024.108149_bib20","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/cells9051076","article-title":"Structure and function of human matrix metalloproteinases","volume":"9","author":"Laronha","year":"2020","journal-title":"Cells"},{"issue":"8","key":"10.1016\/j.compbiolchem.2024.108149_bib21","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.2174\/0929867327666200113154115","article-title":"Marine natural products with high anticancer activities","volume":"27","author":"Matulja","year":"2020","journal-title":"Curr. Med. Chem."},{"issue":"10","key":"10.1016\/j.compbiolchem.2024.108149_bib22","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.1021\/acs.jmedchem.8b00096","article-title":"Development of thioaryl-based matrix metalloproteinase-12 inhibitors with alternative zinc-binding groups: synthesis, potentiometric, NMR, and crystallographic studies","volume":"61","author":"Nuti","year":"2018","journal-title":"J. Med. Chem."},{"issue":"7","key":"10.1016\/j.compbiolchem.2024.108149_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2023.103705","article-title":"Mechanistic elucidation of Juglanthraquinone C targeting breast cancer: a network pharmacology-based investigation","volume":"30","author":"Qayoom","year":"2023","journal-title":"Saudi J. Biol. Sci."},{"issue":"15","key":"10.1016\/j.compbiolchem.2024.108149_bib24","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.3390\/cancers13153778","article-title":"Targeting BRF2 in cancer using repurposed drugs","volume":"13","author":"Rashidieh","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.compbiolchem.2024.108149_bib25","first-page":"1","article-title":"Exploring the potential of biologically active phenolic acids from marine natural products as anticancer agents targeting the epidermal growth factor receptor","author":"Roney","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"01","key":"10.1016\/j.compbiolchem.2024.108149_bib26","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1142\/S2737416523500059","article-title":"Identification of Novel 5-Lipoxygenase-Activating Protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses","volume":"22","author":"Rullah","year":"2023","journal-title":"J. Comput. Biophys. Chem."},{"key":"10.1016\/j.compbiolchem.2024.108149_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2023.107059","article-title":"Advanced network pharmacology study reveals multi-pathway and multi-gene regulatory molecular mechanism of Bacopa monnieri in liver cancer based on data mining, molecular modeling, and microarray data analysis","volume":"161","author":"Sadaqat","year":"2023","journal-title":"Comput. Biol. Med."},{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib28","first-page":"15","article-title":"Epidemiology of bladder cancer","volume":"8","author":"Saginala","year":"2020","journal-title":"Med. Sci."},{"issue":"11","key":"10.1016\/j.compbiolchem.2024.108149_bib29","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.compbiolchem.2024.108149_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111826","article-title":"Prediction of potential cancer-related molecular targets of North African plants constituents using network pharmacology-based analysis","volume":"238","author":"Shawky","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"6","key":"10.1016\/j.compbiolchem.2024.108149_bib31","first-page":"2333","article-title":"Enhanced urinary gelatinase activities (matrix metalloproteinases 2 and 9) are associated with early-stage bladder carcinoma: a comparison with clinically used tumor markers","volume":"6","author":"Sier","year":"2000","journal-title":"Clin. Cancer Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejps.2012.04.012","article-title":"Chemoinformatics in anti-cancer chemotherapy: multi-target QSAR model for the in silico discovery of anti-breast cancer agents","volume":"47","author":"Speck-Planche","year":"2012","journal-title":"Eur. J. Pharm. Sci."},{"issue":"15","key":"10.1016\/j.compbiolchem.2024.108149_bib33","doi-asserted-by":"crossref","first-page":"4848","DOI":"10.1016\/j.bmc.2012.05.071","article-title":"Rational drug design for anti-cancer chemotherapy: multi-target QSAR models for the in silico discovery of anti-colorectal cancer agents","volume":"20","author":"Speck-Planche","year":"2012","journal-title":"Bioorg. Med. Chem."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2024.108149_bib34","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.compbiolchem.2024.108149_bib35","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1165\/rcmb.2018-0118OC","article-title":"Lung adenocarcinoma syndecan-2 potentiates cell invasiveness","volume":"60","author":"Tsoyi","year":"2019","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2024.108149_bib36","first-page":"117","article-title":"Combination of microarray profiling and protein-protein interaction databases delineates the minimal discriminators as a metastasis network for esophageal squamous cell carcinoma","volume":"34","author":"Wong","year":"2009","journal-title":"Int. J. Oncol."},{"issue":"23","key":"10.1016\/j.compbiolchem.2024.108149_bib37","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1080\/07391102.2023.2178506","article-title":"Usnic acid as potential inhibitors of BCL2 and P13K protein through network pharmacology-based analysis, molecular docking and molecular dynamic simulation","volume":"41","author":"Wong","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.compbiolchem.2024.108149_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2024.102003","article-title":"Immune-checkpoint gene expression and BCG response in non-muscle invasive bladder cancer","volume":"46","author":"Zucca","year":"2024","journal-title":"Transl. Oncol."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927124001373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927124001373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T18:00:39Z","timestamp":1725991239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927124001373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":38,"alternative-id":["S1476927124001373"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2024.108149","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehending the pharmacological mechanism of marine phenolic acids in bladder cancer therapy against matrix metalloproteinase 9 protein by integrated network pharmacology and in-silico approaches","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2024.108149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108149"}}