{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:47:00Z","timestamp":1787838420503,"version":"build-2784847793"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2025-696"],"award-info":[{"award-number":["ORF-2025-696"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.compbiolchem.2025.108569","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T12:05:16Z","timestamp":1750939516000},"page":"108569","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Chemical constituents of vegetables and fruits as potential inhibitors of lipoprotein-associated phospholipase A2: An in-silico approach toward mitigating the complications of Alzheimer's disease and atherosclerosis"],"prefix":"10.1016","volume":"119","author":[{"given":"Singamoorthy","family":"Amalraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalaimathi","family":"Karunanithi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasan","family":"Prabhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaliyamoorthy","family":"Dass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia","family":"Awadalkreem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shine","family":"Kadaikunnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muthu","family":"Thiruvengadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108569_bib1","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.3390\/biomedicines11072078","article-title":"Current understanding of polyphenols to enhance bioavailability for better therapies","volume":"11","author":"Aatif","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13050713","article-title":"Comparative metabolite profile, biological activity and overall quality of three lettuce (Lactuca sativa l., asteraceae) cultivars in response to sulfur nutrition","volume":"13","author":"Abdalla","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2014.06.007","article-title":"Genistein isoflavone glycoconjugates in sour cherry (Prunus cerasus L.) cultivars","volume":"166","author":"Abrank\u00f3","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib4","article-title":"Diabetes and hypercholesterolemia increase blood-brain barrier permeability and brain amyloid deposition: beneficial effects of the LpPLA\u2082 inhibitor darapladib","volume":"35","author":"Acharya","year":"2013","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib5","article-title":"Nutritional values of some tropical vegetables","volume":"35","author":"Adenipekun","year":"2010","journal-title":"J. Appl. Biosci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib6","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-015-0594-7","article-title":"Phytochemicals from mangifera pajang kosterm and their biological activities","volume":"15","author":"Ahmad","year":"2015","journal-title":"BMC Complement Alter. Med"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/efd2.70008","article-title":"A review on daidzein as food supplement: exploring its phytopharmacological and preclinical status","volume":"5","author":"Ahmad","year":"2024","journal-title":"eFood"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2012.05.005","article-title":"Sterol stability in functional fruit beverages enriched with different plant sterol sources","volume":"48","author":"Alemany-Costa","year":"2012","journal-title":"Food Res. Int."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib9","article-title":"Overviews of biological importance of quercetin: a bioactive flavonoid","author":"Anand David","year":"2016","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib10","article-title":"Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods","volume":"48","author":"Arts","year":"2000","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib11","article-title":"Rutin content in plant products","volume":"44","author":"Atanassova","year":"2009","journal-title":"J. Univ. Chem. Technol. Metall."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib12","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gky318","article-title":"ProTox-II: a webserver for the prediction of toxicity of chemicals","volume":"46","author":"Banerjee","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib13","doi-asserted-by":"crossref","DOI":"10.1021\/jf9044809","article-title":"Flavonoid composition and antioxidant activity of juices from chinotto (Citrus x myrtifolia Raf.) fruits at different ripening stages","volume":"58","author":"Barreca","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/S0960-894X(03)00058-1","article-title":"The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2","volume":"13","author":"Blackie","year":"2003","journal-title":"Bioorg. Med Chem. Lett."},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108569_bib15","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S1074-5521(02)00245-4","article-title":"Analysis of the pi-pi stacking interactions between the aminoglycoside antibiotic kinase APH(3\u2032)-IIIa and its nucleotide ligands","volume":"9","author":"Boehr","year":"2002","journal-title":"Chem. Biol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2008.06.002","article-title":"Monoamine oxidase inactivation: from pathophysiology to therapeutics","author":"Bortolato","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/molecules23113004","article-title":"Antiproliferative, proapoptotic, antioxidant and antimicrobial effects of sinapis nigra L. And Sinapis alba L. Extracts","volume":"23","author":"Boscaro","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/nu14030623","article-title":"Oleanolic acid: extraction, characterization and biological activity","author":"Castellano","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib19","doi-asserted-by":"crossref","DOI":"10.1007\/s13197-019-03795-6","article-title":"Valorization of papaya (Carica papaya L.) agroindustrial waste through the recovery of phenolic antioxidants by supercritical fluid extraction","volume":"56","author":"Castro-Vargas","year":"2019","journal-title":"J. Food Sci. Technol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.arabjc.2023.104680","article-title":"Camellia sinensis: insights on its molecular mechanisms of action towards nutraceutical, anticancer potential and other therapeutic applications","author":"Chaudhary","year":"2023","journal-title":"Arab. J. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2019.04.008","article-title":"GC\u2013MS analysis of D-pinitol in carob: syrup and fruit (flesh and seed)","volume":"1116","author":"Christou","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102288","article-title":"Dietary quercetin and kaempferol: bioavailability and potential cardiovascular-related bioactivity in humans","author":"Dabeek","year":"2019","journal-title":"Nutrients"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2022.991369","article-title":"In-silico molecular modelling, MM\/GBSA binding free energy and molecular dynamics simulation study of novel pyrido fused imidazo[4,5-c] quinolines as potential anti-tumor agents","volume":"10","author":"Dasmahapatra","year":"2022","journal-title":"Front. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib24","doi-asserted-by":"crossref","DOI":"10.1021\/jf040266f","article-title":"Biologically important thiols in various vegetables and fruits","volume":"52","author":"Demirkol","year":"2004","journal-title":"J. Agric. Food Chem."},{"issue":"19","key":"10.1016\/j.compbiolchem.2025.108569_bib25","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.3390\/foods13193149","article-title":"Effect of fruit and vegetable consumption on human health: an update of the literature","volume":"13","author":"Devirgiliis","year":"2024","journal-title":"Foods"},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108569_bib26","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/nu13010273","article-title":"Polyphenols and human health: the role of bioavailability","volume":"13","author":"Di Lorenzo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib27","doi-asserted-by":"crossref","DOI":"10.1021\/jf60057a008","article-title":"Cystine, tyrosine, and essential amino acid contents of selected foods","volume":"3","author":"Edwards","year":"1955","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib28","doi-asserted-by":"crossref","DOI":"10.1007\/s00217-012-1669-z","article-title":"Sinapic acid derivatives in defatted Oriental mustard (Brassica juncea L.) seed meal extracts using UHPLC-DAD-ESI-MS n and identification of compounds with antibacterial activity","volume":"234","author":"Engels","year":"2012","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib29","article-title":"Food based phytochemical luteolin their derivatives, sources and medicinal benefits","volume":"3","author":"Faisal Manzoor","year":"2017","journal-title":"Int. J. Agric. Life Sci. IJALS"},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108569_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10030664","article-title":"Structure of Some Green Tea Catechins and the Availability of Intracellular Copper Influence Their Ability to Cause Selective Oxidative DNA Damage in Malignant Cells","volume":"10","author":"Farhan","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib31","series-title":"Food and Agriculture Organisation","article-title":"The state of food security and nutrition in the world","author":"FAO","year":"2020"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib32","article-title":"Review of scopoletin: isolation, analysis process, and pharmacological activity","author":"Firmansyah","year":"2021","journal-title":"Biointerface Res Appl. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.atherosclerosis.2014.04.032","article-title":"Lipoprotein-associated phospholipase A2 and risk of dementia in the Cardiovascular Health Study","volume":"235","author":"Fitzpatrick","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib34","article-title":"Targeted-analysis of \u03b2-carboline alkaloids in passionfruit (\u201cMaracuj\u00e1\u201d) by SBSE(PDMS)-LC\/Flu and UHPLC-MS","author":"Freire","year":"2018","journal-title":"J. Braz. Chem. Soc. 29"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s00217-012-1709-8","article-title":"Comparison of fatty acid profiles and contents of seed oils recovered from dessert and cider apples and further Rosaceous plants","volume":"234","author":"Fromm","year":"2012","journal-title":"Eur. Food Res. Technol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/1750-3841.14666","article-title":"Phenolic content and antioxidant activity of extracts of 12 melon (cucumis melo) peel powders prepared from commercial melons","volume":"84","author":"Ganji","year":"2019","journal-title":"J. Food Sci."},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108569_bib37","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/ddr.21515","article-title":"Structure-activity study of fluorine or chlorine-substituted cinnamic acid derivatives with tertiary amine side chain in acetylcholinesterase and butyrylcholinesterase inhibition","volume":"80","author":"Gao","year":"2019","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib38","doi-asserted-by":"crossref","DOI":"10.1021\/jf9811065","article-title":"Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries","volume":"47","author":"H\u00e4kkinen","year":"1999","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2009.11.056","article-title":"Isolation and characterisation of the sesquiterpene lactones from Lactuca sativa L var. anagustata","volume":"120","author":"Han","year":"2010","journal-title":"Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2014.03.001","article-title":"Quantitative estimation of (-)-hinokinin, a trypanosomicidal marker in Piper cubeba, and some of its commercial formulations using HPLC-PDA","volume":"5","author":"Haribabu","year":"2015","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib41","series-title":"Science and Innovations for Food Systems Transformation [Internet]","article-title":"Fruits and Vegetables for Healthy Diets: Priorities for Food System Research and Action. 2023 Jan 2","author":"Harris","year":"2023"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/S0031-6865(99)00062-X","article-title":"Content of CYP3A4 inhibitors, naringin, naringenin and bergapten in grapefruit and grapefruit juice products","volume":"74","author":"Ho","year":"2000","journal-title":"Pharm. Acta Helv."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib43","doi-asserted-by":"crossref","unstructured":"Hussein, H., El-Anssary, R.A., 2019. Plants Secondary Metabolites: The Key Drivers of the Pharmacological Actions of Medicinal Plants, in: Herbal Medicine. https:\/\/doi.org\/10.5772\/intechopen.76139.","DOI":"10.5772\/intechopen.76139"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib44","article-title":"Simultaneous analysis of serotonin, tryptophan and tryptamine levels in common fresh fruits and vegetables in Japan using fluorescence HPLC","volume":"13","author":"Islam","year":"2016","journal-title":"Food Biosci."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108569_bib45","doi-asserted-by":"crossref","first-page":"H97","DOI":"10.1111\/j.1750-3841.2009.01091.x","article-title":"Influence of cooking methods on antioxidant activity of vegetables","volume":"74","author":"Jim\u00e9nez-Monreal","year":"2009","journal-title":"J. Food Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib46","doi-asserted-by":"crossref","DOI":"10.1021\/jf010471k","article-title":"Aromatic profile of aqueous banana essence and banana fruit by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O)","volume":"49","author":"Jord\u00e1n","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0895-3988(09)60001-5","article-title":"Contents of phytosterols in vegetables and fruits commonly consumed in China","volume":"21","author":"Jun-Hua","year":"2008","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib48","doi-asserted-by":"crossref","DOI":"10.2174\/1871527315666160202125519","article-title":"Implication of green tea as a possible therapeutic approach for parkinson disease","volume":"15","author":"Jurado-Coronel","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib49","doi-asserted-by":"crossref","DOI":"10.1007\/s43450-022-00258-6","article-title":"Anti-dengue potential of mangiferin: intricate network of dengue to human genes","volume":"32","author":"Kalaimathi","year":"2022","journal-title":"Rev. Bras. De. Farmacogn."},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108569_bib50","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1007\/s11030-018-9839-y","article-title":"Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors","volume":"22","author":"Kang","year":"2018","journal-title":"Mol. Divers."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib51","first-page":"15","article-title":"Content of gallic acid in selected plant extracts","author":"Karama\u00e6","year":"2006","journal-title":"J. Food Nutr. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbalip.2006.06.017","article-title":"Clinical aspects of plasma platelet-activating factor-acetylhydrolase","author":"Karasawa","year":"2006","journal-title":"Biochim Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib53","first-page":"179","article-title":"Molecular simulation for screening bioactive compounds as potential candidate for alzheimer\u2019s disease","volume":"24","author":"Kezia","year":"2023","journal-title":"EKSAKTA Berk. Ilm. Bid. MIPA"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib54","article-title":"Object recognition and morris water maze to detect cognitive impairment from neurodegenerative diseases in rats","volume":"45","author":"Khan","year":"2024","journal-title":"J. Adv. Zool."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib55","doi-asserted-by":"crossref","DOI":"10.1021\/jf071302o","article-title":"Free galactose content in selected fresh fruits and vegetables and soy beverages","volume":"55","author":"Kim","year":"2007","journal-title":"J. Agric. Food Chem."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108569_bib56","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1017\/S0007114509992364","article-title":"Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment","volume":"103","author":"Krikorian","year":"2010","journal-title":"Br. J. Nutr."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108569_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158063","article-title":"Ligand docking to intermediate and close-to-bound conformers generated by an elastic network model-based algorithm for highly flexible proteins","volume":"11","author":"Kurkcuoglu","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib58","first-page":"53","article-title":"Development of method of qualitative analysis of bird cherry fruit for inclusion in the monograph of state pharmacopoeia of Ukraine","volume":"50","author":"Lenchyk","year":"2016","journal-title":"Ann. Mechnikov\u2019S. Inst."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib59","doi-asserted-by":"crossref","first-page":"916","DOI":"10.3390\/antiox10060916","article-title":"Procyanidin B2 reduces vascular calcification through inactivation of ERK1\/2-RUNX2 pathway","volume":"10","author":"Liang","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/foods10092089","article-title":"Biologically active compounds in mustard seeds: a toxicological perspective","author":"Lietzow","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib61","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.6b00282","article-title":"Structural and thermodynamic characterization of protein-ligand interactions formed between lipoprotein-associated phospholipase A2 and inhibitors","volume":"59","author":"Liu","year":"2016","journal-title":"J. Med Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2022.105046","article-title":"Castanea mollissima shell polyphenols regulate JAK2 and PPAR\u03b3 expression to suppress inflammation and lipid accumulation by inhibiting M1 macrophages polarization","volume":"92","author":"Liu","year":"2022","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib63","doi-asserted-by":"crossref","DOI":"10.1080\/09168451.2017.1374830","article-title":"Inhibition of phosphatidylinositide 3-kinase impairs the benzyl isothiocyanate-induced accumulation of autophagic molecules and Nrf2 in human colon cancer cells","volume":"81","author":"Liu","year":"2017","journal-title":"Biosci. Biotechnol. Biochem"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnu.2018.03.006","article-title":"Effects of long-term consumption of broccoli sprouts on inflammatory markers in overweight subjects","volume":"38","author":"L\u00f3pez-Chill\u00f3n","year":"2019","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib65","doi-asserted-by":"crossref","first-page":"1144231","DOI":"10.3389\/fpsyg.2023.1144231","article-title":"Effects of a polyphenol-rich grape and blueberry extract (Memophenol\u2122) on cognitive function in older adults with mild cognitive impairment: A randomized, double-blind, placebo-controlled study","volume":"14","author":"Lopresti","year":"2023","journal-title":"Front. Psychol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib66","article-title":"Nitrogen-containing flavonoid and their analogs with diverse B-ring in acetylcholinesterase and butyrylcholinesterase inhibition","author":"Lu","year":"2020","journal-title":"Drug"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib67","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0120480","article-title":"Identification of proanthocyanidins from litchi (Litchi chinensis Sonn.) pulp by LC-ESI-Q-TOF-MS and their antioxidant activity","volume":"10","author":"Lv","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib68","doi-asserted-by":"crossref","DOI":"10.2147\/CLEP.S164497","article-title":"Intake of glucosinolates and risk of coronary heart disease in three large prospective cohorts of US men and women","volume":"10","author":"Ma","year":"2018","journal-title":"Clin. Epidemiol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.807447","article-title":"Profiling phenolic composition in pomegranate peel from nine selected cultivars using UHPLC-QTOF-MS and UPLC-QQQ-MS","volume":"8","author":"Man","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib70","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.580550","article-title":"Impact of household cooking techniques on african nightshade and chinese cabbage on phenolic compounds, antinutrients, in vitro antioxidant, and \u03b2-glucosidase activity","volume":"7","author":"Managa","year":"2020","journal-title":"Front Nutr."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib71","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0280847","article-title":"Integrated network pharmacology and molecular modeling approach for the discovery of novel potential MAPK3 inhibitors from whole green jackfruit flour targeting obesity-linked diabetes mellitus","volume":"18","author":"Maradesha","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib72","doi-asserted-by":"crossref","DOI":"10.1055\/s-2003-38881","article-title":"Glucosinolates in Moringa stenopetala","volume":"69","author":"Mekonnen","year":"2003","journal-title":"Planta Med"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/s12870-022-03746-y","article-title":"Anthocyanins accumulation analysis of correlated genes by metabolome and transcriptome in green and purple peppers (Capsicum annuum)","volume":"22","author":"Meng","year":"2022","journal-title":"BMC Plant Biol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib74","doi-asserted-by":"crossref","DOI":"10.1021\/jf000892m","article-title":"Flavonoid (myricetin, quercetin, kaempferol, luteolin, and apigenin) content of edible tropical plants","volume":"49","author":"Miean","year":"2001","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib75","article-title":"Flavonoids as promising neuroprotectants and their therapeutic potential against alzheimer's disease","volume":"28","author":"Minocha","year":"2022","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib76","doi-asserted-by":"crossref","DOI":"10.1002\/cbdv.201600311","article-title":"Identification of glucosinolates in seeds of three brassicaceae species known to hyperaccumulate heavy metals","volume":"14","author":"Montaut","year":"2017","journal-title":"Chem. Biodivers."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140277","article-title":"Comparative study for metabolomics, antioxidant activity, and molecular docking simulation of the newly bred Korean red rice accessions","volume":"458","author":"Moon","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib78","doi-asserted-by":"crossref","DOI":"10.1021\/jf070623x","article-title":"Fructan and free fructose content of common Australian vegetables and fruit","volume":"55","author":"Muir","year":"2007","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/nrd4381","article-title":"GSK\u2019s darapladib failures dim hopes for anti-inflammatory heart drugs","author":"Mullard","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib80","volume":"49","author":"Murakami","year":"2001","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib81","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10040807","article-title":"The biosynthesis and medicinal properties of taraxerol","author":"Mus","year":"2022","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108569_bib82","doi-asserted-by":"crossref","first-page":"47","DOI":"10.22207\/JPAM.14.1.08","article-title":"Polyphenols more than an antioxidant: role and scope","volume":"14","author":"Mustafa","year":"2020","journal-title":"J. Pure Appl. Microbiol"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib83","unstructured":"Najima, M., Miyata, A., Miki, S., Ozaki, S., 2019. Effects of Food Containing Benzyl Glucosinolate on Bowel Movement and Intestinal Environment in Healthy Japanese: A Randomized, Placebo-controlled, Double-blind, Crossover Study. 56,105-116."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib84","article-title":"Alzheimer\u2019s disease puzzle: delving into pathogenesis hypotheses","author":"Nasb","year":"2024","journal-title":"Aging Dis."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.chroma.2015.01.001","article-title":"Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry","volume":"1381","author":"Naumoska","year":"2015","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib86","article-title":"Endophytic fungi of citrus plants","author":"Nicoletti","year":"2019","journal-title":"Agric. (Switz. )"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib87","doi-asserted-by":"crossref","DOI":"10.3390\/toxins15020098","article-title":"Emerging issues on tropane alkaloid contamination of food in Europe","author":"de Nijs","year":"2023","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib88","doi-asserted-by":"crossref","DOI":"10.1021\/jf0108765","article-title":"Antioxidant activities of pomegranate fruit extract and its anthocyanidins: delphinidin, cyanidin, and pelargonidin","volume":"50","author":"Noda","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib89","article-title":"Physiological functions of solanaceous and tomato steroidal glycosides","author":"Nohara","year":"2007","journal-title":"J. Nat. Med"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9673(00)82688-6","article-title":"Chemotaxonomic study of neutral coumarins in roots of Citrus and Poncirus by thin-layer, gas-liquid and high-performance liquid chromatographic analyses","volume":"207","author":"Nordby","year":"1981","journal-title":"J. Chromatogr. A"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108569_bib91","doi-asserted-by":"crossref","first-page":"270","DOI":"10.4161\/oxim.2.5.9498","article-title":"Plant polyphenols as dietary antioxidants in human health and disease","volume":"2","author":"Pandey","year":"2009","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102665","article-title":"Quercetin-functionalized nanomaterials: innovative therapeutic avenues for Alzheimer's disease management","volume":"104","author":"Pei","year":"2025","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib93","doi-asserted-by":"crossref","DOI":"10.1017\/S0714980823000776","article-title":"Risk factors associated with missing incidents among persons living with dementia: a scoping review","author":"Perez","year":"2024","journal-title":"Can. J. Aging"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib94","doi-asserted-by":"crossref","DOI":"10.1002\/jsfa.2979","article-title":"Analysis of furanocoumarins in vegetables (Apiaceae) and citrus fruits (Rutaceae)","volume":"87","author":"Peroutka","year":"2007","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib95","article-title":"The different molecular targets and its significant role in alzheimer\u2019s disease: a review","volume":"8","author":"Perumal","year":"2024","journal-title":"Asian J. Med. Biomed."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib96","article-title":"Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils","volume":"89","author":"Pinto","year":"2017","journal-title":"Acad. Bras. Cienc."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/jsfa.1163","article-title":"The content of chlorogenic acids in tropical fruits","volume":"82","author":"Pontes","year":"2002","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib98","doi-asserted-by":"crossref","DOI":"10.1007\/s11103-008-9296-6","article-title":"The molecular and biochemical basis for varietal variation in sesquiterpene content in melon (Cucumis melo L.) rinds","volume":"66","author":"Portnoy","year":"2008","journal-title":"Plant Mol. Biol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib99","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1142\/S2737416524500133","article-title":"Cyanobacterial metabolites as promising neuroprotective agents by targeting phosphoglycerate kinase 1: dynamic in silico approaches","volume":"23","author":"Prabhu","year":"2024","journal-title":"J. Comput. Biophys. Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib100","article-title":"In vivo anticancer activity of the leaves and fruits of Moringa oleifera on mouse melanoma","volume":"1","author":"Purwal","year":"2010","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib101","doi-asserted-by":"crossref","DOI":"10.1016\/j.sajb.2023.01.005","article-title":"A comparative analysis of leaf essential oil profile, in vitro biological properties and in silico studies of four Indian Guava (Psidium guajava L.) cultivars, a promising source of functional food","volume":"153","author":"Raj","year":"2023","journal-title":"South Afr. J. Bot."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib102","doi-asserted-by":"crossref","DOI":"10.3390\/foods12030643","article-title":"UHPLC-MS phenolic fingerprinting, aorta endothelium relaxation effect, antioxidant, and enzyme inhibition activities of azara dentata ruiz & pav berries","volume":"12","author":"Ramos","year":"2023","journal-title":"Foods"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib103","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s42250-022-00421-5","article-title":"Uncovering of anti-dengue molecules from plants prescribed for dengue: a computational investigation","volume":"5","author":"Rani","year":"2022","journal-title":"Chem. Afr."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib104","article-title":"A pharmacological update of ellagic acid","author":"R\u00edos","year":"2018","journal-title":"Planta Med"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib105","doi-asserted-by":"crossref","DOI":"10.2307\/3573125","article-title":"Effect of gamma radiation on the synthesis of scopoletin and scopolin in grapefruit peel in relation to radiation damage","volume":"45","author":"Riov","year":"1971","journal-title":"Radiat. Res"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2017.10.139","article-title":"Procyanidins extracted from the litchi pericarp attenuate atherosclerosis and hyperlipidemia associated with consumption of a high fat diet in apolipoprotein-E knockout mice","volume":"97","author":"Rong","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib107","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.806470","article-title":"Dietary polyphenols and their role in oxidative stress-induced human diseases: insights into protective effects, antioxidant potentials and mechanism(s) of action","volume":"13","author":"Rudrapal","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib108","series-title":"5th International Conference on Biomedical Engineering (IBIOMED)","first-page":"51","article-title":"Multi-Ligand Simultaneous Docking Analysis of Moringa oleifera Phytochemicals Reveals Enhanced BCL-2 Inhibition via Synergistic Action, in: 2024","author":"Saha","year":"2024"},{"issue":"1-26","key":"10.1016\/j.compbiolchem.2025.108569_bib109","article-title":"Recent advances in the conjugation approaches for enhancing the bioavailability of polyphenols","author":"Sahraeian","year":"2024","journal-title":"Food Hydrocoll. 146 (2024) 109221"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2009.04.033","article-title":"Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene","author":"Saleem","year":"2009","journal-title":"Cancer Lett."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbalip.2006.07.011","article-title":"The phospholipase A2 superfamily and its group numbering system","author":"Schaloske","year":"2006","journal-title":"Biochim Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib112","doi-asserted-by":"crossref","DOI":"10.1007\/s11130-019-00792-0","article-title":"Determination of phenolic compounds in three edible ripening stages of yellow guava (psidium cattleianum sabine) after acidic hydrolysis by LC-MS\/MS","volume":"75","author":"Schulz","year":"2020","journal-title":"Plant Foods Hum. Nutr."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108569_bib113","first-page":"589","article-title":"Computational transformation in drug discovery: a comprehensive study on molecular docking and quantitative structure activity relationship (QSAR)","volume":"2","author":"Shah","year":"2024","journal-title":"Intell. Pharm."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib114","article-title":"Computational identification of drug lead compounds for COVID-19 from moringa oleifera","author":"Shaji","year":"2020","journal-title":"ChemRxiv"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib115","article-title":"Catechins: protective mechanism of antioxidant stress in atherosclerosis","author":"Sheng","year":"2023","journal-title":"Front Pharm."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib116","doi-asserted-by":"crossref","DOI":"10.1021\/jf00092a009","article-title":"Studies on vegetables. Investigation of an Arabinan from Parsnip (Pastinica Sativa)","volume":"38","author":"Siddiqui","year":"1990","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib117","doi-asserted-by":"crossref","unstructured":"Sieniawska, E., Ortan, A., Fierascu, I., Fierascu, R.C., 2021. Procyanidins in food, in: Handbook of Dietary Phytochemicals. https:\/\/doi.org\/10.1007\/978-981-15-4148-3_43.","DOI":"10.1007\/978-981-15-4148-3_43"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib118","article-title":"LC-MS-MS analysis and the antioxidant activity of flavonoids from eggplant skins grown in organic and conventional environments","volume":"08","author":"Singh","year":"2017","journal-title":"Food Nutr. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib119","doi-asserted-by":"crossref","DOI":"10.1186\/s43094-023-00478-0","article-title":"The promising guide to LC\u2013MS analysis and cholinesterase activity of Luffa cylindrica (L.) fruit using in vitro and in-silico analyses","volume":"9","author":"Singh","year":"2023","journal-title":"Futur J. Pharm. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib120","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.1066029","article-title":"A role of salt bridges in mediating drug potency: a lesson from the Nmyristoyltransferase inhibitors","volume":"9","author":"Spassov","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib121","doi-asserted-by":"crossref","unstructured":"STABILITY, 2014. Darapladib for Preventing Ischemic Events in Stable Coronary Heart Disease. New England Journal of Medicine 370.","DOI":"10.1056\/NEJMoa1315878"},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108569_bib122","doi-asserted-by":"crossref","first-page":"915","DOI":"10.3390\/ijms26030915","article-title":"Plant polyphenols as heart\u2019s best friends: from health properties, to cellular effects, to molecular mechanisms of action","volume":"26","author":"Stankovic","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib123","doi-asserted-by":"crossref","DOI":"10.1016\/j.ophtha.2014.12.014","article-title":"Darapladib, a lipoprotein-associated phospholipase A2 inhibitor, in diabetic macular edema: a 3-month placebo-controlled study","volume":"122","author":"Staurenghi","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.961626","article-title":"Integrative analysis of the metabolome and transcriptome reveals the molecular mechanism of chlorogenic acid synthesis in peach fruit","volume":"9","author":"Su","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib125","doi-asserted-by":"crossref","DOI":"10.1007\/s40203-018-0039-3","article-title":"Molecular docking and ADME properties of bioactive molecules against human acid-beta-glucosidase enzyme, cause of Gaucher\u2019s disease","volume":"6","author":"Subramaniyan","year":"2018","journal-title":"Silico Pharm."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib126","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-023-04198-z","article-title":"The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches","volume":"23","author":"Sultan","year":"2023","journal-title":"BMC Complement Med Ther."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2007.11.053","article-title":"Flavonols (kaempeferol, quercetin, myricetin) contents of selected fruits, vegetables and medicinal plants","volume":"108","author":"Sultana","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib128","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.5b00023","article-title":"Characterization and quantitative analysis of phenylpropanoid amides in eggplant (Solanum melongena L.) by high performance liquid chromatography coupled with diode array detection and hybrid ion trap time-of-flight mass spectrometry","volume":"63","author":"Sun","year":"2015","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib129","doi-asserted-by":"crossref","DOI":"10.1002\/jsfa.9271","article-title":"Preliminary evaluation of quince (Cydonia oblonga Mill.) fruit as extraction source of antioxidant phytoconstituents for nutraceutical and functional food applications","volume":"99","author":"Sut","year":"2019","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib130","doi-asserted-by":"crossref","DOI":"10.3892\/or.2016.4577","article-title":"Benzyl isothiocyanate alters the gene expression with cell cycle regulation and cell death in human brain glioblastoma GBM 8401 cells","volume":"35","author":"Tang","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib131","doi-asserted-by":"crossref","DOI":"10.1002\/pld3.612","article-title":"Xanthohumol and echinocystic acid induces PSTVd tolerance in tomato","volume":"8","author":"Tang","year":"2024","journal-title":"Plant Direct"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib132","doi-asserted-by":"crossref","DOI":"10.2174\/1381612820666140622200916","article-title":"Pathophysiological role and clinical significance of lipoprotein-associated phospholipase A2 (Lp-PLA\u2082) Bound to LDL and HDL","volume":"20","author":"Tellis","year":"2014","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib133","doi-asserted-by":"crossref","DOI":"10.1038\/374549a0","article-title":"Anti-inflammatory properties of a platelet-activating factor acetylhydrolase","volume":"374","author":"Tjoelker","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib134","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfca.2004.06.008","article-title":"-Catechin and (-)-epicatechin in Bulgarian fruits","volume":"18","author":"Tsanova-Savova","year":"2005","journal-title":"J. Food Compos. Anal."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib135","first-page":"905","article-title":"Dietary phenolic compounds: biochemistry, metabolism and significance in animal and human health","volume":"18","author":"Tufarelli","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib136","doi-asserted-by":"crossref","DOI":"10.3390\/cosmetics7010012","article-title":"A promising view of kudzu plant, Pueraria montana var. lobata (willd.) sanjappa & pradeep: flavonoid phytochemical compounds, taxonomic data, traditional uses and potential biological activities for future cosmetic application","author":"Tungmunnithum","year":"2020","journal-title":"Cosmetics"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib137","article-title":"Kaempferol rhamnoside catabolism in rosette leaves of senescing Arabidopsis and postharvest stored radish","volume":"256","author":"Unterlander","year":"2022","journal-title":"Planta"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib138","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.397","article-title":"Phospholipase PLA\u2082G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins","volume":"2","author":"Vainio","year":"2011","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108569_bib139","doi-asserted-by":"crossref","first-page":"132","DOI":"10.2174\/1570162X18666200129112509","article-title":"Binding Insight of Anti-HIV Phytocompounds with Prime Targets of HIV: A Molecular Dynamics Simulation Analysis","volume":"18","author":"Vora","year":"2020","journal-title":"Curr. HIV Res."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2016.06.005","article-title":"Spirostanol saponins from Chinese onion (Allium chinense) exert pronounced anti-inflammatory and anti-proliferative activities","volume":"25","author":"Wang","year":"2016","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib141","doi-asserted-by":"crossref","DOI":"10.1021\/jf026250b","article-title":"Distribution of hydroxycinnamic acid conjugates in fruit of commercial eggplant (Solanum melongena l.) cultivars","volume":"51","author":"Whitaker","year":"2003","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib142","unstructured":"World Health Organisation, 2003. Diet, nutrition and the prevention of chronic diseases. WHO technical report series 916."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib143","article-title":"An experimental study(II) on the inhibition of prostatic hyperplasia by extract of seeds of Brassica alba","volume":"28","author":"Wu","year":"2003","journal-title":"Zhongguo Zhongyao Zazhi"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib144","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23660","article-title":"Implications of organophosphate pesticides on brain cells and their contribution toward progression of Alzheimer\u2019s disease","author":"Yadav","year":"2024","journal-title":"J. Biochem Mol. Toxicol."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib145","article-title":"Isolation of ursolic acid from apple peels and its specific efficacy as a potent antitumor agent","volume":"54","author":"Yamaguchi","year":"2008","journal-title":"J. Health Sci."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib146","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12060483","article-title":"Identification and quantification of flavonoids in okra (Abelmoschus esculentus L. Moench) and antiproliferative activity in vitro of four main components identified","volume":"12","author":"Yang","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.compbiolchem.2025.108569_bib147","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2015.06.068","article-title":"Characterization and biological activities of a novel polysaccharide isolated from raspberry (Rubus idaeus L.) fruits","volume":"132","author":"Yu","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib148","doi-asserted-by":"crossref","DOI":"10.5455\/aim.2022.30.91-95","article-title":"Molecular docking approach of bryophyllum pinnatum compounds as atherosclerosis therapy by targeting adenosine monophosphate-activated protein kinase and inducible nitric oxide synthase","volume":"30","author":"Yuniwati","year":"2022","journal-title":"Acta Inform. Med."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib149","first-page":"6742","article-title":"Study of phytochemical screening and in vitro antioxidant activity of ethanol extract of solanum sisymbriifolium leaf","volume":"2","author":"Zafreen","year":"2024","journal-title":"Mol. Mech. Res."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib150","article-title":"l-serine is the direct precursor for the pyrazine ring construction in the biosynthesis of 3-isobutyl-2-methoxypyrazine in bell pepper fruits (Capsicum annuum L.). chemistry","volume":"29","author":"Zamolo","year":"2023","journal-title":"A Eur. J."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib151","article-title":"Current knowledge and development of hederagenin as a promising medicinal agent: A comprehensive review","author":"Zeng","year":"2018","journal-title":"RSC Adv."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib152","doi-asserted-by":"crossref","DOI":"10.1080\/10942912.2010.494759","article-title":"Determination of glutamic acid and aspartic acid in tomato juice by capillary isotachophoresis","volume":"15","author":"Zgola-Grze\u015bkowiak","year":"2012","journal-title":"Int J. Food Prop."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib153","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.0c05031","article-title":"A comparative metabolomics study of flavonoids in radish with different skin and flesh colors (Raphanus sativus L.)","volume":"68","author":"Zhang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib154","article-title":"The absorption, distribution, metabolism and excretion of procyanidins","author":"Zhang","year":"2016","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108569_bib155","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s11658-024-00679-2","article-title":"Sphingolipid metabolites involved in the pathogenesis of atherosclerosis: perspectives on sphingolipids in atherosclerosis","volume":"30","author":"Zhao","year":"2025","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.compbiolchem.2025.108569_bib156","doi-asserted-by":"crossref","DOI":"10.1080\/10408398.2017.1418284","article-title":"Proanthocyanidins in cereals and pseudocereals","author":"Zhu","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125002294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125002294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T10:45:15Z","timestamp":1779446715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927125002294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":156,"alternative-id":["S1476927125002294"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108569","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemical constituents of vegetables and fruits as potential inhibitors of lipoprotein-associated phospholipase A2: An in-silico approach toward mitigating the complications of Alzheimer's disease and atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108569","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108569"}}