{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T03:18:37Z","timestamp":1794367117329,"version":"4.9.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012232","name":"National Key Clinical Specialty Discipline Construction Program of China","doi-asserted-by":"publisher","award":["TJYXZDXK-037A"],"award-info":[{"award-number":["TJYXZDXK-037A"]}],"id":[{"id":"10.13039\/501100012232","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070929"],"award-info":[{"award-number":["82070929"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.compbiolchem.2025.108634","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T01:01:04Z","timestamp":1755651664000},"page":"108634","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"P1","title":["Exploring potential therapeutic targets for myopia: Causal analysis and biological annotation with gut microbiota"],"prefix":"10.1016","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8207-9442","authenticated-orcid":false,"given":"Zixun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yimeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-898X","authenticated-orcid":false,"given":"Desheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1916-0384","authenticated-orcid":false,"given":"Jingtao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxue","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-0355","authenticated-orcid":false,"given":"Ruihua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7346","key":"10.1016\/j.compbiolchem.2025.108634_bib1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/nature09944","article-title":"Enterotypes of the human gut microbiome","volume":"473","author":"Arumugam","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108634_bib2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.immuni.2017.04.008","article-title":"Homeostatic immunity and the microbiota","volume":"46","author":"Belkaid","year":"2017","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108634_bib3","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J. Epidemiol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108634_bib4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108634_bib5","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/gepi.21758","article-title":"Mendelian randomization analysis with multiple genetic variants using summarized data","volume":"37","author":"Burgess","year":"2013","journal-title":"Genet Epidemiol."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108634_bib6","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jclinepi.2014.09.005","article-title":"Cochran's q test was useful to assess heterogeneity in likelihood ratios in studies of diagnostic accuracy","volume":"68","author":"Cohen","year":"2015","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.compbiolchem.2025.108634_bib7","doi-asserted-by":"crossref","DOI":"10.4093\/dmj.2024.0731","article-title":"The causal relationship and association between biomarkers, dietary intake, and diabetic retinopathy: insights from mendelian randomization and Cross-Sectional study","author":"Cui","year":"2025","journal-title":"Diabetes Metab. J."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108634_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1113\/JP273106","article-title":"Gut instincts: microbiota as a key regulator of brain development, ageing and neurodegeneration","volume":"595","author":"Dinan","year":"2017","journal-title":"J. Physiol."},{"issue":"19","key":"10.1016\/j.compbiolchem.2025.108634_bib9","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","article-title":"Mendelian randomization","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.compbiolchem.2025.108634_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1306048","article-title":"Causal relationship between gut microflora and dementia: a mendelian randomization study","volume":"14","author":"Fu","year":"2024","journal-title":"Front Microbiol"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108634_bib11","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1093\/ije\/dyz200","article-title":"Education protects against coronary heart disease and stroke independently of cognitive function: evidence from mendelian randomization","volume":"48","author":"Gill","year":"2019","journal-title":"Int J. Epidemiol."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108634_bib12","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41588-019-0344-8","article-title":"Identification of common genetic risk variants for autism spectrum disorder","volume":"51","author":"Grove","year":"2019","journal-title":"Nat. Genet"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108634_bib13","first-page":"921","article-title":"Myopia prediction: a systematic review","volume":"36","author":"Han","year":"2022","journal-title":"Eye Lond. Engl."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108634_bib14","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108634_bib15","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.immuni.2015.07.014","article-title":"Microbiota-Dependent activation of an autoreactive t cell receptor provokes autoimmunity in an immunologically privileged site","volume":"43","author":"Horai","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.compbiolchem.2025.108634_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s40168-020-00988-6","article-title":"Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson\u2019s disease","volume":"9","author":"Hou","year":"2021","journal-title":"Microbiome"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108634_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199640","article-title":"Alterations in the gut bacterial microbiome in fungal keratitis patients","volume":"13","author":"Kalyana Chakravarthy","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108634_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/nri.2017.7","article-title":"Dysbiosis and the immune system","volume":"17","author":"Levy","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.compbiolchem.2025.108634_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1251243","article-title":"Gut microbiome and plasma metabolome alterations in myopic mice","volume":"14","author":"Li","year":"2023","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108634_bib20","article-title":"Covariation of scleral remodeling and PI3K\/Akt signaling pathway in experimental myopia","volume":"15","author":"Li","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108634_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2024.100684","article-title":"Causal links between gut microbiota, blood metabolites, immune cells, inflammatory proteins, and myopia: a mendelian randomization study","volume":"5","author":"Lv","year":"2024","journal-title":"Ophthalmol. Sci."},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108634_bib22","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s13167-024-00387-z","article-title":"Lactobacillaceae-mediated eye-brain-gut axis regulates high myopia-related anxiety: from the perspective of predictive, preventive, and personalized Medicine","volume":"15","author":"Mi","year":"2024","journal-title":"EPMA J."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108634_bib23","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.65.5.2","article-title":"Gut microbiota profiles in myopes and nonmyopes","volume":"65","author":"Omar","year":"2024","journal-title":"Invest Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108634_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in Sj\u00f6gren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108634_bib25","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/OPX.0000000000000516","article-title":"The age-specific prevalence of myopia in Asia: a meta-analysis","volume":"92","author":"Pan","year":"2015","journal-title":"Optom. Vis. Sci."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108634_bib26","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ije\/dyq151","article-title":"Power and instrument strength requirements for mendelian randomization studies using multiple genetic variants","volume":"40","author":"Pierce","year":"2011","journal-title":"Int J. Epidemiol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108634_bib27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41746-024-01204-7","article-title":"A deep learning system for myopia onset prediction and intervention effectiveness evaluation in children","volume":"7","author":"Qi","year":"2024","journal-title":"Npj Digit Med"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108634_bib28","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41588-021-00991-z","article-title":"Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort","volume":"54","author":"Qin","year":"2022","journal-title":"Nat. Genet"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108634_bib29","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.mib.2011.12.009","article-title":"The bacterial chemical repertoire mediates metabolic exchange within gut microbiomes","volume":"15","author":"Rath","year":"2012","journal-title":"Curr. Opin. Microbiol"},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108634_bib30","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases","volume":"7","author":"Rinninella","year":"2019","journal-title":"Microorganisms"},{"issue":"24","key":"10.1016\/j.compbiolchem.2025.108634_bib31","doi-asserted-by":"crossref","first-page":"13440","DOI":"10.3390\/ijms222413440","article-title":"Human gut microbiota in health and selected cancers","volume":"22","author":"Se \u0328dzikowska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.compbiolchem.2025.108634_bib32","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1001\/jama.2021.18236","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomization: the STROBE-MR statement","volume":"326","author":"Skrivankova","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.compbiolchem.2025.108634_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.110067","article-title":"Study on the relationship between adolescent myopia and gut microbiota via 16S rRNA sequencing","volume":"247","author":"Sun","year":"2024","journal-title":"Exp. Eye Res"},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108634_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108634_bib35","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1042\/BCJ20160510","article-title":"Introduction to the human gut microbiota","volume":"474","author":"Thursby","year":"2017","journal-title":"Biochem J."},{"key":"10.1016\/j.compbiolchem.2025.108634_bib36","doi-asserted-by":"crossref","first-page":"k2179","DOI":"10.1136\/bmj.k2179","article-title":"Role of the gut microbiota in nutrition and health","volume":"361","author":"Valdes","year":"2018","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108634_bib37","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet"},{"issue":"12","key":"10.1016\/j.compbiolchem.2025.108634_bib38","doi-asserted-by":"crossref","DOI":"10.1177\/03000605241286985","article-title":"Causal association between glaucoma and risk of retinal vascular occlusion: a mendelian randomization study","volume":"52","author":"Wang","year":"2024","journal-title":"J. Int Med Res"},{"key":"10.1016\/j.compbiolchem.2025.108634_bib39","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/s12920-023-01673-x","article-title":"Mendelian randomization study confirms causal relationship between myopia and vitreous disorders","volume":"16","author":"Xu","year":"2023","journal-title":"BMC Med Genom."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108634_bib40","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/mi.2016.75","article-title":"Mechanisms of inflammation-driven bacterial dysbiosis in the gut","volume":"10","author":"Zeng","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.compbiolchem.2025.108634_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1115014","article-title":"Roles of gut microbiome in epilepsy risk: a mendelian randomization study","volume":"14","author":"Zeng","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1016\/j.compbiolchem.2025.108634_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/srep40826","article-title":"Association of the intestinal microbiome with the development of neovascular Age-Related macular degeneration","volume":"7","author":"Zinkernagel","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125002956?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125002956?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:24:45Z","timestamp":1772889885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927125002956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":42,"alternative-id":["S1476927125002956"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108634","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exploring potential therapeutic targets for myopia: Causal analysis and biological annotation with gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108634","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108634"}}