{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T19:48:52Z","timestamp":1777232932110,"version":"3.51.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["CCCX2023014"],"award-info":[{"award-number":["CCCX2023014"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008402","name":"Chengdu University of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2022XT41"],"award-info":[{"award-number":["2022XT41"]}],"id":[{"id":"10.13039\/501100008402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["S202310633026"],"award-info":[{"award-number":["S202310633026"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013254","name":"National College Students Innovation and Entrepreneurship Training Program","doi-asserted-by":"publisher","award":["202310633033"],"award-info":[{"award-number":["202310633033"]}],"id":[{"id":"10.13039\/501100013254","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82105054"],"award-info":[{"award-number":["82105054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.compbiolchem.2025.108660","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T23:26:40Z","timestamp":1756164400000},"page":"108660","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"P1","title":["Discovery and validation of novel drug combinations for pulmonary fibrosis via Traditional Chinese Medicine insights and computer screening"],"prefix":"10.1016","volume":"120","author":[{"given":"Haiting","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beibei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0318-5931","authenticated-orcid":false,"given":"Hua","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2025.108660_bib1","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1021\/acs.jcim.1c01122","volume":"62","author":"Andrade","year":"2022","journal-title":"J. Chem. Inf. Model"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib2","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13075-016-1182-z","volume":"18","author":"Andr\u00e9asson","year":"2016","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/s41419-024-06702-w","volume":"15","author":"Bao","year":"2024","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib4","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1038\/s41467-023-38177-2","volume":"14","author":"Bian","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1146\/annurev.nutr.28.061807.155443","volume":"28","author":"Bogan","year":"2008","journal-title":"Annu Rev. Nutr."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaf9794","volume":"357","author":"Cervenka","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib7","first-page":"672","volume":"29","author":"Duan","year":"2023","journal-title":"J. Basic Chin. Med."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib8","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s00408-019-00270-z","volume":"197","author":"Durheim","year":"2019","journal-title":"Lung"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1137\/140976649","volume":"57","author":"Gleich","year":"2015","journal-title":"SIAM Rev."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib10","first-page":"4551","volume":"37","author":"Huang","year":"2022","journal-title":"Guangming J. Chin. Med."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib11","doi-asserted-by":"crossref","DOI":"10.7717\/peerj-cs.1686","volume":"9","author":"Janyasupab","year":"2023","journal-title":"PeerJ Comput. Sci."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib12","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.2006.0030-1299.14714.x","volume":"113","author":"Jost","year":"2006","journal-title":"Oikos"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2025.144808","volume":"316","author":"Kamel","year":"2025","journal-title":"Int J. Biol. Macromol."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib14","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1007\/s12602-020-09733-9","volume":"13","author":"Keshavarz Azizi Raftar","year":"2021","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib15","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.immuni.2016.01.001","volume":"44","author":"Larson-Casey","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jep.2016.12.042","volume":"198","author":"Li","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib17","first-page":"334","volume":"49","author":"Liang","year":"2024","journal-title":"China J. Chin. Mater. Med."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11418-021-01484-3","volume":"75","author":"Makino","year":"2021","journal-title":"J. Nat. Med"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib19","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/s41572-024-00538-6","volume":"10","author":"Mall","year":"2024","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib20","volume":"174","author":"Pei","year":"2023","journal-title":"Micro Pathog."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib21","first-page":"89","volume":"36","author":"Qin","year":"2023","journal-title":"Tradit. Chin. Med. Res."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13020-023-00797-7","volume":"18","author":"Qin","year":"2023","journal-title":"Chin. Med"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib23","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/s41419-020-03119-z","volume":"11","author":"Quaresma","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib24","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1164\/rccm.201506-1063ST","volume":"192","author":"Raghu","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib25","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1164\/rccm.202202-0399ST","volume":"205","author":"Raghu","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/s41420-021-00437-9","volume":"7","author":"She","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib27","first-page":"252","volume":"50","author":"Shi","year":"2023","journal-title":"Prog. Biochem. Biophys."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo5254","volume":"14","author":"Stancil","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib29","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/s41467-020-17358-3","volume":"11","author":"Strunz","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib30","volume":"18","author":"Tan","year":"2022","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1755-1536-5-11","volume":"5","author":"Todd","year":"2012","journal-title":"Fibrogenes. Tissue Repair"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib32","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/s11418-019-01386-5","volume":"74","author":"Tsuge","year":"2020","journal-title":"J. Nat. Med"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib33","first-page":"135","volume":"20","author":"Wu","year":"2024","journal-title":"AsiaPac. Tradit. Med."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib34","first-page":"254","volume":"41","author":"Xu","year":"2020","journal-title":"Shaanxi J. Tradit. Chin. Med."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib35","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/j.dld.2021.02.013","volume":"53","author":"Yamamoto","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib36","volume":"14","author":"Yan","year":"2024","journal-title":"Clin. Transl. Med"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib37","volume":"238","author":"Yin","year":"2023","journal-title":"Expert Syst. Appl."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib38","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.21037\/jtd.2018.03.11","volume":"10","author":"Zhang","year":"2018","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib39","author":"Zhang","year":"2023","journal-title":"Commun. Methods Meas."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib40","volume":"297","author":"Zhao","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib41","doi-asserted-by":"crossref","unstructured":"R. Zhou, in, 2019.","DOI":"10.1155\/2019\/9159605"},{"key":"10.1016\/j.compbiolchem.2025.108660_bib42","volume":"318","author":"Zhou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.compbiolchem.2025.108660_bib43","first-page":"6100","volume":"38","author":"Zhuang","year":"2023","journal-title":"China J. Tradit. Chin. Med. Pharm."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125003214?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125003214?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:23:39Z","timestamp":1772889819000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927125003214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":43,"alternative-id":["S1476927125003214"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108660","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Discovery and validation of novel drug combinations for pulmonary fibrosis via Traditional Chinese Medicine insights and computer screening","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108660","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108660"}}