{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T15:51:16Z","timestamp":1782402676313,"version":"3.54.5"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.compbiolchem.2025.108774","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T10:30:31Z","timestamp":1763029831000},"page":"108774","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A network pharmacology analysis of curcumin in the treatment of oral submucous fibrosis"],"prefix":"10.1016","volume":"121","author":[{"given":"Fangping","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuxin","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.compbiolchem.2025.108774_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib2","doi-asserted-by":"crossref","first-page":"D789","DOI":"10.1093\/nar\/gku1205","article-title":"OMIM.org: online mendelian inheritance in Man (OMIM\u00ae), an online catalog of human genes and genetic disorders","volume":"43","author":"Amberger","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/jop.12581","article-title":"Oral submucous fibrosis: An update on current theories of pathogenesis","author":"Arakeri","year":"2017","journal-title":"J. Oral. Pathol. Med."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib4","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.phrs.2018.10.009","article-title":"Effects of curcumin on hypoxia-inducible factor as a new therapeutic target","volume":"137","author":"Bahrami","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib5","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/jop.12580","article-title":"Oral submucous fibrosis-an increasing global healthcare problem","author":"Brennan","year":"2017","journal-title":"J. Oral. Pathol. Med.46"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib6","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00280-017-3301-1","article-title":"Curcumin inhibits prostate cancer by targeting PGK1 in the FOXD3\/miR-143 axis","volume":"79","author":"Cao","year":"2017","journal-title":"Cancer Chemother. Pharm."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib7","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejmech.2018.09.023","article-title":"Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer","volume":"160","author":"Carabet","year":"2018","journal-title":"Eur. J. Med. Chem."},{"issue":"12","key":"10.1016\/j.compbiolchem.2025.108774_bib8","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1177\/00220345010800120601","article-title":"Association between genetic polymorphism of tumor necrosis factor-alpha and risk of oral submucous fibrosis, a pre-cancerous condition of oral cancer","volume":"80","author":"Chiu","year":"2001","journal-title":"J. Dent. Res."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.oraloncology.2011.11.021","article-title":"Review of drug treatment of oral submucous fibrosis","volume":"48","author":"Chole","year":"2012","journal-title":"Oral. Oncol."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2025.108774_bib10","doi-asserted-by":"crossref","first-page":"D1724","DOI":"10.1093\/nar\/gkae1185","volume":"53","author":"Correction to 'Comparative Toxicogenomics Database's 20th anniversary: update 2025'","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.mam.2011.12.002","article-title":"Human serum albumin: from bench to bedside","volume":"33","author":"Fanali","year":"2012","journal-title":"Mol. Asp. Med."},{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108774_bib12","doi-asserted-by":"crossref","first-page":"815","DOI":"10.7150\/ijbs.20052","article-title":"FOXO signaling pathways as therapeutic targets in cancer","volume":"13","author":"Farhan","year":"2017","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/bioinformatics\/btv557","article-title":"Cytoscape.js: a graph theory library for visualisation and analysis","volume":"32","author":"Franz","year":"2016","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108774_bib14","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12906-022-03662-6","article-title":"Network pharmacology and molecular docking technology-based predictive study of the active ingredients and potential targets of rhubarb for the treatment of diabetic nephropathy","volume":"22","author":"Fu","year":"2022","journal-title":"BMC Complement. Med. Ther."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.jobcr.2020.05.004","article-title":"Treatment outcomes of laser therapy in oral submucous fibrosis-a systematic review","author":"Gondivkar","year":"2020","journal-title":"J. Oral. Biol. Craniofac Res."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4103\/0975-962X.135266","article-title":"Serum vitamin c and iron levels in oral submucous fibrosis","volume":"5","author":"Guruprasad","year":"2014","journal-title":"Indian. J. Dent."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib17","article-title":"Exploring the mechanism of curcumin in the treatment of colon cancer based on network pharmacology and molecular docking","volume":"14","author":"He","year":"2023","journal-title":"Front. Pharm."},{"issue":"Pt 1","key":"10.1016\/j.compbiolchem.2025.108774_bib18","article-title":"Curcumin activates the Wnt\/\u03b2-catenin signaling pathway to alleviate hippocampal neurogenesis abnormalities caused by intermittent hypoxia: a study based on network pharmacology and experimental verification","volume":"143","author":"He","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"22","key":"10.1016\/j.compbiolchem.2025.108774_bib19","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.3390\/molecules24224179","article-title":"Curcumin Nicotinate Selectively Induces Cancer Cell Apoptosis and Cycle Arrest through a P53-Mediated Mechanism","volume":"24","author":"He","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.compbiolchem.2025.108774_bib20","article-title":"Network pharmacology identifies therapeutic targets and the mechanisms of glutathione action in ferroptosis occurring in oral cancer","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib21","article-title":"Historical overview of the interleukin-6 family cytokine","volume":"217","author":"Kang","year":"2020","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.compbiolchem.2025.108774_bib22","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.3390\/pharmaceutics14091970","article-title":"Molecular mechanisms of cassia fistula against epithelial ovarian cancer using network pharmacology and molecular docking approaches","volume":"14","author":"Kanwal","year":"2022","journal-title":"Pharmaceutics"},{"issue":"17","key":"10.1016\/j.compbiolchem.2025.108774_bib23","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2174\/1381612823666170222122822","article-title":"Curcumin and endothelial function: evidence and mechanisms of protective effects","volume":"23","author":"Karimian","year":"2017","journal-title":"Curr. Pharm. Des."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","article-title":"AP-1 function and regulation","volume":"9","author":"Karin","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib25","first-page":"713","article-title":"Multi\u2011layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT\/\u03b2\u2011catenin signaling activation (Review)","volume":"42","author":"Katoh","year":"2018","journal-title":"Int. J. Mol. Med."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib26","first-page":"587","article-title":"Molecular genetics and targeted therapy of WNT-related human diseases (Review)","volume":"40","author":"Katoh","year":"2017","journal-title":"Int. J. Mol. Med."},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108774_bib27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.5125\/jkaoms.2015.41.4.171","article-title":"Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis","volume":"41","author":"Kaur","year":"2015","journal-title":"J. Korean Assoc. Oral. Maxillofac. Surg."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101600","article-title":"Curcumin blunts epithelial-mesenchymal transition of hepatocytes to alleviate hepatic fibrosis through regulating oxidative stress and autophagy","volume":"36","author":"Kong","year":"2020","journal-title":"Redox Biol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib29","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/jop.13292","article-title":"N6-methyladenosine modification contributes to arecoline-mediated oral submucosal fibrosis","volume":"51","author":"Li","year":"2022","journal-title":"J. Oral. Pathol. Med."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.105389","article-title":"Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of Huanglian Jiedu Decoction against sepsis","volume":"144","author":"Li","year":"2022","journal-title":"Comput. Biol. Med."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib31","first-page":"323","article-title":"Network pharmacology approaches for research of Traditional Chinese Medicines","volume":"21","author":"Li","year":"2023","journal-title":"Chin. J. Nat. Med."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib32","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/mnfr.201000221","article-title":"Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention","volume":"55","author":"Lima","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108774_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13491","article-title":"Expression and correlation of the Pi3k\/Akt pathway and VEGF in oral submucous fibrosis","volume":"56","author":"Lin","year":"2023","journal-title":"Cell Prolif."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib34","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s00404-019-05058-3","article-title":"Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT\/mTOR\/p70S6K pathway in human ovarian cancer cells","volume":"299","author":"Liu","year":"2019","journal-title":"Arch. Gynecol. Obstet."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108774_bib35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13048-023-01120-6","article-title":"Curcumin: a natural organic component that plays a multi-faceted role in ovarian cancer","volume":"16","author":"Liu","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103756","article-title":"Therapeutic targeting of \"undruggable\" MYC","volume":"75","author":"Llombart","year":"2022","journal-title":"EBioMedicine"},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108774_bib37","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.7314\/APJCP.2015.16.4.1327","article-title":"Serum levels of MMP9 and MMP2 in patients with oral squamous cell carcinoma","volume":"16","author":"Lotfi","year":"2015","journal-title":"Asian Pac. J. Cancer Prev."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108774_bib38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/lipd.12023","article-title":"Curcumin Attenuates Lipopolysaccharide-Induced Hepatic Lipid Metabolism Disorder by Modification of m6A RNA Methylation in Piglets","volume":"53","author":"Lu","year":"2018","journal-title":"Lipids"},{"issue":"16","key":"10.1016\/j.compbiolchem.2025.108774_bib39","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00204-020-02926-9","article-title":"Genetic toxicology and toxicokinetics of arecoline and related areca nut compounds: an updated review","volume":"95","author":"Oliveira","year":"2021","journal-title":"J. Arch. Toxicol."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib41","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/hed.20561","article-title":"Clinical significance of MMP-2 and MMP-9 in patients with oral cancer","volume":"29","author":"Patel","year":"2007","journal-title":"Head. neck"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib42","first-page":"2735","article-title":"Curcumin: a Polyphenol with Molecular Targets for Cancer Control, Asian","volume":"17","author":"Qadir","year":"2016","journal-title":"Pac. J. Cancer Prev."},{"issue":"13","key":"10.1016\/j.compbiolchem.2025.108774_bib43","doi-asserted-by":"crossref","first-page":"102","DOI":"10.14715\/cmb\/2023.69.13.16","article-title":"Curcumin ameliorates pulmonary fibrosis progression by inhibiting the fibrotic process of lung fibroblasts","volume":"69","author":"Qiao","year":"2023","journal-title":"Cell. Mol. Biol. (Sarreguemines Fr. Print)"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib44","doi-asserted-by":"crossref","first-page":"4992","DOI":"10.3390\/ijms24054992","article-title":"Oral submucous fibrosis: etiological mechanism, malignant transformation, therapeutic approaches and targets","volume":"24","author":"Qin","year":"2023","journal-title":"Int. J. Mo. l Sci."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib45","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1472-6750-8-84","article-title":"Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications","volume":"8","author":"Quitschke","year":"2008","journal-title":"BMC Biotechnol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108774_bib46","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4103\/0970-9290.29870","article-title":"Expression of matrix metalloproteinases (MMP-1, MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) in oral submucous fibrosis","volume":"17","author":"Rajendran","year":"2006","journal-title":"Indian. J. Dent. Res."},{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108774_bib47","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1111\/odi.13544","article-title":"Herbal derivatives in the management of mouth opening in oral submucous fibrosis-A network meta-analysis","volume":"27","author":"Rajesh Kashyap","year":"2021","journal-title":"Oral. Dis."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/2045-9912.260651","article-title":"Clinical utility of hyperbaric oxygen therapy in dentistry","volume":"9","author":"Re","year":"2019","journal-title":"Med. Gas. Res."},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108774_bib49","doi-asserted-by":"crossref","first-page":"7597","DOI":"10.1007\/s11033-021-06768-1","article-title":"Cardiac fibrosis and curcumin: a novel perspective on this natural medicine","volume":"48","author":"Sadoughi","year":"2021","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108774_bib50","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/jcb.22558","article-title":"Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells","volume":"110","author":"Saydmohammed","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijom.2023.11.005","article-title":"Curcumin in the treatment of oral submucous fibrosis: a systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Shao","year":"2024","journal-title":"Int. J. Oral. Surg."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib52","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijom.2023.11.005","article-title":"Curcumin in the treatment of oral submucous fibrosis: a systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Shao","year":"2024","journal-title":"Int. J. Oral. Surg."},{"issue":"12","key":"10.1016\/j.compbiolchem.2025.108774_bib53","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/ijms20122940","article-title":"Oral submucous fibrosis: a review on etiopathogenesis, diagnosis, and therapy","volume":"20","author":"Shih","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108774_bib54","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/sj.bjc.6605290","article-title":"Salivary analysis of oral cancer biomarkers","volume":"101","author":"Shpitzer","year":"2009","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108774_bib55","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1159\/000539393","article-title":"Exploring the mechanism of cardiorenal protection with finerenone based on network pharmacology","volume":"14","author":"Si","year":"2024","journal-title":"Cardiorenal Med."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib56","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1111\/j.2042-7158.1973.tb09131.x","article-title":"Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent","volume":"25","author":"Srimal","year":"1973","journal-title":"J. Pharm. Pharm."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib57","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1021\/acs.biomac.5b00229","article-title":"EGFR inhibition by curcumin in cancer cells: a dual mode of action","volume":"16","author":"Starok","year":"2015","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.compbiolchem.2025.108774_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/2418671","article-title":"Recent advances of curcumin in the prevention and treatment of renal fibrosis","volume":"2017","author":"Sun","year":"2017","journal-title":"BioMed. Res. Int."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2025.108774_bib59","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108774_bib60","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.3390\/biom12111636","article-title":"Curcumin and its analogs in non-small cell lung cancer treatment: challenges and expectations","volume":"12","author":"Tang","year":"2022","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib61","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.oraloncology.2005.08.005","article-title":"Oral submucous fibrosis: review on aetiology and pathogenesis","volume":"42","author":"Tilakaratne","year":"2006","journal-title":"Oral. Oncol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib62","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1053\/j.gastro.2020.07.046","article-title":"Loss of HIF1A from pancreatic cancer cells increases expression of PPP1R1B and degradation of p53 to promote invasion and metastasis","volume":"159","author":"Tiwari","year":"2020","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib63","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.3892\/ol.2016.5148","article-title":"Curcumin suppresses colon cancer cell invasion via AMPK-induced inhibition of NF-\u03baB, uPA activator and MMP9","volume":"12","author":"Tong","year":"2016","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib64","doi-asserted-by":"crossref","first-page":"474","DOI":"10.4103\/0973-029X.190951","article-title":"Expression of matrix metalloproteinase-9 in oral potentially malignant disorders: A systematic review","volume":"20","author":"Venugopal","year":"2016","journal-title":"J. Oral. Maxillofac. Pathol."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib65","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/5971080","article-title":"All-Trans Retinoic Acid Enhances Matrix Metalloproteinase 2 Expression and Secretion in Human Myeloid Leukemia THP-1 Cells","volume":"2018","author":"Vu","year":"2018","journal-title":"BioMed. Res. Int."},{"issue":"W1","key":"10.1016\/j.compbiolchem.2025.108774_bib66","doi-asserted-by":"crossref","first-page":"W356","DOI":"10.1093\/nar\/gkx374","article-title":"PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database","volume":"45","author":"Wang","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib67","doi-asserted-by":"crossref","first-page":"5039","DOI":"10.2147\/JIR.S459867","article-title":"Curcumin alleviates osteoarthritis through the p38MAPK Pathway: network pharmacological prediction and experimental confirmation","volume":"17","author":"Wang","year":"2024","journal-title":"J. Inflamm. Res."},{"issue":"9","key":"10.1016\/j.compbiolchem.2025.108774_bib68","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jfma.2015.05.011","article-title":"High frequencies of vitamin B12 and folic acid deficiencies and gastric parietal cell antibody positivity in oral submucous fibrosis patients","volume":"114","author":"Wang","year":"2015","journal-title":"J. Formos. Med. Assoc."},{"issue":"12","key":"10.1016\/j.compbiolchem.2025.108774_bib69","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1177\/00220345211014795","article-title":"Oral cancer screening: past, present, and future","volume":"100","author":"Warnakulasuriya","year":"2021","journal-title":"J. Dent. Res."},{"issue":"D1","key":"10.1016\/j.compbiolchem.2025.108774_bib70","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108774_bib71","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3892\/ijo.2014.2420","article-title":"Extracellular signal-regulated kinase signaling-mediated induction and interaction of FOXO3a and p53 contribute to the inhibition of nasopharyngeal carcinoma cell growth by curcumin","volume":"45","author":"Wu","year":"2014","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108774_bib72","first-page":"2515","article-title":"Identification of MMP9 as a novel key gene in mantle cell lymphoma based on bioinformatic analysis and design of cyclic peptides as MMP9 inhibitors based on molecular docking","volume":"40","author":"Yan","year":"2018","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108774_bib73","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s13104-024-07031-z","article-title":"Exploring the mechanism of fibrates regulating HIF-1A in the treatment of ischemic stroke based on network pharmacology and molecular docking","volume":"17","author":"Yang","year":"2024","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.compbiolchem.2025.108774_bib74","doi-asserted-by":"crossref","first-page":"218","DOI":"10.18433\/jpps32911","article-title":"Progress and prospects of research ideas and methods in the network pharmacology of traditional chinese medicine","volume":"25","author":"Yuan","year":"2022","journal-title":"J. Pharm. Pharm. Sci."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108774_bib75","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ccr.2006.12.017","article-title":"Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity","volume":"11","author":"Yun","year":"2007","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108774_bib76","first-page":"1879","article-title":"p53 overexpression in oral mucosa in relation to shisha smoking in Syria and Lebanon","volume":"19","author":"Zaid","year":"2018","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib77","article-title":"The potential protective effect of curcumin on Amyloid-\u03b2-42 induced cytotoxicity in HT-22 cells","volume":"2018","author":"Zhang","year":"2018","journal-title":"Biomed. Res Int"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108774_bib78","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20203520","article-title":"Exploring the mechanisms underlying the therapeutic effect of Salvia miltiorrhiza in diabetic nephropathy using network pharmacology and molecular docking","volume":"41","author":"Zhang","year":"2021","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155066","article-title":"Astragaloside IV protects against lung injury and pulmonary fibrosis in COPD by targeting GTP-GDP domain of RAS and downregulating the RAS\/RAF\/FoxO signaling pathway","volume":"120","author":"Zhang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.compbiolchem.2025.108774_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117044","article-title":"Curcumin potentiates the galbanic acid-induced anti-tumor effect in non-small cell lung cancer cells through inhibiting Akt\/mTOR signaling pathway","volume":"239","author":"Zhang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib81","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8912961","article-title":"Curcumin inhibits ERK\/c-jun expressions and phosphorylation against endometrial carcinoma","volume":"2019","author":"Zhang","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib82","article-title":"Prognostic role of pre-treatment serum ALB in Patients with oropharyngeal cancer: a retrospective cohort study","volume":"12","author":"Zhu","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108774_bib83","article-title":"CTNNB1 in neurodevelopmental disorders","volume":"14","author":"Zhuang","year":"2023","journal-title":"Front. Mol. Psychiatry"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125004360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125004360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T19:45:30Z","timestamp":1773863130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927125004360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":83,"alternative-id":["S1476927125004360"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108774","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A network pharmacology analysis of curcumin in the treatment of oral submucous fibrosis","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108774","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108774"}}