{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:48:30Z","timestamp":1773892110139,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["76160\\u201354990001"],"award-info":[{"award-number":["76160\\u201354990001"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515012286"],"award-info":[{"award-number":["2022A1515012286"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025A1515012335"],"award-info":[{"award-number":["2025A1515012335"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2022A1515110268"],"award-info":[{"award-number":["2022A1515110268"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20250604174809012"],"award-info":[{"award-number":["JCYJ20250604174809012"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220530145217040"],"award-info":[{"award-number":["JCYJ20220530145217040"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["JCYJ20220530145217039"],"award-info":[{"award-number":["JCYJ20220530145217039"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.compbiolchem.2025.108832","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:35:34Z","timestamp":1765326934000},"page":"108832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["MethylMSI: Prediction of microsatellite instability based on DNA methylation profile and SVM model"],"prefix":"10.1016","volume":"121","author":[{"given":"Chenzhi","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0079-3156","authenticated-orcid":false,"given":"Qijie","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5483-3667","authenticated-orcid":false,"given":"Runtian","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing-Ding","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7669-7364","authenticated-orcid":false,"given":"Mi Ni","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"23","key":"10.1016\/j.compbiolchem.2025.108832_bib1","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1158\/1078-0432.CCR-05-1030","article-title":"Microsatellite instability and colorectal cancer prognosis","volume":"11","author":"Benatti","year":"2005","journal-title":"Clin. Cancer Res"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108832_bib2","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1053\/j.gastro.2009.12.064","article-title":"Microsatellite instability in colorectal cancer","volume":"138","author":"Boland","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.compbiolchem.2025.108832_bib3","article-title":"Landscape of Microsatellite Instability Across 39 Cancer Types","volume":"2017","author":"Bonneville","year":"2017","journal-title":"JCO Precis Oncol."},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108832_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/genes14112060","article-title":"MLH1 promoter methylation could be the second hit in lynch syndrome carcinogenesis","volume":"14","author":"Carnevali","year":"2023","journal-title":"Genes (Basel)"},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108832_bib5","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1097\/PAI.0000000000000575","article-title":"Microsatellite instability: a predictive biomarker for cancer immunotherapy","volume":"26","author":"Chang","year":"2018","journal-title":"Appl. Immunohistochem. Mol. Morphol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2025.108832_bib6","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1186\/s12864-019-6135-x","article-title":"A gastric cancer LncRNAs model for MSI and survival prediction based on support vector machine","volume":"20","author":"Chen","year":"2019","journal-title":"BMC Genom."},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108832_bib7","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1016\/j.csda.2010.12.001","article-title":"Gene selection and prediction for cancer classification using support vector machines with a reject option","volume":"55","author":"Choi","year":"2011","journal-title":"Comput. Stat. Data Anal."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108832_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ejca.2010.09.008","article-title":"Oncogenic mutations in gastric cancer with microsatellite instability","volume":"47","author":"Corso","year":"2011","journal-title":"Eur. J. Cancer"},{"issue":"11","key":"10.1016\/j.compbiolchem.2025.108832_bib9","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1111\/j.1440-1746.1996.tb00040.x","article-title":"Studies on the hypomethylation of c-myc, c-Ha-ras oncogenes and histopathological changes in human gastric carcinoma","volume":"11","author":"Fang","year":"1996","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"23","key":"10.1016\/j.compbiolchem.2025.108832_bib10","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.3748\/wjg.v10.i23.3394","article-title":"Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer","volume":"10","author":"Fang","year":"2004","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108832_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jmoldx.2023.10.005","article-title":"MLH1 promotor hypermethylation in colorectal and endometrial carcinomas from patients with Lynch syndrome","volume":"26","author":"Helderman","year":"2024","journal-title":"J. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.compbiolchem.2025.108832_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/ng.298","article-title":"The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores","volume":"41","author":"Irizarry","year":"2009","journal-title":"Nat. Genet"},{"issue":"19","key":"10.1016\/j.compbiolchem.2025.108832_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13194956","article-title":"Interaction between Microsatellite Instability (MSI) and Tumor DNA Methylation in the Pathogenesis of Colorectal Carcinoma","volume":"13","author":"Jasmine","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108832_bib14","first-page":"808","article-title":"Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines","volume":"57","author":"Kane","year":"1997","journal-title":"Cancer Res"},{"issue":"7","key":"10.1016\/j.compbiolchem.2025.108832_bib15","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1002\/ijc.25495","article-title":"MSI phenotype and MMR alterations in familial and sporadic gastric cancer","volume":"128","author":"Leite","year":"2011","journal-title":"Int J. Cancer"},{"key":"10.1016\/j.compbiolchem.2025.108832_bib16","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.csbj.2020.03.007","article-title":"PreMSIm: an R package for predicting microsatellite instability from the expression profiling of a gene panel in cancer","volume":"18","author":"Li","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"issue":"8","key":"10.1016\/j.compbiolchem.2025.108832_bib17","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/annonc\/mdz116","article-title":"ESMO recommendations on microsatellite instability testing for immunotherapy in cancer, and its relationship with PD-1\/PD-L1 expression and tumour mutational burden: a systematic review-based approach","volume":"30","author":"Luchini","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.compbiolchem.2025.108832_bib18","doi-asserted-by":"crossref","first-page":"vii97","DOI":"10.1093\/annonc\/mdl960","article-title":"Patterns of genomic instability in gastric cancer: clinical implications and perspectives","volume":"17","author":"Ottini","year":"2006","journal-title":"Ann. Oncol."},{"issue":"3","key":"10.1016\/j.compbiolchem.2025.108832_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106127","article-title":"MSIMEP: Predicting microsatellite instability from microarray DNA methylation tumor profiles","volume":"26","author":"Santamarina-Garc\u00eda","year":"2023","journal-title":"iScience"},{"issue":"5","key":"10.1016\/j.compbiolchem.2025.108832_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064420","article-title":"MYC deregulation in gastric cancer and its clinicopathological implications","volume":"8","author":"de Souza","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.compbiolchem.2025.108832_bib21","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ejca.2022.07.020","article-title":"Deficient mismatch repair\/microsatellite unstable colorectal cancer: diagnosis, prognosis and treatment","volume":"175","author":"Taieb","year":"2022","journal-title":"Eur. J. Cancer"},{"issue":"4","key":"10.1016\/j.compbiolchem.2025.108832_bib22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","article-title":"Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability","volume":"96","author":"Umar","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108832_bib23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.2217\/epi-2018-0153","article-title":"DNA methylation of shelf, shore and open sea CpG positions distinguish high microsatellite instability from low or stable microsatellite status colon cancer stem cells","volume":"11","author":"Visone","year":"2019","journal-title":"Epigenomics"},{"issue":"6","key":"10.1016\/j.compbiolchem.2025.108832_bib24","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1111\/cas.16160","article-title":"Microsatellite instability: a 2024 update","volume":"115","author":"Yamamoto","year":"2024","journal-title":"Cancer Sci."},{"issue":"8","key":"10.1016\/j.compbiolchem.2025.108832_bib25","doi-asserted-by":"crossref","first-page":"752","DOI":"10.5732\/cjc.010.10046","article-title":"Inhibitory effect of S-adenosylmethionine on the growth of human gastric cancer cells in vivo and in vitro","volume":"29","author":"Zhao","year":"2010","journal-title":"Chin. J. Cancer"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125004967?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927125004967?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T01:09:08Z","timestamp":1773882548000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927125004967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":25,"alternative-id":["S1476927125004967"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108832","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MethylMSI: Prediction of microsatellite instability based on DNA methylation profile and SVM model","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2025.108832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108832"}}