{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T14:35:58Z","timestamp":1784039758316,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T00:00:00Z","timestamp":1770508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011349","name":"University of Texas at El Paso","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.compbiolchem.2026.108939","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:46:25Z","timestamp":1770565585000},"page":"108939","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Targeting the MPO\/LCN2\/GMPPB axis in IBS-depression comorbidity: Integrated multi-omics and bidirectional network pharmacology for precision diagnostics and therapeutics"],"prefix":"10.1016","volume":"122","author":[{"given":"Shirui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-9995","authenticated-orcid":false,"given":"Xiuyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10312","key":"10.1016\/j.compbiolchem.2026.108939_bib1","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Anon","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.compbiolchem.2026.108939_bib2","unstructured":"Anon, Global Health Data Exchange (GHDx) 2021b, [\u3008https:\/\/vizhub.healthdata.org\/gbd-results\/\u3009]."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib3","doi-asserted-by":"crossref","DOI":"10.1007\/s11655-012-1027-9","article-title":"Benefit of aloe vera and matricaria recutita mixture in rat irritable bowel syndrome: combination of antioxidant and spasmolytic effects","author":"Asadi-Shahmirzadi","year":"2012","journal-title":"Chin. J. Integr. Med"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib4","doi-asserted-by":"crossref","DOI":"10.1038\/ctg.2016.69","article-title":"Psychological interventions for irritable bowel syndrome and inflammatory bowel diseases","volume":"8","author":"Ballou","year":"2017","journal-title":"Clin. Transl. Gastroenterol."},{"issue":"32","key":"10.1016\/j.compbiolchem.2026.108939_bib5","doi-asserted-by":"crossref","first-page":"4696","DOI":"10.3748\/wjg.v25.i32.4696","article-title":"Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome","volume":"25","author":"Bao","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.108939_bib6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.chembiol.2020.03.014","article-title":"Achieving life through death: redox biology of lipid peroxidation in ferroptosis","volume":"27","author":"Bay\u0131r","year":"2020","journal-title":"Cell Chem. Biol."},{"issue":"2s-2","key":"10.1016\/j.compbiolchem.2026.108939_bib7","doi-asserted-by":"crossref","first-page":"568S","DOI":"10.1093\/jn\/131.2.568S","article-title":"Iron biology in immune function, muscle metabolism and neuronal functioning","volume":"131","author":"Beard","year":"2001","journal-title":"J. Nutr."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.108939_bib8","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41575-020-0286-8","article-title":"Global burden of irritable bowel syndrome: trends, predictions and risk factors","volume":"17","author":"Black","year":"2020","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib9","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1073\/pnas.0907697107","article-title":"Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats","volume":"107","author":"Braniste","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.compbiolchem.2026.108939_bib10","first-page":"2022","article-title":"Effects of artemisia argyi powder on egg quality, antioxidant capacity, and intestinal development of roman laying hens","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.108939_bib12","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.cell.2005.10.027","article-title":"A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake","volume":"123","author":"Devireddy","year":"2005","journal-title":"Cell"},{"issue":"22","key":"10.1016\/j.compbiolchem.2026.108939_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20225771","article-title":"Quercetin exposure suppresses the inflammatory pathway in intestinal organoids from winnie mice","volume":"20","author":"Dicarlo","year":"2019","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jad.2025.05.013","article-title":"Further elucidation of GMPPB as a risk gene for depression through integrative multi-omics analyses","volume":"384","author":"Du","year":"2025","journal-title":"J. Affect Disord."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.108939_bib15","first-page":"3219","article-title":"Resveratrol alleviates nerve injury after cerebral ischemia and reperfusion in mice by inhibiting inflammation and apoptosis","volume":"8","author":"Fang","year":"2015","journal-title":"Int J. Clin. Exp. Med"},{"issue":"7474","key":"10.1016\/j.compbiolchem.2026.108939_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/nature12605","article-title":"LARGE glycans on dystroglycan function as a tunable matrix scaffold to prevent dystrophy","volume":"503","author":"Goddeeris","year":"2013","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib17","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/JS9.0000000000002039","article-title":"Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic study","volume":"111","author":"Huang","year":"2025","journal-title":"Int J. Surg."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.4103\/0019-5545.105520","article-title":"Prevalence of depression and anxiety in irritable bowel syndrome: a clinic based study from India","volume":"55","author":"Kabra","year":"2013","journal-title":"Indian J. Psychiatry"},{"issue":"20","key":"10.1016\/j.compbiolchem.2026.108939_bib19","doi-asserted-by":"crossref","first-page":"8080","DOI":"10.1021\/jf071741n","article-title":"Resveratrol inhibits the activity of equine neutrophil myeloperoxidase by a direct interaction with the enzyme","volume":"55","author":"Kohnen","year":"2007","journal-title":"J. Agric. Food Chem."},{"issue":"13","key":"10.1016\/j.compbiolchem.2026.108939_bib20","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/jcc.23899","article-title":"New ways to boost molecular dynamics simulations","volume":"36","author":"Krieger","year":"2015","journal-title":"J. Comput. Chem."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.108939_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004651","article-title":"Neutrophils: between host defence, immune modulation, and tissue injury","volume":"11","author":"Kruger","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.compbiolchem.2017.08.006","article-title":"Molecular dynamics-assisted pharmacophore modeling of caspase-3-isatin sulfonamide complex: recognizing essential intermolecular contacts and features of sulfonamide inhibitor class for caspase-3 binding","volume":"71","author":"Kumar","year":"2017","journal-title":"Comput. Biol. Chem."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s40168-019-0656-z","article-title":"Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis","volume":"7","author":"Labus","year":"2019","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14309\/ajg.0000000000001036","article-title":"ACG clinical guideline: management of irritable bowel syndrome","volume":"116","author":"Lacy","year":"2021","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib25","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jep.2016.05.015","article-title":"Jujube-containing herbal decoctions induce neuronal differentiation and the expression of anti-oxidant enzymes in cultured PC12 cells","volume":"188","author":"Lam","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.108939_bib26","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.freeradbiomed.2008.05.021","article-title":"Microglia and myeloperoxidase: a deadly partnership in neurodegenerative disease","volume":"45","author":"Lefkowitz","year":"2008","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.compbiolchem.2026.108939_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2025.04.161","article-title":"Investigating causal relationships between gene expression and major depressive disorder via brain bulk-tissue and cell type-specific eQTL: a Mendelian randomization and Bayesian colocalization study","volume":"383","author":"Liao","year":"2025","journal-title":"J. Affect. Disord."},{"issue":"W1","key":"10.1016\/j.compbiolchem.2026.108939_bib28","doi-asserted-by":"crossref","first-page":"W159","DOI":"10.1093\/nar\/gkac394","article-title":"CB-Dock2: improved protein\u2013ligand blind docking by integrating cavity detection, docking and homologous template fitting","volume":"50","author":"Liu","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12871-024-02876-0","article-title":"Quercetin can improve anesthesia induced neuroinflammation and cognitive dysfunction by regulating miR-138-5p\/ LCN2","volume":"25","author":"Lou","year":"2025","journal-title":"BMC Anesth."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.tiv.2019.05.013","article-title":"Bisphenol A promotes macrophage proinflammatory subtype polarization via upregulation of IRF5 expression in vitro","volume":"60","author":"Lu","year":"2019","journal-title":"Toxicol. Vitr."},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.108939_bib31","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1631\/jzus.B2000594","article-title":"Research advances in bioactive components and health benefits of jujube (Ziziphus jujuba Mill.) fruit","volume":"22","author":"Lu","year":"2021","journal-title":"J. Zhejiang Univ. Sci. B"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.108939_bib32","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"},{"key":"10.1016\/j.compbiolchem.2026.108939_bib33","doi-asserted-by":"crossref","DOI":"10.34133\/research.0537","article-title":"Deciphering and targeting the ESR2\u2013miR-10a-5p\u2013BDNF axis in the prefrontal cortex: advancing postpartum depression understanding and therapeutics","volume":"7","author":"Luo","year":"2024","journal-title":"Research"},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.108939_bib34","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1074\/jbc.M807731200","article-title":"Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease","volume":"284","author":"Maki","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"18","key":"10.1016\/j.compbiolchem.2026.108939_bib35","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1056\/NEJMoa1915784","article-title":"Association between mental disorders and subsequent medical conditions","volume":"382","author":"Momen","year":"2020","journal-title":"N. Engl. J. Med"},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.108939_bib36","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3346\/jkms.2012.27.6.644","article-title":"Bisphenol A impairs mitochondrial function in the liver at doses below the no observed adverse effect level","volume":"27","author":"Moon","year":"2012","journal-title":"J. Korean Med Sci."},{"issue":"6896","key":"10.1016\/j.compbiolchem.2026.108939_bib37","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/nature00838","article-title":"Deletion of brain dystroglycan recapitulates aspects of congenital muscular dystrophy","volume":"418","author":"Moore","year":"2002","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.108939_bib38","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1620\/tjem.218.251","article-title":"Resveratrol, a natural antioxidant, attenuates intestinal ischemia\/reperfusion injury in rats","volume":"218","author":"Ozkan","year":"2009","journal-title":"Tohoku J. Exp. Med"},{"issue":"15","key":"10.1016\/j.compbiolchem.2026.108939_bib39","doi-asserted-by":"crossref","first-page":"3938","DOI":"10.1080\/07391102.2017.1404931","article-title":"Pharmacophore-based virtual screening of catechol-o-methyltransferase (COMT) inhibitors to combat Alzheimer's disease","volume":"36","author":"Patel","year":"2018","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.108939_bib40","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1080\/10799893.2019.1660893","article-title":"Cardiotonic steroids as potential Na(+)\/K(+)-ATPase inhibitors - a computational study","volume":"39","author":"Patel","year":"2019","journal-title":"J. Recept Signal Transduct. Res"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1080\/01635581.2019.1615515","article-title":"Dietary ziziphus jujuba fruit attenuates colitis-associated tumorigenesis: a pivotal role of the NF-\u03baB\/IL-6\/JAK1\/STAT3 pathway","volume":"72","author":"Periasamy","year":"2020","journal-title":"Nutr. Cancer"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.108939_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/jgh3.70116","article-title":"Anxiety and depression disorders in vietnamese patients with irritable bowel syndrome: a cross-sectional clinic-based study","volume":"9","author":"Phan","year":"2025","journal-title":"JGH Open"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.108939_bib43","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1053\/j.gastro.2017.05.003","article-title":"Probiotic bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: a pilot study in patients with irritable bowel syndrome","volume":"153","author":"Pinto-Sanchez","year":"2017","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.108939_bib44","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s00401-021-02371-7","article-title":"PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression","volume":"142","author":"Qin","year":"2021","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib45","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.neubiorev.2016.06.031","article-title":"Myeloperoxidase: bridging the gap in neurodegeneration","volume":"68","author":"Ray","year":"2016","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J. Chemin.."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib47","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.3389\/fimmu.2023.1243834","article-title":"Astragalus improves intestinal barrier function and immunity by acting on intestinal microbiota to treat T2DM: a research review","volume":"14","author":"Su","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.108939_bib48","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.200105003","article-title":"A stoichiometric complex of neurexins and dystroglycan in brain","volume":"154","author":"Sugita","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2025.01.056","article-title":"Clinical heterogeneity in major depressive disorder underlies comorbidity with functional disorders","volume":"183","author":"Thomas","year":"2025","journal-title":"J. Psychiatr. Res"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.108939_bib50","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1021\/acs.jafc.0c06335","article-title":"Quercetin attenuated myeloperoxidase-dependent HOCl generation and endothelial dysfunction in diabetic vasculature","volume":"69","author":"Tian","year":"2021","journal-title":"J. Agric. Food Chem."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.108939_bib51","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nri2653","article-title":"Intestinal mucosal barrier function in health and disease","volume":"9","author":"Turner","year":"2009","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.108939_bib52","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.biopsych.2008.04.023","article-title":"Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study","volume":"64","author":"Vaccarino","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.108939_bib53","doi-asserted-by":"crossref","DOI":"10.1192\/j.eurpsy.2024.1785","article-title":"Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders","volume":"67","author":"Wan","year":"2024","journal-title":"Eur. Psychiatry"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.108939_bib54","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1007\/s11130-020-00796-1","article-title":"Quantitative assessment of phenolic acids, flavonoids and antioxidant activities of sixteen jujube cultivars from China","volume":"75","author":"Wang","year":"2020","journal-title":"Plant Foods Hum. Nutr."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib55","first-page":"1","article-title":"Impact of mechanical barrier damage and interleukin-17 on symptoms in patients with post-infectious irritable bowel syndrome","volume":"85","author":"Zhao","year":"2024","journal-title":"Br. J. Hosp. Med."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib56","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1096\/fj.201801575R","article-title":"PROKR2 mutations in idiopathic hypogonadotropic hypogonadism: selective disruption of the binding to a G\u03b1-protein leads to biased signaling","volume":"33","author":"Zhao","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.compbiolchem.2026.108939_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.157264","article-title":"Pathogenic mechanisms of cerebral ischemia and potential gut-brain axis-oriented therapeutic strategies","volume":"148","author":"Zhuang","year":"2025","journal-title":"Phytomedicine"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126000642?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126000642?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T13:25:36Z","timestamp":1772544336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126000642"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":57,"alternative-id":["S1476927126000642"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.108939","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting the MPO\/LCN2\/GMPPB axis in IBS-depression comorbidity: Integrated multi-omics and bidirectional network pharmacology for precision diagnostics and therapeutics","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.108939","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108939"}}