{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:57:24Z","timestamp":1781816244353,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.compbiolchem.2026.109099","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T15:06:52Z","timestamp":1777648012000},"page":"109099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P1","title":["Comparative analysis of biomarker profiles in chronic kidney disease with and without hepatitis B co-infection in Iraq"],"prefix":"10.1016","volume":"124","author":[{"given":"Abdulhamed Majeed","family":"Mohamed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram Mohammed","family":"Abood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Hamad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouhaned Y.","family":"Al-darwesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib1","doi-asserted-by":"crossref","DOI":"10.1111\/jvh.14016","article-title":"Hepatitis B virus-associated liver carcinoma: the role of iron metabolism and its modulation","volume":"32","author":"Ali","year":"2025","journal-title":"J. Viral Hepat."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.36346\/sarjbab.2023.v05i04.003","article-title":"Prevalence of hepatitis B virus among renal dialysis patients in Diyala Province, Iraq","volume":"5","author":"Ali","year":"2023","journal-title":"South Asian Res. J. Bio Appl. Biosci."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109099_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s00467-017-3663-y","article-title":"Anemia in chronic kidney disease","volume":"33","author":"Atkinson","year":"2018","journal-title":"Pediatr. Nephrol."},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109099_bib4","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3390\/metabo13070795","article-title":"Effects of exercise on inflammatory markers in individuals with chronic kidney disease: a systematic review and meta-analysis","volume":"13","author":"Bai\u00e3o","year":"2023","journal-title":"Metabolites"},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1089\/jicm.2022.0587","article-title":"Effects of Shenkang decoction on creatinine and blood urea nitrogen in chronic renal failure hemodialysis patients: a randomized controlled trial","volume":"29","author":"Cao","year":"2023","journal-title":"J. Integr. Complement. Med."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-024-09546-z","article-title":"Hepatitis B virus infection as a risk factor for chronic kidney disease: a systematic review and meta-analysis","volume":"24","author":"Chen","year":"2024","journal-title":"BMC Infect. Dis."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109099_bib7","first-page":"1756","article-title":"A cross-sectional study on gut microbiota in patients with chronic kidney disease undergoing kidney transplant or hemodialysis","volume":"15","author":"Chen","year":"2023","journal-title":"Am. J. Transl. Res."},{"issue":"17","key":"10.1016\/j.compbiolchem.2026.109099_bib8","doi-asserted-by":"crossref","first-page":"13323","DOI":"10.3390\/ijms241713323","article-title":"The ferritin, hepcidin and cytokines link in the diagnoses of iron deficiency anaemia during pregnancy: a review","volume":"24","author":"Chibanda","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109099_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17091190","article-title":"Personalized therapeutic advances in erythropoietin signaling: From anemia management to extensive clinical applications","volume":"17","author":"Creang\u0103","year":"2025","journal-title":"Pharmaceutics"},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109099_bib10","article-title":"Hepatitis B and C infections in patients with prolonged hemodialysis secondary to chronic renal failure","volume":"12","author":"Elahi","year":"2020","journal-title":"Cureus"},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109099_bib11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4269\/ajtmh.22-0345","article-title":"High prevalence of occult hepatitis B virus infection among Iranian hemodialysis patients","volume":"108","author":"Farshadpour","year":"2023","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.3390\/nu11040722","article-title":"Lipid accumulation and chronic kidney disease","volume":"11","author":"Gai","year":"2019","journal-title":"Nutrients"},{"issue":"17","key":"10.1016\/j.compbiolchem.2026.109099_bib13","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033558","article-title":"The association of hepcidin, reticulocyte hemoglobin equivalent and anemia-related indicators on anemia in chronic kidney disease","volume":"102","author":"Gao","year":"2023","journal-title":"Medicine"},{"issue":"10","key":"10.1016\/j.compbiolchem.2026.109099_bib14","article-title":"Anemia and hypoxia impact on chronic kidney disease onset and progression: review and updates","volume":"15","author":"Habas Sr","year":"2023","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s12325-020-01524-6","article-title":"Burden of anemia in chronic kidney disease: beyond erythropoietin","volume":"38","author":"Hanna","year":"2021","journal-title":"Adv. Ther."},{"issue":"12","key":"10.1016\/j.compbiolchem.2026.109099_bib16","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1093\/ndt\/gfad096","article-title":"Association between serum iron markers, iron supplementation and cardiovascular morbidity in pre-dialysis chronic kidney disease","volume":"38","author":"Hasegawa","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/ndt\/gfac165","article-title":"Increasing numbers and improved overall survival of patients on kidney replacement therapy over the last decade in Europe: an ERA Registry study","volume":"38","author":"Huijben","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib18","doi-asserted-by":"crossref","first-page":"156","DOI":"10.51173\/jt.v5i4.1923","article-title":"Effect of chronic hepatitis B virus (HBV) infection on lipid profile in Iraqi patients","volume":"5","author":"Ibrahim","year":"2023","journal-title":"J. Tech."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109099_bib19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1134\/S1990750824600948","article-title":"Hepatitis C specificity in lowering serum lipids of patients with chronic renal failure","volume":"19","author":"Jabbar","year":"2025","journal-title":"Biochem. (Moscow) Suppl. Ser. B Biomed. Chem."},{"issue":"12","key":"10.1016\/j.compbiolchem.2026.109099_bib20","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.3390\/cells12121581","article-title":"The role of inflammation in CKD","volume":"12","author":"Kadatane","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.compbiolchem.2026.109099_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejim.2019.10.025","article-title":"Creatinine: from physiology to clinical application","volume":"72","author":"Kashani","year":"2020","journal-title":"Eur. J. Intern. Med."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109099_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.4236\/ojneph.2020.102008","article-title":"Hematological disorders during chronic kidney disease stages 3\u20135 non-dialyzed in Cameroon","volume":"10","author":"Kaze","year":"2020","journal-title":"Open J. Nephrol."},{"key":"10.1016\/j.compbiolchem.2026.109099_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2023.106080","article-title":"Global epidemiology of HBV infection among hemodialysis patients: a systematic review and meta-analysis","volume":"179","author":"Khalesi","year":"2023","journal-title":"Microb. Pathog."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib24","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1093\/ndt\/gfac045","article-title":"Urea levels and cardiovascular disease in patients with chronic kidney disease","volume":"38","author":"Laville","year":"2023","journal-title":"Nephrol. Dial. Transplant."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109099_bib25","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s11255-022-03433-9","article-title":"Association between the triglyceride\u2013glucose index and chronic kidney disease in adults","volume":"55","author":"Liu","year":"2023","journal-title":"Int. Urol. Nephrol."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109099_bib26","first-page":"OC15","article-title":"A comparative study of lipid profile and cardiovascular risk biomarkers among chronic hemodialysis patients and healthy individuals","volume":"10","author":"Lokesh","year":"2016","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.compbiolchem.2026.109099_bib27","first-page":"9","article-title":"HDL and chronic kidney disease","volume":"52","author":"Pavanello","year":"2023","journal-title":"Atherosclerosis"},{"issue":"22","key":"10.1016\/j.compbiolchem.2026.109099_bib28","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.3390\/nu14224814","article-title":"Assessment of the nutritional status and quality of life in chronic kidney disease and kidney transplant patients: a comparative analysis","volume":"14","author":"Pawlaczyk","year":"2022","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12882-022-03014-z","article-title":"The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease","volume":"24","author":"Pistis","year":"2023","journal-title":"BMC Nephrol."},{"issue":"5","key":"10.1016\/j.compbiolchem.2026.109099_bib30","doi-asserted-by":"crossref","first-page":"S4804","DOI":"10.4103\/jpbs.jpbs_1207_24","article-title":"Comparative assessment of blood parameters including RBC, Hb, PCV, red cell indices, serum ferritin, and salivary candidal growth in female patients with iron deficiency anemia and iron deficiency","volume":"16","author":"Saba","year":"2024","journal-title":"J. Pharm. Bioallied Sci."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib31","article-title":"The study of pattern of lipid profile in chronic kidney disease patients on conservative management and hemodialysis: a comparative study","volume":"14","author":"Saini","year":"2022","journal-title":"Cureus"},{"issue":"7","key":"10.1016\/j.compbiolchem.2026.109099_bib32","doi-asserted-by":"crossref","first-page":"115","DOI":"10.14715\/cmb\/2024.70.7.16","article-title":"Evaluation of serum ferritin level and hepatitis B and hepatitis C viral infection in chronic hemodialysis patients","volume":"70","author":"Shawgery","year":"2024","journal-title":"Cell. Mol. Biol."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109099_bib33","doi-asserted-by":"crossref","first-page":"141","DOI":"10.18231\/j.ijpo.2023.030","article-title":"Clinico-pathological correlation study in chronic kidney disease patients undergoing hemodialysis","volume":"10","author":"Shruthi","year":"2023","journal-title":"Indian J. Pathol. Oncol."},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109099_bib34","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3390\/nu10091173","article-title":"Impact of inflammation on ferritin, hepcidin and the management of iron deficiency anemia in chronic kidney disease","volume":"10","author":"Ueda","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.compbiolchem.2026.109099_bib35","first-page":"181","article-title":"Iron deficiency anemia, anemia of chronic disease, iron overload: use of hepcidin as a laboratory marker in the diagnosis along with its therapeutic implications and management of iron homeostasis","volume":"12","author":"Varghese","year":"2022","journal-title":"Int J. Sci. Res Pub"},{"issue":"4","key":"10.1016\/j.compbiolchem.2026.109099_bib36","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/ckj\/sfac266","article-title":"Interaction effect between fasting plasma glucose and lipid profiles on mortality of peritoneal dialysis patients","volume":"16","author":"Xu","year":"2023","journal-title":"Clin. Kidney J."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109099_bib37","doi-asserted-by":"crossref","first-page":"835","DOI":"10.5551\/jat.RV22006","article-title":"Role of chronic kidney disease (CKD)\u2013mineral and bone disorder (MBD) in the pathogenesis of cardiovascular disease in CKD","volume":"30","author":"Yamada","year":"2023","journal-title":"J. Atheroscler. Thromb."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib38","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1038\/s41598-018-36437-6","article-title":"Association of hepatitis C and B virus infection with CKD and impact of hepatitis C treatment on CKD","volume":"9","author":"Zhang","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109099_bib39","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12981-023-00546-8","article-title":"Prevalence and risk factors for kidney disease among hospitalized PLWH in China","volume":"20","author":"Zhao","year":"2023","journal-title":"AIDS Res. Ther."},{"issue":"11","key":"10.1016\/j.compbiolchem.2026.109099_bib40","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/14728222.2022.2161887","article-title":"Kidney and lipids: novel potential therapeutic targets for dyslipidemia in kidney disease?","volume":"26","author":"Zuzda","year":"2022","journal-title":"Expert Opin. Ther. Targets"}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126002240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126002240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T20:26:20Z","timestamp":1781814380000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126002240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":40,"alternative-id":["S1476927126002240"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109099","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of biomarker profiles in chronic kidney disease with and without hepatitis B co-infection in Iraq","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109099"}}