{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:07:13Z","timestamp":1785546433091,"version":"3.56.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.compbiolchem.2026.109205","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T06:22:51Z","timestamp":1782109371000},"page":"109205","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["An optimized cascaded transformer with progressive attention for lung and colon cancer diagnosis from histopathological images"],"prefix":"10.1016","volume":"124","author":[{"given":"Azam","family":"Pasha MD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Narayana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.compbiolchem.2026.109205_bib1","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.3390\/cancers15133300","article-title":"Al-biruni Earth radius optimization with transfer learning based histopathological image analysis for lung and colon cancer detection","volume":"15","author":"AlGhamdi","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109205_bib2","doi-asserted-by":"crossref","first-page":"20434","DOI":"10.1038\/s41598-024-71302-9","article-title":"Exploiting histopathological imaging for early detection of lung and colon cancer via ensemble deep learning model","volume":"14","author":"Alotaibi","year":"2024","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109205_bib3","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1007\/s10462-019-09732-5","article-title":"Novel meta-heuristic bald eagle search optimisation algorithm","volume":"53","author":"Alsattar","year":"2020","journal-title":"Artif. Intell. Rev."},{"issue":"12","key":"10.1016\/j.compbiolchem.2026.109205_bib4","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.3390\/diagnostics12122926","article-title":"A framework for lung and colon cancer diagnosis via lightweight deep learning models and transformation methods","volume":"12","author":"Attallah","year":"2022","journal-title":"Diagnostics"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2023.104692","article-title":"Deep feature selection using adaptive \u03b2-Hill Climbing aided whale optimization algorithm for lung and colon cancer detection","volume":"83","author":"Bhattacharya","year":"2023","journal-title":"Biomed. Signal. Process. Control."},{"issue":"3","key":"10.1016\/j.compbiolchem.2026.109205_bib6","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1007\/s11517-023-02984-y","article-title":"A feature engineering-based machine learning technique to detect and classify lung and colon cancer from histopathological images","volume":"62","author":"Chhillar","year":"2024","journal-title":"Med. Biol. Eng. Comput."},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109205_bib7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3390\/life13020348","article-title":"Gaussian blurring technique for detecting and classifying acute lymphoblastic leukemia cancer cells from microscopic biopsy images","volume":"13","author":"Devi","year":"2023","journal-title":"Life"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.eswa.2024.124114","article-title":"A novel hybrid model for lung and colon cancer detection using pre-trained deep learning and KELM","volume":"252","author":"Gowthamy","year":"2024","journal-title":"Expert. Syst. Appl."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib9","series-title":"International Conference on Advanced Intelligent Systems and Informatics","first-page":"86","article-title":"A deep learning-based classification framework for annotated histopathology lung cancer images","author":"Hamed","year":"2023"},{"issue":"15","key":"10.1016\/j.compbiolchem.2026.109205_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11760-025-04891-1","article-title":"Resource efficient attention guided deep learning for histopathology based lung and colon cancer classification","volume":"19","author":"Hossain","year":"2025","journal-title":"Signal. Image Video Process."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib11","series-title":"2022 12th International Conference on Cloud Computing, Data Science & Engineering","first-page":"411","article-title":"Lung cancer detection using ensemble of machine learning models","author":"Jehangir","year":"2022"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.130856","article-title":"Recent achievements and challenges on nanomaterial based electrochemical biosensors for the detection of colon and lung cancer biomarkers","volume":"351","author":"Kaya","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib13","series-title":"2024 2nd International Conference on Computer, Communication and Control (IC4)","first-page":"1","article-title":"Detecting colon and lung cancer through deep learning CNN model","author":"Kumar","year":"2024"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bspc.2022.103596","article-title":"An empirical study of handcrafted and dense feature extraction techniques for lung and colon cancer classification from histopathological images","volume":"75","author":"Kumar","year":"2022","journal-title":"Biomed. Signal. Process. Control."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109205_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13045-021-01213-z","article-title":"Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990\u20132019","volume":"14","author":"Lin","year":"2021","journal-title":"J. Hematol. & Oncol."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib16","doi-asserted-by":"crossref","first-page":"25657","DOI":"10.1109\/ACCESS.2022.3150924","article-title":"Malignancy detection in lung and colon histopathology images using transfer learning with class selective image processing","volume":"10","author":"Mehmood","year":"2022","journal-title":"IEEe Access."},{"issue":"6","key":"10.1016\/j.compbiolchem.2026.109205_bib17","doi-asserted-by":"crossref","first-page":"17491","DOI":"10.1007\/s11042-023-16141-y","article-title":"Non-linear kernel-based error function for extended Kalman filter oriented robust control of cancer chemotherapy","volume":"83","author":"Mohite","year":"2024","journal-title":"Multimed. Tools Appl."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib18","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/j.procs.2023.01.164","article-title":"Classification of lung cancer using lightweight deep neural networks","volume":"218","author":"Mothkur","year":"2023","journal-title":"Procedia Comput. Sci."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109205_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/cpe.7444","article-title":"Removal of noise on mammogram breast images using filtering methods","volume":"35","author":"Mudrakola","year":"2023","journal-title":"Concurr. Comput. Pract. Exp."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib20","doi-asserted-by":"crossref","first-page":"64396","DOI":"10.1109\/ACCESS.2024.3397040","article-title":"Advancing oncology diagnostics: AI-enabled early detection of lung cancer through hybrid histological image analysis","volume":"12","author":"Noaman","year":"2024","journal-title":"IEEE Access."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2020.104003","article-title":"A comprehensive review of deep learning in colon cancer","volume":"126","author":"Pacal","year":"2020","journal-title":"Comput. Biol. Med."},{"issue":"03","key":"10.1016\/j.compbiolchem.2026.109205_bib22","doi-asserted-by":"crossref","DOI":"10.1142\/S0219467825500275","article-title":"Development of trio optimal feature extraction model for attention-based adaptive weighted rnn-based lung and colon cancer detection framework using histopathological images","volume":"25","author":"Pasha","year":"2025","journal-title":"Int. J. Image Graph."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib23","first-page":"438","article-title":"Ensemble transfer learning for lung cancer detection","author":"Phankokkruad","year":"2021","journal-title":"2021 4th Int. Conf. data Sci. Inf. Technol."},{"issue":"17","key":"10.1016\/j.compbiolchem.2026.109205_bib24","doi-asserted-by":"crossref","first-page":"52867","DOI":"10.1007\/s11042-023-17616-8","article-title":"Ensemble methods for computed tomography scan images to improve lung cancer detection and classification","volume":"83","author":"Quasar","year":"2024","journal-title":"Multimed. Tools Appl."},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109205_bib25","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3390\/biom12081021","article-title":"Molecular biomarkers in cancer","volume":"12","author":"Sarhadi","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib26","series-title":"2024 2nd International Conference on Electrical Engineering and Automatic Control (ICEEAC) 1-6","article-title":"Deep learning techniques for colorectal cancer detection: convolutional neural networks vs vision transformers","author":"Sari","year":"2024"},{"issue":"9","key":"10.1016\/j.compbiolchem.2026.109205_bib27","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.3390\/cancers13092025","article-title":"A review of colorectal cancer in terms of epidemiology, risk factors, development, symptoms and diagnosis","volume":"13","author":"Sawicki","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib28","article-title":"Lung and colon cancer histopathological image classification using 1d convolutional channel-based attention networks","volume":"37","author":"Shahadat","year":"2024","journal-title":"Int. FLAIRS Conf. Proc."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib29","article-title":"Prediction of lung cancer using ensemble classifiers","volume":"2161","author":"Shanbhag","year":"2022"},{"issue":"8","key":"10.1016\/j.compbiolchem.2026.109205_bib30","first-page":"4149","article-title":"An approach to classify lung and colon cancer of histopathology images using deep feature extraction and an ensemble method","volume":"15","author":"Singh","year":"2023","journal-title":"Int. J. Inf. Technol."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib31","series-title":"2023 International conference on electrical, computer and communication engineering (ECCE)","first-page":"1","article-title":"Detection of colon cancer using inception v3 and ensembled cnn model","author":"Swarna","year":"2023"},{"key":"10.1016\/j.compbiolchem.2026.109205_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.eswa.2022.117695","article-title":"Machine learning-based lung and colon cancer detection using deep feature extraction and ensemble learning","volume":"205","author":"Talukder","year":"2022","journal-title":"Expert. Syst. Appl."},{"key":"10.1016\/j.compbiolchem.2026.109205_bib33","article-title":"Lung and colon cancer detection with convolutional neural networks on histopathological images","volume":"2654","author":"Wahid","year":"2023"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109205_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0298452","article-title":"EPANet-KD: Efficient progressive attention network for fine-grained provincial village classification via knowledge distillation","volume":"19","author":"Zhang","year":"2024","journal-title":"Plos. One"},{"issue":"2","key":"10.1016\/j.compbiolchem.2026.109205_bib35","doi-asserted-by":"crossref","first-page":"852","DOI":"10.3390\/ijms23020852","article-title":"Novel diagnostic biomarkers in colorectal cancer","volume":"23","author":"Zygulska","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003324?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003324?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:42:24Z","timestamp":1785541344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126003324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S1476927126003324"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109205","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An optimized cascaded transformer with progressive attention for lung and colon cancer diagnosis from histopathological images","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109205","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"109205"}}