{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:07:00Z","timestamp":1785546420876,"version":"3.56.0"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100016724","name":"Postgraduate Institute of Medical Education and Research, Chandigarh","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016724","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["IIRPSG\\u22122024\\u201301\\u201306555"],"award-info":[{"award-number":["IIRPSG\\u22122024\\u201301\\u201306555"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Computational Biology and Chemistry"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.compbiolchem.2026.109210","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T16:28:20Z","timestamp":1782404900000},"page":"109210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Blood-based biomarker discovery through integrative transcriptomic and miRNA network analyses in schizophrenia, major depressive disorder, and bipolar disorder"],"prefix":"10.1016","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7501-9502","authenticated-orcid":false,"given":"Shubhankhi","family":"Dey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5202-2904","authenticated-orcid":false,"given":"Adhish","family":"Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-1587","authenticated-orcid":false,"given":"Prasenjit","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.compbiolchem.2026.109210_bib1","doi-asserted-by":"crossref","first-page":"24128","DOI":"10.1021\/acsomega.1c03637","article-title":"mRNA expression of the CUB and sushi multiple domains 1 (CSMD1) and its serum protein level as predictors for psychosis in the familial high-risk children and young adults","volume":"6","author":"Abd El Gayed","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s40263-025-01195-3","article-title":"Peripheral immune-inflammatory pathways in major depressive disorder, bipolar disorder, and schizophrenia: exploring their potential as treatment targets","volume":"39","author":"Almulla","year":"2025","journal-title":"CNS Drugs"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib3","doi-asserted-by":"crossref","first-page":"D1038","DOI":"10.1093\/nar\/gky1151","article-title":"OMIM.org: leveraging knowledge across phenotype\u2013gene relationships","volume":"47","author":"Amberger","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib4","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-025-04351-0","article-title":"A comprehensive review on schizophrenia: epidemiology, pathogenesis, diagnosis, conventional treatments, and proposed natural compounds used for management","author":"Anwar","year":"2025","journal-title":"Naunyn-Schmiede \u2019S. Arch. Pharmacol."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.905328","article-title":"Advancements in genomic and behavioral neuroscience analysis for the study of normal and pathological brain function","volume":"15","author":"Baratta","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib6","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/jnr.22647","article-title":"Transcription and pathway analysis of the superior temporal cortex and anterior prefrontal cortex in schizophrenia","volume":"89","author":"Barnes","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib7","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.15","article-title":"ImmPort, toward repurposing of open access immunological assay data for translational and clinical research","volume":"5","author":"Bhattacharya","year":"2018","journal-title":"Sci. Data"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3390\/genes16060665","article-title":"The complex role of the miR-17-92 cluster in stroke: mechanistic insights and biomarker potential","volume":"16","author":"Braicu","year":"2025","journal-title":"Genes. (Basel)"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib10","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09915","article-title":"Modelling schizophrenia using human induced pluripotent stem cells","volume":"473","author":"Brennand","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib11","doi-asserted-by":"crossref","first-page":"D1467","DOI":"10.1093\/nar\/gkae1128","article-title":"Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery","volume":"53","author":"Buniello","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib12","series-title":"Transcription Factor Regulatory Networks","first-page":"185","article-title":"MicroRNA regulatory network analysis using miRNet 2.0","author":"Chang","year":"2023"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib13","doi-asserted-by":"crossref","first-page":"W244","DOI":"10.1093\/nar\/gkaa467","article-title":"miRNet 2.0: network-based visual analytics for miRNA functional analysis and systems biology","volume":"48","author":"Chang","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib14","article-title":"A Conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib15","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.jad.2025.02.069","article-title":"Schizophrenia, bipolar disorder and major depressive disorder are probably not risk factors for cardiovascular disease: a Mendelian randomized study","volume":"377","author":"Chen","year":"2025","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41537-025-00564-7","article-title":"Classification of schizophrenia, bipolar disorder and major depressive disorder with comorbid traits and deep learning algorithms","volume":"11","author":"Chen","year":"2025","journal-title":"Schizophr"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib17","doi-asserted-by":"crossref","first-page":"D138","DOI":"10.1093\/nar\/gkad965","article-title":"NCBI GEO: archive for gene expression and epigenomics data sets: 23-year update","volume":"52","author":"Clough","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuron.2019.05.013","article-title":"Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia","volume":"103","author":"Collado-Torres","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41392-024-01738-y","article-title":"Major depressive disorder: hypothesis, mechanism, prevention and treatment","volume":"9","author":"Cui","year":"2024","journal-title":"Sig Transduct. Target. Ther."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.609487","article-title":"Concepts of neuroinflammation and their relationship with impaired mitochondrial functions in bipolar disorder","volume":"15","author":"Cyrino","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib21","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1038\/s41380-025-03085-y","article-title":"Central-peripheral neuroimmune dynamics in psychological stress and depression: insights from current research","volume":"30","author":"Feng","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"9","author":"GBD 2019 Mental Disorders Collaborators","year":"2022","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib23","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib24","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.3390\/brainsci14121199","article-title":"Mitochondrial Dysfunction as a Biomarker of Illness State in Bipolar Disorder: A Critical Review","volume":"14","author":"Gim\u00e9nez-Palomo","year":"2024","journal-title":"Brain Sci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib25","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41380-019-0634-7","article-title":"The genetics of bipolar disorder","volume":"25","author":"Gordovez","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib26","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3390\/ijms19030879","article-title":"The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors","volume":"19","author":"Gruszka","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib27","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1590\/1516-4446-2020-0650","article-title":"Prevalence and correlates of major depressive disorder: a systematic review","volume":"42","author":"Guti\u00e9rrez-Rojas","year":"2020","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib28","doi-asserted-by":"crossref","first-page":"D514","DOI":"10.1093\/nar\/gki033","article-title":"Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders","volume":"33","author":"Hamosh","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003964","article-title":"The Cerebral Microvasculature in Schizophrenia: A Laser Capture Microdissection Study","volume":"3","author":"Harris","year":"2008","journal-title":"PLoS. ONE"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib30","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12859-015-0611-3","article-title":"InteractiVenn: a web-based tool for the analysis of sets through Venn diagrams","volume":"16","author":"Heberle","year":"2015","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib31","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.mp.4001437","article-title":"Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders","volume":"9","author":"Iwamoto","year":"2004","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib32","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkae909","article-title":"KEGG: biological systems database as a model of the real world","volume":"53","author":"Kanehisa","year":"2024","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib33","doi-asserted-by":"crossref","first-page":"5920","DOI":"10.1038\/s41598-022-10038-w","article-title":"Alteration of cortical functional networks in mood disorders with resting-state electroencephalography","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib34","first-page":"12","article-title":"Excitatory and inhibitory synaptic dysfunction in mania: an emerging hypothesis from animal model studies","volume":"50","author":"Lee","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib35","doi-asserted-by":"crossref","DOI":"10.5498\/wjp.v15.i8.106887","article-title":"Global burden of mental disorders in 204 countries and territories results from the Global Burden of Disease Study 2021","volume":"15","author":"Mao","year":"2025","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1356817","article-title":"Editorial: Comorbidity in bipolar disorder and schizophrenia, volume III","volume":"14","author":"Martinotti","year":"2024","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib37","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/mp.2009.18","article-title":"Analysis of gene expression in two large schizophrenia cohorts identifies multiple changes associated with nerve terminal function","volume":"14","author":"Maycox","year":"2009","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib38","doi-asserted-by":"crossref","first-page":"7212","DOI":"10.3390\/ijms26157212","article-title":"Microglia-Mediated Neuroinflammation Through Phosphatidylinositol 3-Kinase Signaling Causes Cognitive Dysfunction","volume":"26","author":"Maziz","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib39","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.biopha.2018.08.097","article-title":"The emerging roles of the polycistronic miR-106b\u223c25 cluster in cancer \u2013 A comprehensive review","volume":"107","author":"Mehlich","year":"2018","journal-title":"Biomed. & Pharmacother."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2017.00083","article-title":"Neurovascular Unit Dysfunction and Blood\u2013Brain Barrier Hyperpermeability Contribute to Schizophrenia Neurobiology: A Theoretical Integration of Clinical and Experimental Evidence","volume":"8","author":"Najjar","year":"2017","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib41","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res. 48 D845D855"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib42","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2025.1574458","article-title":"Deciphering transcriptomic signatures in schizophrenia, bipolar disorder, and major depressive disorder","volume":"16","author":"Priyanka","year":"2025","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib43","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.neubiorev.2014.11.005","article-title":"Mitochondrial dysfunction in schizophrenia: Pathways, mechanisms and implications","volume":"48","author":"Rajasekaran","year":"2015","journal-title":"Neurosci. & Biobehav. Rev."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib44","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3390\/antiox13060709","article-title":"The Underlying Neurobiological Mechanisms of Psychosis: Focus on Neurotransmission Dysregulation, Neuroinflammation, Oxidative Stress, and Mitochondrial Dysfunction","volume":"13","author":"Rawani","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib45","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib46","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.mito.2020.11.009","article-title":"Mitochondrial dysfunction in schizophrenia: With a focus on postmortem studies","volume":"56","author":"Roberts","year":"2021","journal-title":"Mitochondrion"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib47","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/sj.mp.4001875","article-title":"Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes","volume":"11","author":"Ryan","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib48","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1016\/j.csbj.2022.08.037","article-title":"Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders","volume":"20","author":"Sadeghi","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib49","series-title":"Practical Guide to Life Science Databases","first-page":"27","article-title":"The GeneCards Suite","author":"Safran","year":"2021"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0020141","article-title":"A Systematic Review of the Prevalence of Schizophrenia","volume":"2","author":"Saha","year":"2005","journal-title":"PLOS Med."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib51","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s00702-022-02567-5","article-title":"Neurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors","volume":"130","author":"Schmitt","year":"2023","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.119464","article-title":"Transdiagnostic findings across major depressive disorder, bipolar disorder and schizophrenia: A qualitative review","volume":"387","author":"Stein","year":"2025","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.compbiolchem.2026.109210_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/cpbi.5","article-title":"The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses","volume":"54","author":"Stelzer","year":"2016","journal-title":"Curr. Protoc. Bioinforma."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib54","doi-asserted-by":"crossref","first-page":"D730","DOI":"10.1093\/nar\/gkae1113","article-title":"The STRING database in 2025: protein networks with directionality of regulation","volume":"53","author":"Szklarczyk","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib55","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/pro.3307","article-title":"The human protein atlas: A spatial map of the human proteome","volume":"27","author":"Thul","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib56","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.3390\/ijms23052810","article-title":"Neuroinflammation in Schizophrenia: The Key Role of the WNT\/\u03b2-Catenin Pathway","volume":"23","author":"Vall\u00e9e","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib57","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.4","article-title":"Immune involvement in the pathogenesis of schizophrenia: a meta-analysis on postmortem brain studies","volume":"7","author":"van Kesteren","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib58","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/15366367.2019.1565254","article-title":"ggplot2: Elegant Graphics for Data Analysis (2nd ed.)","volume":"17","author":"Villanueva","year":"2019","journal-title":"Meas. Interdiscip. Res. Perspect."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib59","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gkv403","article-title":"DIANA-miRPath v3.0: deciphering microRNA function with experimental support","volume":"43","author":"Vlachos","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib60","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/s41398-020-0694-0","article-title":"Circadian rhythm disruption and mental health","volume":"10","author":"Walker","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib61","article-title":"Identification of differentially expressed genes of blood leukocytes for Schizophrenia","volume":"15","author":"Wang","year":"2024","journal-title":"Front. Genet."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib62","article-title":"Therapeutic target database 2020: enriched resource for facilitating research and early development of targeted therapeutics","author":"Wang","year":"2020","journal-title":"Nucleic Acids Res. 48 D1031D1041"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib63","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s43856-025-00957-w","article-title":"Temporal trends of blood-based markers in various psychiatric disorders and their cross-sectional brain structure associations","volume":"5","author":"Wang","year":"2025","journal-title":"Commun. Med."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib64","article-title":"TLR4 identified as a major depressive disorder gene signature mediating effects through multiple immune cells","volume":"15","author":"Wei","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib65","series-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"10.1016\/j.compbiolchem.2026.109210_bib66","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.tins.2020.08.004","article-title":"Circuit-based biomarkers for mood and anxiety disorders","volume":"43","author":"Xia","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114755","article-title":"Role of MAPK and PI3K-Akt signaling pathways in cuprizone-induced demyelination and cognitive impairment in mice","volume":"458","author":"Xu","year":"2024","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib68","doi-asserted-by":"crossref","first-page":"5054","DOI":"10.1016\/j.csbj.2022.09.014","article-title":"Classification for psychiatric disorders including schizophrenia, bipolar disorder, and major depressive disorder using machine learning","volume":"20","author":"Yang","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2023.1192544","article-title":"Differentiation between bipolar disorder and major depressive disorder in adolescents: from clinical to biological biomarkers","volume":"17","author":"Yang","year":"2023","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib70","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2174\/1570159X14666160119094646","article-title":"Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets","volume":"14","author":"Zhang","year":"2016","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib71","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jpsychires.2024.07.054","article-title":"Change in the global burden of depression from 1990-2019 and its prediction for 2030","volume":"178","author":"Zhang","year":"2024","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib72","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: a visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.compbiolchem.2026.109210_bib73","doi-asserted-by":"crossref","first-page":"D1465","DOI":"10.1093\/nar\/gkad751","article-title":"TTD: therapeutic target database describing target druggability information","volume":"52","author":"Zhou","year":"2024","journal-title":"Nucleic Acids Res."}],"container-title":["Computational Biology and Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1476927126003373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:45:18Z","timestamp":1785541518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1476927126003373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":73,"alternative-id":["S1476927126003373"],"URL":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109210","relation":{},"ISSN":["1476-9271"],"issn-type":[{"value":"1476-9271","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blood-based biomarker discovery through integrative transcriptomic and miRNA network analyses in schizophrenia, major depressive disorder, and bipolar disorder","name":"articletitle","label":"Article Title"},{"value":"Computational Biology and Chemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.compbiolchem.2026.109210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"109210"}}